Renal injury study in critical ill patients in accordance with the new definition given by the Acute Kidney Injury Network

2011 ◽  
Vol 26 (2) ◽  
pp. 206-212 ◽  
Author(s):  
Nelson Javier Fonseca Ruiz ◽  
Diana Paola Cuesta Castro ◽  
Ana Milena Mesa Guerra ◽  
Francisco Molina Saldarriaga ◽  
Juan Diego Montejo Hernández
Keyword(s):  
Acute Kidney Injury ◽  
Renal Injury ◽  
Kidney Injury ◽  
Acute Kidney Injury Network ◽  
Critical Ill Patients ◽  
Critical Ill

scholarly journals Acute kidney injury at early stage as a negative prognostic indicator of patients with COVID-19: a hospital-based retrospective analysis

2020 ◽  
Author(s):  
Shen Xu ◽  
Lin Fu ◽  
Jun Fei ◽  
Hui-Xian Xiang ◽  
Ying Xiang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Kidney Injury ◽  
Early Stage ◽  
Kidney Injury ◽  
Oxygenation Index ◽  
Prognostic Indicator ◽  
Critical Ill Patients ◽  
Patients With Diabetes ◽  
Independent Risk Factors ◽  
Critical Ill

AbstractCoronavirus disease 2019 (COVID-19) is a newly emerged infection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and has been pandemic all over the world. This study described acute kidney injury (AKI) at early stage of COVID-19 and its clinical significance. Three-hundred and fifty-five COVID-19 patients with were recruited and clinical data were collected from electronic medical records. Patient’s prognosis was tracked and risk factors of AKI was analyzed. Of 355 COVID-19 patients, common, severe and critical ill cases accounted for 63.1%, 16.9% and 20.0%, respectively. On admission, 56 (15.8%) patients were with AKI. Although AKI was more common in critical ill patients with COVID-19, there was no significant association between oxygenation index and renal functional indices among COVID-19 patients with AKI. By multivariate logistic regression, male, older age and comorbidity with diabetes were three important independent risk factors predicting AKI among COVID-19 patients. Among 56 COVID-19 patients with AKI, 33.9% were died on mean 10.9 day after hospitalization. Fatality rate was obviously higher among COVID-+19 patients with AKI than those without AKI (RR=7.08, P<0.001). In conclusion, male elderly COVID-19 patients with diabetes are more susceptible to AKI. AKI at early stage may be a negative prognostic indicator for COVID-19.

Comparison of hemodynamic parameters among continuous, intermittent and hybrid renal replacement therapy in acute kidney injury: a systematic review of randomized clinical trials

2019 ◽  
Author(s):  
Diana Silva Russo ◽  
Claudia Severgnini Eugênio ◽  
Illan George Balestrin ◽  
Clarissa Garcia Rodrigues ◽  
Regis Goulart Rosa ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Clinical Trials ◽  
Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Randomized Clinical Trials ◽  
Kidney Injury ◽  
Continuous Venovenous Hemofiltration ◽  
Hemodynamic Parameters ◽  
Critical Ill Patients ◽  
Critical Ill

Abstract Backround: The use of renal replacement therapy (RRT) in acute kidney injury (AKI) patients in the intensive care unit (ICU) is associated with high hemodynamic instability leading to a probable increase in hospital mortality. The aim of this study was to compare hemodynamic parameters among continuous, intermittent and hybrid renal replacement therapy in critical ill patients. Methods: We conducted in accordance with the PRISMA guidelines which was registered at the PROSPERO Database (CRD42018086504). Randomized clinical trials involving patients with AKI in the ICU treated with continuous, intermittent or hybrid RRT were included. We investigated the PubMed, Embase and Cochrane databases. Two reviewers independently performed study selection, evaluation of methodological quality and data extraction. Results: Out of 3442 citations retrieved, 12 randomized clinical trials (RCTs) were included, representing 1419 patients. Most of the studies (n=8) did not report or find differences in hemodynamic parameters across different RTT modalities. However, continuous venovenous hemofiltration (CVVH) was associated with a reduction in heart rate (after 1 and 4 hours) in comparison with intermittent haemodialysis (IHD) patients. CVVH was also associated with an increase in systolic blood pressure (after 0.5 and 2h) when compared with patients treated with IHD. In addition, dobutamine doses were higher in patients submitted to continuous venovenous hemodiafiltration (CVVHDF) compared to patients submitted to IHD. Lower baseline mean arterial pressure (MAP), greater MAP variation on dialysis, higher number of pressors at baseline, and increase in pressor dose during dialysis were associated with shorter survival time; and greater MAP variation on dialysis was negatively correlated with renal recovery. Conclusions: Changes in hemodynamic pattern appear be similar in different dialytic methods used in critical ill patients; however continuous venovenous hemofiltration seems be safer than other renal replacement modalities.

scholarly journals Acute kidney injury in critical ill patients affected by influenza A (H1N1) virus infection

