scholarly journals Innate Protection of Mycobacterium smegmatis against the Antimicrobial Activity of Nitric Oxide Is Provided by Mycothiol

2007 ◽  
Vol 51 (9) ◽  
pp. 3364-3366 ◽  
Author(s):  
Christopher C. Miller ◽  
Mamta Rawat ◽  
Todd Johnson ◽  
Yossef Av-Gay
Keyword(s):  
Nitric Oxide ◽  
Antimicrobial Activity ◽  
Antimicrobial Agent ◽  
Mycobacterium Smegmatis

ABSTRACT Nitric oxide (NO) is an efficient antimicrobial agent. A role for mycothiol in protecting mycobacteria from nitrosative damage was revealed by showing that a Mycobacterium smegmatis mutant is sensitive to NO. A direct correlation between NO and mycothiol levels confirmed that mycothiol is important for protecting mycobacteria from NO attack.

scholarly journals Synthesis and characterization of green tea (Camellia sinensis (L.) Kuntze) extract and its major components-based nanoflowers: a new strategy to enhance antimicrobial activity

RSC Advances ◽  
2017 ◽  
Vol 7 (70) ◽  
pp. 44303-44308 ◽  
Author(s):  
Ayşe Baldemir ◽  
N. Buse Köse ◽  
Nilay Ildız ◽  
Selen İlgün ◽  
Sadi Yusufbeyoğlu ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Agent ◽  
Green Tea ◽  
Camellia Sinensis ◽  
Synthesis And Characterization ◽  
New Strategy ◽  
Main Components ◽  
First Time

In this study, for the first time, a novel organic–inorganic nanobio-antimicrobial agent called “nanoflowers” (Nfs) from Camellia sinensis (L.) Kuntze extracts and its main components were produced and the increase in the antimicrobial activity of Nfs was elucidated.

scholarly journals Terpenoids, Flavonoids and Acetogenins from Some Malagasy Plants

2016 ◽  
Vol 11 (2) ◽  
pp. 1934578X1601100 ◽  
Author(s):  
Fumihiro Nagashima ◽  
Yuki Tabuchi ◽  
Takuya Ito ◽  
Liva Harinantenaina ◽  
Yoshinori Asakawa
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Mycobacterium Smegmatis ◽  
Nmr Analysis

Humulanes, drimanes, ent-kaurane, lupane, cycloartane, flavanone, flavones and quinol derivatives were isolated from Malagasy Cussonia vantsilana, Helichrysum gymnocephalum, Phyllarthron madagascariense, Gomphocarpus fructicosus, Cinnamosma sp. and C. fragrans, and their structures elucidated by using extensive NMR analysis. A mixture of a few flavones and/or lupane triterpene showed antimicrobial activity against Mycobacterium smegmatis and Pseudomonas aeruginosa.

scholarly journals A REVIEW ON PYRAZOLINE DERIVATIVES AS ANTIMICROBIAL AGENT

2020 ◽  
pp. 15-24
Author(s):  
SARAS KUMAR JAIN ◽  
ROHIT SINGHAL
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Agent ◽  
Heterocyclic Compound ◽  
Pharmacological Action ◽  
Heterocyclic Ring ◽  
Ring Structure ◽  
Double Bonds ◽  
Antitumor Properties ◽  
Anti Inflammatory ◽  
Pyrazoline Derivative

At present, there is a lot of research about the pyrazoline heterocyclic compound, its ring structure is being changed and new derivatives are being made, many of which have antimicrobial activity over the derivatives. Pyrazoline is the five-member heterocyclic ring which have two N atoms in nearby position and contains two endocyclic double bonds. Noteworthy consideration has been concentrated on pyrazolines and pyrazoline derivative due to their important pharmacological action. Some replaced pyrazolines have been stated near retain particular important pharmacological actions as antimicrobial, antifungal, antineoplastic, antidepressant, insecticidal, anticonvulsant, anti-inflammatory, antibacterial and antitumor properties.

scholarly journals Simultaneous Control of Staphylococcus aureus and Bacillus cereus Using a Hybrid Endolysin LysB4EAD-LysSA11

