scholarly journals Antinociceptive Activity of Methanol Extract of Tamarix indica

1970 ◽  
pp. 1-3
Author(s):  
MAM Sarker ◽  
Md Abdul Matin Sarker
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Reducing Sugars ◽  
Diclofenac Sodium ◽  
Antinociceptive Activity ◽  
Standard Drug ◽  
Swiss Albino Mice ◽  
Phytochemical Investigation ◽  
Albino Mice ◽  
Dose Dependent

The antinociceptive activity of the methanolic extract of the barks of Tamarix indica Roxb. was investigated using acetic acid-induced writhing model in swiss albino mice. The extract produced about 26.89%( P< 0.01) and 43.55% (P< 0.001) writhing inhibition at the dose of 250 and 500 mg/ kg of body weight respectively, which was comparable to the standard drug diclofenac sodium where the inhibition was about 63.64% (P< 0.001) at the dose of 25 mg/kg of body weight. At the above doses, the extract exhibited significant and dose dependent antinociceptive activity in acetic acid-induced writhing model in swiss albino mice. Phytochemical investigation of the extract indicate the presence of reducing sugars, tannins, gums, flavonoids and saponin. Key words: Tamarix indica; antinociceptive activity; acetic acid-induced writhing; phytochemical test. DOI: 10.3329/bjpp.v25i1.5736Bangladesh J Physiol Pharmacol 2009; 25(1&2) : 1-3

scholarly journals Antinociceptive activity of methanolic extract of the leaves of Feronia limonia Linn

2014 ◽  
Vol 26 (1-2) ◽  
pp. 21-24
Author(s):  
Moni Rani Saha ◽  
Sheikh Zahir Raihan ◽  
Akm Shahidur Rahman
Keyword(s):  
Body Weight ◽  
Methanolic Extract ◽  
Diclofenac Sodium ◽  
Antinociceptive Activity ◽  
Tail Flick ◽  
Immersion Method ◽  
Tail Flick Test ◽  
Standard Drug ◽  
Swiss Albino Mice ◽  
Albino Mice

The antinociceptive activity of the methanolic extract of the leaves of Feronia limonia Linn. (Family Rutaceae) was investigated using acetic acid-induced writhing model and tail flick test in swiss albino mice. The extract produced about 26.01% ( p< 0.01), 39.88% ( p< 0.01) and 57.07% (p< 0.01) writhing inhibition at the dose of 100, 200 and 400 mg/kg of body weight respectively, which was comparable to the standard drug diclofenac sodium where the inhibition was about 63.58% (p< 0.01) at the dose of 25 mg/kg of body weight. All doses of extracts significantly (p<0.05) increased latency of flick tail in tail immersion method. The methanolic extract showed dose dependent antinociceptive activity in both type of test in swiss albino mice. Phytochemical investigations of the leaves extract indicate the presence of tannins, saponins, steroids, alkaloids and flavonoids. The preliminary study of the methanolic extract showed antinociceptive activity in both writhing and tail flick test in mice. http://dx.doi.org/10.3329/bjpp.v26i1-2.19962 Bangladesh J Physiol Pharmacol 2010; 26(1&2) : 21-24

scholarly journals Screening of analgesic activity of Phoenix sylvestris leaves in rodents

2018 ◽  
Vol 4 (1) ◽  
pp. 22-24
Author(s):  
Pankaj Jain ◽  
◽  
Sonika Jain ◽  
Surendra Kumar Swarnkar ◽  
Swapnil Sharma ◽  
...  
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Analgesic Activity ◽  
Leaf Extract ◽  
Methanolic Extract ◽  
Standard Drug ◽  
Swiss Albino Mice ◽  
Tail Immersion ◽  
Albino Mice ◽  
Withdrawal Reflexes

Aim: The present study evaluated the central and peripheral analgesic activity of methanolic leaf extract of Phoenix sylvestris (PSLME) in swiss albino mice. Method: Peripheral and central analgesic activity was evaluated by tail immersion and acetic acid writhing in swiss albino mice. Dextropropoxyphene was used as a standard drug in the dose of 65mg/kg body weight in both models. PSLME was tested at 100 and 500mg/kg dose level. Results: The result revealed that methanolic extract exhibit 48% and 40.5% writhing inhibition at 500 and 100 mg/kg doses whereas ~30% tail withdrawal reflexes inhibition at 500mg/kg which was analogous to the standard drug dextropropoxyphene. Conclusion: Methanolic extract of leaves of P. sylvestris possesses both peripheral and central analgesic activity in experimental animal.