Critical Care ◽  
2011 ◽  
Vol 15 (1) ◽  
pp. R66 ◽  
Author(s):  
Ignacio Martin-Loeches ◽  
Elisabeth Papiol ◽  
Alejandro Rodríguez ◽  
Emili Diaz ◽  
Rafael Zaragoza ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Virus Infection ◽  
Influenza A ◽  
H1n1 Virus ◽  
Kidney Injury ◽  
Critical Ill Patients ◽  
Influenza A H1n1 ◽  
Critical Ill ◽  
H1n1 Virus Infection

scholarly journals Kahweol Ameliorates Cisplatin-Induced Acute Kidney Injury through Pleiotropic Effects in Mice

Biomedicines ◽  
2020 ◽  
Vol 8 (12) ◽  
pp. 572
Author(s):  
Jung-Yeon Kim ◽  
Jungmin Jo ◽  
Jaechan Leem ◽  
Kwan-Kyu Park
Keyword(s):  
Oxidative Stress ◽  
Acute Kidney Injury ◽  
Renal Injury ◽  
Manganese Superoxide Dismutase ◽  
Immune Cell ◽  
Nicotinamide Adenine Dinucleotide Phosphate ◽  
Kidney Injury ◽  
Pleiotropic Effects ◽  
Induced Apoptosis ◽  
Vascular Adhesion

Cisplatin is an effective chemotherapeutic agent, but its clinical use is frequently limited by its nephrotoxicity. The pathogenesis of cisplatin-induced acute kidney injury (AKI) remains incompletely understood, but oxidative stress, tubular cell death, and inflammation are considered important contributors to cisplatin-induced renal injury. Kahweol is a natural diterpene extracted from coffee beans and has been shown to possess anti-oxidative and anti-inflammatory properties. However, its role in cisplatin-induced nephrotoxicity remains undetermined. Therefore, we investigated whether kahweol exerts a protective effect against cisplatin-induced renal injury. Additionally, its mechanisms were also examined. Administration of kahweol attenuated renal dysfunction and histopathological damage together with inhibition of oxidative stress in cisplatin-injected mice. Increased expression of nicotinamide adenine dinucleotide phosphate oxidase 4 and decreased expression of manganese superoxide dismutase and catalase after cisplatin treatment were significantly reversed by kahweol. Moreover, kahweol inhibited cisplatin-induced apoptosis and necroptosis in the kidneys. Finally, kahweol reduced inflammatory cytokine production and immune cell accumulation together with suppression of nuclear factor kappa-B pathway and downregulation of vascular adhesion molecules. Together, these results suggest that kahweol ameliorates cisplatin-induced renal injury via its pleiotropic effects and might be a potential preventive option against cisplatin-induced nephrotoxicity.

Elevated Levels of Urinary Biomarkers TIMP-2 and IGFBP-7 Predict Acute Kidney Injury in Neonates after Congenital Heart Surgery

2021 ◽  
Author(s):  
Michelle Ramírez ◽  
Sujata Chakravarti ◽  
Jaclyn McKinstry ◽  
Yasir Al-qaqaa ◽  
Raj Sahulee ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Congenital Heart ◽  
Heart Surgery ◽  
Kidney Injury ◽  
Acute Kidney Injury Network ◽  
Congenital Heart Surgery ◽  
Adverse Outcomes ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Stress Injury ◽  
Stage 1

Abstract Objectives: This article investigated the utility of urine biomarkers tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding protein-7 (IGFBP-7) in identifying acute kidney injury (AKI) in neonates after congenital heart surgery (CHS). TIMP-2 and IGFBP-7 are cell cycle arrest proteins detected in urine during periods of kidney stress/injury. Methods: We conducted a single-center, prospective study between September 2017 and May 2019 with neonates undergoing CHS requiring cardiopulmonary bypass (CPB). Urine samples were analyzed using NephroCheck prior to surgery and 6, 12, 24, and 96 hours post-CPB. All patients were evaluated using the Acute Kidney Injury Network (AKIN) criteria. Wilcoxon rank sum tests were used to compare the medians of the [TIMP-2*IGFBP-7] values in the AKIN negative and positive groups at each time point. Receiver operating characteristic curves were used to measure how well the [TIMP-2*IGFBP-7] values predict AKIN status. Results: Thirty-six patients were included. No patients met the AKIN criteria for AKI preoperatively. Postoperatively, 19 patients (53%) met the AKIN criteria for AKI diagnosis: 13 (36%) stage 1, 5 (14%) stage 2, and 1 (3%) stage 3. None required renal replacement therapy. At the 24-hour time points, patients who met the AKIN criteria for AKI had a statistically significantly higher [TIMP-2*IGFBP7] values than the patients without AKI (1.1 vs. 0.27 [ng/mL]2/1,000) at 24 hours (adj-p = 0.0019). Conclusion: AKI is a serious complication associated with adverse outcomes in patients undergoing cardiac surgery. [TIMP-2*IGFBP-7] urinary level 24 hours after CPB is a good predictor of AKI in this population.

scholarly journals Biomarkers of Renal Injury in Cirrhosis: Association with Acute Kidney Injury and Recovery after Liver Transplantation

Nephron ◽  
2017 ◽  
Vol 138 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Ashwani K. Singal ◽  
Bradford Jackson ◽  
Glauber B. Pereira ◽  
Kirk B. Russ ◽  
Paul Stephen Fitzmorris ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Kidney Injury ◽  
Renal Injury ◽  
Kidney Injury
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