Morpho-functional alterations in lymphocytes and erythrocytes of Japanese quail due to prolonged in vivo exposure to heavy metal complexes

2020 ◽  
Vol 59 ◽  
pp. 126472 ◽  
Author(s):  
Damir Suljević ◽  
Lejla Hodžić-Klapuh ◽  
Nejira Handžić ◽  
Muhamed Fočak
Keyword(s):  
Heavy Metal ◽  
Metal Complexes ◽  
Japanese Quail

Induction of Apoptosis by Nano‐Synthesized Complexes of H2L and its Cu(II) Complex in Human Hepatocellular Carcinoma Cells

2020 ◽  
Vol 20 ◽  
Author(s):  
Thoria Diab ◽  
Tarek M. Mohamed ◽  
Alaa Hamed ◽  
Mohamed Gaber
Keyword(s):  
Cell Cycle ◽  
Metal Complexes ◽  
Hepg2 Cells ◽  
Therapeutic Potential ◽  
Free Ligand ◽  
Organometallic Complexes ◽  
Phase Cell ◽  
Sod Activity ◽  
Induced Apoptosis

Background: Chemotherapy is currently the most utilized treatment for cancer. Therapeutic potential of metal complexes in cancer therapy has attracted a lot of interest. The mechanisms of action of most organometallic complexes are poorly understood. Objective: This study was designed to explore the mechanisms governing the anti-proliferative effect of the free ligand N1,N6‐bis((2‐hydroxynaphthalin‐1‐yl)methinyl)) adipohydrazone (H2L) and its complexes of Mn(II), Co(II), Ni(II) and Cu(II). Methods: Cells were exposed to H2L or its metal complexes where cell viability determined by MTT assay. Cell cycle was analysed by flow cytometry. In addition, qRT-PCR was used to monitor the expression of Bax and Bcl-2. Moreover, molecular docking was carried out to find the potentiality of Cu(II) complex as an inhibitor of Adenosine Deaminase (ADA). ADA, Superoxide Dismutase (SOD) and reduced Glutathione (GSH) levels were measured in the most affected cancer cell line. Results: The obtained results demonstrated that H2L and its Cu(II) complex exhibited a strong cytotoxic activity compared to other complexes against HepG2 cells (IC50 = 4.14±0.036μM/ml and 3.2±0.02μM/ml), respectively. Both H2L and its Cu(II) complex induced G2/M phase cell cycle arrest in HepG2 cells. Additionally, they induced apoptosis in HepG2 cells via upregulation of Bax and downregulation of Bcl-2. Interestingly, the activity of ADA was decreased by 2.8 fold in HepG2 cells treated with Cu(II) complex compared to untreated cells. An increase of SOD activity and GSH level in HepG2 cells compared to control was observed. Conclusion: The results concluded that Cu(II) complex of H2L induced apoptosis in HepG2 cells. Further studies are needed to confirm its anti-cancer effect in vivo.

scholarly journals Anticancer gold(iii)-bisphosphine complex alters the mitochondrial electron transport chain to induce in vivo tumor inhibition

2021 ◽  
Author(s):  
Jong Hyun Kim ◽  
Samuel Ofori ◽  
Sean Parkin ◽  
Hemendra Vekaria ◽  
Patrick G. Sullivan ◽  
...  
Keyword(s):  
Electron Transport ◽  
Metal Complexes ◽  
Electron Transport Chain ◽  
Chemical Diversity ◽  
Mitochondrial Electron Transport Chain ◽  
Generate Functional ◽  
Tumor Inhibition ◽  
Transport Chain

Expanding the chemical diversity of metal complexes provides a robust platform to generate functional bioactive reagents.

scholarly journals Design of BODIPY dyes as triplet photosensitizers: electronic properties tailored for solar energy conversion, photoredox catalysis and photodynamic therapy

2021 ◽  
Author(s):  
Elena Bassan ◽  
Andrea Gualandi ◽  
Pier Giorgio Cozzi ◽  
Paola Ceroni
Keyword(s):  
Heavy Metal ◽  
Photodynamic Therapy ◽  
Solar Energy ◽  
Metal Complexes ◽  
Energy Conversion ◽  
Electronic Properties ◽  
Solar Energy Conversion ◽  
Photoredox Catalysis

BODIPYs offer a versatile platform to build organic triplet photosensitisers for PDT, TTA upconversion and photocatalysis. Tuning their properties provides the opportunity of replacing heavy-metal complexes and can lead to improved sustainability.

Phosphorescent heavy-metal complexes for bioimaging

2011 ◽  
Vol 40 (5) ◽  
pp. 2508 ◽  
Author(s):  
Qiang Zhao ◽  
Chunhui Huang ◽  
Fuyou Li
Keyword(s):  
Heavy Metal ◽  
Metal Complexes

scholarly journals In vivo and in vitro studies on heavy metal tolerance in Sesbania grandiflora L

2009 ◽  
Vol 3 (2) ◽  
pp. 48-64
Author(s):  
Kadhim M. Ibrahim ◽  
Shaimaa A. Yousir
Keyword(s):  
Heavy Metals ◽  
Heavy Metal ◽  
Metal Tolerance ◽  
Heavy Metal Tolerance ◽  
Heavy Metal Concentration ◽  
Callus Cultures ◽  
Metal Levels ◽  
Whole Plants

