Protective effects of medicinal plant against diabetes induced cardiac disorder: A review

2021 ◽  
Vol 265 ◽  
pp. 113328
Author(s):  
Sadegh Shabab ◽  
Zahra Gholamnezhad ◽  
Maryam Mahmoudabady
Keyword(s):  
Medicinal Plant ◽  
Protective Effects ◽  
Cardiac Disorder

Protective effects of Emblica officinalis Gaertn. in cyclophosphamide-treated mice

2001 ◽  
Vol 20 (12) ◽  
pp. 643-650 ◽  
Author(s):  
R Haque ◽  
B Bin-Hafeez ◽  
I Ahmad ◽  
S Parvez ◽  
S Pandey ◽  
...  
Keyword(s):  
Body Weight ◽  
Antioxidant Enzymes ◽  
Side Effects ◽  
Medicinal Plant ◽  
Plant Extract ◽  
Reduced Glutathione ◽  
Protective Effects ◽  
Emblica Officinalis ◽  
Immunological Parameters ◽  
Indian Gooseberry

Cyclophosphamide (CP) is one of the most popular alkylating anticancer drugs in spite of its toxic side effects including immunotoxicity, hematotoxicity, mutagenicity and a host of others. The present study was undertaken to assess the protective effects of total aqueous extract of a medicinal plant, Indian gooseberry (Emblica officinalis Gaertn.) in mice treated with CP. These protective effects were studied on immunological parameters and kidney and liver antioxidants. Plant extract treatment at a dose of 100 mg/kg body weight per os (p.o.) for 10 days resulted in the modulation of these parameters in normal as well as CP (50 mg/kg)-treated animals. Plant extract in particular was very effective in reducing CP-induced suppression of humoral immunity. Plant extract treatment in normal animals modulated certain antioxidants of kidney and liver. In CP-exposed animals, plant pretreatment provided protection to antioxidants of kidney. Not only were the reduced glutathione levels significantly (p<0.001) increased but plant extract treatment resulted in restoration of antioxidant enzymes in CP-treated animals. It is suggested that E. officinalis or its medicinal preparations may prove to be useful as a component of combination therapy in cancer patients under CP treatment regimen. Human & Experimental Toxicology (2001) 20, 643–650.

scholarly journals Protective Effects of Medicinal Plant Decoctions on Macrophages in the Context of Atherosclerosis

Nutrients ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 280
Author(s):  
Eloïse Checkouri ◽  
Stéphane Ramin-Mangata ◽  
Nicolas Diotel ◽  
Wildriss Viranaicken ◽  
Claude Marodon ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Medicinal Plant ◽  
Lipid Lowering ◽  
Protective Effects ◽  
Lipid Uptake ◽  
E Coli ◽  
Ldl Uptake ◽  
Anti Inflammatory ◽  
The Impact

Atherosclerosis is a hallmark of most cardiovascular diseases. The implication of macrophages in this pathology is widely documented, notably for their contribution to lipid accumulation within the arterial wall, associated with oxidative stress and inflammation processes. In order to prevent or limit the atherosclerosis damage, nutritional approaches and medicinal plant-based therapies need to be considered. In Reunion Island, medicinal plant-based beverages are traditionally used for their antioxidant, lipid-lowering and anti-inflammatory properties. The aim of our study was to assess the protective effects of eight medicinal plant decoctions in an in vitro model of RAW 264.7 murine macrophages exposed to pro-atherogenic conditions (oxidized low-density lipoproteins—ox-LDL—E. coli Lipopolysaccharides—LPS). The impact of polyphenol-rich medicinal plant decoctions on cell viability was evaluated by Neutral Red assay. Fluorescent ox-LDL uptake was assessed by flow cytometry and confocal microscopy. Activation of NF-κB was evaluated by quantification of secreted alkaline phosphatase in RAW-Blue™ macrophages. Our results show that medicinal plant decoctions limited the cytotoxicity induced by ox-LDL on macrophages. Flow cytometry analysis in macrophages demonstrated that medicinal plant decoctions from S. cumini and P. mauritianum decreased ox-LDL uptake and accumulation by more than 70%. In addition, medicinal plant decoctions also inhibited NF-κB pathway activation in the presence of pro-inflammatory concentrations of E. coli LPS. Our data suggest that medicinal plant decoctions exert protective effects on ox-LDL-induced cytotoxicity and limited macrophage lipid uptake. Moreover, herbal preparations displayed anti-inflammatory properties on macrophages that can be of interest for limiting the atherosclerotic process.

