Protective effect of ω-3 polyunsaturated fatty acids (PUFA) on sodium nitrite induced nephrotoxicity and oxidative damage in rat kidney

The effects of red wine and ethanol on plasma lipoproteins and the fatty acid composition of kidney lipids and erythrocytes phospholipids were studied. Lipid peroxidation is one of the main deleterious effects of oxidant attack on biomolecules, due to the disruption of the structural integrity of membranes. The vulnerability of the kidney to oxidative damage has been partly attributed to its high content of long-chain polyunsaturated fatty acids. Antioxidants, such as flavonoids, would be a means of reducing the risk of oxidative damage to membranes. Nutritional sources rich in antioxidants, including those provided by wine, are expected to attenuate the effects of oxidative challenges. Adult rats were fed red wine rich in flavonols, ethanol (125 ml/l), or alcohol-free red wine. The control group drank water. After 10 weeks, blood samples served to measure plasma lipoproteins and antioxidant capacity. Kidney lipids and erythrocyte phospholipids were extracted. The samples were assayed by GLC. Energy intake did not differ between all the groups, but the weight gain of the ethanol group was less than the other three groups. Blood HDL and triacylglycerols were increased by both ethanol and red wine. Ethanol decreased arachidonic and docosahexaenoic acids in both kidney lipids and erythrocyte phospholipids, as compared with either water, red wine or alcohol-free red wine groups. These results indicate that non-alcoholic components of red wine could contribute to avoiding the unfavourable effects of ethanol on plasma lipoproteins, kidney lipids and membrane erythrocyte phospholipids.

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Omega 3 polyunsaturated fatty acids enhance the protective effect of levetiracetam against seizures, cognitive impairment and hippocampal oxidative DNA damage in young kindled rats

Pharmacology Biochemistry and Behavior ◽

10.1016/j.pbb.2015.05.020 ◽

2015 ◽

Vol 135 ◽

pp. 105-113 ◽

Cited By ~ 9

Author(s):

Basel A. Abdel-Wahab ◽

Ibrahim A. Shaikh ◽

Masood M. Khateeb ◽

Shafiuddin M. Habeeb

Keyword(s):

Fatty Acids ◽

Dna Damage ◽

Cognitive Impairment ◽

Polyunsaturated Fatty Acids ◽

Protective Effect ◽

Oxidative Dna Damage ◽

Omega 3

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Protective effect of green tea extract against proline-induced oxidative damage in the rat kidney

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2016.08.057 ◽

2016 ◽

Vol 83 ◽

pp. 1422-1427 ◽

Cited By ~ 15

Author(s):

Débora Delwing-Dal Magro ◽

Roberto Roecker ◽

Gustavo M. Junges ◽

André F. Rodrigues ◽

Daniela Delwing-de Lima ◽

...

Keyword(s):

Oxidative Damage ◽

Protective Effect ◽

Green Tea ◽

Rat Kidney ◽

Green Tea Extract ◽

Tea Extract

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Lack of Oxidative Damage in Serum Polyunsaturated Fatty Acids before and after Dialysis in Chronic Uremic Patients

The International Journal of Artificial Organs ◽

10.1177/039139888901200806 ◽

1989 ◽

Vol 12 (8) ◽

pp. 515-518 ◽

Cited By ~ 11

Author(s):

M. Taccone-Gallucci ◽

R. Lubrano ◽

A. Belli ◽

G. Citti ◽

M. Morosetti ◽

...

Keyword(s):

Fatty Acids ◽

Oxidative Damage ◽

Polyunsaturated Fatty Acids ◽

Fatty Acid Pattern ◽

Chronic Hemodialysis ◽

Serum Concentrations ◽

Serum Fatty Acid ◽

Before And After ◽

Uremic Patients ◽

Mononuclear Blood Cells

We described previously that in the erythrocytes and mononuclear blood cells from uremic patients on chronic hemodialysis, the membrane concentrations of malonyldialdehyde (MDA), resulting from peroxidation of polyunsaturated fatty acids (PUFA) in the membrane itself increased, and the concentrations of vitamin E (VIT E), the major antioxidizing agent, were lower. In the present study we analysed whether similar oxidative damage is seen in the serum from hemodialysis patients and whether the serum fatty acid pattern is affected. No evidence was found of oxidative damage in the serum during hemodialysis, serum concentrations of MDA and VIT E remaining constant before and after dialysis. No change was observed in serum pattern of PUFA, particularly linoleic acid. We therefore assume that the oxidative damage described in uremic patients is mainly intracellular.

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