Several experiments were carried out to study heavy metal tolerance in tissue cultures or whole plants of S. grandiflora., Callus was induced and maintained on modified Murashige and Skoog, 1962 medium (MS) supplemented with (0.5)mg/l benzyl adenine and (2)mg/l 2,4-phenoxy acetic acid . Heavy metals (Cd, Co, Cu, Cr or Zn) were added to the culture medium at different concentrations as contamination agents. In order to asses the effect of these heavy metals on seed germination; seeds were sown in soil contaminated with different concentrations of heavy metals for 3 weeks. Atomic Absorption Spectrophotometer was used for analysis of samples taken from whole plants and callus cultures. Results showed that callus fresh weight decreased with increasing heavy metal concentration in cultural medium. Germination percentages and plant heights increased over time. However, a reduction occurred in these parameters with increasing heavy metal levels. Percentages of metals accumulated in calli were (0.001, 0.011, 0.012 and 0.013%) at (0.0, 0.05, 0.075 and 0.1)mg/l Cd respectively; (0.001, 0.008, 0.016 and 0.006%) at (0.0, 0.1, 0.25 and 0.5)mg/l Co respectively; (0.001, 0.020, 0.034 and 0.015%) at (0.0, 0.075, 0.2 and 0.5)mg/l Cu respectively; (0.001, 0.013, 0.012 and 0.010%) at (0.0, 0.25, 0.4 and 0.5)mg/l Cr respectively and (0.027, 0.051, 0.059 and 0.056%) at (0.0 , 0.75, 1.0 and 1.5)mg/l Zn respectively. Percentages of metals accumulated in whole plants were (0.08, 0.55, 1.11, 0.83 and 0.44%) at (0.0, 1.0, 2.0, 3.0 and 4.0)mg/Kg soil Cd respectively; (0.11, 0.22, 0.55, 0.47 and 0.44%) at (0.0, 15.0, 30.0 45.0 and 60.0)mg/Kg soil Co respectively; (0.01, 0.10, 0.57, 0.58 and 0.72%) at (0.0, 25.0, 50.0, 75.0 and 100.0)mg/Kg soil Cu respectively. (0.08, 0.80, 1.28, 1.31 and 0.88%) at (0.0, 25.0, 50.0, 75.0 and 100.0)mg/Kg soil Cr respectively and (0.06, 1.11, 1.20, 1.83 and 2.22%) at (0.0, 100.0, 200.0, 300.0 and 400.0)mg/Kg soil Zn respectively.

scholarly journals A Review on in vitro and in vivo Bioremediation Potential of Environmental and Probiotic Species of Bacillus and other Probiotic Microorganisms for Two Heavy Metals, Cadmium and Nickel

2019 ◽  
Vol 16 (1) ◽  
pp. 01-13 ◽  
Author(s):  
Pragya Goyal ◽  
Pranoti Belapurkar ◽  
Anand Kar
Keyword(s):  
Heavy Metals ◽  
Heavy Metal ◽  
Industrial Effluents ◽  
Eukaryotic Cell ◽  
Genus Bacillus ◽  
Form Of Life ◽  
Heavy Metal Remediation ◽  
Remediation Strategies

Microbial assisted remediation is the ray of hope in the current scenario of tremendous heavy metal pollution. The indiscriminate release of heavy metal laden industrial effluents in the water bodies and soil is now manifesting itself in the form of life threatening health hazards to humans. The conventional heavy metal remediation strategies are not only expensive but are ineffective in low metal concentrations. Microbial assisted remediation of heavy metals has come forward as the cheap and easy alternative. Amongst the various bacterial genera actively involved in bioremediation of cadmium and nickel in the environment, genus Bacillus has shown remarkable ability in this respect owing to its various biochemical and genetic pathways. It can perform bioremediation using multiple mechanisms including biosorption and bioaccumulation. This genus has also been able to reduce toxicity caused by cadmium and nickel in eukaryotic cell lines and in mice, a property also found in probiotic genera like Lactobacillus and Bifidobacterium. This paper reviews the role of environmentally present and known probiotic species of genus Bacillus along with different probiotic genera for their various mechanisms involved for remediation of cadmium and nickel.

scholarly journals Medicinal Utility of Some Schiff Bases and their Complexes with First Transition Series Metals: A Review

2021 ◽  
Vol 37 (5) ◽  
pp. 1051-1061
Author(s):  
Tahmeena Khan ◽  
Saima Zehra ◽  
Almas Alvi ◽  
Umama Fatima ◽  
Alfred J. Lawrence
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Present Review ◽  
Potential Drug ◽  
Drug Candidates ◽  
Transition Series ◽  
Low Toxicity ◽  
Activity Enhancement

Schiff based ligands and their complexes have emerged as potential drug candidates. Owing to their excellent chelating tendency, they easily coordinate with transition metals which have vacant orbitals. Transition metal complexes have several advantages because of their better acceptability and low toxicity in biological systems. These metals also serve as micronutrients and as co-factors of various metallo-enzymes which justifies the need of their designing and synthesis. Many modifications have been suggested in the ligand moiety for the purpose of activity enhancement and some of them have been described in the present review. These modifications have enhanced better potency against a number of diseases and resulting in low toxicity and better solubility in vivo. The transition metal complexes with Schiff based complexes have exhibited an array of activities including anticancer, antioxidant and antimicrobial. Their analytical applications have also been reported. The present review summarizes some of the recent advances in the field of synthesis and designing of new Schiff based complexes particularly with first transition series metals and their medicinal applications.

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