Serum neuron specific enolase could predict subclinical brain damage and the subsequent occurrence of brain related vascular events during follow up in essential hypertension

2016 ◽  
Vol 363 ◽  
pp. 158-163 ◽  
Author(s):  
Alina González-Quevedo ◽  
Sergio González-García ◽  
Zenaida Hernández-Díaz ◽  
Otman Fernández Concepción ◽  
Luis Quevedo Sotolongo ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Brain Damage ◽  
Neuron Specific Enolase ◽  
Vascular Events ◽  
Serum Neuron Specific Enolase

SERUM NEURON ??? SPECIFIC ENOLASE AS A PROGNOSTIC MAKER FOR HYPOXIC BRAIN DAMAGE AFTER CARDIAC ARREST IN MAN

Shock ◽  
1995 ◽  
Vol 4 (Supplement) ◽  
pp. 58
Author(s):  
Hitoshi Imaizumi ◽  
Masashi Yoshida ◽  
Morihito Satoh ◽  
Yasuo Shichinohe ◽  
Tomoyuki Kawamata ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Brain Damage ◽  
Neuron Specific Enolase ◽  
Hypoxic Brain Damage ◽  
Hypoxic Brain ◽  
Prognostic Maker ◽  
Serum Neuron Specific Enolase

scholarly journals Brain injury markers (S100B and NSE) in chronic cocaine dependents

2007 ◽  
Vol 29 (2) ◽  
pp. 134-139 ◽  
Author(s):  
Felix Henrique Paim Kessler ◽  
George Woody ◽  
Luís Valmor Cruz Portela ◽  
Adriano Bretanha Lopes Tort ◽  
Raquel De Boni ◽  
...  
Keyword(s):  
Brain Damage ◽  
Illicit Drugs ◽  
Cell Injury ◽  
Neuron Specific Enolase ◽  
Serum Levels ◽  
Blood Levels ◽  
Probabilistic Sampling ◽  
Chronic Cocaine ◽  
Cocaine Users ◽  
Serum Neuron Specific Enolase

OBJECTIVE: Studies have shown signs of brain damage caused by different mechanisms in cocaine users. The serum neuron specific enolase and S100B protein are considered specific biochemical markers of neuronal and glial cell injury. This study aimed at comparing blood levels of S100B and NSE in chronic cocaine users and in volunteers who did not use cocaine or other illicit drugs. METHOD: Twenty subjects dependent on cocaine but not on alcohol or marijuana, and 20 non-substance using controls were recruited. Subjects were selected by consecutive and non-probabilistic sampling. Neuron specific enolase and S100B levels were determined by luminescence assay. RESULTS: Cocaine users had significantly higher scores than controls in all psychiatric dimensions of the SCL-90 and had cognitive deficits in the subtest cubes of WAIS and the word span. Mean serum S100B level was 0.09 ± 0.04 µg/l among cocaine users and 0.08 ± 0.04 µg/l among controls. Mean serum neuron specific enolase level was 9.7 ± 3.5 ng/l among cocaine users and 8.3 ± 2.6 ng/l among controls. CONCLUSIONS: In this first study using these specific brain damage markers in cocaine users, serum levels of S100B and neuron specific enolase were not statistically different between cocaine dependent subjects and controls.

Serum Neuron-Specific Enolase in Diagnosis and Follow-Up of Gastrointestinal Neuroendocrine Tumors

Tumor Biology ◽  
1992 ◽  
Vol 13 (5-6) ◽  
pp. 352-357 ◽  
Author(s):  
Mariadomenica D’Alessandro ◽  
Paola Mariani ◽  
Davide Lomanto ◽  
Francesco Carlei ◽  
Emanuele Lezoche ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Neuron Specific Enolase ◽  
Serum Neuron Specific Enolase

Postural Changes in Essential Hypertension under Treatment and their Effect on the Renogram