scholarly journals Protective effects of three selected standardized medicinal plant extracts used in Sri Lankan traditional medicine in adriamycin induced nephrotoxic Wistar rats

2020 ◽  
Vol 259 ◽  
pp. 112933
Author(s):  
Sachinthi S. Amarasiri ◽  
Anoja P. Attanayake ◽  
Liyanagae D.A.M. Arawwawala ◽  
Kamani A.P.W. Jayatilaka ◽  
Lakmini K.B. Mudduwa
Keyword(s):  
Medicinal Plant ◽  
Traditional Medicine ◽  
Plant Extracts ◽  
Wistar Rats ◽  
Sri Lankan ◽  
Protective Effects ◽  
Medicinal Plant Extracts

scholarly journals Radio protective effects of the Ayurvedic medicinal plant Ocimum sanctum Linn. (Holy Basil): A memoir

2016 ◽  
Vol 12 (1) ◽  
pp. 20 ◽  
Author(s):  
ManjeshwarShrinath Baliga ◽  
Suresh Rao ◽  
ManojP Rai ◽  
Prema D'souza
Keyword(s):  
Medicinal Plant ◽  
Ocimum Sanctum ◽  
Protective Effects ◽  
Holy Basil

Melatonin reduces high levels of lipid peroxidation induced by potassium iodate in porcine thyroid

2019 ◽  
pp. 1-7 ◽  
Author(s):  
Paulina Iwan ◽  
Jan Stepniak ◽  
Malgorzata Karbownik-Lewinska
Keyword(s):  
Lipid Peroxidation ◽  
Oxidative Damage ◽  
Membrane Lipids ◽  
Chemical Properties ◽  
Iodine Concentration ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Protective Effects ◽  
Potassium Iodate ◽  
Hormone Synthesis

Abstract. Iodine is essential for thyroid hormone synthesis. Under normal iodine supply, calculated physiological iodine concentration in the thyroid is approx. 9 mM. Either potassium iodide (KI) or potassium iodate (KIO3) are used in iodine prophylaxis. KI is confirmed as absolutely safe. KIO3 possesses chemical properties suggesting its potential toxicity. Melatonin (N-acetyl-5-methoxytryptamine) is an effective antioxidant and free radical scavenger. Study aims: to evaluate potential protective effects of melatonin against oxidative damage to membrane lipids (lipid peroxidation, LPO) induced by KI or KIO3 in porcine thyroid. Homogenates of twenty four (24) thyroids were incubated in presence of either KI or KIO3 without/with melatonin (5 mM). As melatonin was not effective against KI-induced LPO, in the next step only KIO3 was used. Homogenates were incubated in presence of KIO3 (200; 100; 50; 25; 20; 15; 10; 7.5; 5.0; 2.5; 1.25 mM) without/with melatonin or 17ß-estradiol. Five experiments were performed with different concentrations of melatonin (5.0; 2.5; 1.25; 1.0; 0.625 mM) and one with 17ß-estradiol (1.0 mM). Malondialdehyde + 4-hydroxyalkenals (MDA + 4-HDA) concentration (LPO index) was measured spectrophotometrically. KIO3 increased LPO with the strongest damaging effect (MDA + 4-HDA level: ≈1.28 nmol/mg protein, p < 0.05) revealed at concentrations of around 15 mM, thus corresponding to physiological iodine concentrations in the thyroid. Melatonin reduced LPO (MDA + 4-HDA levels: from ≈0.97 to ≈0,76 and from ≈0,64 to ≈0,49 nmol/mg protein, p < 0.05) induced by KIO3 at concentrations of 10 mM or 7.5 mM. Conclusion: Melatonin can reduce very strong oxidative damage to membrane lipids caused by KIO3 used in doses resulting in physiological iodine concentrations in the thyroid.

Protective Effects of Self-Forgiveness on Alcohol Abuse Depend on Severity of Shame

2009 ◽  
Author(s):  
Phillip A. Ianni ◽  
Kenneth E. Hart ◽  
Stephen Hibbard ◽  
Michelle Carroll ◽  
Tobi Wilson ◽  
...  
Keyword(s):  
Alcohol Abuse ◽  
Protective Effects ◽  
Self Forgiveness
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