Role of Vitamin D in the Management of COVID-19 Patients Regarding Morbidity and Mortality

2021 ◽  
Vol 15 (6) ◽  
pp. 1231-1233
Author(s):  
A. W. Khan ◽  
H. T. Hussain ◽  
Z.U. Mustafa ◽  
M. A. Qamar ◽  
M. A. Qamar ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Body Mass ◽  
Morbidity And Mortality ◽  
P Value ◽  
Mortality And Morbidity ◽  
Severe Vitamin ◽  
Vitamin D Levels

Aim: To determine the role of vitamin D in the management of COVID-19 patients regarding morbidity and mortality. Study Design: Prospective/Observational Place and Duration: Departments of Medicine & Pulmonology, Allama Iqbal Memorial Teaching Hospital, Sialkot and Department of Medicine, Sughra Shafi Medical Complex Narowal from 1st November 2020 to 30th April 2020. Methodology: One hundred and sixty patients of both genders diagnosed to have COVID-19, were enrolled. Patient’s ages were ranging from 17 to 70 years. The detailed demographics such as age, sex, and body mass index were recorded. 5 ml blood samples were taken from all the patients to check their vitamin D levels. Severe Vitamin D deficiency was defined as 25(OH)D <25 nmol/L (10 ng/dl). Association between mortality and morbidity was examined. Results: Ninety (56.25%) were males while 70 (43.75%) were females with mean age 40.15±17.37 years. Mean body mass index of patients was 24.16±7.26 kg/m2. Severe vitamin D deficiency was observed in 80 (50%) patients. Mortality found in 30 (18.75%) patients. Frequency of morbidity was among 66 (41.25%) patients. Patients with severe vitamin D deficiency had high rate of mortality 20 (25%) and morbidity 50 (62.5%) as compared to patients with no vitamin D deficiency had 10 (8%) mortality and 16 (20%) morbidity. A significant association was observed between severe vitamin D deficiency regarding morbidity and mortality among patients with covid-19 disease with p-value <0.05. Conclusion: The vitamin-D has strongest relationship among patients with covid-19 disease to reduce mortality and morbidity. Keywords: Morbidity, COVID-19, Vitamin D, Mortality

scholarly journals FREQUENCY OF VITAMIN D DEFICIENCY IN PATIENTS PRESENTING WITH FIBROMYALGIA

2021 ◽  
Vol 71 (5) ◽  
pp. 1544-47
Author(s):  
Samina Rashid ◽  
Khuram Haq Nawaz ◽  
Amer Fakhr ◽  
Hammad Ather ◽  
Farzana Hakeem ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Body Mass ◽  
High Body Mass Index ◽  
Common Finding ◽  
Military Hospital ◽  
P Value ◽  
Cross Sectional ◽  
Vitamin D Levels

Objective: To determine frequency of vitamin D deficiency in patients presenting with fibromyalgia and its association with various factors. Study Design: Cross sectional study. Place and Duration of Study: Medicine department, Pak Emirates Military Hospital Rawalpindi, from Sep 2018 to Feb 2019. Methodology: Ninety patients of fibromyalgia were included in the study. Diagnosis of fibromyalgia was made by the consultant rheumatologist on the basis of American College of Rheumatology Criteria needed for fibromyalgia diagnosis and classification. Vitamin D levels <20ng/ml were considered as deficient. Age, education, marital status, menstrual abnormallities and body mass index were correlated with the presence of vitamin D deficiency among the patients suffering from fibromyalgia. Results: Out of 90 patients of fibromyalgia, 57 (63.3%) showed the presence of vitamin D deficiency while 33 (36.7%) had no deficiency of vitamin D. Among the study participants 88 (97.8%) patients were females and only 2 (2.2%) patients were males. Mean age of the patients was 39.4 ± 3.365 years. After applying the binary logistic regression, we found that presence of menstrual abnormalities and high body mass index had significant association with the presence of vitamin D deficiency among the patients of fibromyalgia (p-value<0.05). Conclusion: Vitamin D deficiency emerged as a common finding among the patients of fibromyalgia in a teaching hospital of Pakistan. Vitamin D deficiency should be screened at the rheumatology clinics and special attention should be paid to the patients who are overweight or obese and female patients with the menstrual abnormalities.

