The Vitamin D analogue TX 527 blocks NF-κB activation in peripheral blood mononuclear cells of patients with Crohn's disease

2007 ◽  
Vol 103 (1) ◽  
pp. 51-60 ◽  
Author(s):  
Maria Stio ◽  
Maria Martinesi ◽  
Sara Bruni ◽  
Cristina Treves ◽  
Chantal Mathieu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells ◽  
Vitamin D Analogue

scholarly journals The gene encoding the interleukin-1 receptor antagonist is differentially expressed in the blood and regulatory T-cells of patients with Crohn’s disease and transcriptionally induced in peripheral blood mononuclear cells upon stimulation with muramyl dipeptide.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
T Cells ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Interleukin 1 ◽  
Muramyl Dipeptide ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells

Crohn’s disease, an inflammatory bowel disease (1), is a significant cause of morbidity and economic burden in the United States (2, 3, 4). We performed differential gene expression analyses and identified the interleukin-1 (IL-1) receptor antagonist, IL1RN (5, 6), as among the genes most differentially expressed in the blood and regulatory T-cells of patients with Crohn’s disease using published (7) and public datasets (8). Further analysis of published microarray data (9) revealed that IL1RN was transcriptionally induced upon stimulation of peripheral blood mononuclear cells (PBMC) with muramyl dipeptide, the ligand for the gene product of the Crohn’s disease susceptibility locus NOD2. Interestingly, IL-1RN was expressed at significantly lower quantities in the Treg of patients with Crohn’s disease than in the Treg of non-affected control subjects. This is the first report of differential expression of IL1RN in patients with Crohn’s disease.

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