Antibiotics ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 906
Author(s):  
Bokyung Son ◽  
Minsuk Kong ◽  
Yoyeon Cha ◽  
Jaewoo Bai ◽  
Sangryeol Ryu
Keyword(s):  
Thermal Stability ◽  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Antimicrobial Agent ◽  
Bacillus Cereus ◽  
Foodborne Pathogens ◽  
Lytic Activity ◽  
Antimicrobial Spectrum ◽  
Hybrid Proteins ◽  
Simultaneous Control

Bacteriophage endolysins have attracted attention as promising alternatives to antibiotics, and their modular structure facilitates endolysin engineering to develop novel endolysins with enhanced versatility. Here, we constructed hybrid proteins consisting of two different endolysins for simultaneous control of two critical foodborne pathogens, Staphylococcus aureus and Bacillus cereus. The full-length or enzymatically active domain (EAD) of LysB4, an endolysin from the B. cereus-infecting phage B4, was fused to LysSA11, an endolysin of the S. aureus-infecting phage SA11, via a helical linker in both orientations. The hybrid proteins maintained the lytic activity of their parental endolysins against both S. aureus and B. cereus, but they showed an extended antimicrobial spectrum. Among them, the EAD of LysB4 fused with LysSA11 (LysB4EAD-LyaSA11) showed significantly increased thermal stability compared to its parental endolysins. LysB4EAD-LysSA11 exhibited high lytic activity at pH 8.0–9.0 against S. aureus and at pH 5.0–10.0 against B. cereus, but the lytic activity of the protein decreased in the presence of NaCl. In boiled rice, treatment with 3.0 µM of LysB4EAD-LysSA11 reduced the number of S. aureus and B. cereus to undetectable levels within 2 h and also showed superior antimicrobial activity to LyB4EAD and LysSA11 in combination. These results suggest that LysB4EAD-LysSA11 could be a potent antimicrobial agent for simultaneous control of S. aureus and B. cereus.

scholarly journals Impairment of Antimicrobial Activity and Nitric Oxide Production in Alveolar Macrophages from Smokers of Marijuana and Cocaine

2003 ◽  
Vol 187 (4) ◽  
pp. 700-704 ◽  
Author(s):  
Angela Hanchi Shay ◽  
Ruth Choi ◽  
Katherine Whittaker ◽  
Ken Salehi ◽  
Christina M. R. Kitchen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Antimicrobial Activity ◽  
Alveolar Macrophages ◽  
Nitric Oxide Production ◽  
Oxide Production

scholarly journals Antimicrobial Activity of the Iron-Sulfur Nitroso Compound Roussin's Black Salt [Fe4S3(NO)7] on the Hyperthermophilic Archaeon Pyrococcus furiosus

2009 ◽  
Vol 75 (7) ◽  
pp. 1820-1825 ◽  
Author(s):  
Scott D. Hamilton-Brehm ◽  
Gerrit J. Schut ◽  
Michael W. W. Adams
Keyword(s):  
Nitric Oxide ◽  
Antimicrobial Agent ◽  
Pyrococcus Furiosus ◽  
Cell Lysis ◽  
Nitroso Compound ◽  
Hyperthermophilic Archaeon ◽  
New Class ◽  
Iron Sulfur ◽  
Sulfur Reductase ◽  
Potential Use

ABSTRACT The iron-sulfur nitroso compound [Fe4S3(NO)7]− is a broad-spectrum antimicrobial agent that has been used for more than 100 years to combat pathogenic anaerobes. Known as Roussin's black salt (RBS), it contains seven moles of nitric oxide, the release of which was always assumed to mediate its cytotoxicity. Using the hyperthermophilic archaeon Pyrococcus furiosus, it is demonstrated through growth studies, membrane analyses, and scanning electron microscopy that nitric oxide does not play a role in RBS toxicity; rather, the mechanism involves membrane disruption leading to cell lysis. Moreover, insoluble elemental sulfur (S0), which is reduced by P. furiosus to hydrogen sulfide, prevents cell lysis by RBS. It is proposed that S0 also directly interacts with the membranes of P. furiosus during its transfer into the cell, ultimately for reduction by a cytosolic NADPH sulfur reductase. RBS is proposed to be a new class of inorganic antimicrobial agent that also has potential use as an inert cell-lysing agent.

scholarly journals Synthesis and Characterization of Substituted Bisbenzoxazine as Potent Antimicrobial Agent

2014 ◽  
Vol 40 ◽  
pp. 73-80 ◽  
Author(s):  
Kishor R. Lalcheta ◽  
Bhvin B. Dhaduk ◽  
Jaymin P. Mendapara
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Agent ◽  
Synthesis And Characterization ◽  
Bacterial Strains ◽  
Fungal Strains