Association between vitamin D deficiency and prostate cancer: Prospective case-control study

2021 ◽  
pp. 205141582199360
Author(s):  
Ghanshyam Kumawat ◽  
Vijay Chaudhary ◽  
Anurag Garg ◽  
Nishkarsh Mehta ◽  
Gagan Talwar ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Case Control Study ◽  
Serum Vitamin ◽  
P Value ◽  
Serum Vitamin D ◽  
Severe Vitamin ◽  
Vitamin D Levels ◽  
Control Study

Objective: We aimed to find out the association of low serum vitamin D levels with the incidence of prostate cancer through a prospective case-control study. Material and methods: This study was carried out in the tertiary care hospital (India). All newly diagnosed patients of prostate cancer and age-matched controls were included. Serum vitamin D levels were measured in all of them. Vitamin D status (ng/mL) was classified as severe deficiency <10, moderate deficiency 10–<30, normal 30–100, and toxicity >100. Normality of the data was tested by the Kolmogorov–Smirnov test, statistical analysis was done with Statistical Package for the Social Sciences version 26.0, p-value of <0.05 was considered significant. Results: In our study, 320 cases and 320 controls were included. The mean vitamin D levels in cases and controls were 15.71 ± 6.5 (ng/mL) and 17.63 ± 4.54 (ng/mL), respectively, ( p-Value <0.01). Patients with severe vitamin D deficiency (73.58%) had a Gleason score ⩾8 on biopsy and 79.24% of them had a serum prostate specific antigen (PSA) level >20 ng/mL. Conclusion: We had concluded that there was no significant association between vitamin D deficiency and increased risk of prostate cancer, although patients with higher-grade prostate cancer and with higher PSA level had severe vitamin D deficiency. Level of evidence: Not applicable for this multicentre audit.

P–683 Correlation of vitamin D deficiency with anti-Mullerian hormone (AMH) among infertile women in comparison to fertile women in a tertiary health facility in North-Western Nigeria

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
B Lawal ◽  
A Adesiyun ◽  
M Manu ◽  
J El-Bashir ◽  
A Olorukooba ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Reproductive Age ◽  
P Value ◽  
Infertile Women ◽  
Reproductive Age Women ◽  
Vitamin D Levels ◽  
North Western ◽  
Fertile Women

Abstract Study question is there correlation between Vitamin D Deficiency and AMH levels in infertile and fertile women? Summary answer there is no significant correlation between Vitamin D deficiency and AMH levels in both infertile and fertile women What is known already Vitamin D deficiency and insufficiency is a global health problem affecting over a billion people with higher prevalence among reproductive-age women, and blacks. Vitamin D is well known to play significant role in calcium-phosphate homeostasis and bone metabolism, however, recent studies have demonstrated diverse expression of vitamin D receptors in reproductive organs. This suggest the probable role of vitamin D in reproductive physiology and fertility. The pathogenesis of vitamin D in infertility is poorly understood, but thought to involve hypothalamo-pituitary axis, ovarian folliculogenesis and uterine implantation. Most studies are done in Assisted Reproduction Technology and in developed countries Study design, size, duration A case-control study that involved 128 consecutively consenting women within the reproductive age group; 64 infertile women as the cases and 64 age and body mass index (BMI) matched fertile women as the controls. The study was conducted over a period of six (6) months Participants/materials, setting, methods The study was conducted in Obstetrics and Gynaecology and Chemical pathology departments of Ahmadu Bello University Teaching Hospital Zaria, a tertiary hospital in North-Western Nigeria. It involved all cases of female-factor infertility as cases, while the controls were fertile women from 6 weeks postpartum to 1 year. Venous blood samples were assayed for serum 25(-hydroxy) vitamin D and AMH levels using Enzyme-Linked Immunosorbent Assay (ELISA) and data analysed with level of significance set as &lt; 0.05 Main results and the role of chance The mean ± standard deviation (SD) of serum Vitamin D levels in the infertile women and fertile women were 17.01 ± 7.61ng/ml and 11.34 ± 6.12ng/ml respectively, significantly higher in the infertile women (p-value &lt;0.000). The prevalence of Vitamin D deficiency (&lt;20ng/ml) was found to be significantly higher in the fertile women compared to infertile women (89.1% versus 68.8%; p-value 0.007). Vitamin D levels were found to be positively correlated with age (r 0.374; p-value 0.002) and parity (r 0.338; p-value 0.006). There was no association between vitamin D with type of, and causes of infertility. Vitamin D deficient women were found to be 6.5 times less likely to be infertile than non-deficient women (aOR 95% confidence interval 1.96–21.55; p-value 0.002). There was no significant correlation between vitamin D and AMH levels in vitamin D deficient women of both study groups (rs 0.180; p-value 0.242 and rs 0.088; p-value 0.521). Interestingly, there was significant relationship between AMH levels and causes of infertility (p-value 0.001), with higher levels of AMH found in infertile women with polycystic ovarian syndrome Limitations, reasons for caution There is no consensus on the cut-off values for vitamin D levels as it relates to fertility, and no reference values for vitamin D deficiency and AMH levels in study area. The sample size was limited by cost, and the study was conducted in a single study area Wider implications of the findings: The vitamin D levels in women with infertility was low but yet not significantly correlated with AMH. Overall, prevalence of vitamin D deficiency among reproductive-age women was found high. There is need for life-style and dietary modifications. Further researches are needed to ascertain the effect of vitamin D on fertility. Trial registration number Not applicable

