Codiaeum variegatum (L.) Rumph. ex A. Juss. (Euphorbiaceae): An overview of its botanical diversity, traditional uses, phytochemistry, pharmacological effects and perspectives towards developing its plant-based products

2021 ◽  
pp. 114244
Author(s):  
Emmanuel Mfotie Njoya ◽  
Paul Fewou Moundipa ◽  
Timo H.J. Niedermeyer
2020 ◽  
Vol 66 (3) ◽  
pp. 56-65
Author(s):  
Filip Przerwa ◽  
Arnold Kukowka ◽  
Izabela Uzar

Abstract Ballota nigra, also known as black horehound is a common medical herb used in folk medicine around the world. First reported mentions of its medical properties and use goes as far as the 13th century. The use of black horehound depends on regions and countries. It is used mostly to treat e.g. mild sleep disorders, nervousness, upset stomach, wound healing. It can be used as an anti-inflammatory, antibacterial, antiprotozoal, antifungal drug. Moreover, it has been reported as a potential cancer drug. This extensive usage is particularly interesting for us. The aim of this review is to present available data on B. nigra pharmacological effects and known traditional uses gathered from a wide range of scientific articles published in 1997–2020.


2020 ◽  
Vol 4 (2) ◽  
pp. 97-100
Author(s):  
Zaemeena Yasmeen ◽  
Abdul Basit ◽  
Sidra Tahir

2021 ◽  
Vol 11 ◽  
Author(s):  
Qi Yao ◽  
Ying Wang ◽  
Zhiyu Dong ◽  
Chencen Lai ◽  
Botao Chang ◽  
...  

Ethnopharmacology relevance:Dichondra repens J.R.Forst. and G.Forst (DRF; Convolvulaceae, called Matijin in Chinese), has been traditionally used to treat jaundice, bacillary dysentery, urinary tract infection, edema, contusions, and strains and sprains based on traditional Chinese medicine (TCM) concepts.Aim of study: This paper intends to provide a comprehensive and critical analysis of research on DRF focusing on a relationship between traditional uses and pharmacological effects, evaluating the therapeutic potential of this plant.Methods: Relevant data on DRF were retrieved from available databases.Results: The heat-clearing and detoxifying, and removing the phlegm and turbid urine effects of DRF are linked to its anti-hepatitis B virus (HBV), anti-inflammatory, and hepatoprotective activities. Especially, the hepatoprotective effects of DRF are mainly based on anti-HBV activities of phenylalanine dipeptides Matijin-Su (MTS) and its derivatives derived from this plant. Further, a phase I anti-HBV clinical trial of a candidate compound named bentysrepinine (Y101, Chinese name Tifentai) has been completed. Also, anti-tumor, analgesic, and antibacterial properties have been reported in the extracts and compounds from DRF. Although pharmacy, pharmacodynamics, toxicology, and pharmacokinetics of bentysrepinine have been systemically reported, no studies have reported chemistry, safety, pharmacology of other compounds or extracts systemically.Conclusion: Phenylalanine dipeptide compounds are main components and MTS is a characteristic substance of DRF. The main pharmacological effect of DRF is anti-HBV activity, which is coherent with the traditional use of this plant in China. Except bentysrepinine, few studies have been conducted on toxicities of the extracts or compounds from DRF. Thus, it is still necessary to evaluate safety, chemistry, pharmacology of the extracts or compounds from DRF regarding the link between traditional uses and modern applications before the future clinical trials. Bacterial sepsis, cholecystitis and tumors may be prior therapeutic targets of this plant in the future.


2020 ◽  
Vol 9 (6) ◽  
pp. 438-444
Author(s):  
Bhaskaranand Pancholi ◽  
◽  
AC Rana ◽  

Several plant species are utilized in extraordinary common remedy system around the globe and are viewed as doable marketers for the revelation of new medications. Traditional Chinese medication have a long history of flora therapeutically including multiple species of the genus Rubus (Rosaceae). The pharmacological effects of Rubus include antibacterial, antistress, anticancer, antiaging, antiinflammatory, antigastropathic, antirheumatic, antinocieptive, anxiolytic and antigiardial activities. In India, the roots of Rubus niveus (R. niveus) are utilized to treat women for excessive menstrual bleeding and its juice extract as an antidote of snake bite. R. niveus root helps to relieve rheumatoid pain, clear warmness, detoxify, clear wind damp and deal with dysentery. This review article is focused on the ethanopharmacological, phytochemical and pharmacognostical standardization and pharmacological activity of R. niveus.


