Effects of melatonin on oxidative stress parameters and pathohistological changes in rat skeletal muscle tissue following carbon tetrachloride application

Hemato-ophthalmic barrier is one of the mechanisms of body resistance. One of the complications of mechanical trauma of the eye and violation of the hemato-ophthalmic barrier is the emergence of oxidative stress on the background of the general inflammatory process. Normally, oxidative stress in the skeletal muscle tissue is not a damaging agent, but when intensified by other factors, it promotes pathological changes in the body. Objective: to study the dynamics of superoxiddismutase (SOD) activity in rat skeletal muscle tissue under oxidative stress caused by mechanical action on the hemato-ophthalmic barrier. Materials and methods: The study was carried out on pedigree matured male rats in the amount of 150 pieces. The activity of SOD in skeletal muscle tissue was studied before the experiment, as well as on the 1st, 3rd, 5th, 7th and 14th day of the experiment using the standard technique of V.S. Gurevich. The obtained digital material was subjected to statistical processing by means of non-parametric statistical analysis. Conclusion: SOD activity in rat skeletal muscle tissue under oxidative stress caused by mechanical action on hemato-ophthalmic barrier is most effectively stabilized in standard therapy of mechanical eye injury with the addition of quercetin in the form of injections.

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OR12: Unacylated Ghrelin Normalizes Uremia-Induced Oxidative Stress and Insulin Resistance in Myotubes and Skeletal Muscle Tissue by Stimulating Autophagy

Clinical Nutrition ◽

10.1016/s0261-5614(16)30251-5 ◽

2016 ◽

Vol 35 ◽

pp. S5

Author(s):

G. Gortan Cappellari ◽

A. Semolic ◽

G. Ruozi ◽

M. Zanetti ◽

P. Vinci ◽

...

Keyword(s):

Oxidative Stress ◽

Insulin Resistance ◽

Skeletal Muscle ◽

Muscle Tissue ◽

Skeletal Muscle Tissue ◽

Unacylated Ghrelin

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Hepatoprotective effect of desi and kabuli cultivars of Cicer arietinum L (chick peas) against carbon tetrachloride-induced toxicity in rats

Tropical Journal of Pharmaceutical Research ◽

10.4314/tjpr.v19i3.22 ◽

2020 ◽

Vol 19 (3) ◽

pp. 609-615

Author(s):

Mudasir Majeed ◽

Abdullah Ijaz Hussain ◽

Haseeb Anwar ◽

Shahzad Irfan ◽

Shahzad Ali Shahid Chatha ◽

...

Keyword(s):

Oxidative Stress ◽

Carbon Tetrachloride ◽

Cicer Arietinum ◽

Control Group ◽

Serum Samples ◽

Cicer Arietinum L ◽

Oxidative Stress Parameters ◽

High Doses ◽

Ethanol Extracts ◽

Stress Parameters

Purpose: To determine the hepatoprotective potential of ethanol extracts of desi and kabuli cultivars of Cicer arietinum L. (chick peas). Methods: Hepatotoxicity was induced in rats using oral administration of carbon tetrachloride (CCl4). The rats were then orally administered different doses of the ethanol extracts of desi and kabuli cultivars of Cicer arietinum L. for 21 days. Oxidative stress parameters and hepatoprotective profiles were determined in serum samples using standard procedures. The effect of the treatments on liver histology was also determined. Results: Administration of extracts of desi and kabuli cultivars of Cicer arietinum L. to CCl4 treated rats at a dose of 300 mg/kg resulted in a significant (p ≤ 0.05) decrease in oxidative stress parameters, whereas catalase activity significantly increased (p ≤ 0.05); on the other hand, ALT and AST levels were decreased significantly (p ≤ 0.05), when compared to the control group. Conclusion: High doses of Cicer arietinum L (desi and kabuli cultivars) seem to have hepatoprotective and antioxidant effects on CCl4-induced toxicity in rats. This finding underscores the therapeutic importance of Cicer arietinum L. as a plant with hepatoprotective properties. Keywords: Cicer arietinum, Phenolics, Hepatotoxicity, Chick peas, Catalase

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Protective Effects of Propolis and Probiotic Lactobacillus acidophilus against Carbon Tetrachloride-Induced Hepatotoxicity in Rats

Pharmaceutical Sciences ◽

10.15171/ps.2019.36 ◽

2019 ◽

Vol 25 (3) ◽

pp. 190-197 ◽

Cited By ~ 1

Author(s):

Abdelkader Oumeddour ◽

Djahida Zaroure ◽

Raziqua Haroune ◽

Rima Zaimeche ◽

Karima Riane ◽

...

