Effects of dietary phytase on body weight gain, body composition and bone strength in growing rats fed a low-zinc diet

2006 ◽  
Vol 17 (3) ◽  
pp. 190-196 ◽  
Author(s):  
James P. McClung ◽  
Chad H. Stahl ◽  
Louis J. Marchitelli ◽  
Nelson Morales-Martinez ◽  
Katherine M. Mackin ◽  
...  
2001 ◽  
Vol 137 (1) ◽  
pp. 85-96 ◽  
Author(s):  
R. SANDERSON ◽  
M. S. DHANOA ◽  
C. THOMAS ◽  
A. B. McALLAN

Growth and efficiencies of nitrogen and energy utilization for growth by 72 young British Friesian steers (initial live weight (LW) 110 kg) offered a well preserved, formic acid-treated, perennial ryegrass silage with and without supplements of fish meal were examined. Silage was offered either alone or mixed with 50, 100 or 150 g fish meal/kg silage dry matter (DM) and each diet was offered either ad libitum or intakes were restricted to 16, 19 or 22 g dietary DM/kg LW/day. Treatments were imposed over a period of 132 days. Body component weight gains were determined by comparative slaughter.Increasing the level of either feeding or fish meal increased rates of empty body weight gain linearly (P<0·001) and curvilinearly (P<0·05) respectively. Fish-meal supplementation increased rates of ash and crude protein gain (P<0·001) but, in comparison with the curvilinear response to increasing level of feeding (P<0·001), had small linear effects on fat gain (P>0·01). Consequently, in terms of whole body composition, animals given fish meal were leaner than animals offered silage alone. Fish-meal supplementation had no significant effect on the composition of the carcass but increased the concentration of protein in the liver and gastrointestinal tract.The increase in nitrogen intake associated with feeding fish meal resulted in a reduction in the efficiency of nitrogen utilization as level of fish meal increased. Nitrogen intake required for maintenance was estimated to be 1·054 g/kg LW0·75. In spite of marked differences in the composition of the empty body-weight gain, there was no evidence to support an effect of fish meal on the efficiency of metabolizable energy (ME) utilization for growth (kf) which was estimated to be 0·346 on the basis of data scaled by LW0·75. ME intake required for maintenance (MEm) was estimated to be 0·536 and 0·502 MJ/kg LW0·75 for silage alone and the 150 g fish-meal level respectively.


2008 ◽  
Vol 100 (1) ◽  
pp. 88-93 ◽  
Author(s):  
Peter J. Royle ◽  
Graeme H. McIntosh ◽  
Peter M. Clifton

The effect of feed protein type on body composition and growth has been examined. Evidence exists that whey protein concentrate is effective at limiting body fat expansion. The presence of caseinomacropeptide, a mixture of glycosylated and non-glycosylated carbohydrate residues, in particular glycomacropeptide (GMP) in whey protein concentrate may be important for this effect. The influence of whey protein isolate (WPI) and GMP on weight gain and body composition was examined by feeding Wistar rats ad libitum for 7 weeks with five semi-purified American Institute of Nutrition-based diets differing in protein type: (1) casein; (2) barbequed beef; (3) control WPI (no GMP); (4) WPI+GMP at 100 g/kg; (5) WPI+GMP at 200 g/kg. Body composition was assessed, and plasma samples were assayed for TAG, insulin and glucose. Body-weight gain was lower ( − 21 %) on the control WPI diet relative to casein, with a non-significant influence associated with GMP inclusion ( − 30 %), the effect being equivalent at both levels of GMP addition. Renal and carcass fat mass were reduced in the highest GMP diet when compared with WPI (P < 0·05). Plasma insulin was lowered by GMP at the highest addition compared with WPI alone ( − 53 %; P < 0·01). Plasma TAG in the WPI+GMP (200 g/kg) group were lower ( − 27 %; P < 0·05) than the casein and beef groups. In conclusion, GMP appears to have a significant additional influence when combined with WPI on fat accumulation. WPI alone appears to have the predominant influence accounting for 70 % of the overall effect on body-weight gain. Mechanisms for this effect have not been identified but food intake was not responsible.


2013 ◽  
Vol 91 (5) ◽  
pp. 2355-2366 ◽  
Author(s):  
E. D. Sharman ◽  
P. A. Lancaster ◽  
C. P. McMurphy ◽  
G. G. Mafi ◽  
J. D. Starkey ◽  
...  

1963 ◽  
Vol 41 (1) ◽  
pp. 1449-1453
Author(s):  
John R. Beaton ◽  
T. Orme ◽  
J. Laufer ◽  
A. Turner

Male, growing rats were injected daily with anterior pituitary growth hormone (3 mg/100 g body weight) and fed ad libitum for 7 days at environmental temperatures of 22 °C and 2–3 °C. Body weight gain, nitrogen retention, and four liver enzyme activities were measured. As observed previously, cold exposure retarded body weight gain and decreased nitrogen retention despite an increased food intake. These effects of cold were not eliminated by administration of growth hormone. The increased activities of liver arginase, alanine-glutamic transminase, and phosphate-activated glutaminase consequent upon cold exposure were not significantly affected by growth hormone although, at 22 °C, growth hormone decreased the activities of liver arginase and alanine-glutamic transaminase. Cold exposure eliminated the lowering effect of growth hormone on liver glutamic acid dehydrogenase activity observed at 22 °C. It is concluded that, under these conditions, growth hormone does not overcome the protein catabolic effects of cold exposure but rather, cold exposure eliminates the protein anabolic effects of the hormone.


