Effect of â-tricalcium phosphate and porous hydroxyapatite bone substitutes on bone regeneration in alveolar bone defects around dental implants

2014 ◽  
Vol 72 (9) ◽  
pp. e205-e206 ◽  
Author(s):  
Y. Ioku ◽  
H. Haeniwa ◽  
K. Kakudo
Keyword(s):  
Bone Regeneration ◽  
Dental Implants ◽  
Tricalcium Phosphate ◽  
Alveolar Bone ◽  
Bone Substitutes ◽  
Bone Defects ◽  
Porous Hydroxyapatite

scholarly journals Effect of Electrical Current on the Osteogenesis in Alveolar Bone Defects : Application of Tricalcium Phosphate

1987 ◽  
Vol 41 (5) ◽  
pp. 985-993 ◽  
Author(s):  
Kohzoh Kubota ◽  
Masatoshi Hitaka ◽  
Kazuo Yasumoto ◽  
Takashi Hayashikawa ◽  
Shinichi Umezaki ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Alveolar Bone ◽  
Electrical Current ◽  
Bone Defects

scholarly journals Local delivery of a novel PTHrPviamesoporous bioactive glass scaffolds to improve bone regeneration in a rat posterolateral spinal fusion model

RSC Advances ◽  
2018 ◽  
Vol 8 (22) ◽  
pp. 12484-12493 ◽  
Author(s):  
Bo Liang ◽  
Jinghuan Huang ◽  
Jianguang Xu ◽  
Xiaolin Li ◽  
Jingfeng Li
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Regeneration ◽  
Spinal Fusion ◽  
Bone Substitutes ◽  
Bone Defects ◽  
Local Delivery ◽  
Long Bones ◽  
Fusion Model ◽  
Posterolateral Spinal Fusion

With the development of tissue engineering, bone defects, such as fractured long bones or cavitary lesions, may be efficiently repaired and reconstructed using bone substitutes.

scholarly journals Metformin-loaded β-TCP/CTS/SBA-15 composite scaffolds promote alveolar bone regeneration in a rat model of periodontitis

2021 ◽  
Vol 32 (12) ◽  
Author(s):  
Wanghan Xu ◽  
Wei Tan ◽  
Chan Li ◽  
Keke Wu ◽  
Xinyi Zeng ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Rat Model ◽  
Alveolar Bone ◽  
Composite Scaffold ◽  
Bone Defects ◽  
Promising Strategy ◽  
Good Biocompatibility ◽  
Positive Effect ◽  
Alveolar Bone Defect

AbstractPeriodontitis is a progressive infectious inflammatory disease, which leads to alveolar bone resorption and loss of periodontal attachment. It is imperative for us to develop a therapeutic scaffold to repair the alveolar bone defect of periodontitis. In this study, we designed a new composite scaffold loading metformin (MET) by using the freeze-drying method, which was composed of β-tricalcium phosphate (β-TCP), chitosan (CTS) and the mesoporous silica (SBA-15). The scaffolds were expected to combine the excellent biocompatibility of CTS, the good bioactivity of β-TCP, and the anti-inflammatory properties of MET. The MET-loaded β-TCP/CTS/SBA-15 scaffolds showed improved cell adhesion, appropriate porosity and good biocompatibility in vitro. This MET composite scaffold was implanted in the alveolar bone defects area of rats with periodontitis. After 12 weeks, Micro-CT and histological analysis were performed to evaluate different degrees of healing and mineralization. Results showed that the MET-loaded β-TCP/CTS/SBA-15 scaffolds promoted alveolar bone regeneration in a rat model of periodontitis. To our knowledge, this is the first report that MET-loaded β-TCP/CTS/SBA-15 scaffolds have a positive effect on alveolar bone regeneration in periodontitis. Our findings might provide a new and promising strategy for repairing alveolar bone defects under the condition of periodontitis.

scholarly journals Biomimetic Synthesis of Nanocrystalline Hydroxyapatite Composites: Therapeutic Potential and Effects on Bone Regeneration

2019 ◽  
Vol 20 (23) ◽  
pp. 6002 ◽  
Author(s):  
Chih-Hsiang Fang ◽  
Yi-Wen Lin ◽  
Feng-Huei Lin ◽  
Jui-Sheng Sun ◽  
Yuan-Hung Chao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Bone Regeneration ◽  
Stromal Cell ◽  
Alveolar Bone ◽  
Therapeutic Potential ◽  
Bone Defects ◽  
Stromal Cell Derived Factor ◽  
Biomimetic Hydroxyapatite

The development of a novel alloplastic graft with both osteoinductive and osteoconductive properties is still necessary. In this study, we tried to synthesize a biomimetic hydroxyapatite microspheres (gelatin/nano-hydroxyapatite microsphere embedded with stromal cell-derived factor-1: GHM-S) from nanocrystalline hydroxyapatites and to investigate their therapeutic potential and effects on bone regeneration. In this study, hydroxyapatite was synthesized by co-precipitation of calcium hydroxide and orthophosphoric acid to gelatin solution. The microbial transglutaminase was used as the agent to crosslink the microspheres. The morphology, characterization, and thermal gravimetric analysis of microspheres were performed. SDF-1 release profile and in vitro biocompatibility and relative osteogenic gene expression were analyzed, followed by in vivo micro-computed tomography study and histological analysis. The synthesized hydroxyapatite was found to be similar to hydroxyapatite of natural bone tissue. The stromal cell-derived factor-1 was embedded into gelatin/hydroxyapatite microsphere to form the biomimetic hydroxyapatite microsphere. The stromal cell-derived factor-1 protein could be released in a controlled manner from the biomimetic hydroxyapatite microsphere and form a concentration gradient in the culture environment to attract the migration of stem cells. Gene expression and protein expression indicated that stem cells could differentiate or develop into pre-osteoblasts. The effect of bone formation by the biomimetic hydroxyapatite microsphere was assessed by an in vivo rats’ alveolar bone defects model and confirmed by micro-CT imaging and histological examination. Our findings demonstrated that the biomimetic hydroxyapatite microsphere can enhance the alveolar bone regeneration. This design has potential be applied to other bone defects.

