Coaxial fibers of poly(styrene-co-maleic anhydride)@poly(vinyl alcohol) for wound dressing applications: dual and sustained delivery of bioactive agents promoting fibroblast proliferation with reduced cell adherence

2021 ◽  
pp. 121292
Author(s):  
Laura Tamayo ◽  
Paula Santana ◽  
Juan C. Forero ◽  
Matías Leal ◽  
Nicolás González ◽  
...  
Keyword(s):  
Maleic Anhydride ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Poly Vinyl Alcohol ◽  
Sustained Delivery ◽  
Fibroblast Proliferation ◽  
Cell Adherence ◽  
Bioactive Agents ◽  
Coaxial Fibers

scholarly journals Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

Polymers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 2104
Author(s):  
Sibusiso Alven ◽  
Blessing Atim Aderibigbe
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Chronic Wounds ◽  
Cellular Adhesion ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
High Porosity ◽  
Hybrid Nanofibers

The management of chronic wounds is challenging. The factors that impede wound healing include malnutrition, diseases (such as diabetes, cancer), and bacterial infection. Most of the presently utilized wound dressing materials suffer from severe limitations, including poor antibacterial and mechanical properties. Wound dressings formulated from the combination of biopolymers and synthetic polymers (i.e., poly (vinyl alcohol) or poly (ε-caprolactone) display interesting properties, including good biocompatibility, improved biodegradation, good mechanical properties and antimicrobial effects, promote tissue regeneration, etc. Formulation of these wound dressings via electrospinning technique is cost-effective, useful for uniform and continuous nanofibers with controllable pore structure, high porosity, excellent swelling capacity, good gaseous exchange, excellent cellular adhesion, and show a good capability to provide moisture and warmth environment for the accelerated wound healing process. Based on the above-mentioned outstanding properties of nanofibers and the unique properties of hybrid wound dressings prepared from poly (vinyl alcohol) and poly (ε-caprolactone), this review reports the in vitro and in vivo outcomes of the reported hybrid nanofibers.

Effect of chitosan-gluconic acid conjugate/poly(vinyl alcohol) cryogels as wound dressing on partial-thickness wounds in diabetic rats

2013 ◽  
Vol 24 (10) ◽  
pp. 2479-2487 ◽  
Author(s):  
Takayuki Takei ◽  
Hideki Nakahara ◽  
Sadao Tanaka ◽  
Hiroto Nishimata ◽  
Masahiro Yoshida ◽  
...  
Keyword(s):  
Vinyl Alcohol ◽  
Gluconic Acid ◽  
Wound Dressing ◽  
Diabetic Rats ◽  
Poly Vinyl Alcohol ◽  
Partial Thickness ◽  
Acid Conjugate

scholarly journals Uncommon Sorption Mechanism of Aromatic Compounds onto Poly(Vinyl Alcohol)/Chitosan/Maleic Anhydride-β-Cyclodextrin Hydrogels

Polymers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 877 ◽  
Author(s):  
Cesar M. C. Filho ◽  
Pedro V. A. Bueno ◽  
Alan F. Y. Matsushita ◽  
Bruno H. Vilsinski ◽  
Adley F. Rubira ◽  
...  
Keyword(s):  
Maleic Anhydride ◽  
Aromatic Hydrocarbons ◽  
Aromatic Compounds ◽  
Vinyl Alcohol ◽  
Environmental Pollutants ◽  
Poly Vinyl Alcohol ◽  
Healthy Environment ◽  
First Order Kinetics ◽  
Hydrogel Matrix ◽  
Polycyclic Aromatic

Aromatic hydrocarbons are extensive environmental pollutants occurring in both water and air media, and their removal is a priority effort for a healthy environment. The use of adsorbents is among the several strategies used for the remediation of these compounds. In this paper, we aim the synthesis of an amphiphilic hydrogel with the potential for the simultaneous sorption of a set of monocyclic and polycyclic aromatic hydrocarbons associated with toxicity effects in humans. Thus, we start by the synthesis of a copolymer-based in chitosan and β-cyclodextrin previously functionalized with the maleic anhydride. The presence of β-cyclodextrin will confer the ability to interact with hydrophobic compounds. The resulting material is posteriorly incorporated in a cryogel of poly(vinyl alcohol) matrix. We aim to improve the amphiphilic ability of the hydrogel matrix. The obtained hydrogel was characterized by swelling water kinetics, thermogravimetric analysis, rheological measurements, and scanning electron microscopy. The sorption of aromatic hydrocarbons onto the gel is characterized by pseudo-first-order kinetics and Henry isotherm, suggesting a physisorption mechanism. The results show that the presence of maleic anhydride-β-cyclodextrin and chitosan into hydrogels leads to an increase in the removal efficiency of the aromatic compounds. Additionally, the capacity of this hydrogel for removing these pollutants from a fossil fuel sample has also been tested.

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