Displaced tibial and fibular stress fractures in a female elite pole-vaulter with menstrual dysfunction, vitamin D deficiency, and high serum pentosidine

ObjectiveTo determine the incidence, demography and prognosis of vitamin D deficiency dilated cardiomyopathy (DCM) in Scotland over the last decade.Study designA retrospective review of cases of vitamin D deficiency DCM presenting to a national paediatric cardiac centre between 1 January 2008 and 1 January 2018. The departmental database and electronic and paper case notes were used to identify patients and extract data.ResultsSix patients were identified (three male), three of whom were Caucasian. Median age at presentation was 206 days (range 2–268.) All six patients had high serum parathyroid hormone levels (median 45 pmol/L, range 27–120 pmol/L), a sensitive marker of total body calcium deprivation secondary to vitamin D deficiency. All patients demonstrated clinical and echocardiographic improvement following high dose vitamin D treatment. No patients required cardiac transplant, and only one patient required extracorporeal life support as a bridge to recovery. After an initial improvement, one child died at 5 months as a result of respiratory infection. Three patients lived within some of the most deprived areas in Scotland.ConclusionsThis case series demonstrates a previously unreported demographic in Scotland, as 50% of cases presented in Caucasian children. Although vitamin D deficiency DCM is relatively rare, it is wholly preventable. Our study confirms that vitamin D deficiency cardiomyopathy is reversible with prompt identification and supplementation. The current implementation of public health policy in the UK is failing to prevent children from developing the most severe manifestation of vitamin D deficiency.

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Association of serum 25-hydroxyvitamin D and serum total cholesterol with depressive symptoms in Korean adults: the Fifth Korean National Health and Nutrition Examination Survey (KNHANES V, 2010–2012)

Public Health Nutrition ◽

10.1017/s1368980016001713 ◽

2016 ◽

Vol 20 (10) ◽

pp. 1836-1843 ◽

Cited By ~ 6

Author(s):

Soo-Hyun Lee ◽

Eunkyung Suh ◽

Kyung-Chae Park ◽

Ji-Hee Haam ◽

KyongChol Kim ◽

...

Keyword(s):

Vitamin D ◽

Depressive Symptoms ◽

Total Cholesterol ◽

Vitamin D Deficiency ◽

High Serum ◽

Serum Total Cholesterol ◽

Nutrition Examination Survey ◽

Hydroxyvitamin D ◽

Health And Nutrition ◽

25 Hydroxyvitamin D

AbstractObjectiveTo examine the hypothesis that the association between vitamin D deficiency and depressive symptoms is dependent upon total cholesterol level in a representative national sample of the South Korean population.DesignThis was a population-based cross-sectional study.SettingThe Fifth Korean National Health and Nutrition Examination Survey (KNHANES V, 2010–2012).SubjectsWe included 7198 adults aged 20–88 years.ResultsThe incidence of depressive symptoms in individuals with vitamin D deficiency (serum 25-hydroxyvitamin D<20 ng/ml) was 1·54-fold (95 % CI 1·20, 1·98) greater than in individuals without vitamin D deficiency (serum 25-hydroxyvitamin D ≥20 ng/ml). The relationship was stronger in individuals with normal-to-borderline serum total cholesterol (serum total cholesterol<240 mg/dl; OR=1·60; 95 % CI 1·23, 2·08) and non-significant in individuals with high serum total cholesterol (OR=0·97; 95 % CI 0·52, 1·81) after adjustment for confounding variables (age, sex, BMI, alcohol consumption, smoking status, regular exercise, income level, education level, marital status, changes in body weight, perceived body shape, season of examination date and cholesterol profiles).ConclusionsThe association between vitamin D deficiency and depressive symptoms was weakened by high serum total cholesterol status. These findings suggest that both vitamin D and total cholesterol are important targets for the prevention and treatment of depression.

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Moderate Vitamin D Deficiency and Inflammation Related Markers in Overweight/Obese Schoolchildren

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000197 ◽

2014 ◽

Vol 84 (1-2) ◽

pp. 98-107 ◽

Cited By ~ 8

Author(s):

