Immune response induced by Epstein-Barr virus andMycobacterium aviumsubsp.paratuberculosispeptides in current and past infectious mononucleosis: a risk for multiple sclerosis?

2015 ◽  
Vol 23 (1) ◽  
pp. 140-147 ◽  
Author(s):  
G. Mameli ◽  
G. Madeddu ◽  
D. Cossu ◽  
G. Galleri ◽  
R. Manetti ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Immune Response ◽  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals THE VALUE OF THE IMMUNE RESPONSE IN PATIENTS WITH EBV INFECTIOUS MONONUCLEOSIS IN PREDICTING THE COURSE AND EFFICACY OF ANTIVIRAL AND IMMUNO IMMUNOCORRECTING THERAPY

2013 ◽  
Vol 18 (1) ◽  
pp. 7-14
Author(s):  
T. A. Svintsova ◽  
D. M. Sobchak ◽  
O. V. Korochkina ◽  
G. A Kravchenko ◽  
V. V Novikov
Keyword(s):  
Immune Response ◽  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Mononuclear Cells ◽  
Polyclonal Antibodies ◽  
Severity Of Illness ◽  
Control Group ◽  
Differentiation Antigens ◽  
Barr Virus ◽  
Epstein Barr

The indices of immune response were studied in 68 patients with infectious mononucleosis caused by the Epstein-Barr virus (35 males, 33 females) aged 18 to 30 years. Materials and methods. The content of soluble forms of differentiation antigens (sCD95, sCD18, sCD50, sHLAI, sCD54) has been studied with enzyme immunoassay using monoclonal antibodies Mab IC0-20 and polyclonal antibodies to the antigens of the mononuclear cells of the peripheral blood. The control group included 60 healthy volunteers matched for age and sex with the main group. The aim of this study is the assessment of the content of soluble forms of differentiation antigens in patients with infectious mononucleosis caused by Epstein-Barr virus, depending on gender, age, severity of illness, comorbidities, laboratory values, the presence of viral DNA, as well as a demonstration of their value in predicting the course and outcome of the disease and the efficacy of antiviral and immunocorrecting therapy. In patients with negative results of DNA indication of EBV a significant increase in the content of soluble forms of differentiation antigens characterizing the adhesion of leukocytes (sCD18), the activity of T-lymphocytes (sCD50), the recognition of foreign antigens (sHLAI) in the blood in comparison with patients with a positive DNA indication of EBV was determined. Conclusion. According to the results of this performed work the criterion for an adequate immune response in patients with infectious mononucleosis caused by the Epstein-Barr virus was found to be the increase of the content of soluble forms of differentiation antigens (sCD95, sCD18, sCD50 sHLAI, sCD54). In patients with exanthema, tonsillar syndrome, leukocytosis, elevation of transaminases and the presence of antibodies to capsid antigen (a/VCAIgM) the content of soluble forms of differentiation antigens (sCD95, sCD18, sCD50 sHLAI, sCD54), was higher than in patients without such symptoms. In the treatment with cycloferon in patients with cyclic course of EBV infectious mononucleosis the content of sHLAI and sCD54 at 2nd-4th weeks of treatment increased by 1.5-2 times compared with the corresponding values before treatment. In patients with reactivation of the disease monotonically low indices of all studied soluble forms of differentiation antigens persisted over the 4 weeks during patients following up. In patients with infectious mononucleosis caused by Epstein-Barr virus, the dynamics of sHLAI and sCD54 after 2-4 weeks of treatment serves as secondary efficacy endpoint of antiviral, immunomodulatory therapy and the formation of the cyclic course of the disease.

scholarly journals Identification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosis

2005 ◽  
Vol 115 (5) ◽  
pp. 1352-1360 ◽  
Author(s):  
Sabine Cepok ◽  
Dun Zhou ◽  
Rajneesh Srivastava ◽  
Stefan Nessler ◽  
Susanne Stei ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Immune Response ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr ◽  
Virus Proteins

An altered immune response to Epstein-Barr virus in multiple sclerosis: A prospective study

Neurology ◽  
2004 ◽  
Vol 62 (12) ◽  
pp. 2277-2282 ◽  
Author(s):  
P. Sundstrom ◽  
P. Juto ◽  
G. Wadell ◽  
G. Hallmans ◽  
A. Svenningsson ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Immune Response ◽  
Prospective Study ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Altered Immune Response ◽  
Epstein Barr ◽  
A Prospective Study

scholarly journals Epstein-Barr virus infection as a predisposing factor for multiple sclerosis. An update from molecular biology, immunology and epidemiology

