Combined effects of flow-induced shear stress and micropatterned surface morphology on neuronal differentiation of human mesenchymal stem cells

2014 ◽  
Vol 117 (2) ◽  
pp. 242-247 ◽  
Author(s):  
Kang Jin Jeon ◽  
So Hee Park ◽  
Ji Won Shin ◽  
Yun Gyeong Kang ◽  
Jin-Sook Hyun ◽  
...  
Keyword(s):  
Stem Cells ◽  
Shear Stress ◽  
Mesenchymal Stem Cells ◽  
Surface Morphology ◽  
Neuronal Differentiation ◽  
Human Mesenchymal Stem Cells ◽  
Combined Effects

scholarly journals Graphene nanofiber composites for enhanced neuronal differentiation of human mesenchymal stem cells

Nanomedicine ◽  
2021 ◽  
Author(s):  
Sonali Rawat ◽  
Krishan Gopal Jain ◽  
Deepika Gupta ◽  
Pawan Kumar Raghav ◽  
Rituparna Chaudhuri ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Neuronal Differentiation ◽  
Dopaminergic Neurons ◽  
Human Mesenchymal Stem Cells ◽  
Cost Effective ◽  
Intracellular Ca ◽  
One Step ◽  
Neuronal Arborization ◽  
Temperature Storage

Aim: To differentiate mesenchymal stem cells into functional dopaminergic neurons using an electrospun polycaprolactone (PCL) and graphene (G) nanocomposite. Methods: A one-step approach was used to electrospin the PCL nanocomposite, with varying G concentrations, followed by evaluating their biocompatibility and neuronal differentiation. Results: PCL with exiguous graphene demonstrated an ideal nanotopography with an unprecedented combination of guidance stimuli and substrate cues, aiding the enhanced differentiation of mesenchymal stem cells into dopaminergic neurons. These newly differentiated neurons were seen to exhibit unique neuronal arborization, enhanced intracellular Ca2+ influx and dopamine secretion. Conclusion: Having cost-effective fabrication and room-temperature storage, the PCL-G nanocomposites could pave the way for enhanced neuronal differentiation, thereby opening a new horizon for an array of applications in neural regenerative medicine.

NRSF silencing induces neuronal differentiation of human mesenchymal stem cells

2008 ◽  
Vol 314 (11-12) ◽  
pp. 2257-2265 ◽  
Author(s):  
Yinxiang Yang ◽  
Yanhua Li ◽  
Yang Lv ◽  
Sainan Zhang ◽  
Lin Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Neuronal Differentiation ◽  
Human Mesenchymal Stem Cells

Effect of Tensile Strain and Shear Stress on the Differentiation of Human Mesenchymal Stem Cells into Endothelial Cells

2012 ◽  
Vol 2012 (1) ◽  
pp. 61
Author(s):  
Najmeh Safaei ◽  
Mohammad Tafazzoli-Shadpour ◽  
Nooshin Haghighipour ◽  
Mohammad Ali Shokrgozar ◽  
Shahrokh Shojaei ◽  
...  
Keyword(s):  
Stem Cells ◽  
Endothelial Cells ◽  
Shear Stress ◽  
Mesenchymal Stem Cells ◽  
Tensile Strain ◽  
Human Mesenchymal Stem Cells

scholarly journals Shear stress induces osteogenic differentiation of human mesenchymal stem cells

2010 ◽  
Vol 5 (5) ◽  
pp. 713-724 ◽  
Author(s):  
Gregory Yourek ◽  
Susan M McCormick ◽  
Jeremy J Mao ◽  
Gwendolen C Reilly
Keyword(s):  
Stem Cells ◽  
Shear Stress ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Human Mesenchymal Stem Cells
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