A review on the chemical profiles, quality control, pharmacokinetic and pharmacological properties of Fufang Xueshuantong Capsule

2021 ◽  
Vol 267 ◽  
pp. 113472
Author(s):  
Xuan Zeng ◽  
Yuying Zheng ◽  
Jianwen Luo ◽  
Hong Liu ◽  
Weiwei Su
Keyword(s):  
Quality Control ◽  
Pharmacological Properties ◽  
Chemical Profiles

scholarly journals A Review of Recent Phytomedicinal Investigations and the Need for DNA Barcoding of Endemic Plants of Northern Cyprus

2020 ◽  
pp. 61-70
Author(s):  
Dudu Özkum Yavuz ◽  
Mustapha Bulama- Modu
Keyword(s):  
Quality Control ◽  
Dna Barcoding ◽  
Dna Sequences ◽  
Pharmacological Properties ◽  
Endemic Plants ◽  
Dna Barcodes ◽  
Inclusion Criteria ◽  
Ovid Medline ◽  
Northern Cyprus ◽  
Medicinal Properties

Aims: To review the phytomedicinal researches on endemic plants of Northern Cyprus and to assess the plants of their DNA barcoding status. Study Design: A review. Methodology: This work reviewed available and accessible original articles in EBSCO, Ovid MEDLINE®, PubMed®, ScienceDirectTM, Scopus® and Web of ScienceTM databases on phytomedicinal investigations and BOLD System, MMDBD version 1.5 and GenBank® on DNA barcodes of the endemic plants of Northern Cyprus until May, 2020. Using keywords searches related to phytochemistry, biological activity and DNA barcoding, DNA Sequences and the data obtain evaluated and the information that does not meet the inclusion criteria were excluded. We believe that this information would tentatively help researchers to ethically explore these plants for their Medicinal and Aromatic potentials. Results: Only 6 of the 20 endemic plants of Northern Cyprus were phytopharmaceutically investigated, while DNA sequences of 5 were found to be deposited in the publicly accessible databases accounting for 30% and 25% of the total plants respectively. Conclusion: Endemism is related to uniqueness in features including the phytomedicinal features, thus Northern Cyprus endemic plants hold ample of such. However the results of this review showed that only few were harnessed for their medicinal properties and hence the need for their pharmacological properties and comprehensive barcoding for proper authentication, detection of adulteration, and quality control.

scholarly journals Corrigendum to “Chemical profiles, pharmacological properties, and in silico studies provide new insights on Cycas pectinata” [Heliyon 6 (6), (June 2020) Article e04061]

Heliyon ◽  
2020 ◽  
Vol 6 (7) ◽  
pp. e04280
Author(s):  
Abu Montakim Tareq ◽  
Saifuddin Farhad ◽  
A.B.M. Neshar Uddin ◽  
Muminul Hoque ◽  
Mst. Samima Nasrin ◽  
...  
Keyword(s):  
In Silico ◽  
Pharmacological Properties ◽  
In Silico Studies ◽  
Chemical Profiles

scholarly journals Chemical Fingerprint Analysis for Discovering Markers and Identifying Saussurea involucrata by HPLC Coupled with OPLS-DA

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Qingdong Ma ◽  
Xiaoxiang Chen ◽  
Ke Zhang ◽  
Dahong Yao ◽  
Lu Yang ◽  
...  
Keyword(s):  
Quality Control ◽  
Morphological Characteristics ◽  
Chromatographic Fingerprint ◽  
Saussurea Involucrata ◽  
The Public ◽  
Chemical Profiling ◽  
Integrated Method ◽  
Chemical Profiles ◽  
Related Plant ◽  
Dehydrocostus Lactone

