Role of oxidative stress in the pathophysiology of equine laminitis: a comparison of two experimental models

Epilepsy is considered one of the most common neurological disorders worldwide. Oxidative stress produced by free radicals may play a role in the initiation and progression of epilepsy; the changes in the mitochondrial and the oxidative stress state can lead mechanism associated with neuronal death pathway. Bioenergetics state failure and impaired mitochondrial function include excessive free radical production with impaired synthesis of antioxidants. This review summarizes evidence that suggest what is the role of oxidative stress on induction of apoptosis in experimental models of epilepsy.

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Modulation of Oxidative Stress by Ozone Therapy in the Prevention and Treatment of Chemotherapy-Induced Toxicity: Review and Prospects

Antioxidants ◽

10.3390/antiox8120588 ◽

2019 ◽

Vol 8 (12) ◽

pp. 588 ◽

Cited By ~ 8

Author(s):

Bernardino Clavo ◽

Francisco Rodríguez-Esparragón ◽

Delvys Rodríguez-Abreu ◽

Gregorio Martínez-Sánchez ◽

Pedro Llontop ◽

...

Keyword(s):

Oxidative Stress ◽

Free Radicals ◽

Potential Role ◽

Antioxidant Response ◽

Experimental Models ◽

Ozone Therapy ◽

Oxidative Stress Parameters ◽

Randomized Controlled ◽

Causes Of Mortality

(1) Background: Cancer is one of the leading causes of mortality worldwide. Radiotherapy and chemotherapy attempt to kill tumor cells by different mechanisms mediated by an intracellular increase of free radicals. However, free radicals can also increase in healthy cells and lead to oxidative stress, resulting in further damage to healthy tissues. Approaches to prevent or treat many of these side effects are limited. Ozone therapy can induce a controlled oxidative stress able to stimulate an adaptive antioxidant response in healthy tissue. This review describes the studies using ozone therapy to prevent and/or treat chemotherapy-induced toxicity, and how its effect is linked to a modification of free radicals and antioxidants. (2) Methods: This review encompasses a total of 13 peer-reviewed original articles (most of them with assessment of oxidative stress parameters) and some related works. It is mainly focused on four drugs: Cisplatin, Methotrexate, Doxorubicin, and Bleomycin. (3) Results: In experimental models and the few existing clinical studies, modulation of free radicals and antioxidants by ozone therapy was associated with decreased chemotherapy-induced toxicity. (4) Conclusions: The potential role of ozone therapy in the management of chemotherapy-induced toxicity merits further research. Randomized controlled trials are ongoing.

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FructationIn Vivo: Detrimental and Protective Effects of Fructose

BioMed Research International ◽

10.1155/2013/343914 ◽

2013 ◽

Vol 2013 ◽

pp. 1-9 ◽

Cited By ~ 26

Author(s):

H. M. Semchyshyn

Keyword(s):

Oxidative Stress ◽

Side Effects ◽

Experimental Models ◽

Oxygen Species ◽

Protective Effects ◽

Compelling Evidence ◽

Animal Tissues

There is compelling evidence that long-term intake of excessive fructose can have deleterious side effects in different experimental models. However, the role of fructosein vivoremains controversial, since acute temporary application of fructose is found to protect yeast as well as animal tissues against exogenous oxidative stress. This review suggests the involvement of reactive carbonyl and oxygen species in both the cytotoxic and defensive effects of fructose. Potential mechanisms of the generation of reactive species by fructose in the nonenzymatic reactions, their implication in the detrimental and protective effects of fructose are discussed.

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Sulfur – Containing Amino Acids in Seizures: Current State of the Art

Current Medicinal Chemistry ◽

10.2174/0929867324666170609090613 ◽

2018 ◽

Vol 25 (3) ◽

pp. 378-390 ◽

Cited By ~ 2

Author(s):

Dragan Hrncic ◽

Aleksandra Rasic-Markovic ◽

Duro Macut ◽

Dusan Mladenovic ◽

Veselinka Susic ◽

...

Keyword(s):

Oxidative Stress ◽

Amino Acids ◽

Experimental Models ◽

Neuroprotective Effects ◽

Homocysteine Thiolactone ◽

Current State ◽

Sulfur Containing ◽

And Oxidative Stress

Background: Homocysteine and taurine are non-proteinogenic sulfur-containing amino acids with numerous important physiological roles. Homocysteine and taurine are considered to be neurotransmitters and neuromodulators, the first showing clear hyperexcitability role, while the second is known by its inhibitory and neuroprotective properties. Objective: In this article we addressed the role of homocysteine and its related metabolite homocysteine thiolactone in the development of seizures, focusing on its experimental models in vivo, potential mechanisms of proepileptogenic activity via interactions with glutamatergic neurotransmission, sodium pump activity, oxidative stress, cholinergic system and NO-mediated neuronal signaling, as well as the pharmacological and non-pharmacological approaches to modulate its proconvulsive activity. Additionally, herein we will focus on taurine neuroprotective effects linked with its anticonvulsive properties and mediated by taurine interactions with GABA-ergic and glutamatergic system and oxidative stress.

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Role of Oxidative Stress in Refractory Epilepsy: Evidence in Patients and Experimental Models

International Journal of Molecular Sciences ◽

10.3390/ijms14011455 ◽

2013 ◽

Vol 14 (1) ◽

pp. 1455-1476 ◽

Cited By ~ 57

Author(s):

Noemi Cardenas-Rodriguez ◽

Bernardino Huerta-Gertrudis ◽

Liliana Rivera-Espinosa ◽

Hortencia Montesinos-Correa ◽

Cindy Bandala ◽

...

Keyword(s):

Oxidative Stress ◽

Refractory Epilepsy ◽

Experimental Models

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Oxidative Stress and the Role of NADPH Oxidase in Glaucoma

Antioxidants ◽

10.3390/antiox10020238 ◽

2021 ◽

Vol 10 (2) ◽

pp. 238

Author(s):

Jennifer C. Fan Gaskin ◽

Manisha H. Shah ◽

Elsa C. Chan

Keyword(s):

Oxidative Stress ◽

Nadph Oxidase ◽

Retinal Ganglion Cells ◽

Ganglion Cells ◽

Experimental Models ◽

Retinal Diseases ◽

Retinal Ganglion ◽

Novel Treatment ◽

And Oxidative Stress

Glaucoma is characterised by loss of retinal ganglion cells, and their axons and many pathophysiological processes are postulated to be involved. It is increasingly understood that not one pathway underlies glaucoma aetiology, but rather they occur as a continuum that ultimately results in the apoptosis of retinal ganglion cells. Oxidative stress is recognised as an important mechanism of cell death in many neurodegenerative diseases, including glaucoma. NADPH oxidase (NOX) are enzymes that are widely expressed in vascular and non-vascular cells, and they are unique in that they primarily produce reactive oxygen species (ROS). There is mounting evidence that NOX are an important source of ROS and oxidative stress in glaucoma and other retinal diseases. This review aims to provide a perspective on the complex role of oxidative stress in glaucoma, in particular how NOX expression may influence glaucoma pathogenesis as illustrated by different experimental models of glaucoma and highlights potential therapeutic targets that may offer a novel treatment option to glaucoma patients.

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