Protective effects of berberine hydrochloride on DSS-induced ulcerative colitis in rats

AbstractInflammatory bowel disease (IBD) are a heterogeneous group of disorders in the course dominated by chronic, recurrent gastrointestinal inflammation. It is believed that the activation of IBD occurs in patients with a genetic predisposition to their development. Chronic inflammation develops as a result of an excessive reaction of the immune system principally under the influence of environmental risk factors. Among them, it has been shown that the mechanism of oxidative stress is associated with the pathophysiology of inflammatory bowel disease, responsible for the commencement and progress of these diseases.was the relationship between single nucleotide polymorphisms (SNPs) of individual antioxidant enzymes, and the prevalence of inflammatory bowel disease that may be associated with increased levels of oxidative stress.A total of 111 IBD patients, including 65 patients with ulcerative colitis (UC) and 46 with Crohn’s disease (CD) and 125 healthy controls recruited from the Polish population, were genotyped forThe performed analysis of genetic polymorphisms of antioxidant enzymes showed that polymorphic variant of the CAT -262 C / T may have protective effects in patients with ulcerative colitis in the range of genotype C / T; OR = 0.49 (0.25-0.99), p = 0.044. Trend protective, but statistically unrelated, it was also observed for genotype T / T and T allele of the same polymorphism and genotypes and allelesIt has been shown that the polymorphism of antioxidant enzymes

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Protective effects of citrulline supplementation in ulcerative colitis rats

PLoS ONE ◽

10.1371/journal.pone.0240883 ◽

2020 ◽

Vol 15 (10) ◽

pp. e0240883

Author(s):

Bin Cai ◽

Min-hong Zhou ◽

Hua-li Huang ◽

A-cheng Zhou ◽

Zheng-da Chu ◽

...

Keyword(s):

Ulcerative Colitis ◽

Protective Effects

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Correction to: Protective Effects of Tyrosol Against DSS-Induced Ulcerative Colitis in Rats

Inflammation ◽

10.1007/s10753-019-01039-5 ◽

2019 ◽

Vol 42 (5) ◽

pp. 1692-1692

Author(s):

Mehmet Güvenç ◽

Mustafa Cellat ◽

Hüseyin Özkan ◽

İbrahim Ozan Tekeli ◽

Ahmet Uyar ◽

...

Keyword(s):

Ulcerative Colitis ◽

Protective Effects

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LUEM PUA RICE EXTRACT ATTENUATES THE SEVERITY OF DEXTRAN SULFATE SODIUMINDUCED ULCERATIVE COLITIS IN RATS THROUGH CHOLINOMIMETIC EFFECTS

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2021.v13s1.y0029 ◽

2021 ◽

pp. 5-8

Author(s):

KORNSUDA THIPART ◽

KUTCHARIN PHUNIKHOM ◽

ACHARAPORN NA LAMPANG NOENPLAB ◽

JINTANA SATTAYASAI

Keyword(s):

Ulcerative Colitis ◽

Guinea Pig ◽

Dextran Sulfate ◽

Activity Index ◽

Rice Variety ◽

Final Concentration ◽

Spleen Weight ◽

Dependent Manner ◽

Protective Effects ◽

Guinea Pig Ileum

Objective: The objective of the study was to investigate the effect of aqueous extract of unpolished dark purple glutinous Thai rice variety Luem Pua(LP) in dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in rat and the possible cholinomimetic effects of the extract.Methods: The effect of LP extract (0.5, 1, or 1.5 mg/ml final concentration) on ileum contraction was tested using isolated guinea pig ileum. Certainagonists (acetylcholine, tetramethylammonium, and clonidine) and antagonists (hexamethonium chloride and atropine) were studied to determinethe cholinomimetic effect of the extract. The effects of LP extract (5 g/kg/day) in DSS-induced UC model (drinking water was replaced with 3%DSS in water for 7 days) in rat were evaluated. On each day of treatment, the change of disease activity index (DAI) was recorded. At the end of theexperiments, rats were terminated and disease severity expressed as DAI, colon length, and spleen weight were determined.Results: LP extract at the concentration of 0.5, 1, and 1.5 mg/ml (final concentration) could contract the ileum in a dose-dependent manner and beblocked completely by atropine. Oral administration of LP extract could significantly attenuate the severity of DSS-induced UC as seen by the reductionof DAI, colon length, and spleen weight.Conclusion: Results in isolated guinea pig ileum suggest that LP might contain active substance that could activate muscarinic receptors. In additionto antioxidant activity, through activation of muscarinic receptor, might explain the protective effects of LP extract against DSS-induced UC in rats.

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Gardenia jasminoides Ellis Fruit Extracts Attenuated Colitis in 2,4,6-Trinitrobenzenesulfonic Acid-Induced Rats

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2021/9920379 ◽

2021 ◽

Vol 2021 ◽

pp. 1-11

Author(s):

Jing Liu ◽

Chao Yang ◽

Zhigui Wu ◽

Jianguo Pei ◽

Yao Chen ◽

...

