scholarly journals The role of shockwaves in the enhancement of bone repair - from basic principles to clinical application

Injury ◽  
2021 ◽  
Author(s):  
Rainer Mittermayr ◽  
Nicolas Haffner ◽  
Xaver Feichtinger ◽  
Wolfgang Schaden
Keyword(s):  
Clinical Application ◽  
Bone Repair ◽  
Basic Principles

scholarly journals Quantum postulate vs. quantum nonlocality: on the role of the Planck constant in Bell’s argument

2021 ◽  
Vol 51 (1) ◽  
Author(s):  
Andrei Khrennikov
Keyword(s):  
Quantum Nonlocality ◽  
Quantum Mechanical ◽  
Quantum Foundations ◽  
Planck Constant ◽  
Variable Model ◽  
Basic Principles ◽  
Fundamental Feature ◽  
Hidden Variable ◽  
Bell Model

AbstractWe present a quantum mechanical (QM) analysis of Bell’s approach to quantum foundations based on his hidden-variable model. We claim and try to justify that the Bell model contradicts to the Heinsenberg’s uncertainty and Bohr’s complementarity principles. The aim of this note is to point to the physical seed of the aforementioned principles. This is the Bohr’s quantum postulate: the existence of indivisible quantum of action given by the Planck constant h. By contradicting these basic principles of QM, Bell’s model implies rejection of this postulate as well. Thus, this hidden-variable model contradicts not only the QM-formalism, but also the fundamental feature of the quantum world discovered by Planck.

scholarly journals Direct contribution of skeletal muscle mesenchymal progenitors to bone repair

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Anais Julien ◽  
Anuya Kanagalingam ◽  
Ester Martínez-Sarrà ◽  
Jérome Megret ◽  
Marine Luka ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Bone Healing ◽  
Bone Repair ◽  
Fibrotic Response ◽  
Mesenchymal Progenitors ◽  
Fibrotic Tissue ◽  
Bone Injury ◽  
Single Cell Rna Sequencing ◽  
Musculoskeletal Trauma

AbstractBone regenerates by activation of tissue resident stem/progenitor cells, formation of a fibrous callus followed by deposition of cartilage and bone matrices. Here, we show that mesenchymal progenitors residing in skeletal muscle adjacent to bone mediate the initial fibrotic response to bone injury and also participate in cartilage and bone formation. Combined lineage and single-cell RNA sequencing analyses reveal that skeletal muscle mesenchymal progenitors adopt a fibrogenic fate before they engage in chondrogenesis after fracture. In polytrauma, where bone and skeletal muscle are injured, skeletal muscle mesenchymal progenitors exhibit altered fibrogenesis and chondrogenesis. This leads to impaired bone healing, which is due to accumulation of fibrotic tissue originating from skeletal muscle and can be corrected by the anti-fibrotic agent Imatinib. These results elucidate the central role of skeletal muscle in bone regeneration and provide evidence that skeletal muscle can be targeted to prevent persistent callus fibrosis and improve bone healing after musculoskeletal trauma.

EXECUTIVE FUNCTIONS AND VOLUNTARY ACTIVITY (GENERAL PSYCHOLOGICAL AND NEUROPSYCHOLOGICAL APPROACH): OVERVIEW OF MODERN VIEWS

2021 ◽  
Author(s):  
Елена Владимировна Ординарцева ◽  
Алексей Анатольевич Сергиенко
Keyword(s):  
Executive Functions ◽  
Voluntary Activity ◽  
Basic Principles

В статье рассматриваются современные представления о произвольной деятельности и «исполнительных» функциях. Анализируются основные положения теории деятельности, подходы к изучению произвольной деятельности, а также понятие и роль «исполнительных» функций. Дается нейропсихологический анализ формирования исполни-тельных функций в онтогенезе. The article discusses modern ideas about voluntary activity and “executive” functions. The basic principles of the theory of activity, approaches to the study of voluntary activity, as well as the concept and role of “executive” functions are analyzed. A neuropsychological analysis of the executive functions’ formation in ontogenesis is given.

THE IMPORTANCE OF THE LAW "ON OPERATIONAL INSPECTION ACTIVITIES" IN THE IMPLEMENTATION OF PREVENTION OF OFFENSES

2021 ◽  
Vol 6 (6) ◽  
pp. 71-78
Author(s):  
Farxod Djurayev ◽  
Keyword(s):  
Legal Status ◽  
Legal Protection ◽  
Law Enforcement Officers ◽  
Joint Work ◽  
Basic Principles ◽  
The Law ◽  
Causes Of Crime ◽  
Prevention Of Crime

The article is devoted to the prevention of crime, maintenance of public order and early crime prevention, identification and elimination of the causes of crime in each district, family and individual, classification of each district depending on the crime situation in these regions and joint work to attract all forces and means to identify and eliminate the causes of crime, the role of the law "On operational-search activities" in the prevention of offenses, the concept of operational-search activities, the main tasks, basic principles; bodies carrying out operational-search activities, their legal status; types of operational-search measures and their comments regarding the procedure for conducting a search; social and legal protection of law enforcement officers and persons assisting in the conduct of such events, as well as their family members