2019 ◽  
Vol 67 (3) ◽  
pp. 305-313
Author(s):  
David López-Valencia ◽  
Ángela Medina-Ortega ◽  
Diego Fernando Hoyos-Samboní ◽  
Jhan Sebastián Saavedra-Torres ◽  
Carolina Salguero
Keyword(s):  
Multiple Sclerosis ◽  
Immune Response ◽  
Autoimmune Diseases ◽  
Epstein Barr Virus ◽  
Acute Infection ◽  
Viral Reactivation ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Mesh Terms ◽  
Epstein Barr

Introduction: Epstein-Barr virus is an infectious agent used to immortalize and induce polyclonal activation of B cells. It has been widely described that this virus produces changes in the cells it infects and in the immune response, and stimulates the development of autoimmune diseases.Objective: To characterize the association between Epstein-Barr virus and multiple sclerosis described in current scientific literature.Materials and methods: A 59-years range literature search was conducted in the PubMed, ScienceDirect, Redalyc and SciELO databases using the following MeSH terms: “Epstein-Barr virus, multiple sclerosis autoimmune diseases, autoimmune diseases of the nervous system”.Results: Many studies describe the association between Epstein-Barr virus and multiple sclerosis. It is believed that acute infection and viral reactivation promote the development of multiple sclerosis.Conclusions: It is necessary to conduct further research on the pathogenesis and morphophysiological and neuroimmunological changes –at the ecological, molecular, cellular, tissue, organic and systemic level– induced by the immune response and that favor the development of multiple sclerosis.

Epstein–Barr virus, latitude and multiple sclerosis

2012 ◽  
Vol 19 (3) ◽  
pp. 362-365 ◽  
Author(s):  
Giulio Disanto ◽  
Julia Pakpoor ◽  
Julia M Morahan ◽  
Carolina Hall ◽  
Ute C Meier ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Immune Response ◽  
Odds Ratio ◽  
Epstein Barr Virus ◽  
Serological Markers ◽  
Related Factors ◽  
Barr Virus ◽  
Ebv Infection ◽  
Epstein Barr ◽  
Lines Of Evidence

Several lines of evidence support a role for Epstein–Barr virus (EBV) in the aetiology of multiple sclerosis (MS). This includes the observation that nearly all MS patients show serological markers of past EBV infection. Given the well-known association between MS prevalence and latitude, we investigated whether EBV seropositivity also increases with distance from the equator. We found that the proportion of EBV positive individuals is positively associated with latitude independently of MS status (odds ratio = 1.06, 95% CI = 1.02–1.09, p = 0.002). Latitude-related factors may be implicated in the immune response to EBV and its role in MS aetiology.

Illuminating the in vitro effects of Epstein-Barr virus and vitamin D on immune response in multiple sclerosis patients

2021 ◽  
Author(s):  
Majid Teymoori-Rad ◽  
Mohammad Ali Sahraian ◽  
Talat Mokhtariazad ◽  
Ahmad Nejati ◽  
Razieh Sadat Kazemi Mozdabadi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Immune Response ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr ◽  
In Vitro Effects ◽  
Multiple Sclerosis Patients

The association of multiple sclerosis and Hodgkin's disease: the role of Epstein—Barr virus infection

2007 ◽  
Vol 14 (2) ◽  
pp. 284-287 ◽  
Author(s):  
Mario Habek ◽  
Vesna V Brinar ◽  
Sanja Hajnšek
Keyword(s):  
Multiple Sclerosis ◽  
Infectious Mononucleosis ◽  
Hodgkin's Disease ◽  
Epstein Barr Virus ◽  
Hodgkin’S Disease ◽  
Spastic Paraparesis ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Epstein Barr ◽  
Ms Pathogenesis

The aetiology of multiple sclerosis (MS) is still an unresolved question. Several recently reported studies are implicating Epstein—Barr virus (EBV) as one of the key players in MS pathogenesis. We present a 21-year-old male patient with a history of EBV-related infectious mononucleosis in puberty and Hodgkin's disease two years previously treated with irradiation and chemotherapy. The patient presented with spastic paraparesis that resolved promptly on corticosteroid treatment. There were no signs of Hodgkin's disease relapse. In the next three years he had three more bouts of the disease and he was diagnosed with relapse—remitting MS. There is evidence of EBV involvement in MS pathogenesis; the association of MS with EBV-related infectious mononucleosis and Hodgkin's disease being just one of them. Although there are many unanswered questions, it is clear that without EBV seropositivity MS in adults is extremely rare. Multiple Sclerosis 2008; 14: 284—287. http://msj.sagepub.com

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