A simple procedure for synthesis of 3H-quinazolin-4-one hydrazones under mild conditions

We report a visible light-assisted one-pot method for the synthesis of polynitrophenols through radical tandem hydroxylation and nitration of arylboronic acids by utilizing copper(II) nitrate trihydrate as the nitro source. This method features mild conditions, a simple procedure, and good functional group tolerance. Compared to conventional methods, this work provides a straightforward approach for the polynitration of aromatic compounds.

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Alum (KAl(SO4)2·12H2O)-Catalyzed, Eco-Friendly, and Efficient One-Pot Synthesis of 2-Arylbenzothiazoles and 2-Arylbenzoxazole in Aqueous Medium

Australian Journal of Chemistry ◽

10.1071/ch08122 ◽

2008 ◽

Vol 61 (11) ◽

pp. 905 ◽

Cited By ~ 19

Author(s):

Shivaji S. Pawar ◽

Deepak V. Dekhane ◽

Murlidhar S. Shingare ◽

Shivaji N. Thore

Keyword(s):

Ambient Temperature ◽

Aqueous Medium ◽

Simple Procedure ◽

Reaction Yield ◽

One Pot ◽

Mild Conditions ◽

One Pot Synthesis ◽

Novel Catalyst

Alum (KAl(SO4)2·12H2O) performs as a novel catalyst for the synthesis of 2-arylbenzothiazoles and 2-arylbenzoxazole from o-aminothiophenol and o-aminophenol with various substituted aldehydes in good to excellent isolated yields (85–95%) using water as a solvent at ambient temperature. Several solvents were examined for this reaction; however, in terms of reaction yield and time, water was found to be the optimum solvent. The remarkable advantages offered by this method are an inexpensive and easily available catalyst, a simple procedure, mild conditions, much faster (60–90 min) reactions, and good to excellent yields of products.

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Simple procedure for vacant POM-stabilized palladium (0) nanoparticles in water: structural and dispersive effects of lacunary polyoxometalates

RSC Advances ◽

10.1039/c4ra03104k ◽

2014 ◽

Vol 4 (50) ◽

pp. 26491-26498 ◽

Cited By ~ 15

Author(s):

R. Villanneau ◽

A. Roucoux ◽

P. Beaunier ◽

D. Brouri ◽

A. Proust

Keyword(s):

Aqueous Solutions ◽

Palladium Nanoparticles ◽

Simple Procedure ◽

Mild Conditions ◽

Metallic Palladium ◽

Derivatives Of

Metallic palladium nanoparticles have been generated by hydrogenation in very mild conditions of aqueous solutions of non-organometallic PdII-derivatives of heteropolytungstates.

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Copper-catalyzed one-pot synthesis of benzimidazole derivatives

Canadian Journal of Chemistry ◽

10.1139/v08-153 ◽

2008 ◽

Vol 86 (11) ◽

pp. 1044-1051 ◽

Cited By ~ 38

Author(s):

Hashem Sharghi ◽

Mona Hosseini-Sarvari ◽

Fatemeh Moeini

Keyword(s):

Heterogeneous Catalyst ◽

Simple Procedure ◽

Catalytic Reactions ◽

Environmentally Benign ◽

Benzimidazole Derivatives ◽

Good Recovery ◽

One Pot ◽

Aryl Aldehydes ◽

Mild Conditions ◽

High Yields

A simple, efficient, and environmentally benign method has been developed for the synthesis of 2-substituted benzimidazoles through a one-pot reaction of phenylenediamines with aryl aldehydes in excellent isolated yields under mild conditions using Cu(II) complex as the selective, recyclable, and heterogeneous catalyst at ambient temperature. The Cu(II) complex as a heterogeneous catalyst can be reused in further catalytic reactions, and it was found that its activity remained largely unchanged for eight successive runs. No metal-complex leaching was observed after the consecutive catalytic reactions. The salient features of this method include mild conditions, high yields, simple procedure, and good recovery and reusability of the heterogeneous catalyst.Key words: benzimidazole, o-phenylenediamine, arylaldehydes, heterogeneous catalyst, N,N-bis (2-hydroxyphenyl)pyridine-2,6-dicarboxamide.

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Efficient synthesis of β’-amino-α,β-unsaturated ketones

Beilstein Journal of Organic Chemistry ◽

10.3762/bjoc.9.52 ◽

2013 ◽

Vol 9 ◽

pp. 486-495 ◽

Cited By ~ 10

Author(s):

Isabelle Abrunhosa-Thomas ◽

Aurélie Plas ◽

Nishanth Kandepedu ◽

Pierre Chalard ◽

Yves Troin

Keyword(s):

Simple Procedure ◽

High Yield ◽

Unsaturated Ester ◽

Efficient Synthesis ◽

Unsaturated Ketones ◽

Mild Conditions

A general and simple procedure to access chiral β'-amino-α,β-enones, in seven steps, from an α,β unsaturated ester has been described. The use of a Horner–Wadsworth–Emmons reaction as a key step for generating the β'-amino-α,β-enones, permits access to a range of substrates under mild conditions and in moderate to high yield.