The quality control of Saussurea involucrata has been greatly improved by macroscopic and microscopic identification and chemical profiling described in Chinese Pharmacopoeia since 2005. However, these methods have their own limitations, e.g., their dependence on personal experience and expertise, and it is a huge challenge to identify closely related species that share similar or identical morphological characteristics and chemical profiles. A novel and generally accepted identification strategy is urgently needed as a complement to regulations for protecting the public health interests. In this work, a comprehensive chromatographic fingerprint method was developed and tested on 43 samples from four haplotypes of S. involucrata according to DNA barcoding. Three common patterns consisting of 20, 14, and 7 common peaks were generated by frequency filters of median, upper quartile, and 100%, respectively. Based on two formerly screened patterns, S. involucrata can be effectively identified from its five easily confused snow lotus species, including the most closely related plant (S. orgaadayi) in the orthogonal partial least-squares discriminant analysis (OPLS-DA) models. The model is supported by good R and Q coefficients. In addition, different haplotypes of S. involucrata can be discriminated in the OPLS-DA model using the 20 common peaks. Among them, peaks 9, 11, 16 (zaluzanin C), and 18 (dehydrocostus lactone) have been identified as fingerprint markers of S. involucrata via S-plots and VIP values (>1). Additionally, peaks 19 and 20 were identified as linolenic acid and linoleic acid with anti-inflammatory activity, and they were isolated from the herb for the first time. Collectively, the chromatographic fingerprint of S. involucrata can be an effective and integrated method for the identification of authentic herbs from adulterant species or related plants, and discrimination of its different haplotypes provides an objective and reliable tool for quality control.

scholarly journals Chemical profiles, pharmacological properties, and in silico studies provide new insights on Cycas pectinata

Heliyon ◽  
2020 ◽  
Vol 6 (6) ◽  
pp. e04061 ◽  
Author(s):  
Abu Montakim Tareq ◽  
Saifuddin Farhad ◽  
A.B.M. Neshar Uddin ◽  
Muminul Hoque ◽  
Mst. Samima Nasrin ◽  
...  
Keyword(s):  
In Silico ◽  
Pharmacological Properties ◽  
In Silico Studies ◽  
Chemical Profiles

scholarly journals Review of the Chemical Composition, Pharmacological Effects, Pharmacokinetics, and Quality Control of Boswellia carterii

2022 ◽  
Vol 2022 ◽  
pp. 1-38
Author(s):  
Kai Huang ◽  
Yanrong Chen ◽  
Kaiyong Liang ◽  
Xiaoyan Xu ◽  
Jing Jiang ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Quality Control ◽  
Chemical Composition ◽  
Antioxidant Activities ◽  
Evidence Based ◽  
Pharmacological Properties ◽  
Pharmacological Effects ◽  
Treatment And Prevention ◽  
Boswellia Carterii ◽  
Positive Effect

Objective. This review aimed to systematically summarize studies that investigated the bioactivities of compounds and extracts from Boswellia. Methods. A literature review on the pharmacological properties and phytochemicals of B. carterii was performed. The information was retrieved from secondary databases such as PubMed, Chemical Abstracts Services (SciFinder), Google Scholar, and ScienceDirect. Results. The various Boswellia extracts and compounds demonstrated pharmacological properties, such as anti-inflammatory, antitumour, and antioxidant activities. B. carterii exhibited a positive effect on the treatment and prevention of many ageing diseases, such as diabetes, cancer, cardiovascular disease, and neurodegenerative diseases. Conclusion. Here, we highlight the pharmacological properties and phytochemicals of B. carterii and propose further evidence-based research on plant-derived remedies and compounds.

scholarly journals Quality evaluation of commercial products of Ganoderma lucidum made from its fruiting body and spore

2021 ◽  
Author(s):  
Steven Yeung ◽  
Quanlan Chen ◽  
Yongbang Yu ◽  
Bingsen Zhou ◽  
Wei Wu ◽  
...  
Keyword(s):  
Quality Control ◽  
Fruiting Body ◽  
Ganoderma Lucidum ◽  
Chemical Components ◽  
Specific Marker ◽  
Chemical Markers ◽  
Active Components ◽  
Ganoderic Acid ◽  
Commercial Products ◽  
Chemical Profiles

