Cross-sectional visual comparison of remineralization efficacy of various agents on early smooth surface caries of primary teeth with swept source optical coherence tomography

Abstract Purpose To compare swept-source (SS) versus spectral-domain (SD) optical coherence tomography angiography (OCTA) for the detection of macular neovascularization (MNV). Methods In this prospective cohort study, 72 eyes of 54 patients with subretinal hyperreflective material (SHRM) and/or pigment epithelial detachment (PED) on OCT possibly corresponding to MNV in at least one eye were included. OCTA scans were acquired using two devices, the PLEX Elite 9000 SS-OCTA and the Spectralis SD-OCTA. Fluorescein angiography (FA) was used as reference. Two graders independently evaluated en face OCTA images using a preset slab as well as a manually modified slab, followed by a combination of en face and cross-sectional OCTA. Results Sensitivity (specificity) for the automated slabs was 51.7% (93.0%) for SS-OCTA versus 58.6% (95.3%) for SD-OCTA. Manual modification of segmentation increased sensitivity to 79.3% for SS-OCTA but not for SD-OCTA (58.6%). The combination of en face OCTA with cross-sectional OCTA reached highest sensitivity values (SS-OCTA: 82.8%, SD-OCTA: 86.2%), and lowest number of cases with discrepancies between SS-OCTA and SD-OCTA (4.2%). Fleiss kappa as measure of concordance between FA, SS-OCTA, and SD-OCTA was 0.56 for the automated slabs, 0.60 for the manual slabs, and 0.73 (good agreement) for the combination of en face OCTA with cross-sectional OCTA. Concordance to FA was moderate for the automated slabs and good for manual slabs and combination with cross-sectional OCTA of both devices. Conclusion Both devices reached comparable results regarding the detection of MNV on OCTA. Sensitivity for MNV detection and agreement between devices was best when evaluating a combination of en face and cross-sectional OCTA.

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Comparison between Widefield Optical Coherence Tomography Devices in Eyes with High Myopia

Diagnostics ◽

10.3390/diagnostics11040658 ◽

2021 ◽

Vol 11 (4) ◽

pp. 658

Author(s):

Federico Corvi ◽

Federico Zicarelli ◽

Matteo Airaldi ◽

Salvatore Parrulli ◽

Mariano Cozzi ◽

...

Keyword(s):

Optical Coherence Tomography ◽

High Myopia ◽

Cross Sectional Study ◽

Horizontal Line ◽

Optical Coherence ◽

Cross Sectional ◽

Swept Source ◽

Image Artifact ◽

Control Subjects ◽

And Control

Background: To compare four different optical coherence tomography (OCT) devices for visualization of retinal and subretinal layers in highly myopic eyes. Methods: In this prospective, observational, cross-sectional study, consecutive patients with high myopia and control subjects were imaged by four OCT devices: Spectralis OCT2, PlexElite 2.0 100 kHz, PlexElite 2.0 200 kHz and the Canon Xephilio OCT-S1. The acquisition protocol for comparison consisted of single vertical and horizontal line scans centered on the fovea. Comparison between the devices in the extent of visible retina, presence of conjugate image or mirror artifacts, visibility of the sclerochoroidal interface and retrobulbar tissue. Results: 30 eyes with high myopia and 30 control subjects were analyzed. The visualized RPE length was significantly different between the OCT devices with Xephilio OCT-S1 imaging the largest extent (p < 0.0001). The proportion of eyes with conjugate image artifact was significantly higher with the Spectralis OCT (p < 0.0001), and lower with the PlexElite 200 kHz (p < 0.0001). No difference in visibility of the sclerochoroidal interface was noted among instruments. The retrobulbar tissue was visible in a higher proportion of eyes using swept-source PlexElite 100 kHz and 200 kHz (p < 0.007) compared to the other devices. Conclusions: In highly myopic eyes, the four OCT devices demonstrated significant differences in the extent of the retina imaged, in the prevalence of conjugate image artifact, and in the visualization of the retrobulbar tissue.