2021 ◽  
pp. 113960
Author(s):  
Jiwei Ding ◽  
Linlin Wang ◽  
Chunnian He ◽  
Jun Zhao ◽  
Lijun Si ◽  
...  

2021 ◽  
Vol 12 ◽  
Author(s):  
Ping Zhou ◽  
Jingyan Li ◽  
Qi Chen ◽  
Long Wang ◽  
Jing Yang ◽  
...  

Genus Sanguisorba (family: Rosaceae) comprises nearly 148 species, distributed widely across the temperate and subtropical regions of the Northern Hemisphere. Sanguisorba officinalis L. (S. officinalis) has been used as a hemostatic and scald treating medicine in China for a long time. Numerous studies have demonstrated that plant extracts or monomers from S. officinalis exhibit several pharmacological effects, such as anti-cancer, anti-virus, anti-inflammation, anti-bacteria, neuroprotective and hepatoprotective effects. The other species of genus Sanguisorba are also being studied by researchers worldwide. Sanguisorba minor Scop. (S. minor), as an edible wild plant, is a common ingredient of the Mediterranean diet, and its young shoots and leaves are often mixed with traditional vegetables and consumed as salad. Reports on genus Sanguisorba available in the current literature were collected from Google Scholar, Web of Science, Springer, and PubMed. The Plant List (http://www.theplantlist.org./tpl1.1/search?q=Sanguisorba), International Plant Name Index (https://www.ipni.org/?q=Sanguisorba) and Kew Botanical Garden (http://powo.science.kew.org/) were used for obtaining the scientific names and information on the subspecies and cultivars. In recent years, several in vivo and in vitro experiments have been conducted to reveal the active components and effective monomers of S. officinalis and S. minor. To date, more than 270 compounds have been isolated and identified so far from the species belonging to genus Sanguisorba. Numerous reports on the chemical constituents, pharmacologic effects, and toxicity of genus Sanguisorba are available in the literature. This review provides a comprehensive understanding of the current traditional applications of plants, which are supported by a large number of scientific experiments. Owing to these promising properties, this species is used in the treatment of various diseases, including influenza virus infection, inflammation, Alzheimer’s disease, type 2 diabetes and leukopenia caused by bone marrow suppression. Moreover, the rich contents and biological effects of S. officinalis and S. minor facilitate these applications in dietary supplements and cosmetics. Therefore, the purpose of this review is to summarize the recent advances in the traditional uses, chemical constituents, pharmacological effects and clinical applications of genus Sanguisorba. The present comprehensive review may provide new insights for the future research on genus Sanguisorba.


Author(s):  
Manish Kapoor ◽  
Gurdeep Kaur ◽  
Navneet Kaur ◽  
Chanchal Sharma ◽  
Kajal Batra ◽  
...  

The genus Hibiscus belongs to the mallow family, Malvaceae comprising of about 275 species growing in tropical and sub tropical areas. The various species of genus Hibiscus have been used as traditional medicine all over the world. There are numerous reports of their traditional medicinal uses in various countries like India, Nigeria, China, and Srilanka etc. to cure various ailments such as hypertension, cardiac diseases, stomach-ache, urine problems, skin diseases and many more. Based on the historical knowledge, various pharmacological and phytochemical studies on some species of the genus Hibiscus have been done. Nevertheless, there are no up-to-date articles published which can provide an overview of pharmacological effects of the genus Hibiscus. Therefore, the main objective of the review article is to provide a systematic comprehensive summary of traditional uses, phytochemistry and pharmacology of the genus Hibiscus and to build up a correlation between its traditional ethano-botanical uses and pharmacological activities so as to find some advanced research opportunities in this field. The given information on the ethano-botanical uses, phytoconstituents and various medicinal properties of the genus Hibiscus was gathered from the online scientific databases through search in Google, Google Scholar, Science Direct, NCBI, Pubmed, Springer Link, Research Gate by using some keywords as. Besides these websites other published literature and unpublished Ph.D. thesis and M.Sc. dissertation were also consulted. Previously conducted research revealed that the genus contains good amount of phytoconstituents such as antioxidants, phytosterols, saponins, lignin, essential oils, glycosides, and anthocyanins etc. Presence of these bioactive compounds in the crude extracts of the plants make it suitable for various medicinal properties like anti inflammatory, anti-diabetic, anti-obesity, anti-proliferative, anti-ulcer, hypersensitive, hypolipidemic, hepatoprotective, nephroprotective and many more. Additionally, this review article showed that mainly two species of the genus i.e. H. rosa-sinensis and H. sabdariffa have been explored for their pharmacological activities. There are few reports on some other species like H. tiliaceous, H. microanthus, H. asper, H. acetosella. This review highlights the medicinal potential of the plant Hibiscus due to its unique blend of phytochemicals. These phytoconstituents can be further assessed and subjected to clinical trials for their proper validations. Although large amount of the data regarding pharmacological effects has already been added to the existing reservoir but still potential of certain species like H. radiatus, H. hirtus, H. moschetous, H. trionum and many more is not yet unveiled and can be considered as future prospects that need to be worked out.  Graphical Abstract: 


