Development of tissue conditioner containing cetylpyridinium chloride montmorillonite as new antimicrobial agent: Pilot study on antimicrobial activity and biocompatibility

In this study, for the first time, a novel organic–inorganic nanobio-antimicrobial agent called “nanoflowers” (Nfs) from Camellia sinensis (L.) Kuntze extracts and its main components were produced and the increase in the antimicrobial activity of Nfs was elucidated.

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A REVIEW ON PYRAZOLINE DERIVATIVES AS ANTIMICROBIAL AGENT

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2020v12i6.37456 ◽

2020 ◽

pp. 15-24

Author(s):

SARAS KUMAR JAIN ◽

ROHIT SINGHAL

Keyword(s):

Antimicrobial Activity ◽

Antimicrobial Agent ◽

Heterocyclic Compound ◽

Pharmacological Action ◽

Heterocyclic Ring ◽

Ring Structure ◽

Double Bonds ◽

Antitumor Properties ◽

Anti Inflammatory ◽

Pyrazoline Derivative

At present, there is a lot of research about the pyrazoline heterocyclic compound, its ring structure is being changed and new derivatives are being made, many of which have antimicrobial activity over the derivatives. Pyrazoline is the five-member heterocyclic ring which have two N atoms in nearby position and contains two endocyclic double bonds. Noteworthy consideration has been concentrated on pyrazolines and pyrazoline derivative due to their important pharmacological action. Some replaced pyrazolines have been stated near retain particular important pharmacological actions as antimicrobial, antifungal, antineoplastic, antidepressant, insecticidal, anticonvulsant, anti-inflammatory, antibacterial and antitumor properties.

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Simultaneous Control of Staphylococcus aureus and Bacillus cereus Using a Hybrid Endolysin LysB4EAD-LysSA11

Antibiotics ◽

10.3390/antibiotics9120906 ◽

2020 ◽

Vol 9 (12) ◽

pp. 906

Author(s):

Bokyung Son ◽

Minsuk Kong ◽

Yoyeon Cha ◽

Jaewoo Bai ◽

Sangryeol Ryu

Keyword(s):

Thermal Stability ◽

Staphylococcus Aureus ◽

Antimicrobial Activity ◽

Antimicrobial Agent ◽

Bacillus Cereus ◽

Foodborne Pathogens ◽

Lytic Activity ◽

Antimicrobial Spectrum ◽

Hybrid Proteins ◽

Simultaneous Control

Bacteriophage endolysins have attracted attention as promising alternatives to antibiotics, and their modular structure facilitates endolysin engineering to develop novel endolysins with enhanced versatility. Here, we constructed hybrid proteins consisting of two different endolysins for simultaneous control of two critical foodborne pathogens, Staphylococcus aureus and Bacillus cereus. The full-length or enzymatically active domain (EAD) of LysB4, an endolysin from the B. cereus-infecting phage B4, was fused to LysSA11, an endolysin of the S. aureus-infecting phage SA11, via a helical linker in both orientations. The hybrid proteins maintained the lytic activity of their parental endolysins against both S. aureus and B. cereus, but they showed an extended antimicrobial spectrum. Among them, the EAD of LysB4 fused with LysSA11 (LysB4EAD-LyaSA11) showed significantly increased thermal stability compared to its parental endolysins. LysB4EAD-LysSA11 exhibited high lytic activity at pH 8.0–9.0 against S. aureus and at pH 5.0–10.0 against B. cereus, but the lytic activity of the protein decreased in the presence of NaCl. In boiled rice, treatment with 3.0 µM of LysB4EAD-LysSA11 reduced the number of S. aureus and B. cereus to undetectable levels within 2 h and also showed superior antimicrobial activity to LyB4EAD and LysSA11 in combination. These results suggest that LysB4EAD-LysSA11 could be a potent antimicrobial agent for simultaneous control of S. aureus and B. cereus.

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Innate Protection of Mycobacterium smegmatis against the Antimicrobial Activity of Nitric Oxide Is Provided by Mycothiol

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00347-07 ◽

2007 ◽

Vol 51 (9) ◽

pp. 3364-3366 ◽

Cited By ~ 36

Author(s):

Christopher C. Miller ◽

Mamta Rawat ◽

Todd Johnson ◽

Yossef Av-Gay

Keyword(s):

Nitric Oxide ◽

Antimicrobial Activity ◽

Antimicrobial Agent ◽

Mycobacterium Smegmatis

ABSTRACT Nitric oxide (NO) is an efficient antimicrobial agent. A role for mycothiol in protecting mycobacteria from nitrosative damage was revealed by showing that a Mycobacterium smegmatis mutant is sensitive to NO. A direct correlation between NO and mycothiol levels confirmed that mycothiol is important for protecting mycobacteria from NO attack.

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Synthesis and Characterization of Substituted Bisbenzoxazine as Potent Antimicrobial Agent

International Letters of Chemistry Physics and Astronomy ◽

10.18052/www.scipress.com/ilcpa.40.73 ◽

2014 ◽

Vol 40 ◽

pp. 73-80 ◽

Cited By ~ 1

Author(s):

Kishor R. Lalcheta ◽

Bhvin B. Dhaduk ◽

Jaymin P. Mendapara

Keyword(s):

Antimicrobial Activity ◽

Antimicrobial Agent ◽

Synthesis And Characterization ◽

Bacterial Strains ◽

Fungal Strains

Bisbenoxazines derivatives were synthesized by refluxing substituted bisphenol-C, substituted aniline and formaldehyde in presence of 1,4-dioxane with good yields. All the synthesized compounds were characterized by mass, NMR and IR and also evaluated for antimicrobial activity against four different bacterial and two fungal strains. The compounds 1c, 1h, 1j and 1l has found comparatively good active against all the bacterial strains.

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Synthesis and Antimicrobial Activity of δ-Viniferin Analogues and Isosteres

Molecules ◽

10.3390/molecules26247594 ◽

2021 ◽

Vol 26 (24) ◽

pp. 7594

Author(s):

Luce Micaela Mattio ◽

Cecilia Pinna ◽

Giorgia Catinella ◽

Loana Musso ◽

Kasandra Juliet Pedersen ◽

...

Keyword(s):

Antimicrobial Activity ◽

Antimicrobial Agent ◽

Structural Elements ◽

Promising Candidate

The natural stilbenoid dehydro-δ-viniferin, containing a benzofuran core, has been recently identified as a promising antimicrobial agent. To define the structural elements relevant to its activity, we modified the styryl moiety, appended at C5 of the benzofuran ring. In this paper, we report the construction of stilbenoid-derived 2,3-diaryl-5-substituted benzofurans, which allowed us to prepare a focused collection of dehydro-δ-viniferin analogues. The antimicrobial activity of the synthesized compounds was evaluated against S. aureus ATCC29213. The simplified analogue 5,5′-(2-(4-hydroxyphenyl)benzofuran-3,5-diyl)bis(benzene-1,3-diol), obtained in three steps from 4-bromo-2-iodophenol (63% overall yield), emerged as a promising candidate for further investigation (MIC = 4 µg/mL).

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