The role of elevated levels of microRNA-155-5p and microRNA-124-5p in hyperuricemia and acute ischemic stroke

2021 ◽  
Vol 11 (10) ◽  
pp. 1674-1680
Author(s):  
Yuan Yao ◽  
Jun Yuan ◽  
Yanju Ma ◽  
Runxiu Zhu ◽  
Yong Ma
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Clinical Application ◽  
Cerebral Vasospasm ◽  
Rat Model ◽  
Inner Mongolia ◽  
Neuronal Apoptosis ◽  
Projection Neuron ◽  
Neuron Differentiation

Hyperuricemia is closely related to acute ischemic stroke (AIS). In our study, we investigated the pattern of miRNA-155-5p and miRNA-124-5p expressions along with its clinical application in AIS and hyperuricemia patients and in a hyperuricemia rat model by RT-qPCR. The hyperuricemia rat model was established, and we found that the levels of miRNA-155-5p and miRNA-124-5p were increased in the serum, brain and kidney tissues compared with those in the normal rats. We proved that the levels of miRNA-155-5p and miRNA-124-5p were also elevated in AIS, hyperuricemia and AIS accompanied with hyperuricemia patients enrolled from the department of neurology in Inner Mongolia People’s Hospital (IMPH). The miRNA-155-5p and miRNA-124-5p were mainly associated with neuronal apoptosis, cerebral vasospasm, neuron projection, neuron projection morphogenesis, neuron differentiation and exocytosis. The above results might provide clues for the study the pathogenesis of AIS and hyperuricemia.

The role of microRNA-26a in human cancer progression and clinical application

Tumor Biology ◽  
2016 ◽  
Vol 37 (6) ◽  
pp. 7095-7108 ◽  
Author(s):  
Jing Chen ◽  
Kai Zhang ◽  
Yuejuan Xu ◽  
Yanping Gao ◽  
Chen Li ◽  
...  
Keyword(s):  
Clinical Application ◽  
Cancer Progression ◽  
Human Cancer

Load-Regulating Mechanisms in Gait and Posture: Comparative Aspects

2000 ◽  
Vol 80 (1) ◽  
pp. 83-133 ◽  
Author(s):  
J. Duysens ◽  
F. Clarac ◽  
H. Cruse
Keyword(s):  
Functional Role ◽  
Stance Phase ◽  
Force Feedback ◽  
Sensory Information ◽  
Specific Load ◽  
Afferent Activity ◽  
Basic Principles ◽  
Load Sensing ◽  
The Central Nervous System

How is load sensed by receptors, and how is this sensory information used to guide locomotion? Many insights in this domain have evolved from comparative studies since it has been realized that basic principles concerning load sensing and regulation can be found in a wide variety of animals, both vertebrate and invertebrate. Feedback about load is not only derived from specific load receptors but also from other types of receptors that previously were thought to have other functions. In the central nervous system of many species, a convergence is found between specific and nonspecific load receptors. Furthermore, feedback from load receptors onto central circuits involved in the generation of rhythmic locomotor output is commonly found. During the stance phase, afferent activity from various load detectors can activate the extensor part in such circuits, thereby providing reinforcing force feedback. At the same time, the flexion is suppressed. The functional role of this arrangement is that activity in antigravity muscles is promoted while the onset of the next flexion is delayed as long as the limb is loaded. This type of reinforcing force feedback is present during gait but absent in the immoble resting animal.

scholarly journals Peningkatan Kualitas Sumber Daya Manusia Melalui Pelatihan Peranan Humas bagi Anggota Polresta Tangerang

2020 ◽  
Vol 3 (2) ◽  
pp. 75-82
Author(s):  
Heriyanti Heriyanti ◽  
◽  
Ummanah Ummanah ◽  
Resman Maharul Tambunan ◽  
◽  
...  
Keyword(s):  
Public Relations ◽  
Technology Development ◽  
Police Department ◽  
Media Relations ◽  
Basic Principles ◽  
The Public ◽  
Security Guards ◽  
The Government

The rapid technology development and information made public (community) being so critical to the policies was taken by the government. This requires police institution to maintain of security guards, public order, enforce the law, provides protection, aegis and service to the community. Public Relations (PR) is an agency which have a duty to understand and evaluate a variety of public opinion in order to help to create harmony between particular agencies with the public. In order to increase quality of human resources in Police Department are required personnel with the ability in resolving problems the happens in society. In resolving these problems, that needed cooperation between police department, college and the community. The contribution of college to police department and the community with conducting the devotion to the community in cooperation Polresta Tangerang. The method in use in devotion community is by providing training of the role of public relations to Polresta Tangerang members through zoom cloud meeting. The role of public relations training aimed at giving public knowledge include similarity in communication, public relations function, basic principles of public relations, the management of the community and management of media relations may be good quality police. The evaluation of the training be concluded that the training that performed capable of increase understanding participants on the role of public relations.

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