scholarly journals Bisphenol A-induced DNA damages promote to lymphoma progression in human lymphoblastoid cells through aberrant CTNNB1 signaling pathway

iScience ◽  
2021 ◽  
pp. 102888
Author(s):  
Yin-Kai Chen ◽  
Yan-Yan Tan ◽  
Min Yao ◽  
Ho-Chen Lin ◽  
Mon-Hsun Tsai ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Signaling Pathway ◽  
Lymphoblastoid Cells ◽  
Dna Damages

scholarly journals Bisphenol A Initiates Excessive Premature Activation of Primordial Follicles in Mouse Ovaries via the PTEN Signaling Pathway

2017 ◽  
Vol 25 (4) ◽  
pp. 609-620 ◽  
Author(s):  
Ying Hu ◽  
Dong-zhi Yuan ◽  
Yi Wu ◽  
Lin-lin Yu ◽  
Liang-zhi Xu ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Signaling Pathway ◽  
Primordial Follicles

Bisphenol A and di(2-ethylhexyl) phthalate exert divergent effects on apoptosis and the Wnt/β-catenin pathway in zebrafish embryos: A possible mechanism of endocrine disrupting chemical action

2017 ◽  
Vol 33 (12) ◽  
pp. 901-910 ◽  
Author(s):  
Ünsal Veli Üstündağ ◽  
İsmail Ünal ◽  
Perihan Seda Ateş ◽  
A Ata Alturfan ◽  
Türkan Yiğitbaşı ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Signaling Pathway ◽  
Nuclear Antigen ◽  
Enzyme Linked Immunosorbent Assay ◽  
Minor Effect ◽  
Zebrafish Embryos ◽  
Chemical Action ◽  
Acridine Orange Staining ◽  
Endocrine Disrupting ◽  
Ethylhexyl Phthalate

Polyethylene terephthalate (PET) and polycarbonate (PC) are the most commonly used plastics in water bottles. Di(2-ethylhexyl) phthalate (DEHP) is used as a plasticizer in PET plastics, and bisphenol A (BPA) is used to produce PC. Both DEHP and BPA are known for their potential endocrine disrupting effects. The Wnt/β-catenin signaling pathway has important roles in cell proliferation, cell specification and cell fate determination during embryonic development. Recent reports suggest a link between the Wnt/β-catenin signaling pathway and apoptosis. The aim of this study was to investigate the relation between Wnt/β-catenin signaling and apoptosis in the case of BPA and DEHP exposure in zebrafish embryos. Accordingly, in vivo cell death was assessed using acridine orange staining, and reverse transcription polymerase chain reaction was used to determine the expressions of wnt3a, gsk3β and ccnd1. Proliferative cell nuclear antigen, β-catenin and Wnt3a expressions were determined immunohistochemically. Vitellogenin levels were determined using Enzyme Linked ImmunoSorbent Assay (ELISA). Increased vitellogenin levels, apoptosis, and wnt3a and gsk3β expressions were observed in BPA-exposed zebrafish embryos. Increased apoptosis in the BPA-exposed embryos may be due to the pro-apoptotic changes induced by Wnt3a, whereas DEHP might be suggested to have a minor effect as Wnt3a expression; vitellogenin levels and apoptosis did not increase significantly following exposure to DEHP.

scholarly journals DNA oxidation induced by fetal exposure to BPA agonists impairs female meiosis

2020 ◽  
Author(s):  
Sonia Abdallah ◽  
Delphine Moison ◽  
Margaux Wieckowski ◽  
Sébastien Messiaen ◽  
Emmanuelle Martini ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Endocrine Disruptors ◽  
In Utero ◽  
Dna Oxidation ◽  
Common Mechanism ◽  
Fetal Exposure ◽  
Female Meiosis ◽  
Dna Damages ◽  
Germ Cell Differentiation ◽  
Bpa Analogs

