scholarly journals Synthesis and Antimicrobial Activity of δ-Viniferin Analogues and Isosteres

Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7594
Author(s):  
Luce Micaela Mattio ◽  
Cecilia Pinna ◽  
Giorgia Catinella ◽  
Loana Musso ◽  
Kasandra Juliet Pedersen ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Agent ◽  
Structural Elements ◽  
Promising Candidate

The natural stilbenoid dehydro-δ-viniferin, containing a benzofuran core, has been recently identified as a promising antimicrobial agent. To define the structural elements relevant to its activity, we modified the styryl moiety, appended at C5 of the benzofuran ring. In this paper, we report the construction of stilbenoid-derived 2,3-diaryl-5-substituted benzofurans, which allowed us to prepare a focused collection of dehydro-δ-viniferin analogues. The antimicrobial activity of the synthesized compounds was evaluated against S. aureus ATCC29213. The simplified analogue 5,5′-(2-(4-hydroxyphenyl)benzofuran-3,5-diyl)bis(benzene-1,3-diol), obtained in three steps from 4-bromo-2-iodophenol (63% overall yield), emerged as a promising candidate for further investigation (MIC = 4 µg/mL).

scholarly journals Synthesis and characterization of green tea (Camellia sinensis (L.) Kuntze) extract and its major components-based nanoflowers: a new strategy to enhance antimicrobial activity

RSC Advances ◽  
2017 ◽  
Vol 7 (70) ◽  
pp. 44303-44308 ◽  
Author(s):  
Ayşe Baldemir ◽  
N. Buse Köse ◽  
Nilay Ildız ◽  
Selen İlgün ◽  
Sadi Yusufbeyoğlu ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Agent ◽  
Green Tea ◽  
Camellia Sinensis ◽  
Synthesis And Characterization ◽  
New Strategy ◽  
Main Components ◽  
First Time

In this study, for the first time, a novel organic–inorganic nanobio-antimicrobial agent called “nanoflowers” (Nfs) from Camellia sinensis (L.) Kuntze extracts and its main components were produced and the increase in the antimicrobial activity of Nfs was elucidated.

scholarly journals A REVIEW ON PYRAZOLINE DERIVATIVES AS ANTIMICROBIAL AGENT

2020 ◽  
pp. 15-24
Author(s):  
SARAS KUMAR JAIN ◽  
ROHIT SINGHAL
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Agent ◽  
Heterocyclic Compound ◽  
Pharmacological Action ◽  
Heterocyclic Ring ◽  
Ring Structure ◽  
Double Bonds ◽  
Antitumor Properties ◽  
Anti Inflammatory ◽  
Pyrazoline Derivative

At present, there is a lot of research about the pyrazoline heterocyclic compound, its ring structure is being changed and new derivatives are being made, many of which have antimicrobial activity over the derivatives. Pyrazoline is the five-member heterocyclic ring which have two N atoms in nearby position and contains two endocyclic double bonds. Noteworthy consideration has been concentrated on pyrazolines and pyrazoline derivative due to their important pharmacological action. Some replaced pyrazolines have been stated near retain particular important pharmacological actions as antimicrobial, antifungal, antineoplastic, antidepressant, insecticidal, anticonvulsant, anti-inflammatory, antibacterial and antitumor properties.

scholarly journals Simultaneous Control of Staphylococcus aureus and Bacillus cereus Using a Hybrid Endolysin LysB4EAD-LysSA11

Antibiotics ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 906
Author(s):  
Bokyung Son ◽  
Minsuk Kong ◽  
Yoyeon Cha ◽  
Jaewoo Bai ◽  
Sangryeol Ryu
Keyword(s):  
Thermal Stability ◽  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Antimicrobial Agent ◽  
Bacillus Cereus ◽  
Foodborne Pathogens ◽  
Lytic Activity ◽  
Antimicrobial Spectrum ◽  
Hybrid Proteins ◽  
Simultaneous Control

Bacteriophage endolysins have attracted attention as promising alternatives to antibiotics, and their modular structure facilitates endolysin engineering to develop novel endolysins with enhanced versatility. Here, we constructed hybrid proteins consisting of two different endolysins for simultaneous control of two critical foodborne pathogens, Staphylococcus aureus and Bacillus cereus. The full-length or enzymatically active domain (EAD) of LysB4, an endolysin from the B. cereus-infecting phage B4, was fused to LysSA11, an endolysin of the S. aureus-infecting phage SA11, via a helical linker in both orientations. The hybrid proteins maintained the lytic activity of their parental endolysins against both S. aureus and B. cereus, but they showed an extended antimicrobial spectrum. Among them, the EAD of LysB4 fused with LysSA11 (LysB4EAD-LyaSA11) showed significantly increased thermal stability compared to its parental endolysins. LysB4EAD-LysSA11 exhibited high lytic activity at pH 8.0–9.0 against S. aureus and at pH 5.0–10.0 against B. cereus, but the lytic activity of the protein decreased in the presence of NaCl. In boiled rice, treatment with 3.0 µM of LysB4EAD-LysSA11 reduced the number of S. aureus and B. cereus to undetectable levels within 2 h and also showed superior antimicrobial activity to LyB4EAD and LysSA11 in combination. These results suggest that LysB4EAD-LysSA11 could be a potent antimicrobial agent for simultaneous control of S. aureus and B. cereus.

