Particle dose dependent neurotoxic effect of silver nanoparticles in foetuses of Swiss albino mice

2016 ◽  
Vol 65 ◽  
pp. S74
Author(s):  
J.P. Pani ◽  
S.N. Shamal ◽  
S.P. Mishra ◽  
P. Kumari ◽  
R. Singh
Keyword(s):  
Silver Nanoparticles ◽  
Neurotoxic Effect ◽  
Swiss Albino Mice ◽  
Particle Dose ◽  
Albino Mice ◽  
Dose Dependent

scholarly journals Genotoxicity and histopathological assessment of silver nanoparticles in Swiss albino mice

2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Oluyinka A Iyiola ◽  
Temitope F. Olafimihan
Keyword(s):  
Silver Nanoparticles ◽  
Portal Tract ◽  
Sperm Head ◽  
Mouse Bone Marrow ◽  
Total N ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Head Morphology ◽  
Dose Dependent ◽  
Positive Controls

Silver nanoparticles (AgNPs) are widely used in industrial and medical applications. However, there is a growing concern about the potentialities of AgNPs to induce genotoxicity and DNA damage in humans. In this study, genotoxic and histopathological effects of AgNPs were investigated in mice using two well-characterized genetic assays: mouse bone marrow micronuclei (MN) and mouse sperm morphology assays. Swiss albino mice (total N=18) were exposed to varying concentrations (3,000mg/Kg, 4,000mg/Kg, 5,000mg/Kg and 6,000mg/Kg) of AgNPs for 5 consecutive days and observed for 30 days afterwards. Distilled water and colchicine were used as negative and positive controls, respectively. The MN assay showed that the frequency of micronuclei induction increased with AgNP concentration. Statistically significant differences (p<0,05) were observed for the micronucleus frequency in the blood erythrocytes in all the test concentrations. Sperm head morphology assay also revealed various types of abnormal sperm head morphology and there was statistically significant increase in frequency of sperm abnormalities. Histopathological profiles of the liver also showed enlarge sinusoids, irregular portal tract, and dose-dependent vacuolation. These results suggest that AgNPs is genotoxic and represent a serious health risk to human heatlh.

Determination of nephrotoxicity and genotoxic potential of silver nanoparticles in Swiss albino mice

2016 ◽  
Vol 99 (2) ◽  
pp. 294-301 ◽  
Author(s):  
Saud Alarifi ◽  
Daoud Ali ◽  
Mohammed A Al Gurabi ◽  
Saad Alkahtani
Keyword(s):  
Silver Nanoparticles ◽  
Swiss Albino Mice ◽  
Genotoxic Potential ◽  
Albino Mice

Effect of Commiphora Molmol (Oleo-gum-resin) on the Cytological and Biochemical Changes Induced by Cyclophosphamide in Mice

1994 ◽  
Vol 22 (01) ◽  
pp. 77-82 ◽  
Author(s):  
M.M. AI-Harbi ◽  
S. Qureshi ◽  
M.M. Ahmed ◽  
S. Rafatullah ◽  
A.H. Shah
Keyword(s):  
Nucleic Acids ◽  
Biochemical Changes ◽  
Additive Effect ◽  
Swiss Albino Mice ◽  
Hepatic Cells ◽  
Albino Mice ◽  
Dose Dependent ◽  
Rna Levels

The anticlastogenic and biochemical potentials of Commiphora molmol were studied in Swiss albino mice treated with cyclophosphamide (CP). The C. molmol treatment (125-500 mg/kg) showed no mutagenicity. It caused a highly significant and dose-dependent mitodepressant effect in the femoral cells and reduction of RNA levels in hepatic cells as compared with the control. CP treatment showed significant increase in the frequency of micronuclei, cytotoxicity and reduction in the contents of nucleic acids and proteins. Pretreatment with C. molmol could neither alter the biochemical and cytological effects of CP nor show any additive effect of both treatments.

scholarly journals In vivo DNA damaging and apoptotic potential of silver nanoparticles in Swiss albino mice

2015 ◽  
pp. 295 ◽  
Author(s):  
Daoud Ali ◽  
Saad Alkahtani ◽  
Mohammed A. Al Gurabi ◽  
Saud Alarifi
Keyword(s):  
Silver Nanoparticles ◽  
Swiss Albino Mice ◽  
Albino Mice

scholarly journals Antiarthritic Activity of Achyranthes Aspera on Formaldehyde - Induced Arthritis in Rats

2019 ◽  
Vol 7 (17) ◽  
pp. 2709-2714
Author(s):  
Velmurugan Chinnasamy ◽  
Vetriselvan Subramaniyan ◽  
Sarath Chandiran ◽  
Saminathan Kayarohanam ◽  
Dhanapal Сhidambaram Kanniyan ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Test Dose ◽  
Joint Inflammation ◽  
Negative Control ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
C 50 ◽  
Dose Dependent ◽  
Histopathological Investigation

