Anticancer activities of Zanthoxylum bungeanum seed oil on malignant melanoma

2019 ◽  
Vol 229 ◽  
pp. 180-189 ◽  
Author(s):  
Wenwen Pang ◽  
Shan Liu ◽  
Fangting He ◽  
Xinyang Li ◽  
Baloch Saira ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Seed Oil ◽  
Anticancer Activities ◽  
Zanthoxylum Bungeanum

scholarly journals Inhibitory effect of Zanthoxylum bungeanum seed oil on ovalbumin-induced lung inflammation in a murine model of asthma

2016 ◽  
Vol 13 (5) ◽  
pp. 4289-4302 ◽  
Author(s):  
JUN-QIN WANG ◽  
XIAO-WEI LI ◽  
MINGYI LIU ◽  
SHENG-CHUN WANG ◽  
ZENG-FA CAO
Keyword(s):  
Murine Model ◽  
Lung Inflammation ◽  
Seed Oil ◽  
Inhibitory Effect ◽  
Zanthoxylum Bungeanum

Investigation on Decoloration of Zanthoxylum Bungeanum Seed Oil

2012 ◽  
Vol 460 ◽  
pp. 275-278
Author(s):  
Jian Zhang ◽  
Xuan Jun Wang
Keyword(s):  
Reaction Time ◽  
Influencing Factors ◽  
Reaction Temperature ◽  
Industrial Application ◽  
Seed Oil ◽  
Orthogonal Test ◽  
Optimal Combination ◽  
Single Test ◽  
Zanthoxylum Bungeanum

The decoloration method experiment on ZSO was studied. The different influencing factors on reaction were investigated by single test, such as content of peroxide, reaction temperature, and reaction time. The results of orthogonal test showed that the dominated sequence of influencing on chroma value was content of peroxide, and then was for reaction temperature, the last was reaction time. The optimal combination proved was A2B2C2. On this condition, the chroma value of ZSO could be reduced to 1.45, it fully meets the requirement of industrial application.

Preparation and reaction dynamics on biodiesel made from Zanthoxylum bungeanum seed oil and methanol

2013 ◽  
Vol 5 (4) ◽  
pp. 043123
Author(s):  
Jian Zhang ◽  
Xuanjun Wang ◽  
Zhiyong Huang ◽  
Qilong Han ◽  
Shuyan Li ◽  
...  
Keyword(s):  
Seed Oil ◽  
Reaction Dynamics ◽  
Zanthoxylum Bungeanum

scholarly journals Wound-healing activity of Zanthoxylum bungeanum maxim seed oil on experimentally burned rats

2017 ◽  
Vol 13 (51) ◽  
pp. 363 ◽  
Author(s):  
Wei Cao ◽  
Xiao-Qiang Li ◽  
Rong Kang ◽  
Jun-Cheng Huo ◽  
Yan-Hua Xie ◽  
...  
Keyword(s):  
Wound Healing ◽  
Seed Oil ◽  
Zanthoxylum Bungeanum ◽  
Wound Healing Activity ◽  
Zanthoxylum Bungeanum Maxim

scholarly journals Studi In Silico Bioaktivitas Antikanker Senyawa Aktif Dalam Minyak Biji Buah Wali [Brucea javanica (L.) Merr]

2020 ◽  
Vol 1 (2) ◽  
pp. 26-29
Author(s):  
Agus Dwi Ananto
Keyword(s):  
Binding Energy ◽  
Stearic Acid ◽  
Palmitic Acid ◽  
In Silico ◽  
Seed Oil ◽  
Enoic Acid ◽  
Hexadecanoic Acid ◽  
Anticancer Activities ◽  
Brucea Javanica ◽  
Lower Binding Energy

Insilico study of anticancer bioactivity in oil of “buah wali” [Brucea javanica (L.) Merr] has been successfully carried out. “Buah Wali” (Brucea javanica (L.) Merr) is known to treat various diseases such as diabetes, diarrhea, and malaria. In addition, “buah wali” seeds are supported to have antidiabetic, antioxidant, and anticancer activities. The stages of the study began by taking a sample of “buah wali”seeds, then extracted to get oil of “buah wali”. While GC-MS analysis resulted Octadec-9-enoic acid (56.25%), palmitic acid (13.82%), stearic acid (10.57%), and acids -9-octadecanoate (5.91%) were found as the major components of the seed oil. Based on these compounds, docking molecular was carried out to find anticancer bioactivity. The results obtained are compounds that have lower binding energy than the native ligands [Octadec-9-enoic acid (-72.4518), hexadecanoic acid (-70.2136), octadecanoic (-72.2362).

Zanthoxylum bungeanum Seed Oil Elicits Autophagy and Apoptosis in Human Laryngeal Tumor Cells via PI3K/AKT/mTOR Signaling Pathway

2021 ◽  
Vol 21 ◽  
Author(s):  
Yun’e Bai ◽  
Jing Hou ◽  
Xiao Ting Zhang ◽  
Jian Ping Gao ◽  
Jiang Tao Zhou
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Signaling Pathway ◽  
Western Blotting ◽  
Seed Oil ◽  
Mtor Signaling ◽  
Composition Analysis ◽  
Mtor Signaling Pathway ◽  
Mechanistic Investigation ◽  
Zanthoxylum Bungeanum

Background: Zanthoxylum bungeanum seed oil (ZBSO) is a main extract of the edible drug Zanthoxylum bungeanum seeds. Recently reports proved that it has a significant cytotoxic effect on various cancer cells. However, systematic investigation on the roles of ZBSO in laryngeal carcinoma (LC) is rare. Objective: To reveal the function of ZBSO on human laryngeal squamous carcinoma cells (Hep-2) and to elucidate its underlying mechanism. Methods: In this study, the chemical composition analysis of ZBSO was done using Ultra Performance Liquid Chromatography (UPLC), and the anti-tumor effect of ZBSO on Hep-2 cells was evaluated by cell proliferation, apoptosis and cell cycle experiments. qRT-PCR, immunohistochemistry (IHC) and Western blotting were used for mechanistic investigation at the molecular level. Results: The main compound of ZBSO was identified as polyunsaturated fatty acids. Furthermore, as compared with normal cells, significant inhibitory activities of ZBSO was observed on Hep-2 cells with dose- and time-dependency, which induced apoptosis, blocked cell cycle at the S phase, and inhibited cell proliferation. In addition, IHC results showed difference in the level of protein expression of ZBSO-induced autophagy-related markers. At last, Western blotting results indicated that ZBSO could inhibit the expression and phosphorylation levels of PI3K/AKT/mTOR protein. Conclusions: The anti-LC effect of ZBSO might be intimately associated with the induction of autophagy and the inhibition of PI3K/AKT/mTOR signaling pathway. ZBSO may be a potential anti-laryngocarcinoma agent.

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