Low intensity resistance training improves systolic function and cardiovascular autonomic control in diabetic rats

The purpose of this study was to compare the effects of aerobic, resistance, or combined exercise training on cardiovascular autonomic control and mortality in diabetic ovariectomized rats. Female Wistar rats were divided into one of five groups: euglycemic sedentary (ES), diabetic ovariectomized sedentary (DOS), diabetic ovariectomized aerobic-trained (DOTA), diabetic ovariectomized resistance-trained (DOTR), or diabetic ovariectomized aerobic+resistance-trained (DOTC). Arterial pressure (AP) was directly recorded and baroreflex sensitivity was evaluated by heart rate responses to AP changes. Cardiovascular autonomic modulation was evaluated by spectral analyses. No differences were observed in body weight and glycemia between diabetic rats. Animals in the DOTC and DOTA groups exhibited an increase in running time, whereas animals in the DOTC and DOTR groups showed greater strength. Trained groups exhibited improvement in total power and the high-frequency band of pulse interval and reduced mortality (vs. DOS). Animals in the DOTC (bradycardic and tachycardic responses) and DOTA (tachycardic responses) groups exhibited attenuation in baroreflex dysfunction that was observed in DOS and DOTR animals, and an improvement in AP variance. In conclusion, all training protocols led to reduced mortality, which may be due to an increase in physical capacity and to cardiovascular and autonomic benefits following training, regardless of any improvement in glycemic control. In this model, the aerobic and combined trainings seem to promote additional cardiovascular autonomic benefits when compared with resistance training alone.

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Resistance training improves cardiac function and cardiovascular autonomic control in doxorubicin-induced cardiotoxicity

Cardiovascular Toxicology ◽

10.1007/s12012-020-09627-w ◽

2021 ◽

Author(s):

Larissa Andrade de Sá Feitosa ◽

Jéssica dos Santos Carvalho ◽

Cácia Oliveira Dantas ◽

Diego Santos de Souza ◽

Carla Maria Lins de Vasconcelos ◽

...

Keyword(s):

Resistance Training ◽

Cardiac Function ◽

Autonomic Control ◽

Cardiovascular Autonomic Control

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Resistance training improves cardiovascular autonomic control and biochemical profile of rats exposed to a Western diet in the perinatal period

Revista Portuguesa de Cardiologia (English Edition) ◽

10.1016/j.repce.2018.08.008 ◽

2019 ◽

Vol 38 (5) ◽

pp. 337-345

Author(s):

Michael Nadson Santos Santana ◽

Vitor Ulisses De Melo ◽

Fabricio Nunes Macedo ◽

André Sales Barreto ◽

Robervan Vidal-Santos ◽

...

Keyword(s):

Resistance Training ◽

Perinatal Period ◽

Western Diet ◽

Autonomic Control ◽

Biochemical Profile ◽

Cardiovascular Autonomic Control

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Effects of Low Intensity Resistance Training Speed on Body Composition, Muscle Activity and Muscle Strength in Obese Middle-aged Women

Korean Journal of Sport Studies ◽

10.23949/kjpe.2017.07.56.4.39 ◽

2017 ◽

Vol 56 (4) ◽

pp. 575-584 ◽

Cited By ~ 1

Author(s):

Woo-Jung Lee ◽

Sang-Won Seo ◽

Ho-Seong Lee

Keyword(s):

Body Composition ◽

Resistance Training ◽

Muscle Strength ◽

Muscle Activity ◽

Middle Aged ◽

Low Intensity

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Pulsed high intensity laser versus low intensity laser on healing of full thickness wound in diabetic rats (histological and immunohistochemical study)

International Journal of Pharma and Bio Sciences ◽

10.22376/ijpbs.2017.8.2.b874-888 ◽

2017 ◽

Vol 8 (2) ◽

Cited By ~ 2

Author(s):

HESHAMGALAL MAHRAN ◽

EMAN MOHAMED FARUK ◽

NASER A. ELSAWY ◽

WARDAHABDULLAH MOHAMMED ALASMARI ◽

ABDULLAH GLILRADA ALKUSHI

Keyword(s):

High Intensity ◽

Immunohistochemical Study ◽

Diabetic Rats ◽

Full Thickness ◽

Low Intensity ◽

High Intensity Laser ◽

Intensity Laser ◽

Full Thickness Wound

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Contralateral training effects of low-intensity blood-flow restricted and high-intensity unilateral resistance training

European Journal of Applied Physiology ◽

10.1007/s00421-021-04708-2 ◽

2021 ◽

Author(s):

Goncalo V. Mendonca ◽

Carolina Vila-Chã ◽

Carolina Teodósio ◽

André D. Goncalves ◽

Sandro R. Freitas ◽

...