Porous Hydroxyapatite Scaffolds by Polymer Sponge Method

2008 ◽  
Vol 396-398 ◽  
pp. 703-706 ◽  
Author(s):  
A.C.B.M. Fook ◽  
A.H. Aparecida ◽  
Thiago Bizerra Fideles ◽  
R.C. Costa ◽  
Marcus Vinícius Lia Fook
Keyword(s):  
Chemical Composition ◽  
Bone Regeneration ◽  
Bone Substitutes ◽  
High Porosity ◽  
Porous Hydroxyapatite ◽  
Pore Sizes ◽  
Hydroxyapatite Scaffold

This study aimed to develop porous hydroxyapatite scaffold for bone regeneration using the replica of the polymeric sponge technique. Polyurethane sponges were used with varying densities to obtain the scaffolds. The results indicate the porous HA scaffolds developed in this study as potential materials for application as bone substitutes to have high porosity (> 70%), chemical composition, interconnectivity and pore sizes appropriate to the bone regeneration.

scholarly journals Evaluation of the Biocompatibility and Osteoconduction of the Carbon Nanotube, Chitosan and Hydroxyapatite Nanocomposite with or without Mesenchymal Stem Cells as a Scaffold for Bone Regeneration in Rats

Osteology ◽  
2021 ◽  
Vol 1 (3) ◽  
pp. 118-131
Author(s):  
Geissiane M. Marcondes ◽  
Nicole F. Paretsis ◽  
Joice Fülber ◽  
Pedro Enriqu Navas-Suárez ◽  
Claudia M. C. Mori ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Carbon Nanotube ◽  
Bone Regeneration ◽  
Subcutaneous Tissue ◽  
Bone Substitutes ◽  
Bone Defects ◽  
Regenerative Process ◽  
Control Group ◽  
Marrow Mesenchymal Stem Cells

Background: Bone substitutes have been developed to assist bone regeneration in orthopedic surgeries. Mesenchymal stem cells can be added to these biomaterials to enhance bone regeneration. This study aimed to evaluate the biocompatibility and osteoconduction of a carbon nanotube, chitosan, and hydroxyapatite nanocomposite (CNCHN) that had either been enriched or not enriched with sheep bone marrow mesenchymal stem cells (BM-MSCs) in rats. Methods: A total of sixty rats were divided into groups, and an implant with or without BM-MSCs was performed subcutaneously in 20 animals (euthanized after 7 and 30 days), comparing them to 10 control animals, and in the calvaria of 20 animals (euthanized after 20 and 60 days), comparing to with 10 control animals. Subcutaneous and calvaria histologies were performed after euthanasia. Results: The subcutaneous tissue showed that CNCHN did not prompt an exacerbated inflammatory response or signs of necrosis. The histomorphological analysis by the calvaria score of the rats showed that the control group had lower scores at 20 and 60 days for bone neoformation, relative to the CNCHN groups, which showed no significant statistical differences, suggesting that the nanocomposite assisted in the regenerative process of defects in the calvaria, but with no repair potentiation when using BM-MSCs. Conclusion: CNCHN has biocompatibility and osteoconductive potential, showing promising results in bone defects.

Biologic Responses of Autogenous Bone and Beta-tricalcium Phosphate Ceramics Transplanted into Bone Defects to Orthodontic Forces

1996 ◽  
Vol 33 (4) ◽  
pp. 277-283 ◽  
Author(s):  
Mohammed Zakir Hossain ◽  
Shingo Kyomen ◽  
Kazuo Tanne
Keyword(s):  
Tricalcium Phosphate ◽  
Alveolar Bone ◽  
Tooth Movement ◽  
Root Resorption ◽  
Orthodontic Tooth Movement ◽  
Bone Defects ◽  
Autogenous Bone ◽  
Beta Tricalcium Phosphate ◽  
Orthodontic Forces ◽  
External Stimuli

This study was conducted to evaluate biologic responses of autogenous bone (particulate marrow and cancellous bone; PMCB) and beta-tricalcium phosphate ceramics (TCPC) to orthodontic stimuli. Nine dogs served as the experimental animals; three dogs underwent orthodontic tooth movement after grafting, three dogs received PMCB grafting without tooth movement, and three dogs received TCPC grafting without tooth movement. Immediately after extraction of the upper second and/or third incisors, the maxillary alveolar bone was resected bilaterally. Autogenous PMCB obtained from the iliac bone and TCPC were transplanted into each bone defect. Experimental tooth movement was initiated 2 to 4 weeks after the grafting and continued for 9 to 15 weeks. Sectional archwires with open-coil springs were used for distal movement of the upper first incisors into the extraction sites. Oxytetracycline and calcein were employed as bone markers. Sections of grafted areas including the teeth were prepared for light and fluorescence microscopy. The results revealed that both autogenous bone and TCPC presented similar adaptive changes to the original alveolar bone without any external stimuli. TCPC exhibited more prominent biodegradative responses to orthodontic force in association with new cementum formation. Root resorption was also less in the TCPC area than in the PMCB region. It Is shown that TCPC is biodegradative In nature and adaptive for remodeling during orthodontic tooth movement. This finding indicates that TCPC may be a better biocompatible alternative to autogenous bone transplanted into bone defects subjected to orthodontic tooth movement.

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