Keyword(s):

Oxidative Stress ◽

Lipid Peroxidation ◽

Carbon Tetrachloride ◽

Total Protein ◽

Serum Biochemistry ◽

Protective Effects ◽

Oxidative Stress Parameters ◽

Therapeutic Benefits ◽

Sugar Levels ◽

Stress Parameters

Background: Propolis (PRS) and probiotic bacteria Lactobacillus are natural products used as dietary supplement for their therapeutic benefits. This study was performed to examine the possible hepatoprotective effect of PRS and probiotics (PRCs) against carbon tetrachloride-induced liver injury. Methods: Experimentally, intoxicated rats received 0.5 ml/kg CCl4 (i.p.) daily for six days, pretreated rats received per os PRS 100 mg/kg or PRCs 109 CFU for six days followed by a single dose of 0.5 ml/kg CCl4. Control groups received either PRS, PRCs or olive oil for six days. Then, serum biochemistry (total protein, cholesterol, triglycerides and albumin) and oxidative stress parameters were measured. Results: We showed that CCl4 treatment was associated with an increase of the serum aspartate amino transferase (AST), alanine aminotransferase (ALT), cholesterol and triglycerides levels. In parallel, serum total protein, albumin and blood sugar levels were significantly decreased. Regarding the oxidative stress parameters, catalase and glutathione S-transferase (GST) levels were lower, conversely to the lipid peroxidation (MDA). Conclusion: Our results strongly support that administration of PRS and PRCs may significantly protect liver against CCl4-induced toxicity by enhancing antioxidative stress pathway and preventing lipid peroxidation.

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Angiotensin II Type 1 Receptor-associated Protein Inhibits Angiotensin II-induced Insulin Resistance with Suppression of Oxidative Stress in Skeletal Muscle Tissue

Scientific Reports ◽

10.1038/s41598-018-21270-8 ◽

2018 ◽

Vol 8 (1) ◽

Cited By ~ 7

Author(s):

Kohji Ohki ◽

Hiromichi Wakui ◽

Nozomu Kishio ◽

Kengo Azushima ◽

Kazushi Uneda ◽

...

Keyword(s):

Oxidative Stress ◽

Insulin Resistance ◽

Skeletal Muscle ◽

Angiotensin Ii ◽

Muscle Tissue ◽

Skeletal Muscle Tissue ◽

Receptor Associated Protein

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Iron Supplementation in Experimental Hyperthyroidism: Effects on Oxidative Stress in Skeletal Muscle Tissue

Yonsei Medical Journal ◽

10.3349/ymj.2004.45.3.413 ◽

2004 ◽

Vol 45 (3) ◽

pp. 413 ◽

Cited By ~ 9

Author(s):

Hakki Oktay Seymen ◽

Sabiha Civelek ◽

Arzu Seven ◽

Günnur Yiğit ◽

Hüsrev Hatemi ◽

...

Keyword(s):

Oxidative Stress ◽

Skeletal Muscle ◽

Muscle Tissue ◽

Iron Supplementation ◽

Skeletal Muscle Tissue ◽

Experimental Hyperthyroidism

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Aerobic and strength training induce changes in oxidative stress parameters and elicit modifications of various cellular components in skeletal muscle of aged rats

Experimental Gerontology ◽

10.1016/j.exger.2018.02.014 ◽

2018 ◽

Vol 106 ◽

pp. 21-27 ◽

Cited By ~ 9

Author(s):

Thais Ceresér Vilela ◽

Pauline Souza Effting ◽

Giulia dos Santos Pedroso ◽

Hemelin Farias ◽

Lara Paganini ◽

...

Keyword(s):

Oxidative Stress ◽

Skeletal Muscle ◽

Strength Training ◽

Aged Rats ◽

Oxidative Stress Parameters ◽

Cellular Components ◽

Stress Parameters

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PO-167 Effects of Hydrogen-rich Water on Rat Skeletal Muscles' Oxidative Damage and Autophagy Induced by Repeated Exhaustive Exercise

Exercise Biochemistry Review ◽

10.14428/ebr.v1i4.11943 ◽

2018 ◽

Vol 1 (4) ◽

Author(s):

Zujie Xu ◽

Hongdi Gu ◽

Zhenjun Tian

Keyword(s):

