Exposure to air pollution and incidence of atopic dermatitis in the general population: A national population-based retrospective cohort study

Abstract Background This study investigated the associations between exposure to ambient air pollutants and the incidence of osteoporosis using the Korean National Insurance Service–National Sample Cohort. Methods This nationwide, population-based, retrospective cohort study included 237,149 adults aged ≥40 years that did not have a diagnosis of osteoporosis at baseline between January 1, 2003, and December 31, 2015. Osteoporosis was defined as claim codes and prescriptions of bisphosphonates or selective estrogen receptor modulators at least twice annually. After matching values for PM10, NO2, CO, and SO2 during the 2002–2015 time period and PM2.5 in 2015 with residential areas, the incidence of osteoporosis was analyzed using a Cox proportional hazards regression model according to the quartile of average yearly concentrations of pollutants. Results Overall 22.2% of the study subjects, 52,601 (male: 5.6%, female: 37.6%) adults in total, were newly diagnosed with osteoporosis and treated. Exposure to PM10 was positively associated with incidence of osteoporosis (Q4: 1798 per 100,000 person-years vs. Q1: 1655 per 100,000 person-years). The adjusted hazard ratio (HR) with 95% confidence interval (CI) of Q4 in PM10 was 1.034 (1.009–1.062). The effect of PM10 on osteoporosis incidence was distinct in females (adjusted sub-HR: 1.065, 95% CI: 1.003–1.129), subjects aged < 65 years (adjusted sub-HR: 1.040, 95% CI: 1.010–1.072), and for residents in areas with low urbanization (adjusted sub-HR: 1.052, 95% CI: 1.019–1.087). However, there was no increase in osteoporosis based on exposure to NO2, CO, SO2, or PM2.5. Conclusions Long-term exposure to PM10 was associated with newly diagnosed osteoporosis in Korean adults aged ≥40 years. This finding can aid in policy-making that is directed to control air pollution as a risk factor for bone health.

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Foot Ulcer and Risk of Lower Limb Amputation or Death in People With Diabetes: A National Population-Based Retrospective Cohort Study

Diabetes Care ◽

10.2337/dc21-1596 ◽

2021 ◽

pp. dc211596

Author(s):

Rosemary C. Chamberlain ◽

Kelly Fleetwood ◽

Sarah H. Wild ◽

Helen M. Colhoun ◽

Robert S. Lindsay ◽

...

Keyword(s):

Cohort Study ◽

Retrospective Cohort Study ◽

Lower Limb ◽

Retrospective Cohort ◽

Foot Ulcer ◽

Population Based ◽

Lower Limb Amputation ◽

Limb Amputation ◽

National Population

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Keloid risk in patients with atopic dermatitis: a nationwide retrospective cohort study in Taiwan

BMJ Open ◽

10.1136/bmjopen-2018-022865 ◽

2018 ◽

Vol 8 (7) ◽

pp. e022865 ◽

Cited By ~ 3

Author(s):

Ying-Yi Lu ◽

Chun-Ching Lu ◽

Wei-Wen Yu ◽

Li Zhang ◽

Qing-Rui Wang ◽

...

Keyword(s):

Atopic Dermatitis ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Population Based ◽

Secondary Outcome ◽

Severe Atopic Dermatitis ◽

Secondary Outcome Measure ◽

Research Database ◽

Cox Proportional Hazard Regression

ObjectiveThe pathogenesis of keloid is largely unknown. Because keloid and atopic dermatitis have overlapping pathophysiological mechanisms, we aimed to evaluate keloid risk in patients with atopic dermatitis.Study designPopulation-based retrospective cohort study.SettingThe Taiwan National Health Insurance Research Database was used to analyse data for people who had been diagnosed with atopic dermatitis.ParticipantsWe identified 8371 patients with newly diagnosed atopic dermatitis during 1996–2010. An additional 33 484 controls without atopic dermatitis were randomly identified and frequency matched at a one-to-four ratio.Primary and secondary outcome measureThe association between atopic dermatitis and keloid risk was estimated using Cox proportional hazard regression models.ResultsAfter adjustment for covariates, the atopic dermatitis patients have a 3.19-fold greater risk of developing keloid compared with the non-atopic dermatitis group (3.19vs1.07 per 1000 person-years, respectively). During the study period, 163 patients with atopic dermatitis and 532 patients without atopic dermatitis developed keloid. Notably, keloid risk increased with severity of atopic dermatitis, particularly in patients with moderate to severe atopic dermatitis.ConclusionsOur results indicate that patients with atopic dermatitis had a higher than normal risk of developing keloid and suggest that atopic dermatitis may be an independent risk factor for keloid.

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Primary Sjogren’s syndrome and the risk of acute pancreatitis: a nationwide cohort study

BMJ Open ◽

10.1136/bmjopen-2016-014807 ◽

2017 ◽

Vol 7 (8) ◽

pp. e014807 ◽

Cited By ~ 4

Author(s):

Chi-Ching Chang ◽

Yu-Sheng Chang ◽

Shu-Hung Wang ◽

Shyr-Yi Lin ◽

Yi-Hsuan Chen ◽

...

