PND53 Predictive Models Leveraging Machine Learning and Real-World Data for Early Diagnosis: An Application in Amyotrophic Lateral Sclerosis

2021 ◽  
Vol 24 ◽  
pp. S169
Author(s):  
R. Nathan ◽  
C. Miller ◽  
O. Shukla ◽  
A. Garbayo ◽  
M. Hagan ◽  
...  
Keyword(s):  
Machine Learning ◽  
Amyotrophic Lateral Sclerosis ◽  
Early Diagnosis ◽  
Real World ◽  
Predictive Models ◽  
Real World Data ◽  
World Data ◽  
Lateral Sclerosis

scholarly journals Developing a machine learning environmental allergy prediction model from real world data through a novel decentralized mobile study platform.

2020 ◽  
Author(s):  
Chethan Sarabu ◽  
Sandra Steyaert ◽  
Nirav Shah
Keyword(s):  
Machine Learning ◽  
Real World ◽  
Predictive Models ◽  
Clinical Care ◽  
Sensor Data ◽  
Real World Data ◽  
World Data ◽  
Demographic Groups ◽  
Prediction And Prevention ◽  
Wide Range

Environmental allergies cause significant morbidity across a wide range of demographic groups. This morbidity could be mitigated through individualized predictive models capable of guiding personalized preventive measures. We developed a predictive model by integrating smartphone sensor data with symptom diaries maintained by patients. The machine learning model was found to be highly predictive, with an accuracy of 0.801. Such models based on real-world data can guide clinical care for patients and providers, reduce the economic burden of uncontrolled allergies, and set the stage for subsequent research pursuing allergy prediction and prevention. Moreover, this study offers proof-of-principle regarding the feasibility of building clinically useful predictive models from 'messy,' participant derived real-world data.

scholarly journals Validation of machine learning models to predict dementia-related neuropsychiatric symptoms in real-world data

2020 ◽  
Author(s):  
Javier Mar ◽  
Ania Gorostiza ◽  
Oliver Ibarrondo ◽  
Carlos Cernuda ◽  
Arantzazu Arrospide ◽  
...  
Keyword(s):  
Machine Learning ◽  
Depressive Symptoms ◽  
Real World ◽  
Predictive Models ◽  
Neuropsychiatric Symptoms ◽  
Health Record ◽  
Kappa Index ◽  
Real World Data ◽  
World Data ◽  
Electronic Health

Abstract Background Neuropsychiatric symptoms (NPS) are the leading cause of the social burden of dementia but their role is underestimated. The objective of the study was to validate predictive models to separately identify psychotic and depressive symptoms in patients diagnosed with dementia using clinical databases representing the whole population (real-world data). Methods First, we searched the electronic health records of 4,003 patients with dementia to identify NPS. Second, machine learning (random forest) algorithms were applied to build in the training sample (N=3,003) separate predictive models for psychotic and depressive symptoms. In order to evaluate the classification ability of the models, the following statistics were calculated for each model: the area under the receiver operating curve (AUC), sensitivity, specificity, accuracy, no-information rate and Kappa index. Third, calibration and discrimination were assessed in the validation sample (N= 1,000) to assess the performance of the models. A calibration curve was drawn by plotting the predicted probabilities for groups on the x-axis and the mean observed values on the y-axis. Results Neuropsychiatric symptoms were noted in the electronic health record of 58% of patients. The AUC reached 0.80 for the psychotic symptoms model and 0.74 for the depressive symptoms model. The Kappa index and accuracy also showed better discrimination in the psychotic model. Calibration plots indicated that both types of model had less predictive accuracy when the probability of neuropsychiatric symptoms was < 25%. The most important variables in the psychotic symptom model were use of risperidone, level of sedation, quetiapine and haloperidol and the number of antipsychotics prescribed. In the depressive symptom model, the most important variable was number of antidepressants prescribed, use of escitalopram, level of sedation and age. Conclusions More than half of the sample had NPS as identified by the presence of key terms in the electronic health record. Although NPS are not encoded, they are treated with antipsychotics and antidepressants, which allows developing valid predictive models by joining machine learning tools and real-world data. Given their good performance, the predictive models can be used to estimate prevalence of NPS in population databases.

scholarly journals A Descriptive Review of Global Real World Evidence Efforts to Advance Drug Discovery and Clinical Development in Amyotrophic Lateral Sclerosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Suzanne F. Cook ◽  
Thomas Rhodes ◽  
Courtney Schlusser ◽  
Steve Han ◽  
Chao Chen ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Amyotrophic Lateral Sclerosis ◽  
Natural History ◽  
Rare Disease ◽  
Real World ◽  
Market Access ◽  
Real World Data ◽  
World Data ◽  
Patient Reported ◽  
Lateral Sclerosis

