A Design of Experiment (DOE) approach to correlate PLA-PCL electrospun fibers diameter and mechanical properties for soft tissue regeneration purposes

2022 ◽  
pp. 103060
Author(s):  
Silvia Pisani ◽  
Ida Genta ◽  
Rossella Dorati ◽  
Tiziana Modena ◽  
Enrica Chiesa ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Design Of Experiment ◽  
Electrospun Fibers ◽  
Soft Tissue Regeneration

scholarly journals Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Mary Beth Wandel ◽  
Craig A. Bell ◽  
Jiayi Yu ◽  
Maria C. Arno ◽  
Nathan Z. Dreger ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Biological Tissues ◽  
Soft Tissue Regeneration ◽  
Soft Tissue Engineering ◽  
Degradation Properties ◽  
Enhance Cell Adhesion

AbstractComplex biological tissues are highly viscoelastic and dynamic. Efforts to repair or replace cartilage, tendon, muscle, and vasculature using materials that facilitate repair and regeneration have been ongoing for decades. However, materials that possess the mechanical, chemical, and resorption characteristics necessary to recapitulate these tissues have been difficult to mimic using synthetic resorbable biomaterials. Herein, we report a series of resorbable elastomer-like materials that are compositionally identical and possess varying ratios of cis:trans double bonds in the backbone. These features afford concomitant control over the mechanical and surface eroding degradation properties of these materials. We show the materials can be functionalized post-polymerization with bioactive species and enhance cell adhesion. Furthermore, an in vivo rat model demonstrates that degradation and resorption are dependent on succinate stoichiometry in the elastomers and the results show limited inflammation highlighting their potential for use in soft tissue regeneration and drug delivery.

scholarly journals Tailoring the delivery of therapeutic ions from bioactive scaffolds while inhibiting their apatite nucleation: a coaxial electrospinning strategy for soft tissue regeneration

RSC Advances ◽  
2017 ◽  
Vol 7 (7) ◽  
pp. 3992-3999 ◽  
Author(s):  
Pin Zhou ◽  
Jian Wang ◽  
Anthony L. B. Maçon ◽  
Akiko Obata ◽  
Julian R. Jones ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Shell Thickness ◽  
Coaxial Electrospinning ◽  
Bioactive Scaffolds ◽  
Soft Tissue Regeneration

Control the release of ions as a function of the shell thickness. Inhibit hydroxyapatite nucleation. Improve mechanical properties.

INNOVATIVE REGENERATIVE ENGINEERING TECHNOLOGIES FOR SOFT TISSUE REGENERATION

2014 ◽  
Vol 16 (3) ◽  
pp. 195-214
Author(s):  
Roshan James ◽  
Matthew D. Harmon ◽  
Sangamesh G. Kumbar ◽  
Cato T. Laurencin
Keyword(s):  
Soft Tissue ◽  
Tissue Regeneration ◽  
Regenerative Engineering ◽  
Soft Tissue Regeneration

scholarly journals Promoting musculoskeletal system soft tissue regeneration by biomaterial-mediated modulation of macrophage polarization

2021 ◽  
Vol 6 (11) ◽  
pp. 4096-4109
Author(s):  
Jinchun Ye ◽  
Chang Xie ◽  
Canlong Wang ◽  
Jiayun Huang ◽  
Zi Yin ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Tissue Regeneration ◽  
Musculoskeletal System ◽  
Macrophage Polarization ◽  
Soft Tissue Regeneration

scholarly journals 3D Printing for Soft Tissue Regeneration and Applications in Medicine

Biomedicines ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 336
Author(s):  
Sven Pantermehl ◽  
Steffen Emmert ◽  
Aenne Foth ◽  
Niels Grabow ◽  
Said Alkildani ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Soft Tissue ◽  
3D Printing ◽  
Tissue Regeneration ◽  
Research Area ◽  
Modern Medicine ◽  
Soft Tissue Regeneration ◽  
General Overview

The use of additive manufacturing (AM) technologies is a relatively young research area in modern medicine. This technology offers a fast and effective way of producing implants, tissues, or entire organs individually adapted to the needs of a patient. Today, a large number of different 3D printing technologies with individual application areas are available. This review is intended to provide a general overview of these various printing technologies and their function for medical use. For this purpose, the design and functionality of the different applications are presented and their individual strengths and weaknesses are explained. Where possible, previous studies using the respective technologies in the field of tissue engineering are briefly summarized.

scholarly journals Extracellular matrix‐based scaffolding technologies for periodontal and peri‐implant soft tissue regeneration

2019 ◽  
Vol 91 (1) ◽  
pp. 17-25 ◽  
Author(s):  
Lorenzo Tavelli ◽  
Michael K. McGuire ◽  
Giovanni Zucchelli ◽  
Giulio Rasperini ◽  
Stephen E. Feinberg ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Soft Tissue Regeneration

Soft Tissue Regeneration at Natural Teeth

2022 ◽  
Vol 66 (1) ◽  
pp. 87-101
Author(s):  
Raluca Cosgarea ◽  
Alpdogan Kantarci ◽  
Andreas Stavropoulos ◽  
Nicole Arweiler ◽  
Anton Sculean
Keyword(s):  
Soft Tissue ◽  
Tissue Regeneration ◽  
Soft Tissue Regeneration ◽  
Natural Teeth
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