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Trichloroisocyanuric Acid/Triphenylphosphine-Mediated Synthesis of Benzimidazoles, Benzoxazoles, and Benzothiazoles

Australian Journal of Chemistry ◽

10.1071/ch14037 ◽

2015 ◽

Vol 68 (1) ◽

pp. 145 ◽

Cited By ~ 8

Author(s):

Soodabeh Rezazadeh ◽

Batool Akhlaghinia ◽

Nasrin Razavi

Keyword(s):

Mass Spectrometry ◽

Carboxylic Acids ◽

Efficient Method ◽

Simple Procedure ◽

Mass Spectrometry Data ◽

Acid System ◽

Mild Conditions ◽

Trichloroisocyanuric Acid

A new and efficient method for preparation of benzimidazoles, benzoxazoles, and benzothiazoles from reactions of different carboxylic acids with o-phenylenediamine, o-aminophenol, and o-aminothiophenol in the presence of triphenylphosphine/trichloroisocyanuric acid system is presented. The desired products have been characterised on the basis of spectral (infrared, NMR, mass spectrometry) data, and the mechanism of their formation is proposed. The remarkable advantages are the inexpensive and readily available reagent, simple procedure, mild conditions, and good-to-excellent yields.

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Trimesic Acid-Functionalized Chitosan: A Novel And Efficient Multifunctional Organocatalyst For Green Synthesis of Polyhydroquinolines And Acridinediones Under Mild Conditions

10.21203/rs.3.rs-1054554/v1 ◽

2021 ◽

Author(s):

Rahman Beiranvand ◽

Mohammad G. Dekamin

Keyword(s):

Active Sites ◽

Simple Procedure ◽

Xrd Analysis ◽

Significant Loss ◽

X Ray Diffraction ◽

One Pot ◽

X Ray ◽

Trimesic Acid ◽

Mild Conditions ◽

Hantzsch Condensation

Abstract Trimesic acid-functionalized chitosan (Cs/ECH-TMA) material was prepared through a simple procedure by using chitosan (Cs), epichlorohydrin (ECH) and trimesic acid (TMA). The obtained bio-based Cs/ECH-TMA material was characterized using energy-dispersive X-ray (EDX) and Fourier-transform infrared spectroscopy (FTIR) spectroscopy, field emission scanning electron microscopy (FESEM) and X-ray diffraction (XRD) analysis. The Cs/ECH-TMA material was successfully used, as a multifunctional heterogeneous and sustainable catalyst, for efficient and expeditious synthesis of medicinally important polyhydroquinoline (PHQ) and polyhydroacridinedione (PHA) scaffolds through the Hantzsch condensation in a one-pot reaction. Indeed, the heterogeneous Cs/ECH-TMA material can be considered as a synergistic multifunctional organocatalyst due to the presence of a large number of acidic active sites in its structure as well as hydrophilicity. Both PHQs and PHAs were synthesized in the presence of biodegradable heterogeneous Cs/ECH-TMA catalytic system from their corresponding substrates in EtOH under reflux conditions and high to quantitative yields. The Cs/ECH-TMA catalyst is recyclable and can be reused at least four times without significant loss of its catalytic activity.

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A Simple Procedure for Preparing Liposomes Capable of High Encapsulation Efficiency Under Mild Conditions

Liposome Technology ◽

10.1201/9781351074100-2 ◽

2019 ◽

pp. 19-27 ◽

Cited By ~ 3

Author(s):

Christopher J. Kirby ◽

Gregory Gregoriadis

Keyword(s):

Encapsulation Efficiency ◽

Simple Procedure ◽

Mild Conditions

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Citric acid as a trifunctional organocatalyst for thiocyanation of aromatic and heteroaromatic compounds in aqueous media

Canadian Journal of Chemistry ◽

10.1139/v2012-013 ◽

2012 ◽

Vol 90 (5) ◽

pp. 427-432 ◽

Cited By ~ 16

Author(s):

Ardeshir Khazaei ◽

Mohammad Ali Zolfigol ◽

Mohmmad Mokhlesi ◽

Mahtab Pirveysian

Keyword(s):

Citric Acid ◽

Simple Procedure ◽

Aqueous Media ◽

Reaction Times ◽

Catalytic Amount ◽

Heteroaromatic Compounds ◽

Mild Conditions ◽

High Yields

A green and simple procedure for the thiocynation of aromatic and heteroaromatic rings in the presence of a catalytic amount of citric acid in water are described. The reactions proceed in high yields, with short reaction times and under mild conditions.

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Facile Access to Optically Active Ring C Aromatic Diterpene Derivatives from (+)-Manool. First Synthesis of 13,14-Dihydroxy-8,11,13-podocarpatrien-7-one

Natural Product Communications ◽

10.1177/1934578x1400900317 ◽

2014 ◽

Vol 9 (3) ◽

pp. 1934578X1400900

Author(s):

María L. Nóvoa ◽

Franklin J. Salazar ◽

Carlos Gámez ◽

Ana Y. Angarita ◽

Eleonora Tropper ◽

...

Keyword(s):

Simple Procedure ◽

Optically Active ◽

High Yield ◽

Mild Conditions ◽

Active Ring ◽

Enantiospecific Synthesis ◽

Celastrus Paniculatus ◽

Taiwania Cryptomerioides

14,15,17-Trinorlabdan-8,13-dione 6 was efficiently synthesized via ozonolysis of (+)-manool (4) followed by treatment with aqueous NaOH in the presence of tetra- n-butylammonium bromide as catalyst. This protocol has the advantages of high yield, mild conditions and simple procedure. Utilizing this strategy, the first enantiospecific synthesis of 13,14-dihydroxy-8,11,13-podocarpatrien-7-one (1), a constituent of Taiwania cryptomerioides and Celastrus paniculatus, was achieved starting from (+)-manool (4) after a four-step sequence in 24% overall yield.

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