Epstein-Barr virus and multiple sclerosis: Cellular immune response and cross-reactivity

2010 ◽  
Vol 229 (1-2) ◽  
pp. 238-242 ◽  
Author(s):  
J. William Lindsey ◽  
Landon M. Hatfield
Keyword(s):  
Multiple Sclerosis ◽  
Immune Response ◽  
Cellular Immune Response ◽  
Epstein Barr Virus ◽  
Cross Reactivity ◽  
Barr Virus ◽  
Epstein Barr ◽  
Cellular Immune

scholarly journals Identification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosis

2005 ◽  
Vol 115 (5) ◽  
pp. 1352-1360 ◽  
Author(s):  
Sabine Cepok ◽  
Dun Zhou ◽  
Rajneesh Srivastava ◽  
Stefan Nessler ◽  
Susanne Stei ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Immune Response ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr ◽  
Virus Proteins

An altered immune response to Epstein-Barr virus in multiple sclerosis: A prospective study

Neurology ◽  
2004 ◽  
Vol 62 (12) ◽  
pp. 2277-2282 ◽  
Author(s):  
P. Sundstrom ◽  
P. Juto ◽  
G. Wadell ◽  
G. Hallmans ◽  
A. Svenningsson ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Immune Response ◽  
Prospective Study ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Altered Immune Response ◽  
Epstein Barr ◽  
A Prospective Study

scholarly journals Epstein-Barr virus infection as a predisposing factor for multiple sclerosis. An update from molecular biology, immunology and epidemiology

2019 ◽  
Vol 67 (3) ◽  
pp. 305-313
Author(s):  
David López-Valencia ◽  
Ángela Medina-Ortega ◽  
Diego Fernando Hoyos-Samboní ◽  
Jhan Sebastián Saavedra-Torres ◽  
Carolina Salguero
Keyword(s):  
Multiple Sclerosis ◽  
Immune Response ◽  
Autoimmune Diseases ◽  
Epstein Barr Virus ◽  
Acute Infection ◽  
Viral Reactivation ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Mesh Terms ◽  
Epstein Barr

Introduction: Epstein-Barr virus is an infectious agent used to immortalize and induce polyclonal activation of B cells. It has been widely described that this virus produces changes in the cells it infects and in the immune response, and stimulates the development of autoimmune diseases.Objective: To characterize the association between Epstein-Barr virus and multiple sclerosis described in current scientific literature.Materials and methods: A 59-years range literature search was conducted in the PubMed, ScienceDirect, Redalyc and SciELO databases using the following MeSH terms: “Epstein-Barr virus, multiple sclerosis autoimmune diseases, autoimmune diseases of the nervous system”.Results: Many studies describe the association between Epstein-Barr virus and multiple sclerosis. It is believed that acute infection and viral reactivation promote the development of multiple sclerosis.Conclusions: It is necessary to conduct further research on the pathogenesis and morphophysiological and neuroimmunological changes –at the ecological, molecular, cellular, tissue, organic and systemic level– induced by the immune response and that favor the development of multiple sclerosis.

Epstein–Barr virus, latitude and multiple sclerosis

2012 ◽  
Vol 19 (3) ◽  
pp. 362-365 ◽  
Author(s):  
Giulio Disanto ◽  
Julia Pakpoor ◽  
Julia M Morahan ◽  
Carolina Hall ◽  
Ute C Meier ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Immune Response ◽  
Odds Ratio ◽  
Epstein Barr Virus ◽  
Serological Markers ◽  
Related Factors ◽  
Barr Virus ◽  
Ebv Infection ◽  
Epstein Barr ◽  
Lines Of Evidence

Several lines of evidence support a role for Epstein–Barr virus (EBV) in the aetiology of multiple sclerosis (MS). This includes the observation that nearly all MS patients show serological markers of past EBV infection. Given the well-known association between MS prevalence and latitude, we investigated whether EBV seropositivity also increases with distance from the equator. We found that the proportion of EBV positive individuals is positively associated with latitude independently of MS status (odds ratio = 1.06, 95% CI = 1.02–1.09, p = 0.002). Latitude-related factors may be implicated in the immune response to EBV and its role in MS aetiology.

Illuminating the in vitro effects of Epstein-Barr virus and vitamin D on immune response in multiple sclerosis patients

2021 ◽  
Author(s):  
Majid Teymoori-Rad ◽  
Mohammad Ali Sahraian ◽  
Talat Mokhtariazad ◽  
Ahmad Nejati ◽  
Razieh Sadat Kazemi Mozdabadi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Immune Response ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr ◽  
In Vitro Effects ◽  
Multiple Sclerosis Patients
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