scholarly journals Aortic stiffness is strikingly increased with age ≥50 years in clinically normal individuals and preclinical patients with cardiovascular risk factors: Assessment by the new technique of 2D strain echocardiography

2011 ◽  
Vol 57 (3) ◽  
pp. 354-359 ◽  
Author(s):  
Yoshifumi Oishi ◽  
Hirokazu Miyoshi ◽  
Yukio Mizuguchi ◽  
Arata Iuchi ◽  
Norio Nagase ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Aortic Stiffness ◽  
New Technique ◽  
Clinically Normal ◽  
Normal Individuals ◽  
2D Strain ◽  
Strain Echocardiography

Abstract P359: Non-Alcoholic Fatty Liver Disease Severity is Associated With Aortic Stiffness Independently From Adiposity and Cardiovascular Risk Factors

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Paulo Harada ◽  
Isabela M Bensenor ◽  
Alessandra C Goulart ◽  
Jose G Mill ◽  
Paulo A Lotufo
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Liver Disease ◽  
Waist Circumference ◽  
Fatty Liver ◽  
Cardiovascular Risk Factors ◽  
Fatty Liver Disease ◽  
Aortic Stiffness ◽  
Significant Difference

Background: Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of conditions closely related to adiposity, hypertension, diabetes, and dyslipidemia. NAFLD has been consistently associated with adverse-health cardiovascular outcomes and subclinical atherosclerosis markers. However, there are contradictory findings (most of them with few participants) of the relationship between NAFLD and aortic stiffness: ones describing as an independent association, others as an association mediated by traditional cardiovascular risk factors. Hypothesis: NAFLD presence and severity is associated independently with aortic stiffness. Methods: We addressed this question among civil servants aged 35 to 74 years, 54% of them, women, and free of cardiovascular disease during the baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). The presence and severity of NAFLD were assessed by ultrasound hepatic attenuation validated with computerized tomography. Aortic stiffness was measured by the carotid-femoral pulse wave velocity (cf-PWV) by a non-invasive certified device (Complior SP). We applied ANOVA to compare the estimated cf-PWVs means and 95% Confidence according to NAFLD categories. These values were adjusted for age, sex, race, waist circumference, diabetes, dyslipidemia, high sensitivity C reactive protein, mean arterial pressure, and use of anti-hypertensive drugs. Results: Among 7,156 participants, 63.5% did not have NAFLD, 22.7% were classified as mild NAFLD, 11.7% as moderate, and 2.1% as severe. An overview of crude means from the absence of NAFLD to severe NAFLD there were slightly older individuals, a higher proportion of men, lower frequency of current smokers, and people with at least or hypertension or diabetes or dyslipidemia. In the fully adjusted analysis, the cf-PWV (m/s) values were similar among subjects with absence of NAFLD [9.27 (9.18 to 9.36)] compared with the presence of either grade of NAFLD [9.24 (9.15, 9.32)(p=0.285)]. However, there was a significant difference between cf-PWV for people without NAFLD [9.23 (9.15, 9.32)] compared with subjects with severe NAFLD [9.51 (9.31, 9.70). A significant high cf-PWV was significant thru NAFLD categories. (p-value for trend=0.045)]. There was no effect modification of this association across age strata, sex, race, waist circumference and body mass index strata, and presence of hypertension, diabetes, and dyslipidemia. Conclusion: In a population of individuals free of cardiovascular disease, NAFLD severity was associated with aortic stiffness regardless of adiposity and the traditional cardiometabolic risk factors.

Determinants and prognostic relevance of aortic stiffness in patients with recent ST-elevation myocardial infarction

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
I Lechner ◽  
M Reindl ◽  
C Tiller ◽  
M Holzknecht ◽  
A Mayr ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Aortic Stiffness ◽  
Prognostic Significance ◽  
St Elevation Myocardial Infarction ◽  
Adjusted Analysis ◽  
St Elevation ◽  
The Impact

