A novel non-invasive method for measuring knee joint laxity in four dof: In vitro proof-of-concept and validation

Context:Knee osteoarthritis (OA) is a debilitating disease that affects an estimated 27 million Americans. Changes in lowerextremity alignment and joint laxity have been found to redistribute the medial and/or lateral loads at the joint. However, the effect that changes in anteroposterior knee-joint laxity have on lower-extremity alignment and function in individuals with knee OA remains unclear.Objective:To examine anteroposterior knee-joint laxity, lower-extremity alignment, and subjective pain, stiffness, and function scores in individuals with early-stage knee OA and matched controls and to determine if a relationship exists among these measures.Design:Case control.Setting:Sports-medicine research laboratory.Participants:18 participants with knee OA and 18 healthy matched controls.Intervention:Participants completed the Western Ontario McMaster (WOMAC) osteoarthritis questionnaire and were tested for total anteroposterior knee-joint laxity (A-P) and knee-joint alignment (ALIGN).Main Outcome Measures:WOMAC scores, A-P (mm), and ALIGN (°).Results:A significant multivariate main effect for group (Wilks’ Λ = 0.30, F7,26 = 8.58, P < .0001) was found. Knee-OA participants differed in WOMAC scores (P < .0001) but did not differ from healthy controls on ALIGN (P = .49) or total A-P (P = .66). No significant relationships were identified among main outcome measures.Conclusion:These data demonstrate that participants with early-stage knee OA had worse pain, stiffness, and functional outcome scores than the matched controls; however, ALIGN and A-P were no different. There was no association identified among participants’ subjective scores, ALIGN, or A-P measures in this study.

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Design of an Ingestible Capsule With Wireless Communication and Powering Function for Obesity Treating

Volume 10: Micro- and Nano-Systems Engineering and Packaging ◽

10.1115/imece2013-63599 ◽

2013 ◽

Author(s):

Liang Yan ◽

Tianyi Wang ◽

Zongxia Jiao ◽

Juanjuan Peng

Keyword(s):

Morbid Obesity ◽

Wireless Communication ◽

In Vitro Experiments ◽

Non Invasive ◽

Removal Process ◽

Wireless Control ◽

Invasive Method ◽

Energy Shortage

Intra-gastric balloons have been and effective and non-invasive method for morbid obesity treating since it is proposed. However, traditional balloons lead to complications such as nausea and sickness caused by insertion and removal endoscopes. Despite free of endoscope-guide insertion and removal process, wireless controlled balloons still have to face the problem of energy shortage. This paper proposes a novel wireless controlled and powered endoscope capsule of edible size. The performance of wireless control and powering are tested respectively. In addition, in-vivo and in-vitro experiments are conducted for further evaluation and shows feasibility for treating morbid obesity. This study may contribute to the development of endoscopic devices and surgery as well.

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Decreased Urinary Levels of SIRT1 as Non-Invasive Biomarker of Early Renal Damage in Hypertension

International Journal of Molecular Sciences ◽

10.3390/ijms21176390 ◽

2020 ◽

Vol 21 (17) ◽

pp. 6390

Author(s):

Olga Martinez-Arroyo ◽

Ana Ortega ◽

Miriam Galera ◽

Elena Solaz ◽

Sergio Martinez-Hervas ◽

...

Keyword(s):

