Antidepressant-like effect of the extracted of Kai Xin San, a traditional Chinese herbal prescription, is explained by modulation of the central monoaminergic neurotransmitter system in mouse

2012 ◽  
Vol 139 (2) ◽  
pp. 422-428 ◽  
Author(s):  
Xiao-Jiang Zhou ◽  
Ming Liu ◽  
Juan-Juan Yan ◽  
Yin Cao ◽  
Ping Liu
Keyword(s):  
Neurotransmitter System ◽  
Chinese Herbal ◽  
Herbal Prescription ◽  
Monoaminergic Neurotransmitter

scholarly journals Involvement of the Cerebral Monoamine Neurotransmitters System in Antidepressant-Like Effects of a Chinese Herbal Decoction, Baihe Dihuang Tang, in Mice Model

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Meng-Li Chen ◽  
Jie Gao ◽  
Xin-Rong He ◽  
Qian Chen
Keyword(s):  
Depressive Disorders ◽  
Forced Swim Test ◽  
Tail Suspension Test ◽  
Underlying Mechanism ◽  
Mice Model ◽  
Monoamine Neurotransmitters ◽  
Chinese Herbal ◽  
Thought Disorders ◽  
Immobility Time ◽  
Monoaminergic Neurotransmitter

Baihe Dihuang Tang (BDT) is a renowned Chinese herbal formula which is commonly used for treating patients with mental instability, absentmindedness, insomnia, deficient dysphoria, and other psychological diseases. These major symptoms closely associated with the depressive disorders. BDT was widely popular use for treating emotion-thought disorders for many years in China. In the present study, the antidepressant-like effect of BDT in mice was investigated by using the forced swim test (FST) and the tail suspension test (TST). The underlying mechanism was explored by determining the effect of BDT on the level of cerebral monoamine neurotransmitters. BDT (9 and 18 g/kg, p.o. for 14 days) administration significantly reduced the immobility time in both the FST and the TST without changing locomotion in the open field-test (OFT). Moreover, BDT treatment at the dose of 18 g/kg inhibited reserpine-induced ptosis. Meanwhile, BDT enhanced 5-HT and NA levels in mouse cerebrum as well as decreased the ratio of 5-HT compared to its metabolite, 5-HIAA, (turnover, 5-HIAA/5-HT) after TST. The results demonstrated that the antidepressant-like effect of BDT is mediated, at least partially, via the central monoaminergic neurotransmitter system.

The preliminary study of the effects of a Chinese herbal prescription on osteoblast under stimulated weightlessness

Bone ◽  
2008 ◽  
Vol 43 ◽  
pp. S87-S88
Author(s):  
Sumin Hu ◽  
Haiying Tong ◽  
Yingxian Li ◽  
Qian Fu ◽  
Peng Zhou ◽  
...  
Keyword(s):  
Chinese Herbal ◽  
Preliminary Study ◽  
Herbal Prescription

scholarly journals Effects of Si-Jun-Zi decoction polysaccharides on cell migration and gene expression in wounded rat intestinal epithelial cells

2005 ◽  
Vol 93 (1) ◽  
pp. 21-29 ◽  
Author(s):  
L. Liu ◽  
L. Han ◽  
Daisy Y. L. Wong ◽  
Patrick Y. K. Yue ◽  
W. Y. Ha ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Migration ◽  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Optimal Dose ◽  
Intestinal Epithelial ◽  
Active Components ◽  
Chinese Herbal ◽  
Herbal Prescription

Si-Jun-Zi decoction (SJZD), a traditional Chinese herbal prescription, has been used clinically for treating patients with disorders of the digestive system. Previous studies indicated that the polysaccharides of SJZD (SJZPS) are the active components contributing towards its pharmacological effects in improving gastrointestinal function and immunity. However, the protective and restitutive effects on intestinal epithelial cells remain unknown. In the present study, SJZPS were first extracted and chemically characterized. Then their stimulatory and restitutive effects on intestinal epithelial cells (IEC-6 cells) were elicited by different in vitro models including migration of wounded IEC-6 cells and cell proliferation. Results indicated that SJZPS not only protects the cells against the harmful impairment of indomethacin but also enhances re-epithelialization of a wounded monolayer at an optimal dose of 100 μg/ml at 24 h incubation. To elucidate the modulatory effect of SJZPS on wounded IEC-6 cells at the molecular level, an oligonucleotide microarray was employed to study differential gene expression of SJZPS-treated IEC-6 cells and the candidate genes were validated by RT-PCR. There was increased expression of genes coding for ion channels and transporters, which are critical to cell migration and restoration of wounded intestinal cells, suggesting a possible mechanism for re-epithelialization. In conclusion, our data show for the first time that SJZPS can enhance intestinal restitution and protect against indomethacin-induced damage of intestinal epithelial cells. These findings provide new insight into the mechanism of action of a traditional Chinese herbal prescription, SJZD, in intestinal wound restitution.

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