Faculty Opinions recommendation of High-intensity interval training beneficial effects on body mass, blood pressure, and oxidative stress in diet-induced obesity in ovariectomized mice.

Physical training is used in the control of arterial hypertension (AH), especially in patients with higher levels of blood pressure (BP). However, there are still few studies on the effects of physical training on AH in less advanced stages of the disease. The aim of the present study was to assess the immediate and late acute effects of continuous moderate physical training (CMT) and high intensity interval training (HIIT) in patients with mild AH, and to assess which training method induces a greater hypotensive effect. A female patient, 43 years old, sedentary, diagnosed with mild AH (stage 1), taking Losartana 50 mg twice a day was studied. She underwent one CMT and one HIIT session, one week apart. BP measurements were taken before and after each session, as well as 24 hours before and after the sessions. After the physical training sessions, we observed a drop in the patient's BP that lasted up to 60 minutes, and a reduction in blood pressure levels on the day after the training. We conclude that both training modalities were efficient in reducing the BP of the patient with mild acute immediate and delayed hypertension.

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High-intensity interval training modulates retinal microvascular phenotype and DNA methylation of p66Shc gene: a randomized controlled trial (EXAMIN AGE)

European Heart Journal ◽

10.1093/eurheartj/ehz196 ◽

2019 ◽

Vol 41 (15) ◽

pp. 1514-1519 ◽

Cited By ~ 10

Author(s):

Lukas Streese ◽

Abdul Waheed Khan ◽

Arne Deiseroth ◽

Shafaat Hussain ◽

Rosa Suades ◽

...

Keyword(s):

Oxidative Stress ◽

Gene Expression ◽

Dna Methylation ◽

High Intensity ◽

Interval Training ◽

Retinal Vessel ◽

High Intensity Interval Training ◽

Age Related ◽

High Intensity Interval ◽

Retinal Arteriolar

Abstract Aims Impairments of retinal vessel diameter are associated with major adverse cardiovascular (CV) events. Promoter DNA methylation is a repressor of the mitochondrial adaptor p66Shc gene transcription, a key driver of ageing-induced reactive oxygen species. The study aimed to investigate whether high-intensity interval training (HIIT) affects retinal microvascular phenotype as well as p66Shc expression and oxidative stress in ageing subjects with increased CV risk from the EXAMIN AGE cohort. Methods and results Eighty-four sedentary subjects (mean age 59.4 ± 7.0 years) with ≥2 CV risk factors were randomized into either a 12-week HIIT or standard physical activity recommendations. Retinal arteriolar and venular diameters were measured by use of a retinal vessel analyser. As a marker of oxidative stress plasma 3-nitrotyrosine (3-NT) level was determined by ELISA. Gene expression of p66Shc and DNA methylation were assessed in mononuclear cells by RT-qPCR and methylated-DNA capture (MethylMiner Enrichment Kit) coupled with qPCR, respectively. High-intensity interval training reduced body mass index, fat mass, low-density lipoprotein and increased muscle mass, as well as maximal oxygen uptake (VO2max). Moreover, HIIT restored microvascular phenotype by inducing retinal arteriolar widening (pre: 175 ± 14 µm vs. post: 181 ± 13 µm, P = 0.001) and venular narrowing (pre: 222 ± 14 µm vs. post: 220 ± 14 µm, P = 0.007). After HIIT, restoration of p66Shc promoter methylation (P = 0.034) reduced p66Shc gene expression (P = 0.037) and, in turn, blunted 3-NT plasma levels (P = 0.002). Conclusion High-intensity interval training rescues microvascular dysfunction in ageing subjects at increased CV risk. Exercise-induced reprogramming of DNA methylation of p66Shc gene may represent a putative mechanistic link whereby exercise protects against age-related oxidative stress. Clinical trial registration ClinicalTrials.gov: NCT02796976 (https://clinicaltrials.gov/ct2/show/NCT02796976).

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Ambulatory blood pressure adaptations to high-intensity interval training

Journal of Hypertension ◽

10.1097/hjh.0000000000002630 ◽

2020 ◽

Vol Publish Ahead of Print ◽

Author(s):

Jamie J. Edwards ◽

Katrina A. Taylor ◽

Christian Cottam ◽

Navazh Jalaludeen ◽

Damian A. Coleman ◽

...

Keyword(s):

Blood Pressure ◽

Ambulatory Blood Pressure ◽

High Intensity ◽

Interval Training ◽

High Intensity Interval Training ◽

High Intensity Interval

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Salutary effects of high-intensity interval training in persons with elevated cardiovascular risk

F1000Research ◽

10.12688/f1000research.8778.1 ◽

2016 ◽

Vol 5 ◽

pp. 2254 ◽

Cited By ~ 6

Author(s):

Jerome L. Fleg

Keyword(s):

Cardiovascular Risk ◽

Aerobic Capacity ◽

High Intensity ◽

Interval Training ◽

Aerobic Exercise Training ◽

Moderate Intensity ◽

High Intensity Interval Training ◽

Continuous Training ◽

Beneficial Effects ◽

High Intensity Interval

Although moderate-intensity continuous training (MICT) has been the traditional model for aerobic exercise training for over four decades, a growing body of literature has demonstrated equal if not greater improvement in aerobic capacity and similar beneficial effects on body composition, glucose metabolism, blood pressure, and quality of life from high-intensity interval training (HIIT). An advantage of HIIT over MICT is the shorter time required to perform the same amount of energy expenditure. The current brief review summarizes the effects of HIIT on peak aerobic capacity and cardiovascular risk factors in healthy adults and those with various cardiovascular diseases, including coronary artery disease, chronic heart failure, and post heart transplantation.

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