Angiotensin Ii ◽

High Glucose ◽

Renal Damage ◽

Strong Association ◽

Hypertensive Patients ◽

Non Invasive ◽

Treatment Conditions ◽

Invasive Method ◽

Polymerase Chain

Sirtuins have become important players in renal damage in hypertension and diabetes, but their value as biomarkers is poorly assessed. The aims of the study were to evaluate the levels of sirtuin1 (SIRT1), and two miRNAs that regulate SIRT1 expression in hypertensive patients with incipient renal damage with and without diabetes. We quantified urinary SIRT1 and claudin 1 (CLDN1) mRNA and miR34-a and miR-200a levels by quantitative real-time polymerase chain reaction (RT-qPCR) from patients and in cultured podocytes treated with high glucose and angiotensin II. Western blot and fluorescence analyses were also performed. We found decreased SIRT1 levels in patients with increased urinary albumin excretion (UAE), the lowest with diabetes presence, and a strong association with UAE, discriminating incipient renal damage. In vitro experiments also showed SIRT1 overall decreases in podocyte cultures under treatment conditions. In urine samples, miR-34a was reduced and miR-200a increased, both related to UAE levels. However, both miRNAs were generally increased in podocyte cultures under high glucose and angiotensin-II treatment. These results show a significant urinary SIRT1 decrease in albuminuric hypertensive patients, strongly associated with albuminuria, suggesting that SIRT1 could be a potential and non-invasive method to assess incipient renal damage in hypertensive patients.

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Knee joint laxity and kinematics after anterior cruciate ligament rupture Roentgen stereophotogrammetric and clinical evaluation before and after treatment

Acta Orthopaedica Scandinavica ◽

10.3109/17453679409155649 ◽

1994 ◽

Vol 65 (sup256) ◽

pp. 117-117

Author(s):

Håkan Jonsson

Keyword(s):

Anterior Cruciate Ligament ◽

Knee Joint ◽

Clinical Evaluation ◽

Cruciate Ligament ◽

Joint Laxity ◽

Anterior Cruciate Ligament Rupture ◽

Ligament Rupture ◽

Knee Joint Laxity ◽

Before And After ◽

Anterior Cruciate

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Anterior Cruciate Ligament–Deficient Patients With Passive Knee Joint Laxity Have a Decreased Range of Anterior-Posterior Motion During Active Movements

The American Journal of Sports Medicine ◽

10.1177/0363546513480465 ◽

2013 ◽

Vol 41 (5) ◽

pp. 1051-1057 ◽

Cited By ~ 30

Author(s):

Heide Boeth ◽

Georg N. Duda ◽

Markus O. Heller ◽

Rainald M. Ehrig ◽

Ralf Doyscher ◽

...

Keyword(s):

Anterior Cruciate Ligament ◽

Knee Joint ◽

Cruciate Ligament ◽

Joint Laxity ◽

Knee Joint Laxity ◽

Anterior Cruciate ◽

Anterior Cruciate Ligament Deficient ◽

Anterior Posterior

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Implantable insulin pumps: diagnosis and management of decreased flow rates using radionuclide investigation

The International Journal of Artificial Organs ◽

10.1177/039139889601901208 ◽

1996 ◽

Vol 19 (12) ◽

pp. 723-729

Author(s):

H. Boulahdour ◽

A. Behar ◽

M.-J. Haardt ◽

J-L. Selam

Keyword(s):

Insulin Pumps ◽

Distal Catheter ◽

Non Invasive ◽

Step Procedure ◽

Catheter Obstruction ◽

Catheter Malfunction ◽

Invasive Method ◽

One Step ◽

Isotonic Sodium Chloride

The aim of this study was to develop a diagnostic procedure for pumping unit malfunction by radionuclide imaging (RI) and to validate the method by comparing the results with those obtained using more conventional methods. Fifteen radionuclide investigations were performed in 11 patients with intraperitoneal implantable insulin pumps. One mCi of 99 mTc in 1 ml isotonic sodium chloride was injected into the reservoir. The results based on catheter visualization and peritoneal accumulation were compared blindly to the efficacy of alkaline rinses and laparoscopic findings. In all RI stoppage cases except one alkaline rinses failed to restore flow. Where laparoscopy was performed, comparisons were concordant i.e. no outflow from the tip of the catheter. The RI images obtained were reproduced in vitro using a pump under normal flow conditions and complete proximal and distal catheter obstruction. RI is a safe, quick non invasive method which allows the location of the site of pump/catheter malfunction within a one step procedure and the prediction of the efficacy of sodium hydroxide rinses.

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