Vitamin D Deficiency in Tuberculosis and Diabetes Mellitus - A Cluster Analysis

2021 ◽  
Vol 17 ◽  
Author(s):  
Chaya K Sindaghatta ◽  
Vishwa K Vijetha ◽  
Lokesh Sundararaja Komarla ◽  
Jayaraj Siddaiah Biligere ◽  
Sowmya Malamardi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Vitamin D ◽  
Cluster Analysis ◽  
Pulmonary Tuberculosis ◽  
Vitamin D Deficiency ◽  
Body Mass ◽  
Multinomial Logistic Regression ◽  
Age Distribution ◽  
Vitamin D Levels

Background: Diabetes mellitus and tuberculosis are a dual burden of disease, and diabetes is associated with a threefold risk of developing tuberculosis. Though India is considered to have an abundance of sunlight, the prevalence of deficiency of vitamin D is high, which is shown to cause impairment in the macrophage-initiated immune response against Mycobacterium tuberculosis. Methods: Our study estimated the prevalence of mean levels and determinants of vitamin D deficiency in patients with tuberculosis or diabetes and those with both tuberculosis and diabetes. A cluster analysis was performed to identify whether these patients belong to distinct clusters and evaluate whether vitamin D levels were significantly different between clusters. Results: The study observed that the lowest vitamin D levels were observed among subjects with both pulmonary tuberculosis and diabetes. Multinomial logistic regression analysis observed that higher levels of vitamin D were protective against both diabetes and pulmonary tuberculosis and while higher body mass index lowered odds of pulmonary tuberculosis, it increased the odds of diabetes. The cluster analysis identified five distinct clusters with different characteristics of pulmonary tuberculosis, diabetes mellitus, sputum mycobacterial load, age distribution, body mass index, vitamin D, serum albumin and serum calcium. Conclusion: In South India, among patients with pulmonary tuberculosis and diabetes or either disease alone, hypovitaminosis D is a common phenomenon. The cluster analysis plays an important role in future research on biomarkers to identify specific phenotypes in patients with tuberculosis and diabetes.

Abstract P172: Birth Weight, Maternal Pre-pregnancy Body Mass Index and Adulthood Vitamin D Levels: The Jerusalem Perinatal Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Amy Moore ◽  
Hagit Hochner ◽  
Colleen Sitlani ◽  
Michelle A Williams ◽  
David S Siscovick ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Birth Weight ◽  
Chronic Diseases ◽  
Body Mass ◽  
Study Data ◽  
P Value ◽  
Total Vitamin ◽  
Maternal Characteristics ◽  
Vitamin D Levels

Background: The intrauterine experience and pre-pregnancy maternal characteristics have demonstrated importance in the development of life course risk for chronic diseases. Vitamin D has been associated with several chronic diseases including cardiometabolic diseases. Whether offspring birth weight and maternal pre-pregnancy body mass index (BMI) are associated with adulthood vitamin D levels is unknown. Further, the role of adulthood BMI in these relationships is not clear. Methods: We examined associations of offspring birth weight and maternal pre-pregnancy BMI with offspring adulthood vitamin D levels among a subset of the Jerusalem Perinatal Study (JPS) population, a birth cohort of Jerusalem residents born between 1974 and 1976. Offspring aged 30-35 years, sampled based on maternal pre-pregnancy body mass index (BMI) and offspring birth weight, and their mothers were recruited as part of the JPS-1 study. Data were collected using interviews and field physical examinations. Fasting blood specimens were obtained for vitamin D measurements. We used liquid chromatography-tandem mass spectroscopy to measure total vitamin D (25-[OH] D). Sample-weighted multiple regression models, adjusted for potential confounders, were used to examine associations, and determine coefficients and 95% confidence intervals. Results: Mean total vitamin D levels was 23.48ng/ml among study participants. Birth weight was not related to vitamin D levels in adulthood. Pre-pregnancy BMI was inversely associated with offspring adulthood vitamin D levels, both before (β=-0.24, p-value=0.005) and after adjustment for birth weight (β=-0.24, p-value=0.015). However, the association was attenuated by including current offspring BMI in the models (β=-0.17, p-value=0.061) or both current BMI and birth weight (β=-0.16, p-value=0.120). In addition, the association between maternal pre-pregnancy BMI with current offspring BMI was not altered by adulthood vitamin D level. Conclusion: Maternal pre-pregnancy is potentially associated with adulthood vitamin D levels. This association may be mediated at least in part by offspring current BMI. Future studies are warranted to investigate whether the observed associations are due to genetic factors or other characteristics of the intrauterine environment.

