Asthma control status in pregnancy, body mass index, and maternal vitamin D levels

INTRODUCTION: Obesity is associated with alteration in the vitamin D levels and has been related to vitamin D status. Lower vitamin D levels in higher BMI individuals may be secondary to an alteration in tissue distribution resulting from an increase in adipose mass. Therefore women with higher BMI need higher vitamin D supplementation as compared to women with BMI within normal range. MATERIAL AND METHOD: This was a case control study carried out in Department of Obstetrics and Gynaecology, ESIC-PGIMSR, New Delhi from August 2012-April 2014. A total of 100 patients were divided into two equal groups (control and study groups of 50 each). Control group had women with singleton uncomplicated term normotensive pregnant women in labour while the study group comprised of term preeclamptic women in labour.In all the patients their BMI was analysed .Blood samples for vitamin D, serum calcium, serum phosphorus, serum parathormone, serum alkaline phosphatase levels were drawn and subsequently their levels were evaluated in cord blood; correlation studied between vitamin D & BMI. RESULTS: The mean BMI was relatively higher in the study group (26.34 ± 4.12)kg/m2 than in the control group ( 24.24 ± 3.13)kg/m2. Thus in our study a prevalence of higher BMI was seen in patients of preeclampsia. When all the 100 women are being considered, median vitamin D levels were found to be higher (6.6ng/ml) in normal BMI patients (n=55) as compared to levels (5.6ng/ml) in patients with higher BMI(n=45). CONCLUSION: Vitamin D levels are related to maternal body mass index. Individuals with higher percentage body fat may require higher vitamin D intake to attain optimal 25(OH) D levels, compared with lean individuals and thereby may prevent pregnancy complications like Pre eclampsia.

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Role of Vitamin D in the Management of COVID-19 Patients Regarding Morbidity and Mortality

10.53350/pjmhs211561231 ◽

2021 ◽

Vol 15 (6) ◽

pp. 1231-1233

Author(s):

A. W. Khan ◽

H. T. Hussain ◽

Z.U. Mustafa ◽

M. A. Qamar ◽

...

Keyword(s):

Body Mass Index ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Body Mass ◽

Morbidity And Mortality ◽

P Value ◽

Mortality And Morbidity ◽

Severe Vitamin ◽

Vitamin D Levels

Aim: To determine the role of vitamin D in the management of COVID-19 patients regarding morbidity and mortality. Study Design: Prospective/Observational Place and Duration: Departments of Medicine & Pulmonology, Allama Iqbal Memorial Teaching Hospital, Sialkot and Department of Medicine, Sughra Shafi Medical Complex Narowal from 1st November 2020 to 30th April 2020. Methodology: One hundred and sixty patients of both genders diagnosed to have COVID-19, were enrolled. Patient’s ages were ranging from 17 to 70 years. The detailed demographics such as age, sex, and body mass index were recorded. 5 ml blood samples were taken from all the patients to check their vitamin D levels. Severe Vitamin D deficiency was defined as 25(OH)D <25 nmol/L (10 ng/dl). Association between mortality and morbidity was examined. Results: Ninety (56.25%) were males while 70 (43.75%) were females with mean age 40.15±17.37 years. Mean body mass index of patients was 24.16±7.26 kg/m2. Severe vitamin D deficiency was observed in 80 (50%) patients. Mortality found in 30 (18.75%) patients. Frequency of morbidity was among 66 (41.25%) patients. Patients with severe vitamin D deficiency had high rate of mortality 20 (25%) and morbidity 50 (62.5%) as compared to patients with no vitamin D deficiency had 10 (8%) mortality and 16 (20%) morbidity. A significant association was observed between severe vitamin D deficiency regarding morbidity and mortality among patients with covid-19 disease with p-value <0.05. Conclusion: The vitamin-D has strongest relationship among patients with covid-19 disease to reduce mortality and morbidity. Keywords: Morbidity, COVID-19, Vitamin D, Mortality

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Assessment of serum vitamin D levels in Egyptian children with beta-thalassemia major

Egyptian Pediatric Association Gazette ◽

10.1186/s43054-021-00066-y ◽

2021 ◽

Vol 69 (1) ◽

Author(s):

Ghada Saad Abdelmotaleb ◽

Ola Galal Behairy ◽

Khalid Eid Abd El Azim ◽

Dalia Mohamed Abd El-Hassib ◽

Tasbeh Mohamed Hemeda

Keyword(s):

