In vivo corrosion behavior of pure magnesium in femur bone of rabbit

Fluoride conversion coatings on Mg present many advantages, among which one can find the reduction of the corrosion rate under “in vivo” or “in vitro” conditions and the promotion of the calcium phosphate deposition. Moreover, the fluoride ions released from MgF2 do not present cytotoxic effects and inhibit the biofilm formation, and thus these treated alloys are very suitable for cardiovascular stents and biodegradable orthopedic implants. In this paper, the biodegradation behavior of four new magnesium biodegradable alloys that have been developed in the laboratory conditions, before and after surface modifications by fluoride conversion (and sandblasting) coatings, are analyzed. We performed structural and surface analysis (XRD, SEM, contact angle) before and after applying different surface treatments. Furthermore, we studied the electrochemical behavior and biodegradation of all experimental samples after immersion test performed in NaCl solution. For a better evaluation, we also used LM and SEM for evaluation of the corroded samples after immersion test. The results showed an improved corrosion resistance for HF treated alloy in the NaCl solution. The chemical composition, uniformity, thickness and stability of the layers generated on the surface of the alloys significantly influence their corrosion behavior. Our study reveals that HF treatment is a beneficial way to improve the biofunctional properties required for the studied magnesium alloys to be used as biomaterials for manufacturing the orthopedic implants.

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Influence of Microstructural Evolution Processed by ECAP on Corrosion Behavior of Pure Magnesium in RPMI-1640 Medium

Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies ◽

10.5220/0006143201180125 ◽

2017 ◽

Author(s):

Taito Hosaka ◽

Iman Amanina ◽

Naohiro Saruwatari ◽

Shoichiro Yoshihara ◽

Bryan J. MacDonald

Keyword(s):

Corrosion Behavior ◽

Microstructural Evolution ◽

Pure Magnesium

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Corrosion Behavior of Calcium Phosphate-Coated Biomedical Magnesium Alloy Under in Vitro and In Vivo Environments

ECS Meeting Abstracts ◽

10.1149/ma2016-02/10/1207 ◽

2016 ◽

Keyword(s):

Magnesium Alloy ◽

Calcium Phosphate ◽

Corrosion Behavior

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Corrosion behavior, in vitro and in vivo biocompatibility of a newly developed Ti–16Nb–3Mo–1Sn superelastic alloy

Materials Science and Engineering C ◽

10.1016/j.msec.2019.109906 ◽

2019 ◽

Vol 104 ◽

pp. 109906 ◽

Cited By ~ 1

Author(s):

Yazan Al-Zain ◽

Akiko Yamamoto ◽

Jihad M. AlAjlouni ◽

Mousa A. Al-Abbadi ◽

Manar R. Al-Sayyed ◽

...

Keyword(s):

Corrosion Behavior

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Correlation of Surface Alloyed Microstructure of Pure Magnesium With its Corrosion Behavior

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.472-475.161 ◽

2012 ◽

Vol 472-475 ◽

pp. 161-164

Author(s):

Yu Gao Liu

Keyword(s):

Corrosion Resistance ◽

Corrosion Behavior ◽

Chloride Solution ◽

Diffusion Time ◽

Point Of View ◽

Pure Magnesium ◽

Corrosion Mechanism ◽

Cross Sectional ◽

Microstructure Characteristics ◽

Solid Diffusion

This paper represents a summary of experimental results dealing with the time dependence of surface diffusion alloyed microstructure and its corrosion behavior at given temperature. The experiments were performed at 485°C for different solid diffusion time (6h, 12h, 18h ) and thus the surface alloyed microstructure of pure magnesium has been obtained. Optical and electrical microscopy and EDS compositions analysis were used to examine the cross sectional microstructure characteristics of alloyed layers of treated samples. It is shown that the new phases formed and its continuity, depending on the diffusion treated time at given temperature, have a noticeable influence on corrosion resistance and corrosion mechanism. The new formed phase Al5Mg11Zn4 was inert to the chloride solution compared with pure magnesium and acted as a corrosion barrier. It was concluded that the continuous Al5Mg11Zn4 phase was beneficial from the point of view of corrosion resistance.