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Topographic Analysis of Short Posterior Ciliary Arteries Using Wide-Field Swept-Source En-Face Optical Coherence Tomography

10.21203/rs.3.rs-151008/v1 ◽

2021 ◽

Author(s):

Raphael Lejoyeux ◽

Raphael Atia ◽

Kiran Vupparaboina ◽

Mohamed Ibrahim ◽

Jose-Alain Sahel ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Posterior Pole ◽

Wide Field ◽

Temporal Part ◽

Optical Coherence ◽

Cross Sectional ◽

Swept Source ◽

Topographic Analysis ◽

En Face ◽

Ciliary Arteries

Abstract Purpose: To study the topographic distribution of the short posterior ciliary arteries (SPCA) entry sites into the choroid in normal eyes using structural en-face swept source optical coherence tomography (SS-OCT). Methods: Retrospective analysis of SS-OCT scans (wide-field structural SS-OCT 12x12mm) of 13 healthy subjects was performed. Cross-sectional swept-source OCT scans derived from a volume scan were represented as en-face image display following the Choroid-Scleral Interface to obtain en-face OCT. SPCAs in their last scleral location before choroidal entrance were identified manually, counted and localized by two masked observers. Correlations between two masked observers were analyzed using inter- and intra- class correlation. Results: Accuracy for the choroidal inner and outer border segmentation was 95-99%. Eighteen eyes from 13 normal subjects were included for SPCA analysis. The mean number of arteries was 13.8±3.5 per eye. Thirty-six percent were in the center of the posterior pole image; however, 21% were in the temporal part of the posterior pole. Median accuracy of the detection is 0.94. The correlation between the two observers was fair (0.54).Conclusion: Our algorithm allows visualization of the SPCA at the posterior pole of the eye using wide-field en-face SS-OCT. It can also help the clinicians to study the SPCAs in numerous ocular diseases, particularly its relationship with focal choroidal diseases.

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Quantifying vascular density and morphology using different swept-source optical coherence tomography angiographic scan patterns in diabetic retinopathy

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2018-311942 ◽

2018 ◽

Vol 103 (2) ◽

pp. 216-221 ◽

Cited By ~ 35

Author(s):

Takao Hirano ◽

Jyunya Kitahara ◽

Yuichi Toriyama ◽

Hirotsugu Kasamatsu ◽

Toshinori Murata ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Diabetic Retinopathy ◽

Characteristic Curve ◽

Vascular Density ◽

Optical Coherence ◽

Image Size ◽

Healthy Individuals ◽

Cross Sectional ◽

Swept Source ◽

Retinal Microvasculature

AimsTo evaluate quantitative metrics of the retinal microvasculature in eyes with diabetic retinopathy (DR) using various en face swept-source optical coherence tomography angiography (SS-OCTA) image sizes.MethodsNon-segmented and segmented images were acquired using an SS-OCTA device (PLEX Elite 9000; Carl Zeiss Meditec, Dublin, California, USA). The scanning protocols included the 3×3 mm, 6×6 mm and 12×12 mm fields of view. Quantitative analysis of the perfusion density (PD), vessel length density (VLD) and fractal dimension (FD) was performed. The area under the receiver operating characteristic curve was estimated to assess the ability of each image size to predict DR.ResultsThis prospective, cross-sectional study included 60 eyes, (non-DR, 13 eyes; non-proliferative DR (NPDR), 24 eyes; proliferative DR (PDR), 23 eyes) of 46 patients with diabetes and 21 eyes of 16 healthy individuals. In the 12×12 mm images, the PD of healthy individuals was significantly greater than that of patients with NPDR or PDR for all layers (NPDR, p<0.05; PDR, p<0.001 0.001; FD, p<0.001) or PDR (VLD, p<0.001; FD, p<0.001 for all layers). The results were similar for the 3×3 mm and 6×6 mm images. Overall, PD, VLD and FD progressively decreased with worsening DR severity in segmented and non-segmented layers for all SS-OCTA scan sizes. For detecting DR, 3×3 mm images best predicted DR for all evaluated quantitative parameters.ConclusionsVascular changes in DR can be monitored in detail through quantitative evaluations that combine different SS-OCTA scan sizes and parameters.