Abstract Background The association between aortic stiffness, cardiovascular risk factors and prognosis in patients with recent ST-elevation myocardial infarction (STEMI) is poorly understood. We analyzed the relationship between cardiovascular risk factors and arterial stiffening and assessed its prognostic significance in patients with recent STEMI. Methods We prospectively enrolled 408 consecutive patients who sustained a first STEMI and underwent primary percutaneous coronary intervention (PPCI). Aortic pulse wave velocity (PWV), a direct measure of aortic stiffness, was determined by the transit-time method using velocity-encoded, phase-contrast cardiac magnetic resonance imaging. Patient characteristics were acquired at baseline and major adverse cardiac and cerebrovascular events (MACCE) were assessed at 13 (interquartile range [IQR] 12–31) months. Cox regressionand logistic regression analysis were performed to explore predictors of PWV and MACCE. Results Median aortic PWV was 6.6 m/s (IQR 5.6–8.3m/s). In multivariable analysis, age (odds ratio [OR] 1.10, 95% confidence interval [CI], 1.08–1.14, p<0.001) and hypertension (OR 2.45, 95% CI, 1.53–3.91, p<0.001) were independently associated with increased PWV. Sex, diabetes, smoking status, dyslipidemia, and obesity were not significantly associated with PWV in adjusted analysis (all p>0.05). High PWV significantly and independently predicted occurrence of MACCE in adjusted analysis (hazard ratio [HR] 2.45, 95% CI 1.19–5.04, p=0.014). Conclusion In patients with recent STEMI, the impact of classical cardiovascular risk factors on aortic stiffness is mainly dependent on age and increased blood pressure. Increased aortic stiffness is associated with adverse clinical outcome post-STEMI, suggesting it as a relevant therapeutic target in this population. FUNDunding Acknowledgement Type of funding sources: Public grant(s) – EU funding. Main funding source(s): Austrian Science Fund (FWF)Austrian Society of Cardiology Figure 1. Biorender.com

scholarly journals How Aortic Stiffness in Postmenopausal Women Is Related to Common Cardiovascular Risk Factors

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Maria Maiello ◽  
Annapaola Zito ◽  
Marco Matteo Ciccone ◽  
Pasquale Palmiero
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Postmenopausal Women ◽  
Aortic Stiffness ◽  
Common Femoral Artery ◽  
Ventricular Outflow Tract ◽  
Left Ventricular ◽  
Control Group ◽  
Younger Women

Objective.Our study investigates major common cardiovascular risk factors relation with aortic stiffness on 269 postmenopausal women by global pulse wave velocity (PWVg), useful to relate PWVg to risk of major cardiovascular events.Patients and Methods.Women were categorized as hypertensive (H), hypercholesterolemic (C), or diabetic (D). Aortic stiffness was assessed by PWVg measured with pulsed Doppler, at the left ventricular outflow tract (LVOT) and at the right common femoral artery.Results.All population mean PWVg was 8.2 m/s. 85 (26.5%) women were H; mean PWVg was 7.9 m/s. HC women were 118 (36.7%), with mean PWVg 8.3 m/s. HD women were 30 (9.5%), with mean PWVg 7.8 m/s. HDC women were 36 (11.2%), with mean PWVg 9.3 m/s. 52 (16.1%) menstruate women without risk factor were control group (CG), with mean PWVg 6.5 m/s. Highly significant was the statistical difference in PWVg between HDC women and each other group:P<0.0005versus CG;P<0.01versus H;P<0.03versus HC, andP<0.05versus HD. No difference in PWG was observed comparing the other groups. There was difference for age among all groups, except for CG, made by younger women.Conclusion.PWVg was highly increased in postmenopausal women affected by hypertension, diabetes, and hypercholesterolemia all at once. Hypertension is the major determinant for PWVg. The only addition of diabetes or hypercholesterolemia did not increase significantly PWVg. Our study supports the usefulness of the assessment of aortic stiffness as a marker of cardiovascular disease.

scholarly journals Negative Impact of Cardiovascular Risk Factors on Left Atrial and Left Ventricular Function Related to Aortic Stiffness

2013 ◽  
Vol 77 (6) ◽  
pp. 1490-1498 ◽  
Author(s):  
Yoshifumi Oishi ◽  
Hirokazu Miyoshi ◽  
Arata Iuchi ◽  
Norio Nagase ◽  
Nusrat Ara ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Left Ventricular Function ◽  
Cardiovascular Risk Factors ◽  
Ventricular Function ◽  
Left Atrial ◽  
Aortic Stiffness ◽  
Negative Impact ◽  
Left Ventricular

scholarly journals Determinants and prognostic relevance of aortic stiffness in patients with recent ST-elevation myocardial infarction