Author(s):  
Abere DV

The study investigated the effect of feeding high and low saturated fatty acid based diets to feed female albino rats (Rattusnorvegicus) with a view to evaluating the effects of the fatty diets on the feeding patterns, weight and body composition of the rats. Seven months old female Rattus norvegicus were used for the experiment. The weights of the rats were taken for twelve weeks using Salter balance (Model 250). Four experimental diets were formulated which were made up of 2.5 and 5.0 g of margarine (blue band), 2.5 and 5.0 g canola oil each mixed with the basal diet. The control diet was grower feed and the resultant experimental diets were fed to the experimental rats kept in cages at the rate of 12 rats per cage. The rats were fed with the diets at the rate of 3% of body weight for a period of twelve weeks. The highest weight gain was recorded in the group fed with 5.0 g margarine, followed by 5.0 g canola, 2.5 g margarine, 2.5 g canola and least in the rats fed the control.The mean weight gain of the rats fed with 5.0 g margarine and 5.0 g canola were significantly different (p<0.05) from the mean weight of 2.5 g margarine, 2.5 g canola and the control. The food intake of the rats fed 5.0 g margarine and 5.0 g canola was also significantly different (p<0.05) from the food intake of rats fed 2.5 g margarine, 2.5 g canola and the control. The proximate composition of the carcass of the rats fed the different experimental diets showed that fat content of the rats fed 5.0 g margarine was higher than in the rats fed the other diets. The histology of the liver of rats fed 5.0 g margarine and 5.0 g canola showed greater fat accumulation in the rat’s liver compared to rats fed 2.5 g margarine, 2.5 g canola as well as the control. Rats with the highest body weight gain were considered obesity-prone; those with the lowest body weight were regarded as obesity-resistant while others were considered intermediate. The study concluded that the kind of fat consumed contributes to the weight gained by the rats.


1963 ◽  
Vol 41 (6) ◽  
pp. 1449-1453 ◽  
Author(s):  
John R. Beaton ◽  
T. Orme ◽  
J. Laufer ◽  
A. Turner

Male, growing rats were injected daily with anterior pituitary growth hormone (3 mg/100 g body weight) and fed ad libitum for 7 days at environmental temperatures of 22 °C and 2–3 °C. Body weight gain, nitrogen retention, and four liver enzyme activities were measured. As observed previously, cold exposure retarded body weight gain and decreased nitrogen retention despite an increased food intake. These effects of cold were not eliminated by administration of growth hormone. The increased activities of liver arginase, alanine-glutamic transminase, and phosphate-activated glutaminase consequent upon cold exposure were not significantly affected by growth hormone although, at 22 °C, growth hormone decreased the activities of liver arginase and alanine-glutamic transaminase. Cold exposure eliminated the lowering effect of growth hormone on liver glutamic acid dehydrogenase activity observed at 22 °C. It is concluded that, under these conditions, growth hormone does not overcome the protein catabolic effects of cold exposure but rather, cold exposure eliminates the protein anabolic effects of the hormone.


1977 ◽  
Vol 107 (9) ◽  
pp. 1715-1723 ◽  
Author(s):  
Pi-Yao Lin ◽  
Dale R. Romsos ◽  
Gilbert A. Leveille

1991 ◽  
Vol 130 (2) ◽  
pp. 305-312 ◽  
Author(s):  
M. J. VandeHaar ◽  
B. M. Moats-Staats ◽  
M. L. Davenport ◽  
J. L. Walker ◽  
J.-M. Ketelslegers ◽  
...  

ABSTRACT The serum concentration of insulin-like growth factor-I (IGF-I) is reduced in growing rats fed a low-protein diet, and this decrease is age-dependent, being more pronounced in younger animals. To determine whether this decrease in serum IGF-I is related to a decrease in IGF-I mRNA, growing female rats were given free access to either a 15% protein-sufficient or a 5% protein-deficient diet for 1 week. Protein restriction in 4-week-old rats decreased body weight gain by 44% (P < 0·001) compared with 4-week controls), serum IGF-I concentration by 67% (P < 0·001) and liver IGF-I mRNA abundance by 51% (P < 0·001). During week 6, protein restriction for 1 week resulted in a 20% increase in food intake with no change in weight gain, a 38% reduction in serum IGF-I (P < 0·001 compared with 6-week controls) and a 39% decrease in liver IGF-I mRNA (P < 0·001). The serum IGF-I concentration was highly correlated (r = 0·80; P < 0·001) with the hepatic IGF-I mRNA concentration. Skeletal muscle IGF-I mRNA abundance was also decreased significantly by protein restriction (37% at week 4, P<0·001, and 24% at week 6, P < 0·01) and was closely correlated (r = 0·71; P < 0·001) with body weight gain. Liver GH-binding protein and GH receptor mRNA abundance were reduced by 1 week of protein deprivation at week 6 but not at week 4. We conclude that the reduced serum IGF-I of young rats fed a low-protein diet is due, in part, to reduced liver IGF-I mRNA, and that these changes are not dependent on GH binding. Decreased skeletal muscle IGF-I mRNA during protein restriction is consistent with an autocrine/paracrine action of IGF-I in muscle. Journal of Endocrinology (1991) 130, 305–312


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