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Comparison of two different optical coherence tomography angiography devices in detecting healthy versus glaucomatous eyes – an observational cross-sectional study

BMC Ophthalmology ◽

10.1186/s12886-020-01701-9 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

A. R. Kee ◽

V. C. H. Yip ◽

E. L. T. Tay ◽

C. W. Lim ◽

J. Cheng ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Diagnostic Accuracy ◽

Optic Disc ◽

Optical Coherence Tomography Angiography ◽

Optical Coherence ◽

Cross Sectional ◽

Swept Source ◽

Retest Reliability ◽

Significant Difference ◽

Test Retest Reliability

Abstract Background To understand the differences between two different optical coherence tomography angiography (OCTA) devices in detecting glaucomatous from healthy eyes by comparing their vascular parameters, diagnostic accuracy and test-retest reliability. Methods A cross-sectional observational study was performed on healthy and glaucoma subjects, on whom two sets of OCTA images of optic disc and macula were acquired using both AngioVue (Optovue, USA) and Swept Source (Topcon, Japan) OCTA devices during one visit. A novel in-house software was used to calculate the vessel densities. Diagnostic accuracy of the machines in differentiating healthy versus glaucomatous eyes was determined using area under the receiver operating characteristic curve (AUROC) and test-retest repeatability of the machines was also evaluated. Results A total of 80 healthy and 38 glaucomatous eyes were evaluated. Glaucomatous eyes had reduced mean vessel density compared to healthy controls in all segmented layers of the optic disc and macula using AngioVue (p ≤ 0.001). However, glaucomatous eyes had higher mean vessel density on optic disc scans using Swept Source, with lack of statistically significant difference between healthy and glaucomatous eyes. The AUROC showed better diagnostic accuracy of AngioVue (0.761–1.000) compared to Swept Source (0.113–0.644). The test-retest reliability indices were generally better using AngioVue than Swept Source. Conclusions AngioVue showed better diagnostic capability and test-retest reliability compared to Swept Source. Further studies need to be undertaken to evaluate if there is any significant difference between the various machines in diagnosing and monitoring glaucoma.

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A NEW AND MODERN DIGNOSTIC TECHNIQUE: SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY (SS-OCT)

CODS Journal of Dentistry ◽

10.5005/cods-5-2-31 ◽

2013 ◽

Vol 5 (2) ◽

pp. 31-33

Author(s):

Prakash Lokhande

Keyword(s):

Optical Coherence Tomography ◽

High Resolution ◽

Optical Imaging ◽

Optical Coherence ◽

Cross Sectional ◽

Swept Source ◽

Non Invasive ◽

Treatment Technologies ◽

High Resolution Images ◽

Swept Source Oct

ABSTRACT Innovative technique has been introduced in the field of dentistry for the purpose of diagnosis and treatment. Technologies like laser, composite curing techniques, optical imaging have been utilized in the field of dentistry. OCT(optical coherence tomography) is a recent. technique which creates cross-sectional high resolution images. SS-OCT(Swept -Source optical coherence tomography) is a variant of optical coherence tomography, which provides instant imaging with high resolution, non-invasive and ease of handling. This article provides a overview of Swept -Source OCT and its application in the field of dentistry.

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Cross-sectional Imaging of Paper Sheet by Common-path Swept Source Optical Coherence Tomography

Digital Holography and Three-Dimensional Imaging ◽

10.1364/dh.2011.dwf6 ◽

2011 ◽

Author(s):

Kazuo Fujiwara ◽

Osamu Matoba

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence ◽

Paper Sheet ◽

Cross Sectional ◽

Swept Source ◽

Common Path ◽

Cross Sectional Imaging ◽

Sectional Imaging

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Detection of occlusal caries in primary teeth using swept source optical coherence tomography

Journal of Biomedical Optics ◽

10.1117/1.jbo.19.1.016020 ◽

2014 ◽

Vol 19 (1) ◽

pp. 016020 ◽

Cited By ~ 21

Author(s):

Yukie Nakajima ◽

Yasushi Shimada ◽

Alireza Sadr ◽

Ikumi Wada ◽

Michiyo Miyashin ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Primary Teeth ◽

Optical Coherence ◽

Occlusal Caries ◽

Swept Source

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The Relationship Between Age and the Morphology of the Crystalline Lens, Ciliary Muscle, Trabecular Meshwork, and Schlemm’s Canal: An in vivo Swept-Source Optical Coherence Tomography Study