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
I Lechner ◽  
M Reindl ◽  
C Tiller ◽  
M Holzknecht ◽  
A Mayr ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Aortic Stiffness ◽  
Prognostic Significance ◽  
St Elevation Myocardial Infarction ◽  
Adjusted Analysis ◽  
St Elevation ◽  
The Impact

Abstract Funding Acknowledgements Type of funding sources: None. Background The association between aortic stiffness, cardiovascular risk factors and prognosis in patients with recent ST-elevation myocardial infarction (STEMI) is poorly understood. Purpose We analyzed the relationship between cardiovascular risk factors and arterial stiffening and assessed its prognostic significance in patients with recent STEMI. Methods We prospectively enrolled 408 consecutive patients who sustained a first STEMI and underwent primary percutaneous coronary intervention (pPCI). Aortic pulse wave velocity (PWV), a direct measure of aortic stiffness, was determined by the transit-time method using velocity-encoded, phase-contrast cardiac magnetic resonance imaging. Patient characteristics were acquired at baseline and major adverse cardiac and cerebrovascular events (MACCE) were assessed at 13 (interquartile range [IQR] 12–31) months. Cox regression- and logistic regression analysis were performed to explore predictors of PWV and MACCE. Results Median aortic PWV was 6.6 m/s (IQR 5.6–8.3m/s). In multivariable analysis, age (odds ratio [OR] 1.10, 95% confidence interval [CI], 1.08–1.14, p &lt; 0.001) and hypertension (OR 2.45, 95% CI, 1.53–3.91, p &lt; 0.001) were independently associated with higher PWV. Gender, diabetes, smoking status, dyslipidemia, and obesity were not significantly associated with PWV in adjusted analysis (all p &gt; 0.05). High PWV significantly and independently predicted occurrence of MACCE in adjusted analysis (hazard ratio [HR] 2.45, 95% CI 1.19–5.04, p = 0.014). Conclusion In patients with recent STEMI, the impact of classical cardiovascular risk factors on aortic stiffness is mainly dependent on age and increased blood pressure. Increased aortic stiffness is associated with adverse clinical outcome, suggesting it as a relevant therapeutic target in this population.

scholarly journals Determinants and prognostic relevance of aortic stiffness in patients with recent ST-elevation myocardial infarction

2021 ◽  
Author(s):  
Ivan Lechner ◽  
Martin Reindl ◽  
Christina Tiller ◽  
Magdalena Holzknecht ◽  
Sarah Niederreiter ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Aortic Stiffness ◽  
Prognostic Significance ◽  
St Elevation Myocardial Infarction ◽  
Adjusted Analysis ◽  
St Elevation ◽  
The Impact

AbstractThe association between aortic stiffness, cardiovascular risk factors and prognosis in patients with recent ST-elevation myocardial infarction (STEMI) is poorly understood. We analyzed the relationship between cardiovascular risk factors and arterial stiffening and assessed its prognostic significance in patients with recent STEMI. We prospectively enrolled 408 consecutive patients who sustained a first STEMI and underwent primary percutaneous coronary intervention (PPCI). Aortic pulse wave velocity (PWV), the most widely used measure of aortic stiffness, was determined by the transit-time method using velocity-encoded, phase-contrast cardiac magnetic resonance imaging. Patient characteristics were acquired at baseline and major adverse cardiac and cerebrovascular events (MACCE) were assessed at 13 [interquartile range (IQR) 12–31] months. Cox regression- and logistic regression analysis were performed to explore predictors of aortic stiffness and MACCE. Median aortic PWV was 6.6 m/s (IQR 5.6–8.3 m/s). In multivariable analysis, age [odds ratio (OR) 1.10, 95% confidence interval (CI), 1.08–1.14, p < 0.001] and hypertension (OR 2.45, 95% CI, 1.53–3.91, p < 0.001) were independently associated with increased PWV. Sex, diabetes, smoking status, dyslipidemia, and obesity were not significantly associated with PWV in adjusted analysis (all p > 0.05). High PWV significantly and independently predicted occurrence of MACCE in adjusted analysis [hazard ratio (HR) 2.45, 95% CI 1.19–5.04, p = 0.014]. In patients with recent STEMI, the impact of classical cardiovascular risk factors on aortic stiffness is mainly dependent on age and increased blood pressure. Increased aortic stiffness is associated with adverse clinical outcome post-STEMI, suggesting it as a relevant therapeutic target in this population. Trial (NCT04113356).

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