Novel carrier-free, charge-reversal and DNA-affinity nanodrugs for synergistic cascade cancer chemo-chemodynamic therapy

ABSTRACT The iodine metabolism was investigated in 29 patients with euthyroid non-endemic diffuse goiter. 1 to 14 days before thyroidectomy the patients received carrier-free 131I. The chemical iodine fractions (PBI, BEI and iodide) of the thyroid and the labelled iodine compound were analyzed by means of paper- and column chromatography. In one gland the total iodine content varied only by ± 19.6% of the average, the relative shares of PBI, BEI and iodide as well as that of the iodoamino acids being equal. Monoiodotyrosine, diiodotyrosine and thyroxine were found in the thyroid homogenate without hydrolysis. The homogenate after hydrolysis contained more iodotyrosines at the expense of iodothyronines than do normal glands. 17 goiters with normal 131I-uptake showed a high total iodine content (14.2 ± 5.0 mg) whilst 9 goiters with an increased 131I-uptake had low values (3.58 ± 0.6 mg). The opposite was found for the relative shares of BEI with the chromatographically isolated iodothyronines thyroxine, triiodothyronine and an unidentified iodine compound. Goiters with »high plasma PB131I« were characterized by a faster transfer of 131I into the more heavily iodinated compounds than is found in glands with a normal hormonal secretion rate. The highest values for the iodothyronines were found in goiters with increased 131I-uptake together with a high hormonal secretion rate. From this study it appears that the changes in the iodine-poor glands are due to a defective exo- or endogenous iodine supply. The observed alterations in iodine-rich glands are probably induced by a faulty iodine utilization characterized by an incomplete iodotyrosyl-coupling defect.

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Laser Engineering of Barrier Structures Based on Solid Solution ZnCdHgTe.

MRS Proceedings ◽

10.1557/proc-719-f8.35 ◽

2002 ◽

Vol 719 ◽

Author(s):

Galina Khlyap

Keyword(s):

Room Temperature ◽

Film Surface ◽

Charge Carriers ◽

Barrier Structure ◽

Free Charge ◽

Current Voltage ◽

Capacitance Voltage ◽

Laser Engineering ◽

Charged Defects ◽

Epilayer Surface

AbstractRoom-temperature electric investigations carried out in CO2-laser irradiated ZnCdHgTe epifilms revealed current-voltage and capacitance-voltage dependencies typical for the metal-semiconductor barrier structure. The epilayer surface studies had demonstrated that the cell-like relief has replaced the initial tessellated structure observed on the as-grown samples. The detailed numerical analysis of the experimental measurements and morphological investigations of the film surface showed that the boundaries of the cells formed under the laser irradiation are appeared as the regions of accumulation of derived charged defects of different type of conductivity supplying free charge carriers under the applied electric field.

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Direct Measurement of Charge Reversal on Lipid Bilayers using Heterodyne-Detected Second Harmonic Generation Spectroscopy

10.26434/chemrxiv.8678450.v1 ◽

2019 ◽

Author(s):

HanByul Chang ◽

Paul Ohno ◽

Yangdongling Liu ◽

Franz Geiger

Keyword(s):

Lipid Bilayers ◽

Surface Potential ◽

Second Harmonic ◽

Fluid Phase ◽

Cationic Polyelectrolyte ◽

Charge Reversal ◽

Buried Interfaces ◽

Phase Transition Temperatures ◽

Complementary Techniques ◽

Order Susceptibility

We report the detection of charge reversal induced by the adsorption of a cationic polyelectrolyte, poly(allylamine) hydrochloride (PAH), to buried supported lipid bilayers (SLBs), used as idealized model biological membranes. We observe changes in the surface potential in isolation from other contributors to the total SHG response by extracting the phase-shifted potential-dependent third-order susceptibility from the overall SHG signal. We demonstrate the utility of this technique in detecting both the sign of the surface potential and the point of charge reversal at buried interfaces without any prior information or complementary techniques<i>.</i>Furthermore, isolation of the second-order susceptibility contribution from the overall SHG response allows us to directly monitor changes in the Stern Layer. Finally, we characterize the Stern and Diffuse Layers over single-component SLBs formed from three different zwitterionic lipids of different gel-to-fluid phase transition temperatures (T<sub>m</sub>s). We determine whether the surface potential changes with the physical phase state (gel, transitioning, or fluid) of the SLB and incorporate 20 percent of negatively charged lipids to the zwitterionic SLB to investigate how the surface potential changes with surface charge.

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Synergistic Charge Reversal with Hierarchical Architecture for Self-Adaptive Antibacterial Surface of Polymer Substrate

SSRN Electronic Journal ◽

10.2139/ssrn.3577305 ◽

2020 ◽

Author(s):

Tingwu Liu ◽

Shunjie Yan ◽

Rongtao Zhou ◽

Xu Zhang ◽

Huawei Yang ◽

...

Keyword(s):

Polymer Substrate ◽

Hierarchical Architecture ◽

Charge Reversal ◽

Antibacterial Surface ◽

Self Adaptive

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Carrier-free highly drug-loaded biomimetic nanosuspensions encapsulated by cancer cell membrane based on homology and active targeting for the treatment of glioma

Bioactive Materials ◽

10.1016/j.bioactmat.2021.04.027 ◽

2021 ◽

Vol 6 (12) ◽

pp. 4402-4414

Author(s):

Yueyue Fan ◽

Yuexin Cui ◽

Wenyan Hao ◽

Mengyu Chen ◽

Qianqian Liu ◽

...

Keyword(s):

Cell Membrane ◽

Cancer Cell ◽

Active Targeting ◽

Carrier Free

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pH and redox dual-sensitive drug delivery system constructed based on fluorescent carbon dots

RSC Advances ◽

10.1039/d0ra09164b ◽

2021 ◽

Vol 11 (5) ◽

pp. 2656-2663

Author(s):

Boye Zhang ◽

Qianqian Duan ◽

Yi Li ◽

Jianming Wang ◽

Wendong Zhang ◽

...

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Cancer Cells ◽

Fluorescence Imaging ◽

Drug Delivery System ◽

Delivery System ◽

Carbon Dots ◽

Ph Responsive ◽

Charge Reversal ◽

Fluorescent Carbon Dots

The system is pH-responsive and redox-controlled release. And the charge reversal and size transitions of the system can enhance the targeted ability. Moreover, the system can recognize the cancer cells by the fluorescence imaging.

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