scholarly journals Effects of Vitamin D Supplementation on Female Vitamin D Deficient Teenagers: A Randomized Clinical Trial

2020 ◽  
Author(s):  
Salma Ahi ◽  
Fatemeh Gholami ◽  
Naser Hatami ◽  
Fatemeh Golabi
Keyword(s):  
Clinical Trial ◽  
Body Mass Index ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Randomized Clinical Trial ◽  
Body Mass ◽  
Anthropometric Indices ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Before And After

Abstract Background: Vitamin D deficiency is one of the most prevalent disorders worldwide. Considering the magnitude of growth in adolescence, the aim of this study was to ascertain the prevalence of vitamin D deficiency and discover the association between anthropometric indices and vitamin D levels and the effect of vitamin D treatment on anthropometric indices in adolescent girls. Method: we performed this randomized clinical trial study (approved by Iranian Registry of Clinical Trials with code of IRCT20200615047785N2) conducting 313 high school girl students in a random cluster sampling from Jahrom city schools. Blood samples were collected from participants to determine the serum level (OH) D25. We divided vitamin D deficient patients into two groups: control who received placebo (n=150) and intervention group (n=150) who were prescribed one tablet of 50,000 units of vitamin D per week for eight weeks. Anthropometric indices of participants were measured before and after the intervention. Datas were analyzed by SPSS software version 19.Results: The prevalence of vitamin D deficiency was 95%. Body mass index had no significant difference before the intervention in both groups (P = 0.76). After intervention in the case group, body mass index increased significantly (P = 0.01), but there was no significant difference in the control group after treatment (P = 0.42). There was no significant difference in waist circumference, height and weight before and after the intervention in both groups (P > 0.05). There was also a weak but significant correlation between height, weight, and baseline 25OHD levels of participants.Conclusion: The results of this study showed that there is a reverse and significant relationship between height and weight index with 25OHD. Further monitoring and prolonged studies with extended follow ups might improve the anthropometric parameters after treatment.

scholarly journals The Relationship between Vitamin D Levels and Body Mass Index and Fasting Blood Glucose in Non-Obese Non-Diabetic Women

2021 ◽  
Vol 1 (1) ◽  
pp. 5-8
Author(s):  
Kadir Serkan Yalçın
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Blood Glucose ◽  
Body Mass ◽  
Fasting Blood Glucose ◽  
High Body Mass Index ◽  
Mortality And Morbidity ◽  
Female Patients ◽  
Vitamin D Levels ◽  
The Relationship

Introduction: Obesity is one of the most critical health problems in the world. Obesity is in the etiology of various chronic diseases, thus causes mortality and morbidity. Especially in recent studies, 25 hydroxyvitamin D3 (25-OH D3) deficiency has been associated with many different diseases and became a significant health problem. Although studies are suggesting an association between obesity and 25-OH D3 deficiency, there is no consensus yet. This study investigates the relationship between 25-OH D3 levels and blood glucose level and body mass index in non-obese and non-diabetic women. Methods: In this study, the data of female patients aged between 18–84 years, who were applied to the internal med- icine outpatient clinic between 2016 and 2018 and whose heights and weights were recorded, were retrospectively analyzed. The study included 201 female patients. Results: There was a negative correlation revealed between vitamin D levels and body mass index (r=0.222, p<0.01). Discussion and Conclusion: According to these results, 25-OH D3 deficiency should be considered in patients with a high body mass index.

scholarly journals Role of Vitamin D Levels in Venous Thrombosis

Blood ◽  
2021 ◽  
Vol 138 (Supplement 1) ◽  
pp. 4255-4255
Author(s):  
Marwah W Farooqui ◽  
Yhana Chavis ◽  
Nailah Ghouse ◽  
Julia Bank ◽  
Michelle Chan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Venous Thromboembolism ◽  
Vitamin D Deficiency ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
P Value ◽  
International Studies ◽  
Vitamin D Levels ◽  
Cancer Associated Thrombosis