1971 ◽  
Vol 10 (01) ◽  
pp. 39-46
Author(s):  
C. Alexandrou ◽  
E. Papadakis ◽  
E. Gyftaki ◽  
J. Darsinos
Keyword(s):  
Renal Function ◽  
Essential Hypertension ◽  
Early Diagnosis ◽  
Postural Hypotension ◽  
Antihypertensive Treatment ◽  
Normal Subjects ◽  
Upright Position ◽  
Postural Changes ◽  
Significant Impairment

SummaryRadioisotope renograms were obtained in the upright and prone position in 9 normal subjects, in 5 patients with untreated essential hypertension and in 21 hypertensives under treatment, showing moderate postural hypotension.No significant renographic change were seen in the two positions in normal subjects and untreated hypertensives. Treated hypertensives with postural hypotension showed significant impairment of renal function in the upright position in 15 cases and no change in 6. Renal creatinine clearance was lower in the group that showed renographic changes. Renography in the upright position is suggested as a convenient test for early diagnosis and follow-up of the adverse effects of antihypertensive treatment.

453-P: Metabolic Syndrome Severity Score, All-Cause Mortality, and Incident Vascular Events in Type 2 Diabetes: A 13-Year, Single-Centre, Follow-Up Study

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 453-P
Author(s):  
MONIA GAROFOLO ◽  
ELISA GUALDANI ◽  
DANIELA LUCCHESI ◽  
LAURA GIUSTI ◽  
VERONICA SANCHO-BORNEZ ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Severity Score ◽  
Single Centre ◽  
Vascular Events ◽  
Follow Up Study ◽  
All Cause Mortality

scholarly journals 290Arterial stiffness independently predicts stroke in patients with essential hypertension: Data from a Greek 8-year-follow-up study

2017 ◽  
Vol 38 (suppl_1) ◽  
Author(s):  
D. Konstantinidis ◽  
C. Tsioufis ◽  
K. Dimitriadis ◽  
T. Kalos ◽  
E. Andrikou ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Follow Up Study

scholarly journals Acute Stress-Induced Blood Lipid Reactivity in Hypertensive and Normotensive Men and Prospective Associations with Future Cardiovascular Risk

2021 ◽  
Vol 10 (15) ◽  
pp. 3400
Author(s):  
Cathy Degroote ◽  
Roland von Känel ◽  
Livia Thomas ◽  
Claudia Zuccarella-Hackl ◽  
Jens C. Pruessner ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Cardiovascular Risk ◽  
Stress Reactivity ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Lipoprotein Cholesterol ◽  
Cvd Risk ◽  
P Values ◽  
D Dimer

Hyperreactivity to stress may be one explanation for the increased risk of cardiovascular disease (CVD) in individuals with essential hypertension. We investigated blood lipid reactivity to the Montreal Imaging Stress Task (MIST), a psychosocial stressor, in hypertensive and normotensive men and tested for prospective associations with biological risk factors. Fifty-six otherwise healthy and medication-free hypertensive and normotensive men underwent the MIST. We repeatedly measured cortisol and blood lipid profiles (total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG)) immediately before and up to 1 h after stress. Lipid levels were corrected for stress hemoconcentration. Thirty-five participants completed follow-up assessment 2.9 ± 0.12 (SEM) years later. CVD risk was assessed by prospective changes in TC/HDL-C ratio, IL-6, D-dimer, and HbA1c from baseline to follow-up. The MIST induced significant changes in all parameters except TC (p-values ≤ 0.043). Compared with normotensives, hypertensives had higher TC/HDL-C-ratio and TG (p-values ≤ 0.049) stress responses. Blood lipid stress reactivity predicted future cardiovascular risk (p = 0.036) with increases in HbA1c (ß = 0.34, p = 0.046), IL-6 (ß = 0.31, p = 0.075), and D-dimer (ß = 0.33, p = 0.050). Our results suggest that the greater blood lipid reactivity to psychosocial stress in hypertensives, the greater their future biological CVD risk. This points to lipid stress reactivity as a potential mechanism through which stress might increase CVD risk in essential hypertension.

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