Controllable synthesis of up-conversion nanoparticles UCNPs@MIL-PEG for pH-responsive drug delivery and potential up-conversion luminescence/magnetic resonance dual-mode imaging

2018 ◽  
Vol 749 ◽  
pp. 939-947 ◽  
Author(s):  
Yana Liu ◽  
Cheng Zhang ◽  
Hui Liu ◽  
Yuebin Li ◽  
Zushun Xu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Ph Responsive ◽  
Controllable Synthesis ◽  
Dual Mode

Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

2018 ◽  
Vol 25 (25) ◽  
pp. 3036-3057 ◽  
Author(s):  
Xiao Sun ◽  
Guilong Zhang ◽  
Zhengyan Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Contrast Enhancement ◽  
General Strategy ◽  
Ph Responsive ◽  
Physicochemical Changes ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

Smart polymeric particle encapsulated gadolinium oxide and europium: theranostic probes for magnetic resonance/optical imaging and antitumor drug delivery

2016 ◽  
Vol 4 (6) ◽  
pp. 1100-1107 ◽  
Author(s):  
Ruiqing Liu ◽  
Shuang Liang ◽  
Cun Jiang ◽  
Li Zhang ◽  
Tianmeng Yuan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Optical Imaging ◽  
Emulsion Polymerization ◽  
Gadolinium Oxide ◽  
Antitumor Drug ◽  
Ph Responsive ◽  
Polymeric Particles ◽  
Polymeric Particle

Paramagnetic, luminescent, and temperature/pH-responsive polymeric particles with MR/optical imaging and antitumor drug delivery capability are prepared by emulsifier-free emulsion polymerization.

γ-Fe2O3/La-MOFs@SiO2 for magnetic resonance/fluorescence dual mode imaging and pH-drug delivery

2018 ◽  
Vol 228 ◽  
pp. 216-219 ◽  
Author(s):  
Keke Sun ◽  
Chen Xu ◽  
Tianke Hu ◽  
Caixue Lin ◽  
Yifeng Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Resonance Fluorescence ◽  
Dual Mode

Controllable synthesis of a novel magnetic core–shell nanoparticle for dual-modal imaging and pH-responsive drug delivery

2017 ◽  
Vol 28 (49) ◽  
pp. 495101 ◽  
Author(s):  
Chen Xu ◽  
Cheng Zhang ◽  
Yingxi Wang ◽  
Liu Li ◽  
Ling Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Core ◽  
Core Shell ◽  
Ph Responsive ◽  
Controllable Synthesis

scholarly journals pH-Responsive Tumor-Targetable Theranostic Nanovectors Based on Core Crosslinked (CCL) Micelles with Fluorescence and Magnetic Resonance (MR) Dual Imaging Modalities and Drug Delivery Performance

Polymers ◽  
2016 ◽  
Vol 8 (6) ◽  
pp. 226 ◽  
Author(s):  
Sidan Tian ◽  
Guhuan Liu ◽  
Xiaorui Wang ◽  
Guoying Zhang ◽  
Jinming Hu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Imaging Modalities ◽  
Ph Responsive ◽  
Delivery Performance ◽  
Dual Imaging

A pH-Responsive Yolk-Like Nanoplatform for Tumor Targeted Dual-Mode Magnetic Resonance Imaging and Chemotherapy

ACS Nano ◽  
2017 ◽  
Vol 11 (7) ◽  
pp. 7049-7059 ◽  
Author(s):  
Xiao Sun ◽  
Ruohong Du ◽  
Li Zhang ◽  
Guilong Zhang ◽  
Xiaojia Zheng ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Ph Responsive ◽  
Resonance Imaging ◽  
Dual Mode

pH-responsive magnetic mesoporous silica nanospheres for magnetic resonance imaging and drug delivery

2012 ◽  
Vol 72 (5) ◽  
pp. 329-336 ◽  
Author(s):  
Huixia Wu ◽  
Lihui Tang ◽  
Lu An ◽  
Xue Wang ◽  
Haoqiang Zhang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Magnetic Resonance ◽  
Mesoporous Silica ◽  
Silica Nanospheres ◽  
Ph Responsive ◽  
Resonance Imaging ◽  
Magnetic Mesoporous Silica ◽  
Mesoporous Silica Nanospheres

In situ growth of metal–organic frameworks (MOFs) on the surface of other MOFs: a new strategy for constructing magnetic resonance/optical dual mode imaging materials

2017 ◽  
Vol 46 (40) ◽  
pp. 13686-13689 ◽  
Author(s):  
Xuechuan Gao ◽  
Guanfeng Ji ◽  
Ruixue Cui ◽  
Jingjuan Liu ◽  
Zhiliang Liu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Optical Imaging ◽  
Metal Organic Frameworks ◽  
In Situ Growth ◽  
Dual Mode ◽  
New Strategy ◽  
Metal Organic ◽  
First Time

This work presents for the first time the synthesis of a novel nanoscale Fe-MOF/Eu-MOF heterostructure, which exhibits excellent magnetic resonance/optical imaging capacity and satisfactory drug delivery behavior.

Multifunctional envelope-type mesoporous silica nanoparticles for pH-responsive drug delivery and magnetic resonance imaging

Biomaterials ◽  
2015 ◽  
Vol 60 ◽  
pp. 111-120 ◽  
Author(s):  
Yan Chen ◽  
Kelong Ai ◽  
Jianhua Liu ◽  
Guoying Sun ◽  
Qi Yin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Magnetic Resonance ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Ph Responsive ◽  
Resonance Imaging

Controllable Synthesis of a Smart Multifunctional Nanoscale Metal–Organic Framework for Magnetic Resonance/Optical Imaging and Targeted Drug Delivery

2017 ◽  
Vol 9 (4) ◽  
pp. 3455-3462 ◽  
Author(s):  
Xuechuan Gao ◽  
Manjue Zhai ◽  
Weihua Guan ◽  
Jingjuan Liu ◽  
Zhiliang Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Optical Imaging ◽  
Targeted Drug Delivery ◽  
Metal Organic Framework ◽  
Controllable Synthesis ◽  
Metal Organic ◽  
Targeted Drug ◽  
Organic Framework
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