AbstractGanoderma lucidum (GL), also known as Reishi or Lingzhi, is a medicinal mushroom widely used in traditional and folk medicines. The extracts made from the fruiting body and spore of naturally grown GL are the most frequently used in commercial products. More than 400 compounds have been identified in GL with the triterpenoids considered to be the major active components. Large variations in the chemical components were reported in previous studies and there is no comprehensive study of the content of multiple major triterpenoids in the GL product. In addition, there is no report in the comparison of chemical profiles in different parts of GL (i.e., fruiting body and spore). Determining the chemical composition and comparing the differences between fruiting body and spore are essential for the identity, efficacy and safety of various GL products.In this study, 13 compounds (ganoderenic Acid C, ganoderic Acid C2, ganoderic Acid G, ganoderic Acid B, ganoderenic Acid B, ganoderic Acid A, ganoderic Acid H, ganoderenic Acid D, ganoderic Acid D, ganoderic Acid F, ganoderic Acid DM, ganoderol A, and ergosterol) were selected as the chemical markers. The purpose of this study is to develop an HPLC-DAD fingerprint method for quantification of these active components in GL (spore and fruiting body) and test the feasibility of using the HPLC-DAD fingerprint for quality control or identity determination of GL products.The results showed that this method could determine the levels of the major components accurately and precisely. Among the 13 components, 11 ganoderma acids were identified to be proper chemical markers for quality control of GL products, while ganoderal A was in a very low amount and ergosterol was not a specific marker in GL. The extracts of fruiting body contained more chemical compounds than those of spore, indicating that these 11 compounds could be a better chemical marker for the fruiting body than the spore. The HPLC chemical fingerprint analysis showed higher variability in the quality of GL harvest in different years, while lesser variation in batches harvested in the same year.In conclusion, an HPLC assay detecting 11 major active components and a fingerprinting method was successfully established and validated to be feasible for quality control of most commercial GL products.

scholarly journals Compromised External Validity: Federally Produced Cannabis Does Not Reflect Legal Markets

2016 ◽  
Author(s):  
Daniela Vergara ◽  
L. Cinnamon Bidwell ◽  
Reggie Gaudino ◽  
Anthony Torres ◽  
Gary Du ◽  
...  
Keyword(s):  
Drug Abuse ◽  
External Validity ◽  
Illicit Drug ◽  
Pharmacological Properties ◽  
Physiological Effects ◽  
The Public ◽  
The Us ◽  
Chemical Profiles ◽  
Major Industry ◽  
Research Studies

AbstractAs the most widely used illicit drug, the basis of the fastest growing major industry in the US, and as a source of numerous under-studied psychoactive compounds, understanding the psychological and physiological effects of Cannabis is essential. The National Institute on Drug Abuse (NIDA) is designated as the sole legal producer of Cannabis for use in US research studies. We sought to compare the chemical profiles of Cannabis varieties that are available to consumers in states that have state-legalized use versus what is available to researchers interested in studying the plant and its effects. Our results demonstrate that the federally produced Cannabis has significantly less variety and lower concentrations of cannabinoids. Current research, which has focused on material that is far less diverse and less potent than that used by the public, limits our understanding of the plant’s chemical, biological, psychological, medical, and pharmacological properties. Investigation is urgently needed on the diverse forms of Cannabis used by the public in state-legal markets.

Characterization of different forms of kava (Piper methysticum) products by UPLC-MS/MS

Planta Medica ◽  
2021 ◽  
Author(s):  
Jessica Mamallapalli ◽  
Kanumuri Siva Rama Raju ◽  
Pedro Corral ◽  
Edward Johnston ◽  
Chunlin Zhuang ◽  
...  
Keyword(s):  
Quality Control ◽  
Relative Abundance ◽  
Human Consumption ◽  
Chemical Compositions ◽  
Experimental Measurements ◽  
Pharmacological Properties ◽  
Piper Methysticum ◽  
Product Label ◽  
Content Information

There are several forms of kava (Piper methysticum) products available for human consumption, and many factors are known to influence their chemical compositions and therefore their pharmacological properties. Because of the increased popularity of kava intake, a rigorous characterization of their content diversity is prerequisite, particularly due to its known potential to cause hepatotoxicity. To understand the composition diversity of kavalactones and flavokavains in commercial kava products, we developed a UPLC-MS/MS-based analytical method for the quantification of six kavalactones (kavain, dihydrokavain, methysticin, dihydromethysticin, yangonin and desmethoxyyangonin) and two flavokavains (flavokavains A and B) and analyzed their contents in 28 different kava products in the form of capsules, tinctures, traditional aqueous suspensions and dried powders. Our results demonstrated a great variation in terms of the total and relative abundance of the analyzed kavalactones and flavokavains among the analyzed kava preparations. More importantly, the kavalactone abundance in the product label could differ up to 90% from our experimental measurements. Therefore, more rigorous and comprehensive quality control of kava products is required with respect to the content of individual kavalactones and flavokavains. Accurate content information is essential to understand the pharmacological properties and safety of different kava products.

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