Elena Rodríguez-Rodríguez ◽

Aránzazu Aparicio ◽

Pedro Andrés ◽

Rosa M. Ortega

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

High Sensitivity ◽

High Serum ◽

Obese Children ◽

Reactive Protein ◽

Tnf Α ◽

Obese Subjects ◽

Hs Crp ◽

Necrosis Factor

Objective: Obesity has been associated with vitamin D deficiency and increased oxidative stress, which can lead to the dysregulation of adipokines and inflammation. The aim of the present work was to examine the association of vitamin D status [25(OH)D] on inflammatory related markers in overweight/obese children. Subjects/Methods: A total of 137 Spanish schoolchildren between 9 and 12 years of age (31.4 % with overweight/obesity) were studied. Being overweight was defined as BMI ≥ 85th percentile and obesity as BMI ≥ 97th percentile using the reference tables of Hernández. Serum 25(OH)D concentrations were measured by chemiluminescent assay. Plasma tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) were measured by immunoenzyme assay. Serum adiponectin was determined using an ELISA kit. Serum high-sensitivity C-reactive protein (hs-PCR) was tested by immunonephelometry. Results: IL-6 concentrations were higher in the overweight/obese children with deficient serum 25(OH)D (< 20 ng/mL) than in those in this group but whose serum 25(OH)D concentrations were adequate (≥ 20 ng/mL). Serum 25(OH)D was inversely associated with IL-6 concentrations in the overweight/obese subjects taking into account different covariates; thus, for every 1 ng/mL rise in the former, the latter fell by 0.160 pg/mL (β = - 0.160 ± 0.068; R2 = 0.131; p = 0.023). The obese subjects with concentrations of ≥ 25 ng/mL had lower hs-CRP values compared to those with concentrations of < 25 ng/mL (0.053 ± 0.035 vs. 0.356 ± 0.613 mg/dL; p = 0.035). Conclusion: Low serum 25(OH)D was significantly associated high serum IL-6 in overweight/obese children, and with increased hs-CRP in obese children.

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Association between Vitamin D Deficiency and High Serum Levels of Small Dense LDL in Middle-Aged Adults

Biomedicines ◽

10.3390/biomedicines9050464 ◽

2021 ◽

Vol 9 (5) ◽

pp. 464

Author(s):

Yin-Yi Han ◽

Sandy Huey-Jen Hsu ◽

Ta-Chen Su

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Fasting Blood Glucose ◽

Serum Levels ◽

High Serum ◽

Lipid Profiles ◽

Atherogenic Dyslipidemia ◽

Middle Aged ◽

Vitamin D Levels ◽

Middle Aged Adults

Recent studies suggested a potential link between vitamin D deficiency and cardiovascular risk factors, including dyslipidemia. This study aimed to investigate the association between serum 25(OH)D levels and atherogenic lipid profiles, specifically, that of small dense low-density lipoprotein-cholesterol (sdLDL-C). From 2009 to 2011, a total of 715 individuals aged 35–65 without evident cardiovascular disease (CVD) were enrolled. Their levels of serum 25(OH)D and lipid profiles were measured. Vitamin D deficiency was found to be more common in females, smokers, alcohol drinkers, individuals at a younger age, and those who do not exercise regularly. The analysis of lipid profiles revealed that high sdLDL-C levels were associated with low serum vitamin D levels and were more common among cigarette smokers; alcohol drinkers; individuals with hypertension; individuals with high BMI; and those with high levels of fasting blood glucose, triglycerides, LDL-C, and VLDL-C. The use of multivariate logistic regression verified a strong negative correlation between low vitamin D status (serum 25(OH)D < 15 ng/mL) and the three identified biomarkers of atherogenic dyslipidemia: high serum levels of sdLDL-C, triglycerides, and VLDL-C. This study provides strong evidence that vitamin D deficiency is associated with atherogenic dyslipidemia, and in particular, high sdLDL-C levels in middle-aged adults without CVD.

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A Case Report of Mixed Osteomalacia and Low Bone Density from Vitamin D Deficiency as a Cause of Bilateral Tibial Stress Fractures in a Young Male Military Recruit from Singapore

Case Reports in Endocrinology ◽

10.1155/2020/9519621 ◽

2020 ◽

Vol 2020 ◽

pp. 1-5

Author(s):

Wann Jia Loh ◽

Louise Hughes ◽

David Thai Chong Chua ◽

Linsey Gani

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Military Service ◽

Young Male ◽

Stress Fractures ◽

Sudden Increase ◽

Tropical Country ◽

Military Recruit ◽

Military Recruits ◽

Apparently Healthy

Despite being a tropical country, vitamin D deficiency is common in Singapore. All young Singaporean males between the age of 18 and 21 years have to undergo mandatory military service. Stress fractures occur in military recruits, and risk factors include a sudden increase in physical activity and vitamin D deficiency. We report the bone histomorphometry findings from a case of bilateral tibial stress fractures in an 18-year-old military recruit who had vitamin D deficiency. The histomorphometry showed a mixed osteomalacia and osteoporosis pattern. This case is unique as it shows that stress fractures from a marching exercise can occur in apparently healthy well young man with vitamin D deficiency despite living in a tropical country.

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