Impact of the Covid-19 pandemic on primary care utilization: evidence from Sweden using national register data

Objective To analyze changes in primary care utilization as a result of the Covid-19 pandemic. Swedish national register data from 2019 to 2020 on utilization of services were used to compare overall utilization levels and across types of contacts and patient groups. A specific objective was to assess the extent to which remote types of patient consultations were able to compensate for any observed fall in on-site visits. Data were stratified by sex and age to investigate any demographic pattern. Results Findings show significant reductions in overall utilization of services as the pandemic occurred in the first quarter of 2020. On-site visits fell during the first wave of the pandemic and rebounded thereafter. Patients over 65 years of age appear to have reduced utilization to a larger extent compared with younger groups. Simultaneously, remote contacts increased from around 12% before the pandemic to 17% of the total number of consultations. However, the net effect of changes in service utilization suggests an overall reduction of around 12 percent in the number of primary care consultations as a result of the pandemic. No differences between men and women were observed. Further research will continue to monitor changes in primary care utilization as the pandemic continues.

Socioeconomic correlates of incident and fatal opioid overdose among Swedish people with opioid use disorder

Background Opioid overdose (OD) and opioid OD death are major health threats to people with opioid use disorder (OUD). Socioeconomic factors are underexplored potential determinants of opioid OD. In this study, we assessed socioeconomic and other factors and their associations with incident and fatal opioid OD, in a cohort consisting of 22,079 individuals with OUD. Methods We performed a retrospective, longitudinal study based on Swedish national register data for the period January 2005–December 2017. We used Cox proportional hazard models to investigate the risk of incident and fatal opioid OD as a function of several individual, parental and neighborhood covariates. Results Univariate analysis showed that several covariates were associated with incident and fatal opioid OD. In the multivariate analysis, incident opioid OD was associated with educational attainment (Hazard ratio [HR] 0.96; 95% confidence interval [CI] 0.94–0.97), having received social welfare (HR 1.31; 95% CI 1.22–1.39), and criminal conviction (HR 1.53; 95% CI 1.42–1.65). Fatal opioid OD was also associated with criminal conviction (HR 1.93; 95% CI 1.61–2.32). Conclusion Individuals with low education and receipt of social welfare had higher risks of incident opioid OD and individuals with criminal conviction were identified as a risk group for both incident and fatal opioid OD. Our findings should raise attention among health prevention policy makers in general, and among decision-makers within the criminal justice system and social services in particular.

Suicide in prison and after release: a 17-year national cohort study

Background People in prison have an extremely high risk of suicide. The aim of this paper is to describe all suicides in the Norwegian prison population from 2000 to 2016, during and following imprisonment; to investigate the timing of suicides; and to investigate the associations between risk of suicide and types of crime. Methods We used data from the Norwegian Prison Release study (nPRIS) including complete national register data from the Norwegian Prison Register and the Norwegian Cause of Death Register in the period 1.1.2000 to 31.12.2016, consisting of 96,856 individuals. All suicides were classified according to ICD-10 codes X60-X84. We calculated crude mortality rates (CMRs) per 100,000 person-years and used a Cox Proportional-Hazards regression model to investigate factors associated with suicide during imprisonment and after release reported as hazard ratios (HRs). Results Suicide accounted for about 10% of all deaths in the Norwegian prison population and was the leading cause of death in prison (53% of in deaths in prison). The CMR per 100,000 person years for in-prison suicides was 133.8 (CI 100.5–167.1) and was ten times higher (CMR = 1535.0, CI 397.9–2672.2) on day one of incarceration. Suicides after release (overall CMR = 82.8, CI 100.5–167.1) also peaked on day one after release (CMR = 665.7, CI 0–1419.1). Suicide in prison was strongly associated with convictions of homicide (HR 18.2, CI 6.5–50.8) and high-security prison level (HR 15.4, CI 3.6–65.0). Suicide after release was associated with convictions of homicide (HR 3.1, CI 1.7–5.5). Conclusion There is a high risk of suicide during the immediate first period of incarceration and after release. Convictions for severe violent crime, especially homicide, are associated with increased suicide risk, both in prison and after release.

A regression discontinuity analysis of the social distancing recommendations for older adults in Sweden during COVID-19

Objectives: To study the impact of non-mandatory, age-specific social distancing recommendations for older adults (70+ years) in Sweden on isolation behaviors and disease outcomes during the first wave of the COVID-19 pandemic. Methods: Our study relies on self-reported isolation data from COVID Symptom Study Sweden (n = 96,053) and national register data on COVID-19 hospitalizations, deaths, and confirmed cases. We use a regression discontinuity design to account for confounding factors, exploiting the fact that exposure to the recommendation was a discontinuous function of age. Results: By comparing individuals just above to those just below the age limit for the policy, our analyses revealed a sharp drop in the weekly number of visits to crowded places at the 70-year-threshold (-13%). Severe COVID-19 cases (hospitalizations or deaths) also dropped abruptly by 16% at the 70-year-threshold. Our data suggest that the age-specific recommendations prevented approximately 1,800 to 2,700 severe COVID-19 cases, depending on model specification. Conclusion: The non-mandatory, age-specific recommendations helped control the COVID-19 pandemic in Sweden.