Bisbenoxazines derivatives were synthesized by refluxing substituted bisphenol-C, substituted aniline and formaldehyde in presence of 1,4-dioxane with good yields. All the synthesized compounds were characterized by mass, NMR and IR and also evaluated for antimicrobial activity against four different bacterial and two fungal strains. The compounds 1c, 1h, 1j and 1l has found comparatively good active against all the bacterial strains.

scholarly journals Synthesis and Antimicrobial Activity of δ-Viniferin Analogues and Isosteres

Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7594
Author(s):  
Luce Micaela Mattio ◽  
Cecilia Pinna ◽  
Giorgia Catinella ◽  
Loana Musso ◽  
Kasandra Juliet Pedersen ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Agent ◽  
Structural Elements ◽  
Promising Candidate

The natural stilbenoid dehydro-δ-viniferin, containing a benzofuran core, has been recently identified as a promising antimicrobial agent. To define the structural elements relevant to its activity, we modified the styryl moiety, appended at C5 of the benzofuran ring. In this paper, we report the construction of stilbenoid-derived 2,3-diaryl-5-substituted benzofurans, which allowed us to prepare a focused collection of dehydro-δ-viniferin analogues. The antimicrobial activity of the synthesized compounds was evaluated against S. aureus ATCC29213. The simplified analogue 5,5′-(2-(4-hydroxyphenyl)benzofuran-3,5-diyl)bis(benzene-1,3-diol), obtained in three steps from 4-bromo-2-iodophenol (63% overall yield), emerged as a promising candidate for further investigation (MIC = 4 µg/mL).

scholarly journals PERBANDINGAN KADAR FENOLIK DAN AKTIVITAS ANTIMIKROBA RIMPANG JERINGAU (Acorus calamus) SEGAR DAN TERFERMENTASI

2020 ◽  
Vol 3 (1) ◽  
pp. 16
Author(s):  
Fitri Hardiansi ◽  
Dwi Afriliana ◽  
Anita Munteira ◽  
Ernanin Dyah Wijayanti
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Candida Albicans ◽  
Antimicrobial Agent ◽  
Phenolic Content ◽  
Plant Cells ◽  
Acorus Calamus ◽  
Antimicrobial Test

ABSTRACTCalamus rhizome contain phenolic as antimicrobial agent. Fermentation can increase thereleasing of phenolic content from plant cells. The aim of this research was to observe thecomparison of phenolic content and antimicrobial activity between fresh and fermentedcalamus rhizome extract. Phenolic content was determined by using Folin-Ciocalteu method,and antimicrobial test by agar well diffusion. Phenolic content of fresh and fermentedcalamus rhizome extract respectively are 97,272±0,525 and 223,553±3,542 mgGAE/gram.Inhibiton zone against Staphylococcus aureus are 4,04±0,05 and 8,24±0,58 mm, whileagainst Candida albicans are 14,90±0,57 and 18,16±1,47 mm. Fermentation increase phenoliccontent and antimicrobial activity of calamus rhizome.Key words: antimicrobial, calamus rhozome, fermentation, phenolicABSTRAKRimpang jeringau memiliki kandungan senyawa fenolik sebagai antimikroba. Fermentasidapat meningkatkan pelepasan senyawa fenolik pada sel tanaman. Penelitian ini bertujuanuntuk mengetahui perbandingan kadar fenolik dan aktivitas antimikoba ekstrak rimpangjeringau segar dan terfermentasi. Penetapan kadar fenolik dilakukan dengan metode Folin-Ciocalteu dan uji antimikroba dengan metode difusi sumuran. Kadar fenolik ekstrak jeringausegar dan fermentasi secara berurutan sebesar 97,272±0,525 dan 223,553±3,542mgGAE/gram. Daya hambat rimpang jeringau segar dan terfermentasi terhadapStaphylococcus aureus sebesar 4,04±0,05 dan 8,24±0,58 mm, sedangkan terhadap Candidaalbicans sebesar 14,90±0,57 dan 18,16±1,47 mm. Fermentasi dapat meningkatkan kadarfenolik dan aktivitas antimikroba rimpang jeringau.Kata kunci: antimikroba, fenolik, fermentasi, rimpang jeringau

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