Fingertip Skin Wrinkling – the Effect of Varying Tonicity

2005 ◽  
Vol 30 (3) ◽  
pp. 273-275 ◽  
Author(s):  
N. TSAI ◽  
S. KIRKHAM
Keyword(s):  
Healthy Volunteers ◽  
Normal Skin ◽  
Nerve Function ◽  
Digital Nerve ◽  
Bedside Testing ◽  
Skin Wrinkling ◽  
The Relationship

Fingertip skin wrinkling after prolonged immersion in water is a well-recognized phenomenon, whereas a denervated digit does not exhibit normal skin wrinkling while a finger with a regenerated or repaired nerve shows at least partial reappearance of wrinkling. This is the basis for the bedside immersion-wrinkling test of autonomic digital nerve function. The exact mechanism of fingertip skin wrinkling is still subject to controversy. The purpose of this study was to investigate the relationship between the tonicity of a solution and the time elapsed to skin wrinkling. Fourteen healthy volunteers (28 hands) were recruited for investigation. We submerged all 28 hands in solutions of varying tonicity while maintaining all other parameters constant. We found that increased tonicity significantly slowed the time to wrinkling (TTW). Hypotonic solutions such as water should be used when performing clinical bedside testing for autonomic digital nerve function.

scholarly journals Comparison of the CSF dynamics between patients with idiopathic normal pressure hydrocephalus and healthy volunteers

2019 ◽  
Vol 131 (4) ◽  
pp. 1018-1023 ◽  
Author(s):  
Johan Jacobsson ◽  
Sara Qvarlander ◽  
Anders Eklund ◽  
Jan Malm
Keyword(s):  
Healthy Volunteers ◽  
Normal Pressure Hydrocephalus ◽  
Normal Pressure ◽  
Neurological Status ◽  
Idiopathic Normal Pressure Hydrocephalus ◽  
Diagnostic Process ◽  
Clinical Trial Registration ◽  
Resting Pressure ◽  
The Relationship ◽  
Dynamic Investigation

OBJECTIVEIntracranial pressure (ICP), outflow resistance (Rout), and amplitude of cardiac-related ICP pulsations (AMPs) are established parameters to describe the CSF hydrodynamic system and are assumed, but not confirmed, to be disturbed in idiopathic normal pressure hydrocephalus (INPH). The aim of this study was to compare the CSF hydrodynamic profile between patients with INPH and healthy volunteers.METHODSSixty-two consecutive INPH patients (mean age 74 years) and 40 healthy volunteers (mean age 70 years) were included. Diagnosis was made by two independent neurologists who assessed patients’ history, neurological status, and MRI studies. A CSF dynamic investigation through the lumbar route was performed: ICP and other CSF dynamic variables were blinded to the neurologists during the diagnostic process and were not used for establishing the diagnosis of INPH.RESULTSRout was significantly higher in INPH (Rout 17.1 vs 11.1; p < 0.001), though a substantial number of INPH subjects had normal Rout. There were no differences between INPH patients and controls regarding ICP (mean 11.5 mm Hg). At resting pressure, there was a trend that AMP in INPH was increased (2.4 vs 2.0 mm Hg; p = 0.109). The relationship between AMP and ICP was that they shared the same slope, but the curve was significantly shifted to the left for INPH (reduced P0 [p < 0.05]; i.e., higher AMP for the same ICP).CONCLUSIONSThis study established that the CSF dynamic profile of INPH deviates from that of healthy volunteers and that INPH should thus be regarded as a disease in which intracranial hydrodynamics are part of the pathophysiology.Clinical trial registration no.: NCT01188382 (clinicaltrials.gov)

scholarly journals Role of HYBID (Hyaluronan Binding Protein Involved in Hyaluronan Depolymerization), Alias KIAA1199/CEMIP, in Hyaluronan Degradation in Normal and Photoaged Skin

2019 ◽  
Vol 20 (22) ◽  
pp. 5804 ◽  
Author(s):  
Hiroyuki Yoshida ◽  
Yasunori Okada
Keyword(s):  
Binding Protein ◽  
Normal Skin ◽  
Collagen Fibers ◽  
Skin Fibroblasts ◽  
Photoaged Skin ◽  
Skin Photoaging ◽  
Skin Wrinkling ◽  
Initial Process ◽  
Hyaluronan Binding