AIM: To determine the ameliorative potential of aqueous extract of Achyranthesaspera(AEAA) against arthritis using swiss albino mice and Wistar rats, and its possible mechanism of action. METHODS: Swiss albino mice (25-30 g) and Wistar rats (150-180 g) under standard controlled conditions (24 ± 2°C, 50-70 humidity and 12 h light/dark cycle). The groups were divided into 6 groups (n = 6/group) and assigned as control, negative control, standard and, formaldehyde supplemented with two different test dose groups of A. aspera for 4 weeks. Arthritis induced by subplantar administration of 0.1 ml formaldehyde (2% v/v) into the left hind paw in all groups except normal control. Arthritis was assessed using serum Hb, ESR, paw volume, joint diameter, radiological and histopathological investigation. RESULTS: Oral administration of AEAA shown a significant (p < 0.01) dose-dependent protection against formaldehyde induced arthritis. At 21st day, A.asperashown an inhibition of paw volume in the different doses of 250 mg/kg and 500 mg/kg were found to be 30% and, 38.33% respectively. At 14th day the joint swelling was found to be 27.2% and 36.36 respectively. Diclofenac (10 mg/kg) had an effect of 36.61% inhibition of arthritis and joint swelling at 21st and 14th day. CONCLUSION: Thus, the present study revealed that the aqueous extract of A. aspera offered significant protection against arthritis and joint inflammation.

Dose-dependent suppression of haloperidol-induced catalepsy by potentized Agaricus muscarius

1996 ◽  
Vol 85 (03) ◽  
pp. 141-144 ◽  
Author(s):  
Souvik Ghosh ◽  
S.P. Sinha Babu ◽  
N.C. Sukul
Keyword(s):  
Treatment Effect ◽  
Post Treatment ◽  
Active Principle ◽  
Mechanical Agitation ◽  
Swiss Albino Mice ◽  
Before And After ◽  
Albino Mice ◽  
Pre Treatment ◽  
Dose Dependent ◽  
Post Treatment Effect

Abstract Agaricus muscarius 30c, a potentized homoeopathic drug prepared by successive dilution with 90% alcohol followed by sonication, suppressed haloperidol-induced catalepsy in Swiss albino mice significantly. This anticataleptic effect was dose-dependent being greatest with the undiluted Agaricus 30c and least if diluted 1:20,000. Higher dilutions like 1:40,000 and 1:50,000 did not produce an anticataleptic effect. The effect reappeared when the 1:50,000 dilution was sonicated. The anticataleptic effect of potentized Agaricus was observed with the drug administered both before and after haloperidol. However, the pre-treatment effect was more pronounced than the post-treatment effect.It is thought that potentized Agaricus contains an active principle that can be attenuated by dilution and multiplied by mechanical agitation or sonication.

scholarly journals Antinociceptive Activity of Methanol Extract of Tamarix indica

1970 ◽  
pp. 1-3
Author(s):  
MAM Sarker ◽  
Md Abdul Matin Sarker
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Reducing Sugars ◽  
Diclofenac Sodium ◽  
Antinociceptive Activity ◽  
Standard Drug ◽  
Swiss Albino Mice ◽  
Phytochemical Investigation ◽  
Albino Mice ◽  
Dose Dependent

The antinociceptive activity of the methanolic extract of the barks of Tamarix indica Roxb. was investigated using acetic acid-induced writhing model in swiss albino mice. The extract produced about 26.89%( P< 0.01) and 43.55% (P< 0.001) writhing inhibition at the dose of 250 and 500 mg/ kg of body weight respectively, which was comparable to the standard drug diclofenac sodium where the inhibition was about 63.64% (P< 0.001) at the dose of 25 mg/kg of body weight. At the above doses, the extract exhibited significant and dose dependent antinociceptive activity in acetic acid-induced writhing model in swiss albino mice. Phytochemical investigation of the extract indicate the presence of reducing sugars, tannins, gums, flavonoids and saponin. Key words: Tamarix indica; antinociceptive activity; acetic acid-induced writhing; phytochemical test. DOI: 10.3329/bjpp.v25i1.5736Bangladesh J Physiol Pharmacol 2009; 25(1&2) : 1-3

Protective effect of Emblica officinalis ethanolic extract against 7,12-dimethylbenz(a)anthracene (DMBA) induced genotoxicity in Swiss albino mice

2004 ◽  
Vol 23 (11) ◽  
pp. 527-531 ◽  
Author(s):  
S Mumtaz Banu ◽  
K Selvendiran ◽  
J Prince Vijeya Singh ◽  
D Sakthisekaran
Keyword(s):  
Protective Effect ◽  
Ethanolic Extract ◽  
Treated Group ◽  
Maximum Effect ◽  
Emblica Officinalis ◽  
Glutathione S Transferase ◽  
Fruit Extract ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Dose Dependent

Ethanolic extract of Emblica officinalis (EO) fruit extract was evaluated for protection against genotoxicity induced by the rodent carcinogen, 7,12-dimethylbenz(a)anthracene (DMBA). Oral administration of EO fruit extract in various concentrations (100, 250, 500mg/kg b.wt) for seven consecutive days prior to a single intraperitoneal injection of DMBA decreased the frequency of bone marrow micronuclei induced in Swiss albino mice. Significant increases in the liver antioxidants, such as glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GR) and detoxifying enzyme glutathione-S-transferase (GST), were found in the fruit extract treated group. The extract also reduced the hepatic levels of the activating enzymes cytochrome (CYt) P450 and Cyt b5. These increased in the carcinogen treated group, which emphasizes its protective effect against the carcinogen. There was a dose-dependent effect of the extract against the genotoxin with the maximum effect at 500 mg/kg b.wt. The protection afforded by EO may be associated with its antioxidant capacity and through its modulatory effect on hepatic activation and detoxifying enzymes.

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