Molecular pathways in sepsis-induced cardiomyocyte pyroptosis: novel finding on long non-coding RNA ZFAS1/miR-138-5p/SESN2 axis

Background: Long non-coding RNA rhabdomyosarcoma 2-associated transcript (LncRNA RMST) will affect every aspect of tumor progression, such as proliferation, translocation and apoptosis. As a result, RMST can be used as an attractive biomarker for early diagnosis and clinical therapies of different disease states. This article aims to review pathophysiological functions, molecular mechanisms as well as promising biotherapies of RMST in multiple tumors. Methods: Through the systematic induction and summary of 46 papers published in PubMed concerning this study, the molecular mechanisms of RMST in all kinds of tumors have been reviewed. Results: LncRNA RMST is a tumor-related regulatory mediator, aberrantly expressed in diverse tumors, regarding medullary thyroid cancer, hepatocellular carcinoma, endometrial carcinoma, colon cancer, pancreatic cancer, glioma, Wilm’s tumor and breast cancer. Furthermore, as a mechanism-based player, RMST probably guides the translation and post-translation modification, containing DNA methylation and SUMOylation. It is capable of regulating distinct tumor cells and stem cells of biological behaviors via various molecular pathways. Conclusion: LncRNA RMST, potentially as an original therapeutic target, is valuable in the occurrence, development and apoptosis of different tumors.

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STAT3 Pathway in Gastric Cancer: Signaling, Therapeutic Targeting and Future Prospects

Biology ◽

10.3390/biology9060126 ◽

2020 ◽

Vol 9 (6) ◽

pp. 126

Author(s):

Milad Ashrafizadeh ◽

Ali Zarrabi ◽

Sima Orouei ◽

Vahideh Zarrin ◽

Ebrahim Rahmani Moghadam ◽

...

Keyword(s):

Gastric Cancer ◽

Molecular Pathways ◽

Molecular Signaling ◽

Stat Proteins ◽

Stat3 Signaling ◽

Non Coding Rna ◽

Stat3 Signaling Pathway ◽

Proliferation And Metastasis ◽

Transcription 3 ◽

Long Non Coding Rna

Molecular signaling pathways play a significant role in the regulation of biological mechanisms, and their abnormal expression can provide the conditions for cancer development. The signal transducer and activator of transcription 3 (STAT3) is a key member of the STAT proteins and its oncogene role in cancer has been shown. STAT3 is able to promote the proliferation and invasion of cancer cells and induces chemoresistance. Different downstream targets of STAT3 have been identified in cancer and it has also been shown that microRNA (miR), long non-coding RNA (lncRNA) and other molecular pathways are able to function as upstream mediators of STAT3 in cancer. In the present review, we focus on the role and regulation of STAT3 in gastric cancer (GC). miRs and lncRNAs are considered as potential upstream mediators of STAT3 and they are able to affect STAT3 expression in exerting their oncogene or onco-suppressor role in GC cells. Anti-tumor compounds suppress the STAT3 signaling pathway to restrict the proliferation and malignant behavior of GC cells. Other molecular pathways, such as sirtuin, stathmin and so on, can act as upstream mediators of STAT3 in GC. Notably, the components of the tumor microenvironment that are capable of targeting STAT3 in GC, such as fibroblasts and macrophages, are discussed in this review. Finally, we demonstrate that STAT3 can target oncogene factors to enhance the proliferation and metastasis of GC cells.

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Innate immune responses and type 1 diabetes: A role for a long non-coding RNA?

Diabetologie und Stoffwechsel ◽

10.1055/s-0034-1374906 ◽

2014 ◽

Vol 9 (S 01) ◽

Author(s):

MP Ashton ◽

I Tan ◽

L Mackin ◽

C Elso ◽

E Chu ◽

...

Keyword(s):

Type 1 Diabetes ◽

Immune Responses ◽

Innate Immune ◽

Innate Immune Responses ◽

Non Coding Rna ◽

Long Non Coding Rna

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Long non-coding RNA CCAT1 is overexpressed in endometrial cancer and regulates growth and transcriptome of endometrial adenocarcinoma cells

10.1055/s-0040-1718183 ◽

2020 ◽

Author(s):

S Schüler-Toprak ◽

M Skrzypczak ◽

F Weber ◽

O Ortmann ◽

O Treeck

Keyword(s):

Endometrial Cancer ◽

Endometrial Adenocarcinoma ◽

Non Coding Rna ◽

Adenocarcinoma Cells ◽

Long Non Coding Rna

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Long non-coding RNA expression profiles in human parathyroid tumors

Endocrine Abstracts ◽

10.1530/endoabs.49.gp130 ◽

2017 ◽

Author(s):

Annamaria Morotti ◽

Irene Forno ◽

Valentina Andre ◽

Andrea Terrasi ◽

Chiara Verdelli ◽

...

Keyword(s):

Expression Profiles ◽

Rna Expression ◽

Parathyroid Tumors ◽

Non Coding Rna ◽

Long Non Coding Rna

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The Variant rs145204276 of GAS5 is Associated with the Development and Prognosis of Gastric Cancer

Journal of Gastrointestinal and Liver Diseases ◽

10.15403/jgld.2014.1121.271.qjl ◽

2018 ◽

Vol 27 (1) ◽

pp. 19-24 ◽

Cited By ~ 7

Author(s):

Qianjun Li ◽

Gang Ma ◽

Huimin Guo ◽

Suhua Sun ◽

Ying Xu ◽

...

Keyword(s):

Gastric Cancer ◽

Survival Rate ◽

Cancer Progression ◽

Regulatory Mechanism ◽

Tumor Stage ◽

Kaplan Meier ◽

Non Coding Rna ◽

Early Tumor ◽

Long Non Coding Rna ◽

Clinicopathological Variables

Background & Aims: Down-regulation of the growth arrest specific transcript 5 (GAS5) (long non-coding RNA) is associated with cell proliferation of gastric cancer (GC) and a poor prognosis. We aimed to investigate whether the variant rs145204276 of GAS5 is associated with the prognosis of GC in the Chinese population, and to unveil the regulatory mechanism underlying the GAS5 expression in GC tissues.Method: 1,253 GC patients and 1,354 healthy controls were included. The frequency of the genotype del/del and the allele del of rs145204276 were compared between the patients and the controls and between different subgroups of patients classified by clinicopathological variables. The overall survival rate was analyzed according to the Kaplan-Meier method using the log-rank test.Results: The frequency of genotype del/del was significantly lower in patients than in the controls (7.0% vs. 9.1%, p = 0.001). Kaplan-Meier analysis showed that genotype del/del was significantly associated with a higher survival rate (p = 0.01). Patients with late tumor stage were found to have a significantly lower rate of genotype del/del than those with an early tumor stage (4.9% vs. 8.8%, p = 0.01). Patients with UICC III and IV were found to have a significantly lower rate of genotype del/del than those with UICC I and II (5.3% vs. 8.1%, p = 0.02).Conclusion: The variant rs145204276 of GAS5 is associated with the development and prognosis of GC. The allele del of rs145204276 is associated with a remarkably lower incidence of cancer progression and metastasis.

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