scholarly journals Novel biomarker discovery in autoimmune neurology: Building phenotype specific test profiles

2019 ◽  
Vol 405 ◽  
pp. 54
Author(s):  
S. Pittock
Keyword(s):  
Biomarker Discovery ◽  
Specific Test ◽  
Test Profiles

scholarly journals Metabolomic Profiling in Neuromyelitis Optica Spectrum Disorder Biomarker Discovery

Metabolites ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 374
Author(s):  
Maxton E. Thoman ◽  
Susan C. McKarns
Keyword(s):  
Neuromyelitis Optica ◽  
Biomarker Discovery ◽  
Clinical Symptoms ◽  
Water Channel ◽  
Short Chain Fatty Acids ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Specific Test ◽  
Metabolomic Profiling ◽  
The Central Nervous System

There is no specific test for diagnosing neuromyelitis optica spectrum disorder (NMOSD), a disabling autoimmune disease of the central nervous system. Instead, diagnosis relies on ruling out other related disorders with overlapping clinical symptoms. An urgency for NMOSD biomarker discovery is underscored by adverse responses to treatment following misdiagnosis and poor prognosis following the delayed onset of treatment. Pathogenic autoantibiotics that target the water channel aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) contribute to NMOSD pathology. The importance of early diagnosis between AQP4-Ab+ NMOSD, MOG-Ab+ NMOSD, AQP4-Ab− MOG-Ab− NMOSD, and related disorders cannot be overemphasized. Here, we provide a comprehensive data collection and analysis of the currently known metabolomic perturbations and related proteomic outcomes of NMOSD. We highlight short chain fatty acids, lipoproteins, amino acids, and lactate as candidate diagnostic biomarkers. Although the application of metabolomic profiling to individual NMOSD patient care shows promise, more research is needed.

Preparation of Electron Transparent Metal-Matrix Composites

1968 ◽  
Vol 26 ◽  
pp. 334-335 ◽  
Author(s):  
M. R. Pinnel ◽  
A. Lawley
Keyword(s):  
Stainless Steel ◽  
Load Transfer ◽  
Volume Fraction ◽  
Steel Wire ◽  
Initial Step ◽  
Interfacial Region ◽  
Matrix Composites ◽  
Specific Test ◽  
The Matrix ◽  
The One

Numerous phenomenological descriptions of the mechanical behavior of composite materials have been developed. There is now an urgent need to study and interpret deformation behavior, load transfer, and strain distribution, in terms of micromechanisms at the atomic level. One approach is to characterize dislocation substructure resulting from specific test conditions by the various techniques of transmission electron microscopy. The present paper describes a technique for the preparation of electron transparent composites of aluminum-stainless steel, such that examination of the matrix-fiber (wire), or interfacial region is possible. Dislocation substructures are currently under examination following tensile, compressive, and creep loading. The technique complements and extends the one other study in this area by Hancock.The composite examined was hot-pressed (argon atmosphere) 99.99% aluminum reinforced with 15% volume fraction stainless steel wire (0.006″ dia.).Foils were prepared so that the stainless steel wires run longitudinally in the plane of the specimen i.e. the electron beam is perpendicular to the axes of the wires. The initial step involves cutting slices ∼0.040″ in thickness on a diamond slitting wheel.

On the Robustness of Solution Strategy Classifications

2010 ◽  
Vol 31 (2) ◽  
pp. 68-73 ◽  
Author(s):  
María José Contreras ◽  
Víctor J. Rubio ◽  
Daniel Peña ◽  
José Santacreu
Keyword(s):  
Individual Differences ◽  
Study Strategies ◽  
Solution Strategy ◽  
Specific Test ◽  
Spatial Tasks ◽  
The Stability ◽  
Strategy Changes ◽  
Over Time

Individual differences in performance when solving spatial tasks can be partly explained by differences in the strategies used. Two main difficulties arise when studying such strategies: the identification of the strategy itself and the stability of the strategy over time. In the present study strategies were separated into three categories: segmented (analytic), holistic-feedback dependent, and holistic-planned, according to the procedure described by Peña, Contreras, Shih, and Santacreu (2008) . A group of individuals were evaluated twice on a 1-year test-retest basis. During the 1-year interval between tests, the participants were not able to prepare for the specific test used in this study or similar ones. It was found that 60% of the individuals kept the same strategy throughout the tests. When strategy changes did occur, they were usually due to a better strategy. These results prove the robustness of using strategy-based procedures for studying individual differences in spatial tasks.