Author(s):  
Lipi Rani Ray ◽  
Muhammad Shaiful Alam ◽  
Md. Junaid ◽  
Sakia Ferdousy ◽  
Rasheda Akter ◽  
...  

Background: Brassica oleracea var. Capitata F. Alba (white cabbage) is a cruciferous vegetable which used as a vegetable and traditional medicine all over the world. Different preparation from several parts of the plant - roots, shoots, leaves and the whole plant are used to treat a wide range of diseases including diabetes, cancer, gastric, inflammation, hypertension, hypercholesterolemia, bacterial, oxidation, and obesity. Objective: The aim of the current review is to evaluate the botany, distribution, traditional uses, phytochemistry and pharmacological activities of B. oleracea var. Capitata. Moreover, this review will guide to fill the existing gaps in information and highlight additional research prospects in the field of phytochemistry and pharmacology. Method: Various resources including research papers, review papers, books and reports were collected to obtain over all information of Brassica oleracea var. Capitata, which were obtained by an online search of worldwide-accepted scientific databases. Phytochemical constituents’ structures were drawn by ChemDraw software. Results: About 72 isolated phytochemical compounds of B. oleracea var. Capitata have been collected from different article, which included different type of compounds such as alkaloids, flavonoids, organic acids, glucosinolates, steroids, hydrocarbons etc. Crude extracts and phytoconstituents of B. oleracea var. Capitata have various pharmacological effects including antidiabetic, anticancer, antihypertensive, anticholesterolemic, antioxidant, anti-inflammatory, antibacterial, antiobesity, anticoagulant & hepatoprotective. We have enlisted all these pharmacological data along with all the phytochemical constituents of Brassica oleracea var. Capitata. Conclusion: The study was focused on the traditional uses, pharmacological activities and phytochemistry of Brassica oleracea var. Capitata and the findings indicating that B. oleracea var. Capitata is an important medicinal plant which shows several pharmacological effects. We hope our review on this plant will provide more basic and useful information and fill some research gap for further investigation and drug design. Despite we found some important traditional uses and pharmacological activities of Brassica oleracea var. Capitata there are insufficient work found in the field of phytochemical activities.


Molecules ◽  
2019 ◽  
Vol 24 (19) ◽  
pp. 3473 ◽  
Author(s):  
Chunling Zhang ◽  
Linhong Fan ◽  
Shunming Fan ◽  
Jiaqi Wang ◽  
Ting Luo ◽  
...  

Cinnamomum cassia Presl is a tropical aromatic evergreen tree of the Lauraceae family, commonly used in traditional Chinese medicine. It is also a traditional spice, widely used around the world. This paper summarizes the achievements of modern research on C. cassia, including the traditional uses, phytochemistry, pharmacology and toxicology. In addition, this review also discusses some significant issues and the potential direction of future C. cassia research. More than 160 chemicals have been separated and identified from C. cassia. The main constituents of C. cassia are terpenoids, phenylpropanoids, glycosides, etc. Modern studies have confirmed that C. cassia has a wide range of pharmacological effects, including antitumour, anti-inflammatory and analgesic, anti-diabetic and anti-obesity, antibacterial and antiviral, cardiovascular protective, cytoprotective, neuroprotective, immunoregulatory effects, anti-tyrosinase activity and other effects. However, the modern studies of C. cassia are still not complete and more in-depth investigations need to be conducted in alimentotherapy, health product, toxicity and side effects, and more bioactive components and potential pharmacological effects need to be explored in the future.


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