Photoaged skin is characterized clinically by apparent manifestations such as wrinkles and sagging, and histologically by an accumulation of abnormal elastin and a severe loss of collagen fibers in the dermis. Quantitative and qualitative alterations in elastin and collagens are considered to be responsible for the formation of wrinkles and sagging. However, since the integrity of elastin and collagen fibers in the dermis is maintained by their interactions with hyaluronan (HA) and a proteoglycan network structure, HA degradation may be the initial process, prior to the breakdown of the fibrillary components, leading to wrinkles and sagging in photoaged skin. We have recently discovered a new HA-degrading mechanism mediated by HYBID (hyaluronan binding protein involved in hyaluronan depolymerization), alias KIAA1199/CEMIP, in human skin fibroblasts, and examined the implication of HYBID for skin photoaging. In this review, we give an overview of the characteristics of HYBID and its prospective roles in HA turnover in normal skin and excessive HA degradation in photoaged skin. In addition, we describe our data on the inhibition of HYBID activity and expression by plant extracts in skin fibroblasts; and propose novel strategies to prevent or improve photoaging symptoms, such as skin wrinkling, by inhibition of HYBID-mediated HA degradation.

Specific Gravity of Blood and Plasma at 4 and 37 °C

1974 ◽  
Vol 20 (5) ◽  
pp. 615-616 ◽  
Author(s):  
Raymond J Trudnowski ◽  
Rodolfo C Rico
Keyword(s):  
Confidence Interval ◽  
Specific Gravity ◽  
Healthy Volunteers ◽  
Relative Density ◽  
Whole Blood ◽  
Human Whole Blood ◽  
The Relationship ◽  
Density Of Water

Abstract The specific gravity (relative density) of human whole blood and plasma from 25 healthy volunteers was determined gravimetrically. For whole blood it was found to be 1.0621 (95% confidence interval: 1.0652-1.0590) at 4 °C and 1.0506 (95% confidence interval: 1.0537-1.0475) at 37 °C. Plasma specific gravity was 1.0310 (95% confidence interval: 1.0324-1.0296) at 4 °C and 1.0205 (95% confidence interval: 1.0216-1.0193) at 37 °C. All of these values are referred to the density of water at 4 °C. We show the relationship between these values and those given in the literature for measurements at 25 °C. There was a small increase in whole blood specific gravity with increasing hematocrit, but it was not statistically significant over the 40-56 hematocrit range studied.

scholarly journals Chondroitin polymerizing factor (CHPF) promotes development of malignant melanoma through regulation of CDK1

2020 ◽  
Vol 11 (7) ◽  
Author(s):  
Wei Sun ◽  
Fang Zhao ◽  
Yu Xu ◽  
Kai Huang ◽  
Xianling Guo ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Pathway Analysis ◽  
Normal Skin ◽  
Over Expression ◽  
Tumor Promotor ◽  
And Migration ◽  
First Time ◽  
The Relationship

Abstract Chondroitin polymerizing factor (CHPF) is an important member of glycosyltransferases involved in the biosynthesis of chondroitin sulfate (CS). However, the relationship between CHPF and malignant melanoma (MM) is still unknown. In this study, it was demonstrated that CHPF was up-regulated in MM tissues compared with the adjacent normal skin tissues and its high expression was correlated with more advanced T stage. Further investigations indicated that the over-expression/knockdown of CHPF could promote/inhibit proliferation, colony formation and migration of MM cells, while inhibiting/promoting cell apoptosis. Moreover, knockdown of CHPF could also suppress tumorigenicity of MM cells in vivo. RNA-sequencing followed by Ingenuity pathway analysis (IPA) was performed for exploring downstream of CHPF and identified CDK1 as the potential target. Furthermore, our study revealed that knockdown of CDK1 could inhibit development of MM in vitro, and alleviate the CHPF over-expression induced promotion of MM. In conclusion, our study showed, as the first time, CHPF as a tumor promotor for MM, whose function was carried out probably through the regulation of CDK1.

