Experience of pain is correlated to treatment profile in patients with rheumatoid arthritis. Differentiating 5 clusters of patients in a national cohort of 1100 women with rheumatoid arthritis

Abstract Objectives Patients with RA have a higher prevalence of infertility than the general population. This study sought to examine the impact of RA disease activity and treatments on ovarian reserve measured by serum anti-Müllerian hormone (AMH) levels in the ESPOIR cohort. We sought to better define the indications for fertility preservation. Methods Patients and serum analysis data were derived from the French national cohort ESPOIR. Enrolled patients (n = 102; 18–37-year-olds) fulfilled ACR/EULAR 2010 criteria for RA. Serum AMH levels were measured at T0, T6, T12, T24 and T36 months post-diagnosis. The impacts of RA activity (DAS28 and CRP level) and treatments (MTX only or with other medications) were evaluated at each study visit. Results A gradual decrease in patients’ serum AMH levels was observed over time, in line with the descending curve described for healthy women. Serum AMH levels of RA patients in comparison with the values considered normal for age did not reveal any significant differences (P > 0.05). We did not observe any impact of RA treatments. We demonstrated an inverse correlation between AMH variation and disease activity (DAS28: r = –0.27, P = 0.003; CRP: r = –0.16, P = 0.06). Conclusion This is the first study to determine serum AMH levels of a large cohort of RA patients over 36 months. Rapid disease activity control appears to be required to limit changes in the ovarian reserve. Fertility preservation is not likely to be necessary if inflammation is promptly controlled. ClinicalTrials.gov Identifier: NCT03666091.

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A study of the prevalence of sicca symptoms and secondary Sjögren's syndrome in patients with rheumatoid arthritis, and its association to disease activity and treatment profile

International Journal of Rheumatic Diseases ◽

10.1111/j.1756-185x.2012.01717.x ◽

2012 ◽

Vol 15 (3) ◽

pp. 284-288 ◽

Cited By ~ 30

Author(s):

Hans-Jacob Haga ◽

Yusuf Naderi ◽

Alicia Martin Moreno ◽

Elisabeth Peen

Keyword(s):

Rheumatoid Arthritis ◽

Disease Activity ◽

Sjögren's Syndrome ◽

Sjogren’S Syndrome ◽

Sjogren's Syndrome ◽

Secondary Sjögren’S Syndrome ◽

Sicca Symptoms ◽

Secondary Sjögren's Syndrome ◽

Treatment Profile ◽

Sjögren‘S Syndrome

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National cohort study of reproductive risk factors for rheumatoid arthritis in Denmark: a role for hyperemesis, gestational hypertension and pre-eclampsia?

Annals of the Rheumatic Diseases ◽

10.1136/ard.2008.099945 ◽

2009 ◽

Vol 69 (2) ◽

pp. 358-363 ◽

Cited By ~ 27

Author(s):

K T Jørgensen ◽

B V Pedersen ◽

S Jacobsen ◽

R J Biggar ◽

M Frisch

Keyword(s):

Rheumatoid Arthritis ◽

Cohort Study ◽

Gestational Hypertension ◽

Reproductive Factors ◽

First Child ◽

Increased Risk ◽

Fetal Microchimerism ◽

National Cohort ◽

National Register Data ◽

History Of

Objectives:While reproductive factors might plausibly be involved in the aetiology of rheumatoid arthritis (RA), the female predominance remains unexplained. A study was undertaken to address the possible impact of live births, pregnancy losses and pregnancy complications on the subsequent risk of RA in a nationwide cohort study.Methods:National register data were used to link reproductive histories and later RA hospitalisations in a cohort of 4.4 million Danes. As a measure of relative risk associated with different reproductive histories, ratios of first inpatient RA hospitalisation rates (RRs) were used with 95% confidence intervals (CIs) obtained by Poisson regression analysis.Results:Overall, 7017 women and 3041 men were admitted to hospital with RA in 1977–2004 (88.8 million person-years). The risk of RA was inversely associated with age at birth of first child in both women and men (p for trend <0.001). Overall, nulliparity and a history of pregnancy loss were not associated with RA risk but, compared with one-child mothers, women with two (RR 0.84; 95% CI 0.78 to 0.90) or three (RR 0.83; 95% CI 0.77 to 0.91) children were at reduced risk. The risk of RA was increased in women with a history of hyperemesis (RR 1.70; 95% CI 1.06 to 2.54), gestational hypertension (RR 1.49; 95% CI 1.06 to 2.02) or pre-eclampsia (RR 1.42; 95% CI 1.08 to 1.84).Conclusions:One-child mothers and young parents are at increased risk of RA later in life, possibly due to socioeconomic factors. The novel finding of a significantly increased risk of RA in women whose pregnancies were complicated by hyperemesis, gestational hypertension or pre-eclampsia might reflect reduced immune adaptability to pregnancy in women disposed to RA or a role of fetal microchimerism in the aetiology of RA.

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Current risk factors for work disability associated with rheumatoid arthritis: Recent data from a US national cohort

Arthritis & Rheumatism ◽

10.1002/art.24281 ◽

2009 ◽

Vol 61 (3) ◽

pp. 321-328 ◽

Cited By ~ 45

Author(s):

Saralynn Allaire ◽

Frederick Wolfe ◽

Jingbo Niu ◽

Michael P. LaValley ◽

Bin Zhang ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Risk Factors ◽

Work Disability ◽

National Cohort ◽

Current Risk

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Cytomegalovirus infection: friend or foe in rheumatoid arthritis?

Arthritis Research & Therapy ◽

10.1186/s13075-020-02398-3 ◽

2021 ◽

Vol 23 (1) ◽

Author(s):

Jean-Luc Davignon ◽

Bernard Combe ◽

Alain Cantagrel

Keyword(s):

Rheumatoid Arthritis ◽

Human Cytomegalovirus ◽

Cytomegalovirus Infection ◽

Hcmv Infection ◽

Bone Erosion ◽

Binding Protein ◽

Mrna Binding Protein ◽

Latently Infected ◽

National Cohort ◽

Mrna Binding

AbstractHuman cytomegalovirus (HCMV) is a β-herpesvirus that causes inflammation and remains for life in a latent state in their host. HCMV has been at the center of many hypotheses regarding RA.We have recently shown that HCMV infection impairs bone erosion through the induction of the mRNA-binding protein QKI5. Latently infected RA patients display a slower progression of bone erosion in patients from a national cohort. Our observations question the possible association between HCMV and the pathophysiology of RA. In this review, we examine the possibility that HCMV may be an aggravating factor of inflammation in RA while protecting from bone erosion. We also assess its relationship with other pathogens such as bacteria causing periodontitis and responsible for ACPA production.This review thus considers whether HCMV can be regarded as a friend or a foe in the pathogenesis and the course of RA.

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