Abstract Venous thromboembolism (VTE) is a complex condition that impacts over 900,000 people in the United States annually. It is estimated that about 100,000 people in the US die from deep vein thrombosis (DVT) or pulmonary embolism (PE) annually. Several biomarkers, including Vitamin D most recently, have been investigated and linked to the risk of developing VTE or recurrent VTE. Vitamin D is known to control the expression of over 200 genes and it has shown to have anti-thrombotic effects through various mechanisms. There is emerging data regarding its role in the coagulation pathway, platelet activation, inflammatory pathways and endothelial activation (1). There have been a few international studies linking Vitamin D deficiency to VTE(2). However; no such study has been replicated in the North American population where the prevalence of Vitamin D deficiency is 40%. The focus of this study will be to determine the prevalence of Vitamin D deficiency in patients with VTE. Based on the role of Vitamin D in the pathway for thrombogenesis and antithrombin effects, there is likely a correlation between VTE and Vitamin D levels. This is a retrospective chart review of all patients admitted to Franciscan Health- Olympia Fields with VTE between July 2018 and June2020. A total of 181 patients with VTE were reviewed. Data such as age, gender, race, D-dimer, and Vitamin D levels were collected. Vitamin D levels &lt;30ng/mL was defined as deficient. In addition, further data collection, included provoked vs unprovoked VTE, presence of malignancy, and the severity of DVT and PE based on location and extent of the VTE (severity was scored on a scale of 1-3 with 1 being mild and 3 as severe). A regression analysis was done to find a correlation between several variables and T-test was used to determine P-value. Of the 181 patients, 110 had a vitamin D level documented at the time of their VTE and data was specifically analyzed for this subgroup. There were 46 males and 64 females, 53.6%AA, 7.3% Hispanic, 38.2% Caucasian, and 0.9% unknown. 25.5% had an unprovoked VTE event and 74.5% had a provoked event. 39 patients had a known active malignancy and a likely cancer associated thrombosis. 85.7% of patients with unprovoked DVT had a low Vitamin D level. In patients with cancer associated thrombosis there was no significant correlation with vitamin D levels. A strong correlation was noted between vitamin D levels and the severity of PE (p value=0.036). This retrospective chart review from a patient population at a community hospital indicates that there is some correlation between venous thromboembolism and Vitamin D levels. Specifically, it appears that patients with an unprovoked VTE have low Vitamin D levels suggesting that vitamin D deficiency may be a risk factor for VTE development as indicated by previous international studies (2). In addition, it appears that there is an inverse relationship between the severity of PE and vitamin D levels. Perhaps Vitamin D may be used as a biomarker for VTE risk assessment and management. Large scale studies are needed in the future to determine the exact relationship between VTE and Vitamin D and further studies are needed to test the role of vitamin D supplementation and risk of recurrent VTE. Disclosures No relevant conflicts of interest to declare.

scholarly journals Correlation of psoriasis and serum vitamin D

2021 ◽  
Vol 7 (4) ◽  
pp. 320-323
Author(s):  
Ritika Gujrati ◽  
Krishnendra Varma ◽  
Ujjwal Kumar
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Psoriasis Vulgaris ◽  
Systemic Disease ◽  
Serum Vitamin ◽  
Psoriatic Skin ◽  
Control Group ◽  
P Value ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Psoriasis is an immuno-mediated chronic systemic disease involving cytokines of helper Th1 pathway. Vitamin D has an effect on keratinocyte proliferation, differentiation and immune modulation of immune system especially Th1 pathway, which is altered in psoriatic skin suggesting that Vitamin D may have a role in pathogenesis of psoriasis. To study correlation between psoriasis vulgaris and serum vitamin D. To evaluate serum vitamin D level in psoriasis cases and in control group and correlating vitamin D level with severity and duration of the psoriasis. 57 cases (&#62;15years of age) with psoriasis and 57 healthy subjects were recruited. Psoriasis was clinically diagnosed and severity evaluated by PASI scale. Vitamin D was analysed by enhanced chemilumine scence on vitrus Eci autoanalyzer of Orth clinical diagnostic. Vitamin D deficiency defined as &#60;20ng/ml, insufficiency 20-30ng/ml and sufficient 30-100ng/ml. Vitamin D deficiency in the study was 22.8% in patients and 14% in control group. Vitamin D insufficiency was found in 42.1% of cases and 19.3% of control. According to chi-square the p-value is 0.003 showing significant association. There was a tendency towards decrease in vitamin D level with increase in disease duration. There was negative correlation between vitamin D and PASI score. The study found a significant relationship between vitamin D and psoriasis. Further metanalysis involving larger study population will be required to establish whether vitamin D levels benefits patient with psoriasis vulgaris.

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