Body Mass Index ◽

Vitamin D ◽

Body Mass ◽

Serum Calcium ◽

Serum Levels ◽

Thalassemia Major ◽

Beta Thalassemia ◽

Beta Thalassemia Major ◽

Vitamin D Levels ◽

25 Oh Vitamin D

Abstract Background Beta-thalassemia major patients are at increased risk of complications including endocrinopathies and bone disease due to iron overload. So, this study aimed to assess the growth parameters, serum levels of 25-OH-vitamin D, calcium, and phosphorous in children with beta-thalassemia major. This was a case-control study that included 55 children with beta-thalassemia major compared with 30 sex- and age-matched healthy children that served as a control group. All enrolled children were subjected to full history taking, clinical examination including anthropometric measurements, and laboratory investigations including complete blood count, serum ferritin, levels of serum calcium, phosphorus, and 25-OH-vitamin D. Results Body mass index was statistically significantly lower in the thalassemic group (P < 0.001). It was observed that vitamin D levels were significantly lower in thalassemic patients than in controls (P value < .0001). The mean serum 25-OH-vitamin D levels were 19.84 ± 5.79 ng/ml and 44.98 ± 5.77 ng/ml, respectively; 22 cases (40%) had insufficient vitamin D, and 5 cases (9%) had deficient vitamin D. Regarding serum calcium and phosphorous, there was no significant difference between the thalassemic and control groups. Conclusion Children with beta-thalassemia major had low body mass index and metabolic abnormality in the form of lower serum levels of vitamin D that signify the importance of therapeutic interventions.

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Body Mass Index, Vitamin D, and Type 2 Diabetes: A Systematic Review and Meta-Analysis

Nutrients ◽

10.3390/nu10091182 ◽

2018 ◽

Vol 10 (9) ◽

pp. 1182 ◽

Cited By ~ 21

Author(s):

Shamaila Rafiq ◽

Per Jeppesen

Keyword(s):

Systematic Review ◽

Body Mass Index ◽

Vitamin D ◽

Body Mass ◽

Observational Studies ◽

Meta Analysis ◽

Serum Vitamin ◽

Vitamin D Supplementation ◽

Serum Vitamin D ◽

Vitamin D Levels

The deficiency of vitamin D is prevalent all over the world. Studies have shown that vitamin D may play an important role in the development of obesity. The current study was conducted to quantitatively evaluate the association between serum 25-(OH) vitamin D levels and the risk of obesity in both diabetic and non-diabetic subjects. A systematic review and meta-analysis of observational studies was carried out for that purpose. We searched the Medline, PubMed, and Embase databases throughout all of March 2018. A total of fifty five observational studies for both diabetic and non-diabetic subjects were finally included in the meta-analysis. The data were analyzed by comprehensive meta-analysis software version 3 and the random effects model was used to analyze the data. The meta-analysis showed an overall inverse relationship between serum vitamin D status and body mass index (BMI) in studies of both diabetic (r = −0.173, 95% = −0.241 to −0.103, p = 0.000) and non-diabetic (r = −0.152, 95% = −0.187 to −0.116, p = 0.000) subjects. The evidence of publication bias was not found in this meta-analysis. In conclusion, the deficiency of vitamin D is associated with an increased level of BMI in the studies of both diabetic and non-diabetic subjects. Reliable evidence from well-designed future randomized controlled trials is required to confirm the findings from observational studies and to find out the potential regulatory effects of vitamin D supplementation to lower BMI.

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Vitamin D Deficiency in Tuberculosis and Diabetes Mellitus - A Cluster Analysis

Current Respiratory Medicine Reviews ◽

10.2174/1573398x17666210923111637 ◽

2021 ◽

Vol 17 ◽

Author(s):

Chaya K Sindaghatta ◽

Vishwa K Vijetha ◽

Lokesh Sundararaja Komarla ◽

Jayaraj Siddaiah Biligere ◽

Sowmya Malamardi ◽

...

Keyword(s):

Diabetes Mellitus ◽

Body Mass Index ◽

Vitamin D ◽

Cluster Analysis ◽

Pulmonary Tuberculosis ◽

Vitamin D Deficiency ◽

Body Mass ◽

Multinomial Logistic Regression ◽

Age Distribution ◽

Vitamin D Levels

Background: Diabetes mellitus and tuberculosis are a dual burden of disease, and diabetes is associated with a threefold risk of developing tuberculosis. Though India is considered to have an abundance of sunlight, the prevalence of deficiency of vitamin D is high, which is shown to cause impairment in the macrophage-initiated immune response against Mycobacterium tuberculosis. Methods: Our study estimated the prevalence of mean levels and determinants of vitamin D deficiency in patients with tuberculosis or diabetes and those with both tuberculosis and diabetes. A cluster analysis was performed to identify whether these patients belong to distinct clusters and evaluate whether vitamin D levels were significantly different between clusters. Results: The study observed that the lowest vitamin D levels were observed among subjects with both pulmonary tuberculosis and diabetes. Multinomial logistic regression analysis observed that higher levels of vitamin D were protective against both diabetes and pulmonary tuberculosis and while higher body mass index lowered odds of pulmonary tuberculosis, it increased the odds of diabetes. The cluster analysis identified five distinct clusters with different characteristics of pulmonary tuberculosis, diabetes mellitus, sputum mycobacterial load, age distribution, body mass index, vitamin D, serum albumin and serum calcium. Conclusion: In South India, among patients with pulmonary tuberculosis and diabetes or either disease alone, hypovitaminosis D is a common phenomenon. The cluster analysis plays an important role in future research on biomarkers to identify specific phenotypes in patients with tuberculosis and diabetes.

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