Sex Differences in Childlessness in Norway: Identification of Underlying Demographic Drivers

In Norway, as in many other rich countries, childlessness is more common among men than women and has also increased more among men. Over the last 15 years, the gap in childlessness between 45-year-old women and men has widened from 5.8 to 10.2 percentage points, according to national register data. In the Norwegian-born subgroup, the gap has increased by 2.4 percentage points, from 5.8 to 8.2. The goal of the study was to identify the demographic drivers of this development, using a quite simple, but original, decomposition approach. The components reflect changes in relative cohort sizes, whether the child has one native and one immigrant parent, whether the father was older than 45, and whether one of the parents already had a child, no longer lived in Norway at age 45, or was unidentified. It was found that the modestly increasing sex gap in childlessness among the Norwegian-born is largely linked to changes in cohort sizes, i.e. fertility trends. Changes in re-partnership have actually contributed weakly in the opposite direction: It has become more common especially among men to have the first child with a partner who already had a child, and thus not contribute to bringing also that person out of childlessness. The importance of the various components is different for immigrants, among whom the sex gap in childlessness has increased particularly much. This development may also reflect that especially male immigrants perhaps have children in the home country who are not included in the Norwegian register.

Impact of the Covid-19 Pandemic on Primary Care Utilization: Evidence From Sweden Using National Register Data

Objective: To analyze changes in primary care utilization as a result of the Covid-19 pandemic. Swedish national register data from 2019 and 2020 on utilization of services were used to compare overall utilization levels and across types of contacts and patient groups. A specific objective was to assess the extent to which remote types of patient consultations were able to compensate for any observed fall in on-site visits. Data were stratified by sex and age to investigate any demographic pattern. Results: Findings show significant reductions in overall utilization of services as the pandemic occurred the first quarter of 2020. On-site visits fell during the first wave of the pandemic and rebounded thereafter. Patients over 65 years of age appear to have reduced utilization to a larger extent compared with younger groups. Simultaneously, remote contacts increased from around 12% before the pandemic to 17% of total number of consultations. However, the net effect of changes in service utilization suggests an overall reduction of around 12 percent in the number of primary care consultations as a result of the pandemic. No differences between men and women were observed. Further research will continue to monitor changes in primary care utilization as the pandemic continues.

Integrating data from multiple Finnish biobanks and national health-care registers for retrospective studies: Practical experiences

Aim: This case study aimed to investigate the process of integrating resources of multiple biobanks and health-care registers, especially addressing data permit application, time schedules, co-operation of stakeholders, data exchange and data quality. Methods: We investigated the process in the context of a retrospective study: Pharmacogenomics of antithrombotic drugs (PreMed study). The study involved linking the genotype data of three Finnish biobanks (Auria Biobank, Helsinki Biobank and THL Biobank) with register data on medicine dispensations, health-care encounters and laboratory results. Results: We managed to collect a cohort of 7005 genotyped individuals, thereby achieving the statistical power requirements of the study. The data collection process took 16 months, exceeding our original estimate by seven months. The main delays were caused by the congested data permit approval service to access national register data on health-care encounters. Comparison of hospital data lakes and national registers revealed differences, especially concerning medication data. Genetic variant frequencies were in line with earlier data reported for the European population. The yearly number of international normalised ratio (INR) tests showed stable behaviour over time. Conclusions: A large cohort, consisting of versatile individual-level phenotype and genotype data, can be constructed by integrating data from several biobanks and health data registers in Finland. Co-operation with biobanks is straightforward. However, long time periods need to be reserved when biobank resources are linked with national register data. There is a need for efforts to define general, harmonised co-operation practices and data exchange methods for enabling efficient collection of data from multiple sources.

Suicide in Prison and After Release: A 17-Year National Cohort Study

BackgroundTo describe all suicides in the Norwegian prison population from 2000 to 2017, during and following imprisonment; to investigate the timing of suicides; and to investigate the associations between risk of suicide and types of crime.Methods.We used data from the Norwegian Prison Release study (nPRIS) including complete national register data from the Norwegian Prison Register and the Norwegian Cause of Death Register in the period 1.1.2000 to 31.12.2016, consisting of 96 856 individuals. All suicides were classified according to ICD-10 codes X60-X84. We calculated crude mortality rates (CMRs) per 100 000 person-years and used a Cox Proportional-Hazards regression model to investigate factors associated with suicide during imprisonment and after release reported as hazard ratios (HRs).ResultsSuicide accounted for about 10% of all deaths in the Norwegian prison population and was the leading cause of death in prison (53% of in deaths in prison). The CMR per 100 000 person years for in-prison suicides was 133.8 and was ten times higher (CMR = 1535.0) on day one of incarceration. Suicides after release (overall CMR = 82.8) also peaked on day one after release (CMR = 665.7). Suicide in prison and after release were both associated with being convicted of murder (HR: 27.41, CI: 3.42-219.63 and HR: 2.79, CI: 1.54–5.06, respectively).ConclusionThere is a high risk of suicide during the immediate first period of incarceration and after release. Convictions for severe violent crime, especially murder, are associated with increased suicide risk, both in prison and after release.