Cost-Effective Analysis of Hypofractionated Versus Standard 30-Fraction IMRT in Patients With Poor Prognosis Glioblastoma Multiforme

14638 Purpose: Retrospective comparison of treatment out come and cost effective analysis in two chemotherapeutic regimens (BEP vs. VIP) for poor-prognosis metastatic germ cell tumors in India, a resource poor nation. Methods: All male patients with poor risk germ cell tumors were included in the study between 2001–2003. The patients were stratified into two categories depending on the type of the regimens they received. Results: Finally 36 patients were analyzed with median follow up of 21.8 months. Medical 7.5 for windows was used for the analysis. The baseline characters (age, stage, PS, histology and serum markers) were not different in two treatment arms (P > 0.05). The different treatments (BEP vs. VIP) had no statistically significant influence on the outcome. VIP is less cost effective and more toxic compared to BEP. Conclusion: In view of absence of survival advantage and more toxicities as well as cost of therapy it would be appropriate to still treat the patients of high risk germ cell tumors with the conventional BEP rather than VIP in the Indian setting and keeping the later reserved for the relapse. [Table: see text] No significant financial relationships to disclose.

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Rich Patients With Poor Prognosis Get More Treatment

Internal Medicine News ◽

10.1016/s1097-8690(11)70628-x ◽

2011 ◽

Vol 44 (12) ◽

pp. 65

Author(s):

MARY JO M. DALES

Keyword(s):

Poor Prognosis ◽

Patients With Poor Prognosis

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Evaluating Population Programs: International Experience with Cost-Effective Analysis and Cost-Benefit Analysis

Population Studies ◽

10.1080/0032472031000142266 ◽

1986 ◽

Vol 40 (2) ◽

pp. 333-334

Author(s):

C. Chandrasekaran

Keyword(s):

Cost Benefit Analysis ◽

Cost Benefit ◽

Cost Effective ◽

International Experience ◽

Benefit Analysis ◽

Effective Analysis

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Recent Advances on Glioblastoma Multiforme and Nano-drug Carriers: A Review

Current Medicinal Chemistry ◽

10.2174/0929867325666180514113136 ◽

2019 ◽

Vol 26 (31) ◽

pp. 5862-5874 ◽

Cited By ~ 3

Author(s):

Wang Liao ◽

Shengnuo Fan ◽

Yuqiu Zheng ◽

Shaowei Liao ◽

Ying Xiong ◽

...

Keyword(s):

Stem Cells ◽

Glioblastoma Multiforme ◽

Self Assembly ◽

Poor Prognosis ◽

Drug Delivery Systems ◽

Drug Carriers ◽

Therapeutic Resistance ◽

Average Survival ◽

Nano Drug Delivery ◽

New Development

Glioblastoma Multiforme (GBM) is the most frequent glioma with a poor prognosis. The mainstay treatment for GBM is chemotherapy, but the average survival of GBM remains unsatisfactory due to therapeutic resistance. Poor permeability restricted by the Blood Brain Barrier (BBB) and the presence of Glioblastoma Stem Cells (GSCs) remain as two problems for chemotherapy. Recently, nanocarriers have attracted much attention in the research of GBM, owing to their advantages in self-assembly, biosafety, release controllability, and BBB penetrability, making them promising candidates for GBM treatment. This article aims to review the biologic signatures of BBB and GSCs, as well as the new development of nano-drug delivery systems to facilitate our understanding of targeted treatment for GBM.

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Glioblastoma: Prognostic Factors and Predictive Response to Radio and Chemotherapy

Current Medicinal Chemistry ◽

10.2174/0929867327666200131095256 ◽

2020 ◽

Vol 27 (17) ◽

pp. 2814-2825

Author(s):

Francesco Fiorica ◽

Maria Colella ◽

Rosaria Taibi ◽

Andrea Bonetti ◽

Jacopo Giuliani ◽

...

Keyword(s):

Prognostic Factors ◽

Glioblastoma Multiforme ◽

Poor Prognosis ◽

Therapeutic Strategy ◽

Biological Factors ◽

Near Future ◽

Predictive Response

: Glioblastoma multiforme (GBM) is characterized by poor prognosis despite an aggressive therapeutic strategy. In recent years, many advances have been achieved in the field of glioblastoma biology. : Here we try to summarize the main clinical and biological factors impacting clinical prognostication and therapy of GBM patients. From that standpoint, hopefully, in the near future, personalized therapies will be available.

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Meta-analysis and cost effective analysis of portal-superior mesenteric vein resection during pancreatoduodenectomy: Impact on margin status and survival

Surgical Oncology ◽

10.1016/j.suronc.2016.12.007 ◽

2017 ◽

Vol 26 (1) ◽

pp. 53-62 ◽

Cited By ~ 17

Author(s):

Richard Bell ◽

Braden Te Ao ◽

Natasha Ironside ◽

Adam Bartlett ◽

John A. Windsor ◽

...

Keyword(s):

Superior Mesenteric Vein ◽

Meta Analysis ◽

Cost Effective ◽

Margin Status ◽

Mesenteric Vein ◽

Vein Resection ◽

Effective Analysis

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Sustainable development path research on urban transportation based on synergistic and cost-effective analysis: A case of Guangzhou

Sustainable Cities and Society ◽

10.1016/j.scs.2021.102950 ◽

2021 ◽

Vol 71 ◽

pp. 102950

Author(s):

Jiandong Jiao ◽

Ying Huang ◽

Cuiping Liao ◽

Daiqing Zhao

Keyword(s):

Sustainable Development ◽

Urban Transportation ◽

Cost Effective ◽

Development Path ◽

Effective Analysis

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Suprabasin—A Review

Genes ◽

10.3390/genes12010108 ◽

2021 ◽

Vol 12 (1) ◽

pp. 108

Author(s):

Miroslav Pribyl ◽

Zdenek Hodny ◽

Iva Kubikova

Keyword(s):

Glioblastoma Multiforme ◽

Poor Prognosis ◽

Current Knowledge ◽

Original Description ◽

Oesophageal Carcinoma ◽

Secreted Proteins ◽

Cornified Envelope ◽

Physiological Conditions ◽

Signalling Molecules ◽

Human Genes

Among the ~22,000 human genes, very few remain that have unknown functions. One such example is suprabasin (SBSN). Originally described as a component of the cornified envelope, the function of stratified epithelia-expressed SBSN is unknown. Both the lack of knowledge about the gene role under physiological conditions and the emerging link of SBSN to various human diseases, including cancer, attract research interest. The association of SBSN expression with poor prognosis of patients suffering from oesophageal carcinoma, glioblastoma multiforme, and myelodysplastic syndromes suggests that SBSN may play a role in human tumourigenesis. Three SBSN isoforms code for the secreted proteins with putative function as signalling molecules, yet with poorly described effects. In this first review about SBSN, we summarised the current knowledge accumulated since its original description, and we discuss the potential mechanisms and roles of SBSN in both physiology and pathology.

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