Oxidative Stress ◽

Skeletal Muscle ◽

Protein Expression ◽

Muscle Tissue ◽

Skeletal Muscle Tissue ◽

Exhaustive Exercise ◽

Ultrastructural Changes ◽

Sod Activity ◽

Hydrogen Water ◽

Mda Content

Objective This study was carried out to detect the effects of hydrogen-water intervention on oxidative stress and cell autophagy in skeletal muscle of rats with repeated exhaustion. Methods 30 male SD rats in the age of 3 months, weighing 180-210g, were randomly divided into control group (C), repeated exhaustion group (EX), and the repeated exhaustion with hydrogen intervention group (EH), 10 rats in each group. The EX and EH groups were subjected to a four-weeks of repeated-exhaustive exercise. The initial speed of the exercise was 15 m/min, and increasedby 5 m/min every 5 min, the final speed is 35m/min until exhaustion, 5 d/wk, with a total of 4 wk. In EH group, hydro-water was given to rats 30 mins before exercise. The ultrastructural changes of skeletal muscle were observed by using a transmission electron microscopy. Activity of SDH and CK in serum and SOD activity, MDA content and T-AOC level in skeletal muscle tissue were detected. Western blotting was used to detect the proteins expression of autophagy related proteins in skeletal muscle, mTOR, p-mTOR, LC3B-2 and P53. Results Compared with the EX group, in the EH group, the ultrastructural damage and mitochondrial swelling were significantly reduced, and the time of exhaustion was significantly prolonged (p<0.05), Serum SDH activity increased significantly (p<0.05), CK activity decreased significantly (p<0.05), and skeletal muscle tissue SOD activity and total antioxidant capacity significantly increased (p<0.05), MDA content decreased significantly (p<0.01), mTOR and p-mTOR protein expression was significantly increased(p<0.05), the LC3B-2 and P53 protein expression was significantly lower (p<0.05). Conclusions Hydrogen water intervention could significantly improve repeatedly exhaustion exercise result in rat skeletal muscle injury, oxidative stress and cell ultrastructure damage excessive autophagy, improving oxidation resistance of the skeletal muscle and exercise endurance.

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Ethanol-Mediated CYP1A1/2 Induction in Rat Skeletal Muscle Tissue

Experimental and Molecular Pathology ◽

10.1006/exmp.2000.2328 ◽

2000 ◽

Vol 69 (3) ◽

pp. 223-232 ◽

Cited By ~ 14

Author(s):

Cheryl Smith ◽

S.Craig Stamm ◽

Jack E. Riggs ◽

William Stauber ◽

Veronica Harsh ◽

...

Keyword(s):

Skeletal Muscle ◽

Muscle Tissue ◽

Skeletal Muscle Tissue ◽

Rat Skeletal Muscle

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Innovative approaches to identifying the relationship between the distribution of the concentration of enzymes in the blood serum and skeletal muscle tissue of rats

E3S Web of Conferences ◽

10.1051/e3sconf/201913501098 ◽

2019 ◽

Vol 135 ◽

pp. 01098

Author(s):

Pavel Boriskin ◽

Olga Gulenko ◽

Anatoliy Deviatkin ◽

Rufia Karimova ◽

Olga Pavlova

Keyword(s):

Oxidative Stress ◽

Skeletal Muscle ◽

Blood Serum ◽

Muscle Tissue ◽

Functional Activity ◽

Active Oxygen Species ◽

Free Radical Oxidation ◽

The Body ◽

Skeletal Muscle Tissue ◽

Radical Oxidation

One of the reasons for the increase in disability and mortality among the working population is cardiovascular diseases. Long-term studies of the nature of diseases belonging to this group hypertension, renovascular and malignant arterial hypertension, dyslipidemia, diabetic and dilatational cardiomyopathy, atherosclerosis, ischemic heart disease show that the main cause of pathogenesis is the formation of oxidative stress under the influence of internal and external environmental factors. Mismatch between the processes of free-radical oxidation caused by such active oxygen species as superoxide-anion radical, hydroxide-radical radical, lipid radical, hydrogen peroxide, peroxynitrite, chloric acid and the capabilities of the antioxidant system leads to a disruption of the functional activity of cell structures, displacement of homeostatic balance in the body. Despite the rather deep study of cardiovascular system pathologies, data on the functional activity of myocardial cells under destructive effects and oxidative stress are still insufficient.The article presents the study of the interrelation of the concentration distribution of enzymes of the lipidantioxidant peroxidation system in blood serum and skeletal muscle tissue of white non-pedigree rats. By means of Spearman, Gamma and Kendel Tau correlation coefficients it was revealed a reliable presence of a weak force of inverse correlation between the concentration of catalase in blood serum and skeletal muscle (Spearman R = -0.21 at p < 0.011749, Gamma = -0.14 at p < 0.010977; Kendall Tau = -0.14 at p < 0.010977).

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