Frontiers in Physiology ◽

10.3389/fphys.2021.763736 ◽

2021 ◽

Vol 12 ◽

Author(s):

Zhangliang Li ◽

Ziqi Meng ◽

Wenyong Qu ◽

Xiuyuan Li ◽

Pingjun Chang ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Trabecular Meshwork ◽

Crystalline Lens ◽

Ciliary Muscle ◽

Optical Coherence ◽

Cross Sectional ◽

Swept Source ◽

Schlemm's Canal ◽

The Relationship ◽

Healthy Participants

Purpose: To evaluate the effects of age on the morphologies of the crystalline lens, ciliary muscle (CM), Schlemm’s canal (SC), and trabecular meshwork (TM) using swept-source optical coherence tomography (SS-OCT).Methods: Images of the crystalline lens and iridocorneal angle were obtained in healthy participants’ eyes using SS-OCT. Morphological parameters of the crystalline lens, CM, and TM/SC were measured, and the relationship between these parameters and age was evaluated.Results: A total of 62 healthy participants were enrolled, with an age range of 7–79 years. With adjustments for the effects of axial length and sex, both the nasal and temporal SC cross-sectional areas (CSA) and the cross-sectional area of the CM (CMA), distance from the scleral spur to the inner apex of the ciliary muscle (IA-SS), and nasal SC volume were negatively correlated with age (P ≤ 0.041). Meanwhile, the lens thickness (LT) (P < 0.001) and lens vault (LV) (P < 0.001) were positively correlated with age, and the radius of the curvature of the anterior lens (ALR) was negatively correlated with age (P < 0.001).Conclusion: Increasing age was associated with a thicker crystalline lens, a steeper anterior lens curvature, an anteriorly located and smaller CM, and a narrower SC.Clinical Trial Registration:https://register.clinicaltrials.gov/prs/app/action/Select Protocol?sid=S000A3JZ&selectaction=Edit&uid=U00019K7&ts=4&cx=-c5xxp8, identifier [NCT04576884].

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Detection of neovascularisation in the vitreoretinal interface slab using widefield swept-source optical coherence tomography angiography in diabetic retinopathy

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2020-317983 ◽

2020 ◽

pp. bjophthalmol-2020-317983

Author(s):

Edward S Lu ◽

Ying Cui ◽

Rongrong Le ◽

Ying Zhu ◽

Jay C Wang ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Diabetic Retinopathy ◽

Optic Disc ◽

Proliferative Diabetic Retinopathy ◽

Optical Coherence Tomography Angiography ◽

Optical Coherence ◽

Vitreoretinal Interface ◽

Cross Sectional ◽

Swept Source ◽

Detection Rates

AimsTo compare the efficacy of diabetic retinal neovascularisation (NV) detection using the widefield swept-source optical coherence tomography angiography (WF SS-OCTA) vitreoretinal interface (VRI) Angio slab and SS-OCT VRI Structure slab.MethodsA prospective, observational study was performed at Massachusetts Eye and Ear from January 2019 to June 2020. Patients with proliferative diabetic retinopathy (PDR), patients with non-proliferative diabetic retinopathy and patients with diabetes but without diabetic retinopathy were included. All patients were imaged with WF SS-OCTA using the 12×12 mm Angio scan protocol centred on the fovea and optic disc. The en-face SS-OCTA VRI Angio slab and SS-OCT VRI Structure slab were evaluated for the presence or absence of NV. SS-OCTA B-scan was used to classify NV according to cross-sectional morphology (forward, tabletop or flat). All statistical analyses were performed using SPSS V.26.0.ResultsOne hundred and forty-two eyes of 89 participants were included in the study. VRI Angio detected NV at higher rates compared with VRI Structure (p<0.05). Combining VRI Angio and Structure improved detection rates compared with VRI Angio alone (p<0.05). Due to segmentation errors of the internal limiting membrane, NV with flat morphological classification had lower rates of detection on VRI Angio compared with NV with forward and tabletop morphology (p<0.05).ConclusionsWF SS-OCTA 12×12 mm VRI Angio and SS-OCT VRI Structure imaging centred on the fovea and optic disc detected NV with high sensitivity and low false positives. The VRI slab may be useful to diagnose and monitor PDR in clinical practice.

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