High-intensity interval training has beneficial effects on cardiac remodeling through local renin-angiotensin system modulation in mice fed high-fat or high-fructose diets

Life Sciences ◽  
2017 ◽  
Vol 189 ◽  
pp. 8-17 ◽  
Author(s):  
Guilherme de Oliveira Sá ◽  
Vívian dos Santos Neves ◽  
Shyrlei R. de Oliveira Fraga ◽  
Vanessa Souza-Mello ◽  
Sandra Barbosa-da-Silva
Keyword(s):  
Cardiac Remodeling ◽  
High Intensity ◽  
Renin Angiotensin System ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
High Fat ◽  
Angiotensin System ◽  
Beneficial Effects ◽  
High Fructose ◽  
High Intensity Interval

scholarly journals The TOTUM-63 Supplement and High-Intensity Interval Training Combination Limits Weight Gain, Improves Glycemic Control, and Influences the Composition of Gut Mucosa-Associated Bacteria in Rats on a High Fat Diet

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1569
Author(s):  
Marine Dupuit ◽  
Vivien Chavanelle ◽  
Benoit Chassaing ◽  
Fanny Perriere ◽  
Monique Etienne ◽  
...  
Keyword(s):  
Glycemic Control ◽  
High Intensity ◽  
High Fat Diet ◽  
Interval Training ◽  
Standard Diet ◽  
High Intensity Interval Training ◽  
High Fat ◽  
Beneficial Effects ◽  
Α Diversity ◽  
High Intensity Interval

Obesity and prediabetes are the two strongest risk factors of type 2 diabetes. It has been reported that TOTUM-63, a polyphenol-rich plant extract, has beneficial effects on body weight (BW) and insulin resistance in mice fed a high fat diet (HFD). The study aim was to determine whether high-intensity interval training (HIIT) and/or TOTUM-63 supplementation improved body composition and glycemic control and gut microbiota composition in a Western diet-induced obesity rat model. Wistar rats received a standard diet (CTRL; control; n = 12) or HFD (HFD; n = 48) for 16 weeks. Then, HFD rats were divided in four groups: HFD, HFD + TOTUM-63 (T63), HFD + HIIT (HIIT), and HFD + HIIT +T63 (HIIT + T63). Training was performed 4 days/week for 12 weeks. TOTUM-63 was included in diet composition (2%). The HIIT + T63 combination significantly limited BW gain, without any energy intake modulation, and improved glycemic control. BW variation was correlated with increased α-diversity of the colon mucosa microbiota in the HIIT + T63 group. Moreover, the relative abundance of Anaeroplasma, Christensenellaceae and Oscillospira was higher in the HIIT + T63 group. Altogether, these results suggest that the HIIT and TOTUM-63 combination could be proposed for the management of obesity and prediabetes.

Acute effect of high-intensity interval training exercise on redox status in the ovaries of rats fed a high-fat diet

2021 ◽  
Vol 33 (12) ◽  
pp. 713
Author(s):  
Rodrigo L. Furtado ◽  
Jonathan Elias R. Martins ◽  
Maria Alice F. Oliveira ◽  
Denise D. Guerreiro ◽  
Naiza A. R. de Sá ◽  
...  
Keyword(s):  
High Intensity ◽  
High Fat Diet ◽  
Interval Training ◽  
Redox Status ◽  
Female Rats ◽  
Standard Diet ◽  
High Intensity Interval Training ◽  
High Fat ◽  
Antral Follicles ◽  
High Intensity Interval

This study demonstrates the effect of a single high-intensity interval training (HIIT) session on the redox status of rat ovaries with excess adiposity. Forty Wistar female rats (mean (±s.e.m.) weight 94.40 ± 13.40 g) were divided into two groups and fed either a standard diet (SD) or a high-fat diet (HFD) for 62 days. At the end of this period, the rats were subjected to a single HIIT session and were killed 24 h after exercise. Both groups subjected to exercise (SDex and HFDex) generated a significantly higher antioxidant environment by presenting a higher thiol content, which represents a lower oxidation rate of GSH than their respective controls (SD and HFD). The percentage of morphologically normal primary follicles decreased, whereas that of antral follicles increased, in the SDex group. In addition, the HFD group had a higher percentage of degenerated antral follicles than the SD and SDex groups. Cells immunoreactive for α-smooth muscle actin were seen in the cortical stroma and thecal layer enclosing late secondary and tertiary follicles in all groups. Moreover, heme oxygenase and cytochrome P450 family 19 subfamily A member 1 (Cyp19A1) labelling was seen in all antral follicles. Progesterone concentrations were significantly higher in the HFDex than SDex group. In conclusion, this study indicates that a single session of HIIT may result in an improvement in ovary redox status because of metabolic muscle activity by inducing physiological adaptation after exercise in a paracrine manner.