Keyword(s):

Ulcerative Colitis ◽

Chemical Components ◽

Protective Agent ◽

Protective Effects ◽

Trinitrobenzenesulfonic Acid ◽

Fruit Extracts ◽

Gardenia Jasminoides ◽

Tnf Α ◽

Ameliorative Effect ◽

Gardenia Jasminoides Ellis

Ulcerative colitis (UC) is a relapsing inflammatory disease with an unknown precise etiology. The purpose of this study is to investigate the protective effects of Gardenia jasminoides Ellis fruit extracts (GFE) on 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats. GFE (50 mg/kg, 100 mg/kg) were administered orally for 7 days after induction. Meanwhile, the chemical components of GFE were performed by UPLC-QTOF-MS/MS. GFE significantly decreased DAI scores and ameliorated macroscopic and histologic damage. It also reduced the levels of MPO, NO, MDA, IL-1β, TNF-α, and IL-6, while increasing the level of SOD. Moreover, 56 components were identified in GFE using a UPLC-QTOF-MS/MS method, which can be categorized into six structural groups. Our results indicated that GFE has an ameliorative effect on TNBS-induced colitis in rats, which may further verify its anti-inflammatory and antioxidative properties. Therefore, GFE can be a promising protective agent of colitis that deserves further investigation.

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Metformin Exerts Anti-inflammatory and Mucus Barrier Protective Effects by Enriching Akkermansia muciniphila in Mice With Ulcerative Colitis

Frontiers in Pharmacology ◽

10.3389/fphar.2021.726707 ◽

2021 ◽

Vol 12 ◽

Author(s):

Haoran Ke ◽

Fang Li ◽

Wenlin Deng ◽

Zitong Li ◽

Siqi Wang ◽

...

Keyword(s):

Ulcerative Colitis ◽

Gut Microbiota ◽

Treated Group ◽

Protective Effects ◽

Microbiota Composition ◽

16S Rrna Analysis ◽

Akkermansia Muciniphila ◽

Anti Inflammatory ◽

Mucus Barrier ◽

Gut Microbiota Composition

The present study aimed to determine if metformin exerts anti-inflammatory and mucus-protective effects via the gut microbiota. Metformin has extensive benefits including anti-inflammatory effects. Previous studies showed that metformin changed the gut microbiota composition and increases the number of goblet cells. Intestinal dysbiosis and goblet cell depletion are important features of ulcerative colitis (UC). The underlying mechanism and whether metformin can improve the mucus barrier in UC remain unclear. Metformin (400 mg/kg/day) was administered to mice with dextran sulfate sodium (DSS)-induced UC for 2 wk to investigate the effects of metformin on the intestinal mucus barrier. The gut microbiota was depleted, using antibiotics, to explore its role in the mucus-protecting effects of metformin. Akkermansia muciniphila (A. muciniphila), which was enriched in metformin-treated mice, was administered to mice to investigate the effects of the bacteria on UC and the mucus barrier. Metformin attenuated DSS-induced UC in mice, as evidenced by the alleviation of diarrhea, hematochezia, and the decrease in body weight. The expression of mucin2, a prominent mucus barrier protein, was increased in the metformin-treated group compared to the DSS-treated group. Furthermore, fecal 16S rRNA analysis showed that metformin treatment changed the gut microbiota composition by increasing the relative abundance of Lactobacillus and Akkermansia species while decreasing Erysipelatoclostridium at the genus level. Antibiotic treatment partly abolished the anti-inflammatory and mucus-protecting effects of metformin. Administration of A. muciniphila alleviated the colonic inflammation and mucus barrier disruption. Metformin alleviated DSS-induced UC in mice and protected against cell damage via affecting the gut microbiota, thereby providing a new mechanism for the therapeutic effect of metformin in patients with UC. This study also provides evidence that A. muciniphila as a probiotic has potential benefits for UC.

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The protective effects of resveratrol on ulcerative colitis via changing the profile of Nrf2 and IL-1β protein

Molecular Biology Reports ◽

10.1007/s11033-020-05753-4 ◽

2020 ◽

Vol 47 (9) ◽

pp. 6941-6947

Author(s):

Milad Sabzevary-Ghahfarokhi ◽

Amin Soltani ◽

Francesco Luzza ◽

Tiziana Larussa ◽

Ghorbanali Rahimian ◽

...

Keyword(s):

Ulcerative Colitis ◽

Protective Effects

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Protective effects of tryptophan-catabolizing Lactobacillus plantarum KLDS 1.0386 against dextran sodium sulfate-induced colitis in mice

Food & Function ◽

10.1039/d0fo02622k ◽

2020 ◽

Vol 11 (12) ◽

pp. 10736-10747

Author(s):

Jialu Shi ◽

Peng Du ◽

Qinggang Xie ◽

Nana Wang ◽

Huizhen Li ◽

...

Keyword(s):

Ulcerative Colitis ◽

Acetic Acid ◽

Gut Microbiota ◽

Lactobacillus Plantarum ◽

Sodium Sulfate ◽

Dextran Sodium Sulfate ◽

Protective Effects ◽

Stat3 Signaling ◽

Stat3 Signaling Pathway ◽

Indole 3 Acetic Acid

L. plantarum KLDS 1.0386 combined with tryptophan alleviates ulcerative colitis (UC) induced by dextran sodium sulfate (DSS) by increasing the level of indole-3-acetic acid (IAA), stimulating the AHR/IL-22/STAT3 signaling pathway and regulating gut microbiota in mice.

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