scholarly journals Antinociceptive and Anthelmintic Activities of Leaves of Leea aequata

2018 ◽  
Vol 17 (2) ◽  
pp. 251-255 ◽  
Author(s):  
Sushanta Halder ◽  
Nazmus Saqueeb ◽  
Nazmul Qais
Keyword(s):  
Crude Extract ◽  
Methanol Extract ◽  
Diclofenac Sodium ◽  
Anthelmintic Activity ◽  
Radiant Heat ◽  
Antinociceptive Activity ◽  
Dependent Manner ◽  
Standard Drug ◽  
Dose Dependent ◽  
Crude Methanol Extract

The objective of the study was to evaluate the antinociceptive and anthelmintic activities of the crude methanol extract of leaves of Leea aequata and its fractions. The crude extract and its fractions at 200- and 400-mg/kg bw were subjected to assay for their antinociceptive activity using acetic acid induced writhing and radiant heat tail flicking methods. The ethyl acetate soluble fraction at 400 mg/kg bw induced 40.97% inhibition of writhing in mice while the carbon tetrachloride and chloroform soluble fractions of crude extract at the same dose displayed activity with 40.28% inhibition of writhing as compared to standard diclofenac sodium. The crude extract elongated the reaction time by 57.04% after 30 minute of administration in radiant heat tail flicking method, which suggested the central antinociceptive activity as compared to morphine. The methanol extract of the leaves of L. aequata exhibited profound anthelmintic activity in a dose dependent manner with shortest time of paralysis and death at 100 mg/ml concentration. It caused paralysis of the earthworm Pheretima posthuma at 9.44 min and death at 12.9 min when compared to the standard drug albendazole, which at 10 mg/ml concentration revealed the same at 8.21 minutes and 11.18 minutes, respectively. Dhaka Univ. J. Pharm. Sci. 17(2): 251-255, 2018 (December)

Effect of Sorafenib on Sex Hormone Levels in Male Swiss Albino Mice

2021 ◽  
pp. 3883-3888
Author(s):  
Surekha D. Shetty ◽  
Laxminarayana Bairy K. ◽  
AM Prasad ◽  
Satheesha Nayak B. ◽  
Ashwini Aithal P.
Keyword(s):  
Body Weight ◽  
Semen Analysis ◽  
Young Patients ◽  
Differentiated Thyroid Carcinoma ◽  
Positive Control ◽  
Vital Role ◽  
Reproductive Age ◽  
Control Group ◽  
Swiss Albino Mice ◽  
Albino Mice

Background: Hormones play a vital role in initiating and maintenance of male reproductive or testicular function which includes the production of androgens and spermatozoa. Testosterone is essential for the initiation and maintenance of spermatogenesis. FSH is responsible for the stimulation of spermatogenesis. Semen analysis and hormone evaluation are essential parameters in the diagnosis of infertility in males. Objective: The aim of the present study is to evaluate the effect of sorafenib on FSH and intratesticular testosterone levels in male Swiss albino mice. Materials and Methods: The animals were segregated into control, positive control, and treatment groups (n=6). Treatment group received 25, 50 and 100 mg/kg body weight of sorafenib orally for seven consecutive days at intervals of 24 hours between two administrations. Positive control group received 100 mg/kg body weight of imatinib. The animals were sacrificed at the end of 1st, 2nd, 4th, 5th, 7th and 10th week after the last exposure to sorafenib. Results: The intratesticular testosterone level was significantly (P<0.05) reduced in treated groups and severe effect was observed on week 4th and 5th weeks. FSH level was increased significantly (P<0.05) in sorafenib treated groups of mice. Conclusion: The administration of sorafenib does affect testosterone and FSH level significantly, but this effect is reversible once the drug is withdrawn. This finding may help the clinicians to plan and address the fertility-related issues in young patients of reproductive age who are being treated with sorafenib for advanced renal cell carcinoma, hepatocellular carcinoma and differentiated thyroid carcinoma.

scholarly journals Vernonia Amygdalina Del (Bitter Leaf) extract ameliorates isoniazid (INH) induced liver injury in Swiss Albino Mice