scholarly journals Salutary effects of high-intensity interval training in persons with elevated cardiovascular risk

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 2254 ◽  
Author(s):  
Jerome L. Fleg
Keyword(s):  
Cardiovascular Risk ◽  
Aerobic Capacity ◽  
High Intensity ◽  
Interval Training ◽  
Aerobic Exercise Training ◽  
Moderate Intensity ◽  
High Intensity Interval Training ◽  
Continuous Training ◽  
Beneficial Effects ◽  
High Intensity Interval

Although moderate-intensity continuous training (MICT) has been the traditional model for aerobic exercise training for over four decades, a growing body of literature has demonstrated equal if not greater improvement in aerobic capacity and similar beneficial effects on body composition, glucose metabolism, blood pressure, and quality of life from high-intensity interval training (HIIT). An advantage of HIIT over MICT is the shorter time required to perform the same amount of energy expenditure. The current brief review summarizes the effects of HIIT on peak aerobic capacity and cardiovascular risk factors in healthy adults and those with various cardiovascular diseases, including coronary artery disease, chronic heart failure, and post heart transplantation.

scholarly journals Constant-Moderate and High-Intensity Interval Training Have Differential Benefits on Insulin Sensitive Tissues in High-Fat Fed Mice

2019 ◽  
Vol 10 ◽  
Author(s):  
Sergio F. Martinez-Huenchullan ◽  
Linda A. Ban ◽  
Luisa F. Olaya-Agudo ◽  
Babu Raja Maharjan ◽  
Paul F. Williams ◽  
...  
Keyword(s):  
High Intensity ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
High Fat ◽  
High Intensity Interval

Constant-Moderate and High-Intensity Interval Training Induce Differential Metabolic Benefits on Insulin-Sensitive Tissues in High-Fat Fed Mice

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 746-P
Author(s):  
SERGIO F. MARTINEZ-HUENCHULLAN ◽  
LINDA A. BAN ◽  
LUISA F. OLAYA ◽  
BABU R. MAHARJAN ◽  
CHARMAINE TAM ◽  
...  
Keyword(s):  
High Intensity ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
High Fat ◽  
High Intensity Interval

How high-fat diet and high-intensity interval training affect lipid metabolism in the liver and visceral adipose tissue of rats

2018 ◽  
Vol 14 (1) ◽  
pp. 55-62 ◽  
Author(s):  
M. Ebrahimi ◽  
R. Fathi ◽  
Z. Ansari Pirsaraei ◽  
E. Talebi Garakani ◽  
M. Najafi
Keyword(s):  
Weight Gain ◽  
Lipid Profile ◽  
High Intensity ◽  
High Fat Diet ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
High Fat ◽  
Insulin Effect ◽  
Significant Difference ◽  
High Intensity Interval

Lipogenic and lipolytic pathways are tightly regulated by nuclear receptors and binding proteins, such as farnesoid x receptor (FXR) and sterol regulatory element binding protein 1c (SREBP-1c). We designed this research to study the effects of high-intensity interval training (HIIT) and high-fat diet (HFD) on hepatic and adipose FXR and SREBP-1c gene expression beside the plasma levels of lipid profile and insulin. 24 male Wistar rats were randomly divided into normal (~12% fat) and HFD (~56% fat) groups with or without participating in the 8 weeks HIIT protocol. Results from two-way ANOVA and Pearson tests (P<0.05) showed that the HFD rats experienced a larger weight gain correlated with dyslipidemia and hyperinsulinemia, higher hepatic and adipose SREBP-1c expression and lower hepatic FXR expression compared with normal diet fed rats. Although HIIT rats showed higher hepatic FXR and lower hepatic and adipose SREBP-1c expression and lower weight gain compared with untrained rats, plasma lipid profile levels had not any significant difference between trained and untrained rats. Interestingly, hepatic FXR expression was negatively correlated with weight gain and SREBP-1c expression in both tissues while only the hepatic SREBP-1c was positively correlated to insulin levels. In conclusion, HFD-induced dyslipidemia could occur via the activation of the hepatic SREBP-1c pathway under the insulin effect. Although HIIT rats showed lower SREBP-1c correlated to hepatic FXR activation it seems diet is more effective on lipid profile than HIIT. Also, in presence of HFD, HIIT only affects adipose lipolysis.

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