scholarly journals Innate Protection of Mycobacterium smegmatis against the Antimicrobial Activity of Nitric Oxide Is Provided by Mycothiol

2007 ◽  
Vol 51 (9) ◽  
pp. 3364-3366 ◽  
Author(s):  
Christopher C. Miller ◽  
Mamta Rawat ◽  
Todd Johnson ◽  
Yossef Av-Gay
Keyword(s):  
Nitric Oxide ◽  
Antimicrobial Activity ◽  
Antimicrobial Agent ◽  
Mycobacterium Smegmatis

ABSTRACT Nitric oxide (NO) is an efficient antimicrobial agent. A role for mycothiol in protecting mycobacteria from nitrosative damage was revealed by showing that a Mycobacterium smegmatis mutant is sensitive to NO. A direct correlation between NO and mycothiol levels confirmed that mycothiol is important for protecting mycobacteria from NO attack.

scholarly journals Synthesis and Characterization of Substituted Bisbenzoxazine as Potent Antimicrobial Agent

2014 ◽  
Vol 40 ◽  
pp. 73-80 ◽  
Author(s):  
Kishor R. Lalcheta ◽  
Bhvin B. Dhaduk ◽  
Jaymin P. Mendapara
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Agent ◽  
Synthesis And Characterization ◽  
Bacterial Strains ◽  
Fungal Strains

Bisbenoxazines derivatives were synthesized by refluxing substituted bisphenol-C, substituted aniline and formaldehyde in presence of 1,4-dioxane with good yields. All the synthesized compounds were characterized by mass, NMR and IR and also evaluated for antimicrobial activity against four different bacterial and two fungal strains. The compounds 1c, 1h, 1j and 1l has found comparatively good active against all the bacterial strains.

scholarly journals PERBANDINGAN KADAR FENOLIK DAN AKTIVITAS ANTIMIKROBA RIMPANG JERINGAU (Acorus calamus) SEGAR DAN TERFERMENTASI

2020 ◽  
Vol 3 (1) ◽  
pp. 16
Author(s):  
Fitri Hardiansi ◽  
Dwi Afriliana ◽  
Anita Munteira ◽  
Ernanin Dyah Wijayanti
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Candida Albicans ◽  
Antimicrobial Agent ◽  
Phenolic Content ◽  
Plant Cells ◽  
Acorus Calamus ◽  
Antimicrobial Test

ABSTRACTCalamus rhizome contain phenolic as antimicrobial agent. Fermentation can increase thereleasing of phenolic content from plant cells. The aim of this research was to observe thecomparison of phenolic content and antimicrobial activity between fresh and fermentedcalamus rhizome extract. Phenolic content was determined by using Folin-Ciocalteu method,and antimicrobial test by agar well diffusion. Phenolic content of fresh and fermentedcalamus rhizome extract respectively are 97,272±0,525 and 223,553±3,542 mgGAE/gram.Inhibiton zone against Staphylococcus aureus are 4,04±0,05 and 8,24±0,58 mm, whileagainst Candida albicans are 14,90±0,57 and 18,16±1,47 mm. Fermentation increase phenoliccontent and antimicrobial activity of calamus rhizome.Key words: antimicrobial, calamus rhozome, fermentation, phenolicABSTRAKRimpang jeringau memiliki kandungan senyawa fenolik sebagai antimikroba. Fermentasidapat meningkatkan pelepasan senyawa fenolik pada sel tanaman. Penelitian ini bertujuanuntuk mengetahui perbandingan kadar fenolik dan aktivitas antimikoba ekstrak rimpangjeringau segar dan terfermentasi. Penetapan kadar fenolik dilakukan dengan metode Folin-Ciocalteu dan uji antimikroba dengan metode difusi sumuran. Kadar fenolik ekstrak jeringausegar dan fermentasi secara berurutan sebesar 97,272±0,525 dan 223,553±3,542mgGAE/gram. Daya hambat rimpang jeringau segar dan terfermentasi terhadapStaphylococcus aureus sebesar 4,04±0,05 dan 8,24±0,58 mm, sedangkan terhadap Candidaalbicans sebesar 14,90±0,57 dan 18,16±1,47 mm. Fermentasi dapat meningkatkan kadarfenolik dan aktivitas antimikroba rimpang jeringau.Kata kunci: antimikroba, fenolik, fermentasi, rimpang jeringau

scholarly journals Synthesis and Characterization of Fully Substituted Pyrimidines by Using Ketene Dithioacetal as Potent Antimicrobial Agent