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In vivo approach on femur bone regeneration of white rat (Rattus norvegicus) with the use of hydroxyapatite from cuttlefish bone (Sepia spp.) as bone filler

Veterinary World ◽

10.14202/vetworld.2019.809-816 ◽

2019 ◽

Vol 12 (6) ◽

pp. 809-816

Author(s):

Aminatun Aminatun ◽

D.E. Fadhilah Handayani ◽

Prihartini Widiyanti ◽

Dwi Winarni ◽

Siswanto Siswanto

Keyword(s):

Bone Regeneration ◽

Bone Repair ◽

Control Group ◽

Bovine Bone ◽

Lamellar Bone ◽

In Vivo Test ◽

Femur Bone ◽

Woven Bone ◽

Bone Filler

Background: Hydroxyapatite (HA) from bovine bone has been widely used as bone filler in many fractures cases. HA can also be made from cuttlefish bone (Sepia spp.) that has abundant availability in Indonesia and contains 84% CaCO3, which is a basic ingredient of HA. However, research on the effects of HA from cuttlefish bone on bone regeneration parameters has not been done yet. Aim: This study aimed to determine femur bone regeneration of white rats (Rattus norvegicus) through the use of HA from cuttlefish bone (Sepia spp.) as bone filler. Materials and Methods: HA was made using the hydrothermal method by mixing 1M aragonite (CaCO3) from cuttlefish bone and 0.6 M NH4H2PO4 at 200°C for 12 h followed by sintering at 900°C for 1 h. In vivo test was carried out in three groups, including control group, bovine bone-derived HA group, and cuttlefish bone-derived HA group. The generation of femur bone was observed through the number of osteoblasts, osteoclasts, woven bone, lamellar bone, havers system, and repair bone through anatomical pathology test for 28 days and 56 days. Results: Anatomical pathology test results are showed that administration of bovine bone-derived HA and cuttlefish bone-derived HA increased the number of osteoblasts, osteoclasts, woven bone, lamellar bone, havers system, and bone repair at recuperation of 56 days. Statistical test using Statistical Package for the Social Sciences with Kruskal–Wallis and Mann–Whitney U-test was resulted in significant differences between the bovine bone-derived HA control group and the cuttlefish-derived HA control group. There was no significant difference toward the indication of bone formation through the growth of osteoblasts, osteoclasts, woven bone, lamellar bone, havers system, and bone repair in the bovine bone-derived HA and cuttlefish bone-derived HA groups. Conclusion: It can be concluded that cuttlefish bone-derived HA has the potential as bone filler based on the characteristics of bone regeneration through in vivo test.

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Corrosion Modeling of Magnesium and Its Alloys for Biomedical Applications: Review

Corrosion and Materials Degradation ◽

10.3390/cmd1020011 ◽

2020 ◽

Vol 1 (2) ◽

pp. 219-248

Author(s):

Moataz Abdalla ◽

Alexander Joplin ◽

Mohammad Elahinia ◽

Hamdy Ibrahim

Keyword(s):

Corrosion Behavior ◽

Biomedical Applications ◽

Numerical Models ◽

Research Effort ◽

Degradation Process ◽

Medical Implants ◽

Biodegradable Metals ◽

Significant Research

Biodegradable metals have been under significant research as promising alternatives to the currently in-use nonbiodegradable materials in the field of supportive medical implants. In this scope, magnesium and its alloys were widely investigated due to their superior biocompatibility over other metals. Most of the research effort in the literature has been focused on assuring the biocompatibility, improving mechanical properties, and tailoring the corrosion rate of magnesium-based implants. Furthermore, considerable research was done to develop numerical models towards an inexpensive and fast designing tools capable of simulating the degradation/corrosion behavior of magnesium-based implants. Due to the complexity of the degradation process and the various factors that can be involved, several hypotheses were introduced to provide a realistic simulation of the corrosion behavior in vitro and in vivo. A review of the current literature hypothesis and different modeling constitutive equations for modeling the corrosion of magnesium alloys along with a summary of the supplementary experimental methods is provided in this paper.

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