The Use of the Defense Mechanism Test to Aid in Understanding the Personality of Senior Executives and the Implications for Their Careers

2009 ◽  
Vol 30 (1) ◽  
pp. 73-96 ◽  
Author(s):  
Olya Khaleelee
Keyword(s):  
Crisis Intervention ◽  
Defense Mechanisms ◽  
Defense Mechanism ◽  
Senior Executives ◽  
Ideal Types ◽  
The Individual ◽  
Test Profiles ◽  
Real Test

This paper describes the use of the Defense Mechanism Test as an aid in helping to assess senior executives in four areas: for selection, development, career strategy, and crisis intervention. The origins of this test, developed to measure the defense mechanisms used to protect the individual from stress, are described. The paper shows how it was used to predict the capacity of trainee fighter pilots to withstand stress and its later application to other stressful occupations. Finally, some ideal types of the test are shown followed by four real test profiles, two of them with their associated histories.

Optimizing Diagnostic Test Sequences: The Probability Modifying Plot

1999 ◽  
Vol 38 (01) ◽  
pp. 50-55 ◽  
Author(s):  
P. F. de Vries Robbé ◽  
A. L. M. Verbeek ◽  
J. L. Severens
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Decision Trees ◽  
Diagnostic Tests ◽  
Test Sequence ◽  
Optimal Sequence ◽  
Specific Test ◽  
Total Cost ◽  
Modelling Techniques

Abstract:The problem of deciding the optimal sequence of diagnostic tests can be structured in decision trees, but unmanageable bushy decision trees result when the sequence of two or more tests is investigated. Most modelling techniques include tests on the basis of gain in certainty. The aim of this study was to explore a model for optimizing the sequence of diagnostic tests based on efficiency criteria. The probability modifying plot shows, when in a specific test sequence further testing is redundant and which costs are involved. In this way different sequences can be compared. The model is illustrated with data on urinary tract infection. The sequence of diagnostic tests was optimized on the basis of efficiency, which was either defined as the test sequence with the least number of tests or the least total cost for testing. Further research on the model is needed to handle current limitations.

The Androgen Receptor chromatin landscape in prostate tumors: biomarker discovery and beyond

2016 ◽  
Author(s):  
Suzan Stelloo ◽  
Ekaterina Nevedomskaya ◽  
Karianne Schuurman ◽  
Lodewyk FA Wessels ◽  
Rui Henrique ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Biomarker Discovery ◽  
Prostate Tumors

An Overview of Risk-Based EEE Counterfeit Part Detection Based on SAE AS6171

2018 ◽  
Author(s):  
Michael H. Azarian
Keyword(s):  
Risk Assessment ◽  
Multiple Solutions ◽  
Test Equipment ◽  
Assessment Methodology ◽  
Test Plan ◽  
Specific Test ◽  
Risk Assessment Methodology

Abstract As counterfeiting techniques and processes grow in sophistication, the methods needed to detect these parts must keep pace. This has the unfortunate effect of raising the costs associated with managing this risk. In order to ensure that the resources devoted to counterfeit detection are commensurate with the potential effects and likelihood of counterfeit part usage in a particular application, a risk based methodology has been adopted for testing of electrical, electronic, and electromechanical (EEE) parts by the SAE AS6171 set of standards. This paper provides an overview of the risk assessment methodology employed within AS6171 to determine the testing that should be utilized to manage the risk associated with the use of a part. A scenario is constructed as a case study to illustrate how multiple solutions exist to address the risk for a particular situation, and the choice of any specific test plan can be made on the basis of practical considerations, such as cost, time, or the availability of particular test equipment.

Improving Yield Using Scan and DFT Based Analysis for High Performance PowerPC© Microprocessor

2006 ◽  
Author(s):  
Ray Talacka ◽  
Nandu Tendolkar ◽  
Cynthia Paquette
Keyword(s):  
High Performance ◽  
Yield Enhancement ◽  
Test Time ◽  
Balance Test ◽  
Specific Test ◽  
Defect Location ◽  
Test Methodology ◽  
Memory Arrays ◽  
Scan Chain ◽  
Scan Pattern

Abstract The use of memory arrays to drive yield enhancement has driven the development of many technologies. The uniformity of the arrays allows for easy testing and defect location. Unfortunately, the complexities of the logic circuitry are not represented well in the memory arrays. As technologies push to smaller geometries and the layout and timing of the logic circuitry become more problematic the ability to address yield issue is becoming critical. This paper presents the added yield enhancement capabilities of using e600 core Scan Chain and Scan Pattern testing for logic debug, ways to interpret the fail data, and test methodologies to balance test time and acquiring data. Selecting a specific test methodology and using today's advanced tools like Freescale's DFT/FA has been proven to find more yield issues, earlier, enabling quicker issue resolution.

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