2013 ◽  
Vol 24 ◽  
pp. 134-141
Author(s):  
Hasmukh R. Khunt ◽  
Piyush P. Pipaliya ◽  
Satish M. Ghelani ◽  
Jayesh S. Babariya ◽  
Yogesh T. Naliapara
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Agent ◽  
Synthesis And Characterization ◽  
Bacterial Strains ◽  
Fungal Strains ◽  
Ketene Dithioacetals ◽  
Guanidine Nitrate ◽  
Ketene Dithioacetal

Various ketene dithioacetals of acetoacetanilides were reacted with guanidine nitrate in the presence of base to produce the 2-amino-4-isopropyl-6-alkoxy-N-arylpyrimidine-5-carboxamide derivatives with good yields. All the synthesized compounds were characterized by mass, NMR and IR and also evaluated for antimicrobial activity against five different bacterial and fungal strains. The compounds 4i, 4k and 4l has found comparatively good active against all the bacterial strains.

Convergence of Nanotechnology and Microbiology

2015 ◽  
pp. 313-342
Author(s):  
Mussrat Fayaz Khanday
Keyword(s):  
Antimicrobial Activity ◽  
Drinking Water ◽  
Global Health ◽  
Antimicrobial Agent ◽  
Interdisciplinary Research ◽  
Research Area ◽  
Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Synthesis Of Nanoparticles ◽  
The Relationship

The convergence of nanotechnology with microbiology is a nifty interdisciplinary research area that could amplify the limits of technology, enhance global health through formation of different drugs that can be effective against different infectious diseases, and for treatment of drinking water to kill the pathogens and make it safe for public use. Bacteria, fungi, actinomycetes, and plants have been successfully used for the formation of nanoparticles of silver, gold, zinc, etc. As the microorganisms, especially bacteria, are becoming resistant to the commonly used antibiotics, an alternative antimicrobial agent that can be effective against the antibiotic-resistant bacteria is needed. In the present chapter, the author highlights the relationship between these two mighty disciplines. The chapter deals with many aspects like antimicrobial activity of nanoparticles, formation of nanoparticles using microorganisms, etc. The green synthesis of nanoparticles is emerging as a new field of science; hence, it is discussed in detail.

Preparation of a Novel Complex Antimicrobial Agent and its Antimicrobial Activity In Vitro

2012 ◽  
Vol 550-553 ◽  
pp. 1030-1038
Author(s):  
Peng Li ◽  
Wei Guo Wang ◽  
Yu Jia Cui ◽  
Yong Liang Zhao ◽  
Ya Nan Gu ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Antimicrobial Agent ◽  
Antimicrobial Agents ◽  
E Coli ◽  
Orthogonal Experiments ◽  
Novel Complex ◽  
Cefoperazone Sodium ◽  
Complex Antimicrobial Agent

Purpose To develop a novel complex antimicrobial agent and determine the optimal components of the composite antimicrobial agents and its antimicrobial activity in vitro. Methods According to antimicrobial mechanisms，antibacterial spectrums，physical and chemical properties and applicabilities of existing antimicrobial agents in clinical use, select out cefoperazone sodium, sulbactam sodium and cephradine as the basic components to make a novel complex antimicrobial agent. Utilize yeast, staphylococcus aureus and E. coli bacteria as test bacteria. Do the three factors four-level orthogonal experiments by the maximum amount, the middle amount, low amount and Minimum amount of the three-component agent to research the optimum ratio of the drug. Measure the titer of the compound antimicrobial agent by the way of tube-plate method (2 doses). With known contents of Penicillin Sodium for Injection as control, and determine its minimum inhibitory concentration against staphylococcus aureus, E. coli and yeast by using the agar doubling dilution method. The experimental results were analysized by statistical analysis software SPSS16.0. Results The results of the three factors four-level orthogonal experiments indicate the optimum ratios of Cefoperazone Sodium, Sulbactam Sodium and Cephradine against E. coli, yeast and staphylococcus aureus were 2:2:3, 1:2:2 and 2:6:5, their titers were 1353.9U/mg, 982.7U/mg and 1015.5U/mg. With the highest titer proportion 2:2:3 as the composition of the antimicrobial compound. This compound antimicrobial agent had a good antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and Fungi, its minimal inhibitory concentration (MIC) against staphylococcus aureus, E. coli and yeast were 2.000μg/ml, 0.500μg/ml and 16.000μg/ml. Conclusion This research acquires a composite of antibiotics. This antimicrobial compound has a broader spectrum and higher antimicrobial activity in vitro comparing with traditional common single antibiotics, and it especially has a good antimicrobial activity against fungi. The results set a scientific foundation for enriching clinical medicines.

Sign in / Sign up

Export Citation Format

Share Document