SummaryMany endocrine disruptors have been proven to impair the meiotic process that is mandatory to produce healthy gametes. Bisphenol A is emblematic as it impairs meiotic prophase I and causes oocyte aneuploidy following in utero exposure. However, the mechanisms underlying these deleterious effects remain poorly understood. Furthermore, the increasing uses of BPA analogs raise concerns for public health. Here, we investigated the effect on oogenesis in mouse of fetal exposure to two BPA analogs, Bisphenol A Diglycidyl Ether (BADGE) or Bisphenol AF (BPAF). These analogs delay meiosis initiation, increase MLH1 foci per cell and induce oocyte aneuploidy. We further demonstrate that these defects are accompanied by a deregulation of gene expression and aberrant mRNA splicing in fetal premeiotic germ cells. Interestingly, we observed an increase in DNA oxidation after exposure to BPA analogs. Specific induction of oxidative DNA damages during fetal germ cell differentiation causes similar defects during oogenesis, as observed in 8-Oxoguanine DNA Glycosylase (OGG1) deficient mice or after in utero exposure to potassium bromate (KBrO3), an inducer of oxidative DNA damages. Moreover, the supplementation of N-acetylcysteine (NAC) with BPA analogs counteracts the bisphenol-induced meiotic effect. Together our results position oxidative stress as a central event that negatively impacts the female meiosis with major consequences on oocyte quality. This could be a common mechanism of action for so called endocrine disruptors pollutants and it could lead to novel strategies for reprotoxic compounds.

Anti-androgenic mechanisms of Bisphenol A involve androgen receptor signaling pathway

Toxicology ◽  
2017 ◽  
Vol 387 ◽  
pp. 10-16 ◽  
Author(s):  
Hui Wang ◽  
Zhen Ding ◽  
Qiao-Mei Shi ◽  
Xing Ge ◽  
Heng-Xue Wang ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Bisphenol A ◽  
Signaling Pathway ◽  
Receptor Signaling ◽  
Androgen Receptor Signaling ◽  
Receptor Signaling Pathway

Bisphenol A alternatives bisphenol S and bisphenol F interfere with thyroid hormone signaling pathway in vitro and in vivo

2018 ◽  
Vol 237 ◽  
pp. 1072-1079 ◽  
Author(s):  
Yin-Feng Zhang ◽  
Xiao-Min Ren ◽  
Yuan-Yuan Li ◽  
Xiao-Fang Yao ◽  
Chuan-Hai Li ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Bisphenol A ◽  
Signaling Pathway ◽  
Hormone Signaling ◽  
Bisphenol S ◽  
Bisphenol F

scholarly journals Bisphenol-A exposure alters memory consolidation and hippocampal CA1 spine formation through Wnt signaling in vivo and in vitro

2015 ◽  
Vol 4 (3) ◽  
pp. 686-694 ◽  
Author(s):  
Zhi-Hua Liu ◽  
Ye Yang ◽  
Meng-Meng Ge ◽  
Li Xu ◽  
Yuqing Tang ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Memory Consolidation ◽  
Wnt Signaling Pathway ◽  
Spine Formation ◽  
Hippocampal Ca1

Based on Wnt signaling pathway, this study aims to further mechanistically understand memory alteration after BPA exposure.

Oleuropein and hydroxytyrosol rich extracts from olive leaves attenuate liver injury and lipid metabolism disturbance in bisphenol A-treated rats

2018 ◽  
Vol 9 (6) ◽  
pp. 3220-3234 ◽  
Author(s):  
Asma Mahmoudi ◽  
Fatma Hadrich ◽  
Ines Feki ◽  
Hela Ghorbel ◽  
Zouhaier Bouallagui ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Liver Injury ◽  
Bisphenol A ◽  
Signaling Pathway ◽  
Metabolic Disorders ◽  
Antioxidative Defense ◽  
Defense System ◽  
Olive Leaves ◽  
Antioxidative Defense System ◽  
Hepatoprotective Effects

OLE and HYT olive leaves rich extracts possess hypolipidemic and hepatoprotective effects against BPA-induced metabolic disorders by enhancing the antioxidative defense system and regulation of important signaling pathway activities.

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