Dual-mode antibacterial core-shell gold nanorod@mesoporous-silica/curcumin nanocomplexes for efficient photothermal and photodynamic therapy

Sulforaphane (SF) was loaded into the multi-functioned rattle-structured gold nanorod mesoporous silica nanoparticles core-shell to improve its stability and efficacy through its efficient delivery to tumors. The rattle-structured gold nanorod mesoporous silica nanoparticles (rattle-structured AuNR@mSiO2 core-shell NPs) were obtained by covering the surface of Au NPs with Ag and mSiO2 shell and subsequently selective Ag shell etching strategy. Then the surface of rattle-structured AuNR@mSiO2 NPs was decorated with thiolated polyethylene glycol-FITC and thiolated polyethylene glycol-folic acid to the designed form. The obtained FITC/FA@ [rattle-structured AuNR@mSiO2] NPs was characterized by different techniques including energy dispersive X-ray spectroscopy (EDX), scanning and transmission electron microscopy (SEM & TEM), UV-visible spectrophotometer and dynamic light scattering (DLS). The FITC/FA@ [rattle-structured AuNR@mSiO2] NPs has an average diameter around ~33 nm, which increases to ~38 nm after the loading of sulforaphane. The amount of the loaded drug was ~ 2.8×10-4 mol of SF per gram of FITC/FA@ [rattle-structured AuNR@mSiO2] NPs. The rattle-structured AuNR@mSiO2 and FITC/FA@ [rattle-structured AuNR@mSiO2] NPs showed little inherent cytotoxicity, whereas the SF loaded FITC/FA@ [rattle-structured AuNR@mSiO2] NPs was highly cytotoxic in the case of MCF-7 cell line. Finally, Fluorescence microscopy and flow cytometry were used to demonstrate that the nanoparticles could be accumulated in specific regions and SF loaded FITC/FA@ [Fe3O4@Au] NPs efficiently induce apoptosis in MCF-7 cell line Graphical Abstract.

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Enhanced Plasmonic Resonance Energy Transfer in Mesoporous Silica-Encased Gold Nanorod for Two-Photon-Activated Photodynamic Therapy

Theranostics ◽

10.7150/thno.8934 ◽

2014 ◽

Vol 4 (8) ◽

pp. 798-807 ◽

Cited By ~ 51

Author(s):

Nai-Tzu Chen ◽

Kuo-Chun Tang ◽

Ming-Fang Chung ◽

Shih-Hsun Cheng ◽

Ching-Mao Huang ◽

...

Keyword(s):

Photodynamic Therapy ◽

Energy Transfer ◽

Mesoporous Silica ◽

Resonance Energy Transfer ◽

Resonance Energy ◽

Gold Nanorod ◽

Plasmonic Resonance ◽

Two Photon

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Core–shell gold nanorod@mesoporous-MOF heterostructures for combinational phototherapy

Nanoscale ◽

10.1039/d0nr07681c ◽

2021 ◽

Vol 13 (1) ◽

pp. 131-137

Author(s):

Zehao Zhou ◽

Jian Zhao ◽

Zhenghan Di ◽

Bei Liu ◽

Zhaohui Li ◽

...

Keyword(s):

Photodynamic Therapy ◽

Gold Nanorods ◽

Photothermal Therapy ◽

Metal Organic Frameworks ◽

Gold Nanorod ◽

Core Shell ◽

Tumor Treatment ◽

Metal Organic

A core–shell heterostructure consisting of plasmonic gold nanorods and porphyrinic metal–organic frameworks is synthesized as a promising platform to combine photodynamic therapy and photothermal therapy for enhanced tumor treatment.

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Graphene oxide coating core–shell silver sulfide@mesoporous silica for active targeted dual-mode imaging and chemo-photothermal synergistic therapy against tumors

Journal of Materials Chemistry B ◽

10.1039/c8tb00940f ◽

2018 ◽

Vol 6 (29) ◽

pp. 4808-4820 ◽

Cited By ~ 11

Author(s):

Yuan-Yang Song ◽

Cheng Li ◽

Xiao-Quan Yang ◽

Jie An ◽

Kai Cheng ◽

...

Keyword(s):

Graphene Oxide ◽

Mesoporous Silica ◽

Photothermal Therapy ◽

Oxide Coating ◽

Silver Sulfide ◽

Active Targeting ◽

Core Shell ◽

Dual Mode

FA-modified-GO coated core–shell Ag2S@mesoporous silica where DOX was loaded for active targeting FL/PA imaging and synergistic chemo-photothermal therapy of tumors.

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Mesoporous Silica-Coated Upconverting Nanorods for Singlet Oxygen Generation: Synthesis and Performance

Materials ◽

10.3390/ma14133660 ◽

2021 ◽

Vol 14 (13) ◽

pp. 3660

Author(s):

Zhen Zhang ◽

Xiao-Lian Zhang ◽

Bin Li

Keyword(s):

Photodynamic Therapy ◽

Mesoporous Silica ◽

Singlet Oxygen ◽

Rose Bengal ◽

Shell Structure ◽

Near Infrared ◽

Core Shell ◽

Sio2 Shell ◽

Mesoporous Sio2 ◽

Core Shell Structure

Photodynamic therapy (PDT) has been reported as a possible pathway for the treatment of tumors. The exploration for promising PDT systems thus attracts continuous research efforts. This work focused on an ordered core–shell structure encapsulated by mesoporous SiO2 with the upconverting emission property following a surfactant-assisted sol–gel technique. The mesoporous silica shell possessed a high surface area-to-volume ratio and uniform distribution in pore size, favoring photosensitizer (rose bengal) loading. Simultaneously, upconverting nanocrystals were synthesized and used as the core. After modification via hydrophobic silica, the hydrophobic upconverting nanocrystals became hydrophilic ones. Under near-infrared (NIR) light irradiation, the nanomaterials exhibited strong green upconverting luminescence so that rose bengal could be excited to produce singlet oxygen. The photodynamic therapy (PDT) feature was evaluated using a 1O2 fluorescent indicator. It was found that this core–shell structure generates 1O2 efficiently. The novelty of this core–shell structure was the combination of upconverting nanocrystals with a mesoporous SiO2 shell so that photosensitizer rose bengal could be effectively adsorbed in the SiO2 shell and then excited by the upconverting core.

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