2018 ◽  
Author(s):  
Gebreselassie Addisu Tilaye ◽  
Muluken Fekadie Zerihun ◽  
Kasaw Adane Chuffa ◽  
Mahelet Arayaselassie ◽  
Daniel Seifu
Keyword(s):  
Liver Injury ◽  
Leaf Extract ◽  
Drug Clearance ◽  
Vernonia Amygdalina ◽  
Drug Induced ◽  
Standard Drug ◽  
Swiss Albino Mice ◽  
Antitubercular Drugs ◽  
Toxic Injury ◽  
Albino Mice

AbstractLiver plays a central role in the metabolism of drugs. Drug clearance and transformation exposes liver to toxic injury. Antitubercular drugs have been found to be hepatotoxic and potentially lead to drug-induced liver injury. Isoniazid is one of the most hepatotoxic first line antitubercular drugs. Conventional drugs used in the treatment of liver disease are often inadequate and a search for supplementation or alternative drugs for the treatment of hepatic damage is indispensible. Therefore our study aims to investigate the hepatoprotective potential of Vernonia Amygdalina Del (bitter leaf) extract against Isoniazid-induced liver injury in Swiss Albino Mice. Treatment of Mice orally with Vernonia Amygdalina Del extract at dose of 250mg/kg and 375 mg/kg significantly lowered (P<0.05) the serum level of liver enzymes in Isoniazid pretreated mice. The hepatoptotective activity of the extract found to be comparable with the standard drug, Silymarin (100 mg/kg, P.o.). Moreover, treatment with the extract significantly alleviated Isoniazid induced hepatic injury as supported by the photomicrographs of liver section of mice. The data shows aqueous Vernonia Amygdalina Del extract has a very promising hepatoprotective potential against isoniazid-induced liver injury.

scholarly journals PRELIMINARY PHYTOCHEMICAL SCREENING AND EVALUATION OF ANALGESIC AND MUSCLE RELAXANT ACTIVITY OF THE ETHANOLIC EXTRACT OF THE LEAVES OF MIRABILIS JALAPA

2017 ◽  
pp. 81-84
Author(s):  
Deepsikha Bharali ◽  
Dipankar Saha
Keyword(s):  
Muscle Relaxant ◽  
Diclofenac Sodium ◽  
Ethanolic Extract ◽  
Dependent Manner ◽  
Phytochemical Screening ◽  
Standard Drug ◽  
Standard Procedures ◽  
Mirabilis Jalapa ◽  
Muscle Relaxant Activity ◽  
Dose Dependent

Objective: The aim and objectives of the present work is to determine pharmacological activity upon ethnopharmacological survey. The present study deals with phytochemical screening and analgesic as well as muscle relaxant activity of leaves of Mirabilis jalapa.Methods: The present study is aimed at phytochemical screening and evaluating the analgesic and muscle relaxant activities of ethanolic leaf extract of Mirabilis jalapa by using hot plate method and rota rod method respectively [1, 2]. The Phytochemical screening of the extract was done according to the standard procedures to reveal the presence of the active constituents like Alkaloids, flavonoids, phenols, glycosides, tannins, saponins, steroids, carbohydrates etc [3-5].Results: The analgesic and muscle relaxant activity study were dose dependent. The EEMJ extracts (100 mg/kg, 200 mg/kg, 500 mg/kg) and the standard drug Diclofenac sodium (25 mg/kg) shows significant increase in the reaction time when compared with control at 30 min, 60 min, 90 min and 120 min and the effect of standard was found to be highest during the study. Another study was designed to evaluate the skeletal muscle relaxant properties of ethanolic extract of leaves of Mirabilis jalapa. Linn by taking the EEMJ extracts (100 mg/kg, 200 mg/kg, 500 mg/kg) and standard drug Lorzepam (10 mg/kg). Both the extracts and standard drug show decrease in the fall of time in a dose dependent manner when compared with control at 15 min, 30 min, 45 min respectively. Conclusion: Therefore, from the above study it is revealed that Mirabilis jalapa showing better pharmacological activities (Analgesic and Muscle relaxant) in dose dependent manner.

