scholarly journals A Design of Experiment (DoE) approach to optimise spray drying process conditions for the production of trehalose/leucine formulations with application in pulmonary delivery

2019 ◽  
Vol 562 ◽  
pp. 228-240 ◽  
Author(s):  
S. Focaroli ◽  
P.T. Mah ◽  
J.E. Hastedt ◽  
I. Gitlin ◽  
S. Oscarson ◽  
...  
2007 ◽  
Vol 534-536 ◽  
pp. 133-136 ◽  
Author(s):  
Byoung Kee Kim ◽  
Yong Jin Kim ◽  
Jin Chun Kim

Ni59Zr20Ti16Si2Sn3 bulk metallic glass (BMG) powders were produced by a gas atomization process, and ductile Cu powders were coated on the Ni-based BMG powders using a spray drying process in order to increase the ductility. Characteristics of the as-prepared powders with the atomization and spray drying process conditions were investigated. The atomization was conducted at 1450oC under the vacuum of 10-2 torr and the powders were mixed with water-soluble Cu nitrate. The mixture was sprayed at the temperature of 130oC to prepared initial powder. After reduction treatment, sub-micron size Cu powders were successfully coated on the surface of the atomized Ni BMG powders.


2011 ◽  
Vol 421 (1) ◽  
pp. 99-109 ◽  
Author(s):  
Maria Inês Amaro ◽  
Lidia Tajber ◽  
Owen I. Corrigan ◽  
Anne Marie Healy

Author(s):  
Ramona Huelsmann ◽  
Guenter J. Esper ◽  
Reinhard Kohlus

AbstractSpray drying is a widely used process to turn slurries into dry powders and is especially important for thermally-sensitive materials, that are often found in the food or pharmaceutical industry. However, detailed insight into the drying kinetics during spray drying is difficult to investigate due to the boundary conditions in a spray drying tower. As a result, there is a lack of important information on the drying process and subsequent solidification of individual droplets. In this context, an experimental setup for a droplet positioned in a stationary ultrasonic field of an acoustic levitator is designed to enable a non-contacting measurement of the drying kinetics and the subsequent solidification process. To generate a comparable situation like in a real spray drying process, the droplet is positioned in an airflow, where air temperature, humidity, and velocity can be adjusted over wide range. Using an infrared camera to measure the surface temperature and a Complementary Metal Oxide Semiconductor (CMOS) camera for object recognition, the droplet can be observed continuously and drying kinetics of the droplet can be determined from the measured surface temperature and decreasing droplet size. Result of a 10 wt.% aqueous micro particle TiO2 suspension are reported and show that the investigated method is a very valuable and fast tool to safely scale-up spray drying systems very close to real process conditions. Especially when only small sample amounts are available in an early development stage.


2015 ◽  
Vol 68 (1) ◽  
pp. 7509-7520 ◽  
Author(s):  
Esteban Largo Ávila ◽  
Misael Cortés Rodríguez ◽  
Héctor José Ciro Velásquez

Food powder liquid extracts obtained from fruits and vegetables can be manufactured using spray drying technologies while maintaining the quality attributes that are required by the industrial sector. The aim of this study was to evaluate the effect of maltodextrin and spray drying process conditions on sugarcane juice powder. A central composite design was used with a response surface analysis of four factors: (A) maltodextrin (10-20%), (B) inlet air temperature (130-150 °C), (C) outlet air temperature (75-85 °C) and (D) atomization speed (22,000-26,000 rpm). Moisture, hygroscopicity, solubility, effective recovery and formation of deposits on the walls presented significant differences (P<0.05) with respect to all factors, while, for water activity, no statistical differences were observed. The optimization of the factors found for the drying operating conditions were: (A) 20%, (B) 130 °C, (C) 75 °C and (D) 22,000 rpm, respectively.


2019 ◽  
Vol 39 (suppl 1) ◽  
pp. 48-55 ◽  
Author(s):  
Christine Maria Carneiro Maranhão RIBEIRO ◽  
Lidia Cristina dos Santos Alencar MAGLIANO ◽  
Marcella Melo Assis de COSTA ◽  
Taliana Kênia Alencar BEZERRA ◽  
Flavio Luiz Honorato da SILVA ◽  
...  

2019 ◽  
Vol 10 (1) ◽  
pp. 103-131 ◽  
Author(s):  
Elham Assadpour ◽  
Seid Mahdi Jafari

Many natural food bioactive ingredients are sensitive to processing and environmental conditions and thus it is necessary to improve their stability to create products with long shelf lives. Encapsulation by spray drying is a widely used economical strategy to tackle this issue, and many scientists and manufacturers are using it in their research, development, and production activities. In this review, the spray-drying process is described, as are recent trends in the encapsulation of fish oils, essential fatty acids, probiotics, phenolic compounds, and natural food colorants. The formulation and process conditions used in previous research and the results obtained are tabulated. Also, new innovations in bioactive encapsulation using nano–spray drying are described.


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