Keyword(s):

Blood Flow ◽

Resistance Training ◽

High Intensity ◽

Training Effects ◽

Low Intensity

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Optimal parameters of blood flow restriction and resistance training on quadriceps strength and cross-sectional area and pain in knee osteoarthritis

Isokinetics and Exercise Science ◽

10.3233/ies-200235 ◽

2021 ◽

pp. 1-10

Author(s):

Waleed S. Mahmoud ◽

Ahmed Osailan ◽

Ahmed S. Ahmed ◽

Ragab K. Elnaggar ◽

Nadia L. Radwan

Keyword(s):

Blood Flow ◽

Resistance Training ◽

Knee Osteoarthritis ◽

Quadriceps Strength ◽

Sectional Area ◽

Occlusion Pressure ◽

Total Occlusion ◽

Cross Sectional ◽

Flow Restriction ◽

Low Intensity

BACKGROUND: Knee osteoarthritis (KOA) is one of the most common chronic diseases impacting millions of elderly people. OBJECTIVES: The study compared the effects of two intensities of partial blood flow restriction (BFR) with low-intensity resistance training on quadriceps strength and cross-sectional area (CSA), and pain in people with knee osteoarthritis (PwKOA). METHODS: Thirty-five PwKOA, aged 50–65, participated. Quadriceps CSA was measured by ultrasonography, quadriceps strength – by isokinetic dynamometry and pain by VAS. These outcome variables were obtained at the beginning of the study and re-evaluated eight weeks after the intervention. RESULTS: An interaction effect was present for quadriceps CSA (P= 0.042) and quadriceps strength (P= 0.006), showing that using 70% of total occlusion pressure with 30% 1RM had a more significant effect. Knee pain improved significantly through the main effect of BFR (P< 0.001), and low-intensity resistance training (P= 0.011). Pain improved more at 70% of total occlusion pressure, with 30% of 1RM (2.5 ± 1.06) than 50% total occlusion pressure with 10% of 1RM (5.77 ± 1.46). CONCLUSION: A combination of 70% of total occlusion pressure with 30% 1RM could be beneficial in PwKOA in improving pain, and increasing the quadriceps strength. The changes in the quadriceps strength could be a predictor for knee pain.

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The acute effects of different spironolactone doses on cardiac function in streptozotocin-induced diabetic rats

Canadian Journal of Physiology and Pharmacology ◽

10.1139/cjpp-2017-0055 ◽

2017 ◽

Vol 95 (11) ◽

pp. 1343-1350

Author(s):

Aleksandra Vranic ◽

Stefan Simovic ◽

Petar Ristic ◽

Tamara Nikolic ◽

Isidora Stojic ◽

...

Keyword(s):

Diabetes Mellitus ◽

Systolic Function ◽

Diabetic Rats ◽

Diabetic Rat ◽

Albino Rats ◽

Acute Administration ◽

Rat Hearts ◽

Patients With Diabetes ◽

Streptozotocin Induced Diabetes ◽

Wistar Albino Rats

Currently, cardiovascular diseases are the leading cause of global mortality, while diabetes mellitus remains an important cause of cardiovascular morbidity. A recent study showed that patients with diabetes mellitus treated with mineralocorticoid receptor antagonists have improved coronary microvascular function, leading to improved diastolic dysfunction. In this study, we evaluated the influence of acute administration of spironolactone on myocardial function in rats with streptozotocin-induced diabetes mellitus, with special emphasis on cardiodynamic parameters in diabetic rat hearts. The present study was carried out on 40 adult male Wistar albino rats (8 weeks old). Rats were randomly divided into 4 groups (10 animals per group): healthy rats treated with 0.1 μmol/L of spironolactone, diabetic rats treated with 0.1 μmol/L of spironolactone, healthy rats treated with 3 μmol/L of spironolactone, and diabetic rats treated with 3 μmol/L of spironolactone. Different, dose-dependent, acute responses of spironolactone treatment on isolated, working diabetic and healthy rat heart were observed in our study. In healthy rats, better systolic function was achieved with higher spironolactone dose, while in diabetic rats, similar effects of low and high spironolactone dose were observed.

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