Combination of fluoride and endosulfan induced teratogenicity and developmental toxicity in Swiss albino mice exposed during organogenesis

2019 ◽  
Vol 35 (9) ◽  
pp. 604-613
Author(s):  
Anju Sharma ◽  
PJ John ◽  
Pradeep Bhatnagar
Keyword(s):  
Body Weight ◽  
Developmental Toxicity ◽  
Combination Group ◽  
Maternal Weight ◽  
Additive Interaction ◽  
Swiss Albino Mice ◽  
Skeletal Malformations ◽  
Subcutaneous Edema ◽  
Fetal Malformations ◽  
Albino Mice

The present investigation was conducted to evaluate the teratogenic and developmental toxicity of fluoride and endosulfan alone and in combination in pregnant Swiss albino mice exposed during the organogenetic period (5–14 days) of gestation. Fluoride (25.1 mg/kg body weight in water) and endosulfan (1.8 mg/kg bw by oral intubation) when administered alone and in combination (fluoride 25.1 mg/kg bw + endosulfan 1.8 mg/kg bw) to pregnant mice caused significant teratogenic effects in developing fetuses. There was no maternal mortality but significant decreases in maternal weight gain and numbers of live fetuses and significant increases in numbers of fetal resorption were recorded in the treated groups. The fetal body weight and litter size also decreased significantly in all treated groups. No external malformations were observed in any of the fetuses. The percent of visceral and skeletal anomalies increased in the fetuses of all treated groups. The fetal malformations observed were internal hydrocephaly, microphthalmia, anophthalmia, pulmonary edema, subcutaneous edema, reduced ossification of skull bones, widened cranial sutures, rib anomalies (short, wavy, partially ossified, or absent ribs), and reduced ossification of phalanges. The occurrence of visceral and skeletal malformations was more severe in the combination group, suggesting additive interaction of fluoride and endosulfan in inducing developmental toxicity in Swiss albino mice.

Effect of exercise duration on feed intake and body composition of Swiss albino mice

1985 ◽  
Vol 58 (2) ◽  
pp. 500-505 ◽  
Author(s):  
R. Bulbulian ◽  
K. K. Grunewald ◽  
R. R. Haack
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Protein Content ◽  
Feed Intake ◽  
Exercise Duration ◽  
The Body ◽  
Control Group ◽  
Swiss Albino Mice ◽  
Daily Exercise ◽  
Albino Mice

The purpose of this study was to examine the effects of daily exercise of varying duration on the body composition, weight, and feed intake of mature Swiss albino mice. Fifty-four male mice were equally divided into a control group and five exercise groups (n = 9) performing 20, 40, 60, 120, and 240 min of daily exercise on a treadmill (7.2 m/min). Feed intake and body weight were measured weekly for 10 wk. At the completion of the study the mice were killed and the animal carcasses were chemically analyzed for fat, dry matter, and protein content. The results of this study demonstrate no differences in the body weight among groups (P less than 0.97) with all groups gaining 4.5–5.8 g during the 10-wk period. However, fat content decreased significantly from 15.7% in the control to 12.0% in the 120- and 240-min exercise groups (P less than 0.05). In contrast, protein content showed an insignificant rising trend from 13.0 to 14.6% with increasing duration of exercise. Feed intake showed a nonsignificant drop during the 20-min exercise treatment and remained unchanged among groups. These data show a slight but variable appetite-suppressing effect of light exercise in mice accompanied by favorable body composition changes even in the absence of differences in body weight. These findings suggest the mouse to be an acceptable experimental model for body composition and exercise studies.

scholarly journals Analgesic and Antidiarrheal Activities of Leaf of Podocarpus neriifolius D. Don

2016 ◽  
Vol 19 (2) ◽  
pp. 215-218
Author(s):  
Md Rahatullah Razan ◽  
Muhammed Mahfuzur Rahman ◽  
Faiza Tahia ◽  
Md Khalid Hossain ◽  
Mohammad A Rashid
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Analgesic Activity ◽  
Castor Oil ◽  
Methanol Extract ◽  
Methanolic Extract ◽  
Pharmaceutical Journal ◽  
Activity Assay ◽  
Swiss Albino Mice

The methanol extract of leaf of Podocarpus neriifolius D. Don exhibited in vivo peripheral analgesic and antidiarrheal activities in Swiss Albino mice. In the peripheral analgesic activity assay, the methanolic extract showed 50.00 ± 8.57% and 70.25 ± 1.18% inhibition of acetic acid-induced writhing at 200 and 400 mg/kg body weight, respectively. In addition, the extract also revealed a dose dependant inhibition of castor oil- induced diarrhea with 43.77 ± 3.13% and 56.23 ± 6.49% inhibition of feces at 200 and 400 mg/kg body weight, respectivelyBangladesh Pharmaceutical Journal 19(2): 215-218, 2016

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