Weightbearing and Nonweightbearing Ankle Dorsiflexion Range of Motion

2012 ◽  
Vol 102 (5) ◽  
pp. 406-411 ◽  
Author(s):  
Alon Rabin ◽  
Zvi Kozol
Keyword(s):  
Healthy Volunteers ◽  
Range Of Motion ◽  
Ankle Dorsiflexion ◽  
Moderate Correlation ◽  
The Relationship

Background: Ankle dorsiflexion range of motion has been measured in weightbearing and nonweightbearing conditions. The different measurement conditions may contribute to inconsistent conclusions regarding the role of ankle dorsiflexion in several pathologic conditions. The purpose of this study was to examine the relationship between ankle dorsiflexion range of motion as measured in weightbearing and nonweightbearing conditions. Methods: We compared ankle dorsiflexion range of motion as measured in a weightbearing versus a nonweightbearing position in 43 healthy volunteers. Measurements were taken separately by two examiners. Results: Weightbearing and nonweightbearing ankle dorsiflexion measurements produced significantly different results (P &lt; .0001). The two measurements correlated moderately (r = 0.6 and r = 0.64 for examiners 1 and 2, respectively; P &lt; .001). Conclusions: Weightbearing and nonweightbearing ankle dorsiflexion measurements produce significantly different results and only a moderate correlation, suggesting that these two measurements should not be used interchangeably as measures of ankle dorsiflexion range of motion. (J Am Podiatr Med Assoc 102(5): 406–411, 2012)

scholarly journals Study of the skin anatomy with high-frequency (22 MHz) ultrasonography and histological correlation

2015 ◽  
Vol 48 (5) ◽  
pp. 324-329 ◽  
Author(s):  
Elisa de Oliveira Barcaui ◽  
Antonio Carlos Pires Carvalho ◽  
Juan Piñeiro-Maceira ◽  
Carlos Baptista Barcaui ◽  
Heleno Moraes
Keyword(s):  
High Frequency ◽  
Normal Skin ◽  
Skin Structure ◽  
Cutaneous Tissue ◽  
High Frequency Ultrasonography ◽  
Skin Conditions ◽  
The Relationship ◽  
Subsequent Staining ◽  
Excellent Tool ◽  
Hematoxylin Eosin

AbstractThe present essay is aimed at getting the radiologist familiar with the basic histological skin structure, allowing for a better correlation with sonographic findings. A high-frequency (22 MHz) ultrasonography apparatus was utilized in the present study. The histological analysis was performed after the skin specimens fixation with formalin, inclusion in paraffin blocks and subsequent staining with hematoxylin-eosin. The authors present a literature review showing the relationship between sonographic and histological findings in normal cutaneous tissue, and discuss the technique for a better performance of the sonographic scan. High-frequency ultrasonography is an excellent tool for the diagnosis of different skin conditions. However, as this method is operator-dependent, it is crucial to understand the normal skin structure as well as the correlation between histological and sonographic findings.

scholarly journals Ultrasonographic findings of re-epithelialized skin after partial-thickness burns

2018 ◽  
Vol 6 ◽  
Author(s):  
Jong Dae Kim ◽  
Suk Joon Oh ◽  
Sun Gyu Kim ◽  
Song Vogue Ahn ◽  
Yu Jin Jang ◽  
...  
Keyword(s):  
Medical Records ◽  
Normal Skin ◽  
Healing Time ◽  
Ultrasound Images ◽  
Strongly Correlated ◽  
Varying Thickness ◽  
Partial Thickness ◽  
The Difference ◽  
Partial Thickness Burns ◽  
The Relationship

Abstract Background This study aimed to investigate the difference between ultrasonographic findings of normal skin and those of re-epithelialized skin after partial-thickness burns and to evaluate the relationship between these findings and clinical outcomes. Methods This study retrospectively analysed the ultrasound images of re-epithelialized skin after partial-thickness burns and contralateral normal skin from January 2016 to December 2016. A total of 155 lesions from 148 patients were analysed with ultrasound images, and healing time was documented. The scar status of each lesion was evaluated through medical records and photographs. We analysed the difference in ultrasonographic findings between normal skin and re-epithelialized skin after partial-thickness burns and statistically analysed the relationship between healing time, scar status and ultrasonographic findings. Results The re-epithelialized skin after partial-thickness burns was significantly thicker than the contralateral normal skin, and the echogenicity was significantly lower. The ultrasound images of the re-epithelialized skin after partial-thickness burns showed the characteristic findings of low-echogenic bands (LEB), and the proportion of LEB thickness is strongly correlated with healing time. In the multivariate analysis of scar status, only the proportion of LEB thickness was statistically significant. Conclusion In this study, we found that there were ultrasonographic differences between re-epithelialized skin after partial-thickness burns and normal skin and that an LEB of varying thickness was formed after re-epithelialization. The thickness of the LEB in re-epithelialized skin after partial-thickness burns increased with healing time and was related to scar status.

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