Keyword(s):

Acute Pancreatitis ◽

Cohort Study ◽

General Population ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Population Based ◽

Sjogren's Syndrome ◽

Primary Sjögren’S Syndrome ◽

Primary Sjogren’S Syndrome ◽

Primary Sjögren's Syndrome

ObjectiveStudies on the risk of acute pancreatitis in patients with primary Sjogren’s syndrome (pSS) are limited. We evaluated the effects of pSS on the risk of acute pancreatitis in a nationwide, population-based cohort in Taiwan.Study designPopulation-based retrospective cohort study.SettingWe studied the claims data of the >97% Taiwan population from 2002 to 2012.ParticipantsWe identified 9468 patients with pSS by using the catastrophic illness registry of the National Health Insurance Database in Taiwan. We also selected 37 872 controls that were randomly frequency matched by age (in 5 year bands), sex and index year from the general population.Primary outcome measureWe analysed the risk of acute pancreatitis by using Cox proportional hazards regression models including sex, age and comorbidities.ResultsFrom 23.74 million people in the cohort, 9468 patients with pSS (87% women, mean age=55.6 years) and 37 872 controls were followed-up for 4.64 and 4.74 years, respectively. A total of 44 cases of acute pancreatitis were identified in the pSS cohort versus 105 cases in the non-pSS cohort. Multivariate Cox regression analysis indicated that the incidence rate of acute pancreatitis was significantly higher in the pSS cohort than in the non-pSS cohort (adjusted HR (aHR) 1.48, 95% CI 1.03 to 2.12). Cyclophosphamide use increased the risk of acute pancreatitis (aHR 5.27, 95% CI 1.16 to 23.86). By contrast, hydroxychloroquine reduced the risk of acute pancreatitis (aHR 0.23, 95% CI 0.09 to 0.55).ConclusionThis nationwide, retrospective cohort study demonstrated that the risk of acute pancreatitis was significantly higher in patients with pSS than in the general population.

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Long-Term Exposure to Ambient Air Pollution and Respiratory Disease Mortality in Shenyang, China: A 12-Year Population-Based Retrospective Cohort Study

Respiration ◽

10.1159/000332930 ◽

2012 ◽

Vol 84 (5) ◽

pp. 360-368 ◽

Cited By ~ 60

Author(s):

Guang-Hui Dong ◽

Pengfei Zhang ◽

Baijun Sun ◽

Liwen Zhang ◽

Xi Chen ◽

...

Keyword(s):

Air Pollution ◽

Cohort Study ◽

Respiratory Disease ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Ambient Air ◽

Population Based ◽

Ambient Air Pollution ◽

Disease Mortality

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Suicide in cancer patients: a population-based retrospective cohort study in taiwan

European Psychiatry ◽

10.1016/s0924-9338(11)72691-8 ◽

2011 ◽

Vol 26 (S2) ◽

pp. 986-986

Author(s):

P.H. Lin ◽

M.B. Lee ◽

M.C. Tseng ◽

C.C. Lin ◽

H.C. Chen ◽

...

Keyword(s):

Cohort Study ◽

General Population ◽

Cancer Patients ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Asian Country ◽

Population Based ◽

Suicide Death ◽

Care Givers ◽

Commit Suicide

IntroductionLittle is known about the suicide risk among cancer patients in Asian country.ObjectivesTo identify the risk and correlates of suicide death among cancer patients in Taiwan.AimsTo provide the references for policy-making of suicide prevention and information for clinicians and care-givers.MethodsWe conducted a retrospective cohort study of cancer patients in Taiwan from 1985 to 2007 by linking two national-wide databases of the Taiwan Cancer Registry and the National Mortality File. Standardized mortality ratios (SMR) and 95% confidence intervals (CIs) were estimated based on the general population rates of suicide stratified by age, sex, and calendar year.ResultsAmong 930,230 registry cancer patients observed for 4,376,574 person-years, 2614 suicides were ascertained. Individuals with diagnosis of cancer had significantly higher risk to die by suicide (Man SMR = 2.46, 95% CI = 2.35–2.58; Woman SMR = 2.12, 95% CI = 1.98–2.28). Patients with cancers of head/neck, esophagus, and lung had additional higher risk to commit suicide. The risk of suicide elevated soon within first 3 months after cancer was diagnosed (Man SMR = 6.57, 95% CI = 5.82–7.41; Woman SMR = 5.83, 95% CI = 4.71–7.21).ConclusionsCompared with general population, cancer patients had significantly higher risk to commit suicide in Taiwan. In addition to the prevention works focused on common risk factors of suicide death, clinicians and caretakers should pay special attention to patients with certain types of cancers and to those who were newly diagnosed to have cancers.

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