Understanding patient clinical progression is a key gateway to planning effective clinical trials and ultimately enabling bringing treatments to patients in need. In a rare disease like amyotrophic lateral sclerosis (ALS), studies of disease natural history critically depend on collaboration between clinical centers, regions, and countries to enable creation of platforms to allow patients, caregivers, clinicians, and researchers to come together and more fully understand the condition. Rare disease registries and collaborative platforms such as those developed in ALS collect real-world data (RWD) in standardized formats, including clinical and biological specimen data used to evaluate risk factors and natural history of disease, treatment patterns and clinical (ClinROs) and patient- reported outcomes (PROs) and validate novel endpoints. Importantly, these data support the development of new therapeutics by supporting the evaluation of feasibility and design of clinical trials and offer valuable information on real-world disease trajectory and outcomes outside of the clinical trial setting for comparative purposes. RWD may help to accelerate therapy development by identifying and validating outcome measures and disease subpopulations. RWD can also make potential contributions to the evaluation of the safety and effectiveness of new indications for approved products and to satisfy post-approval regulatory and market access requirements. There is a lack of amalgamated information on available registries, databases, and other sources of real-world data on ALS; thus, a global review of all available resources was warranted. This targeted review identifies and describes ALS registries, biobanks and collaborative research networks that are collecting and synthesizing RWD for the purposes of increasing patient awareness and advancing scientific knowledge with the hope of expediting future development of new therapies.

scholarly journals ADES: A New Ensemble Diversity-Based Approach for Handling Concept Drift

2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Tinofirei Museba ◽  
Fulufhelo Nelwamondo ◽  
Khmaies Ouahada
Keyword(s):  
Machine Learning ◽  
Real World ◽  
Data Streams ◽  
Predictive Models ◽  
Concept Drift ◽  
Dynamic Environments ◽  
Real World Data ◽  
World Data ◽  
Different Types ◽  
Concept Drifts

Beyond applying machine learning predictive models to static tasks, a significant corpus of research exists that applies machine learning predictive models to streaming environments that incur concept drift. With the prevalence of streaming real-world applications that are associated with changes in the underlying data distribution, the need for applications that are capable of adapting to evolving and time-varying dynamic environments can be hardly overstated. Dynamic environments are nonstationary and change with time and the target variables to be predicted by the learning algorithm and often evolve with time, a phenomenon known as concept drift. Most work in handling concept drift focuses on updating the prediction model so that it can recover from concept drift while little effort has been dedicated to the formulation of a learning system that is capable of learning different types of drifting concepts at any time with minimum overheads. This work proposes a novel and evolving data stream classifier called Adaptive Diversified Ensemble Selection Classifier (ADES) that significantly optimizes adaptation to different types of concept drifts at any time and improves convergence to new concepts by exploiting different amounts of ensemble diversity. The ADES algorithm generates diverse base classifiers, thereby optimizing the margin distribution to exploit ensemble diversity to formulate an ensemble classifier that generalizes well to unseen instances and provides fast recovery from different types of concept drift. Empirical experiments conducted on both artificial and real-world data streams demonstrate that ADES can adapt to different types of drifts at any given time. The prediction performance of ADES is compared to three other ensemble classifiers designed to handle concept drift using both artificial and real-world data streams. The comparative evaluation performed demonstrated the ability of ADES to handle different types of concept drifts. The experimental results, including statistical test results, indicate comparable performances with other algorithms designed to handle concept drift and prove their significance and effectiveness.

scholarly journals Validation and calibration of machine‐learning predictive models aimed to identify dementia‐related neuropsychiatric symptoms on real‐world data (RWD)

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Javier Mar ◽  
Ania Gorostiza ◽  
Oliver Ibarrondo ◽  
Carlos Cernuda ◽  
Ane Alberdi ◽  
...  
Keyword(s):  
Machine Learning ◽  
Real World ◽  
Predictive Models ◽  
Neuropsychiatric Symptoms ◽  
Real World Data ◽  
World Data

scholarly journals An application of machine learning based on real-world data: Mining features of fibrinogen in clinical stages of lung cancer between sexes

2021 ◽  
Vol 9 (8) ◽  
pp. 623-623
Author(s):  
Fangtao Yin ◽  
Hongyu Zhu ◽  
Songlin Hong ◽  
Chen Sun ◽  
Jie Wang ◽  
...  
Keyword(s):  
Machine Learning ◽  
Lung Cancer ◽  
Data Mining ◽  
Real World ◽  
Real World Data ◽  
World Data ◽  
Clinical Stages
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